The hottest Biomarkers Substack posts right now

Better AI-designed molecules won't automatically make clinical trials faster, because timelines are set by human biology, patient recruitment, logistics, and regulatory processes that take real calendar time.
Clinical trials do two jobs—validation and learning—and AI needs rich human trial data to improve; many important outcomes, especially for chronic diseases and aging, take years to observe so trials remain slow even with better drugs.
Real acceleration requires institutional and regulatory reforms—like validated surrogate endpoints, streamlined review pathways, and better data sharing—because AI alone can only improve trials at the margins until those systems change.

Recent studies shed light on the disrupted blood-brain barrier in Long Covid, with implications for brain fog and inflammation.
Persistent SARS-CoV-2 infections increase the risk of Long Covid, with viral loads indicating active replication.
Interferon-gamma biomarker shows promise in diagnosing and treating Long Covid, potentially aiding in clinical trials.

Tests ordered in health space often don't go deep enough to uncover root causes.
When analyzing health biomarkers, considering the main fuels of mitochondria is crucial.
Understanding the ratios and interactions of biomarkers like lactate, pyruvate, and ketones can reveal important insights for mitochondrial function.

Bryan Johnson spends $2 million annually on his longevity routine.
Bryan Johnson aims to make longevity strategies accessible to everyone.
There are three key types of data that Bryan Johnson may be missing in his longevity plan.

The most useful tests are often overlooked by experts in the health space.
Understanding and supporting mitochondrial function requires analyzing key fuels of the mitochondria.
To truly address health issues, experts should prioritize in-depth analyses over surface-level lab tests.

Get a weekly roundup of the best Substack posts, by hacker news affinity:

Clinical sequencing market is surpassing research in sequencing.
Oncology is the largest clinical market, with a significant revenue.
Companies like Exact Sciences are prominent players in precision oncology testing.

Gil Blander dedicated his life's work to understanding aging and delaying diseases associated with it.
Inside Tracker provides personalized blood and physiological marker testing to help improve health and longevity.
Maintaining low fasting glucose levels, LDL cholesterol, and managing inflammation can extend health span for a better life.