The hottest DNA Sequencing Substack posts right now

And their main takeaways
Category
Top Science Topics

Sarmal - FLASH Sequencing!

ASeq Newsletter • 14 implied HN points • 18 Mar 26
🔬 Science DNA Sequencing
  1. Sarmal is a new company working on DNA sequencing and is pitching a technology called FLASH.
  2. FLASH stands for Fluorescence Activation by Serial Hybridization and is described as involving a polymerase, but the explanation and figure are unclear.
  3. There is a patent for the technology, and deeper details are gated behind a paid subscription paywall.

A Dark Horse.

News Items • 216 implied HN points • 31 Jan 24
🔬 Science DNA Sequencing
  1. Ultima Genomics is launching a machine that can read a human genome for as little as $100.
  2. The Human Genome Project was a significant scientific effort that initially cost ~$3 billion, but now it's only $100.
  3. Advances in technology have greatly reduced the cost of sequencing a human genome.

Ultima Genomics - More Reads Per Bead?

ASeq Newsletter • 36 implied HN points • 20 Feb 24
🔬 Science DNA Sequencing
  1. In DNA sequencing, methods that ensure one bead and one template per droplet can significantly increase throughput.
  2. Ultima Genomics has been working on a method that allows 100% of beads to have product from a single template, potentially doubling throughput.
  3. Ultima's approach shows promise in reducing polyclonal rates, potentially offering an advantage over existing platforms.

DNA Tubes - The HiSeq X Fluidic System

ASeq Newsletter • 29 implied HN points • 13 Dec 23
🔬 Science DNA Sequencing
  1. The HiSeq X DNA sequencer contains about 100 meters of tubing inside for its fluidics system.
  2. The majority of the tubing in the HiSeq X appears to be around 1.5mm OD and 1mm ID, possibly made of PTFE.
  3. The fluidic path of the HiSeq X is structured similarly to the Solexa Genome Analyzer and uses components from the same vendors.
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