The hottest Dietary fats Substack posts right now

Higher seed oil intake (measured by linoleic acid) is not linked to worse health and is associated with lower long‑term mortality and better markers like lower inflammation and healthier lipids.
Most anti‑seed‑oil arguments rely on mechanistic, animal, or cherry‑picked evidence and are inconsistent; high‑quality human studies and trials don’t support the claim that seed oils are harmful.
Using stronger methods and measurements (plasma biomarkers, propensity matching, doubly‑robust estimation) removes signals of harm and fails to confirm mechanistic worries like raised arachidonic acid, oxidative damage, vitamin E depletion, or clotting—while saturated fat shows worse associations.

The 2026 U.S. dietary guidelines emphasize "eat real food" and cut back on ultra-processed foods. They stop demonizing saturated fat and explicitly include full-fat dairy and traditional fats like butter and tallow.
The guidelines push prioritizing protein (about 1.2–1.6 g/kg), which will likely nudge people from processed, seed‑oil‑heavy foods toward more meat and dairy and may help population health, though some individuals do better with lower protein.
Because government guidance shapes hospital, school, military, and packaged food choices, this shift could meaningfully reduce seed oil use and change what Americans actually eat, making the institutional impact as important as the individual advice.

Hypothyroidism can present without abnormal hormone levels and might lead to conditions like Chronic Fatigue Syndrome, Fibromyalgia, or Major Depression.
Mitochondrial dysfunction, like in Chronic Fatigue Syndrome, can be linked to low levels of thyroid hormones which normally stimulate mitochondria.
Linoleic acid in the inner mitochondrial membrane plays a crucial role in providing stability through polymerization, despite being an unstable and rare substance.

Cutting out seed oils led to significant health benefits for the author, including weight loss and improved overall well-being.
While the link between PUFAs and obesity is not 100% proven, there is substantial evidence and personal anecdotes supporting the idea.
The author believes that the risks of consuming seed oils outweigh any potential benefits, and will continue to avoid them based on the evidence available.

Teleoanalysis is a technique to determine outcomes of studies that were never conducted, revealing some outrageous scientific approaches.
Critique of statin drugs and cholesterol-lowering industry highlights the minimal life-lengthening benefits at exorbitant costs.
Kendrick's humorous take on saturated fats and cholesterol levels challenges conventional lipid hypothesis, emphasizing the role of stress and blood clotting in heart disease.

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The total-to-HDL cholesterol ratio is an important predictor of heart disease mortality risk, with lower ratios associated with reduced risk across different age groups.
The ratio can indicate how long LDL particles stay in the blood, potentially reflecting the efficiency of LDL receptor activity.
Different dietary fats have varying effects on the total-to-HDL cholesterol ratio, with unsaturated fats and specific saturated fats like lauric acid decreasing the ratio, while trans fats increase it.