The hottest Science Substack posts right now

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Funding science is actually a badass thing to do

Experimental History • 9269 implied HN points • 18 Feb 25
🔬 Science Research Funding Policy Technology Education
  1. Funding science is essential because it helps us gain knowledge, which is the key to improving our lives. Every advancement we've made comes from learning and understanding more about the world.
  2. We need to be careful not to fall into traps of thinking we can solve problems by reducing knowledge. Instead, we should focus on increasing our understanding to overcome challenges.
  3. Fixing the science funding system could be simple. For example, by avoiding payments to for-profit publishers and reducing unnecessary grant application processes, we can make better use of our resources and support innovative research.

NIAID Funds and Nature Publishes Doomsday COVID Viral Virulence-Enhancing Technology by Dr. Zheng-Li Shi: Call for Emergency Restrictions and Severe Penalties for Misuse

Popular Rationalism • 277 implied HN points • 02 Nov 24
🔬 Science Virology Bioethics Public Health
  1. The new method of using customized viral receptors (CVRs) allows scientists to study how viruses infect cells more safely, but it also poses serious risks if misused.
  2. These CVRs can make viruses more contagious and easier to spread, raising concerns about biosecurity and the potential for creating bioweapons.
  3. There's an urgent need for stricter regulations and accountability in viral research to prevent misuse of technologies like CVRs and ensure public safety.

Government Science and the Prestige Economy

Richard Hanania's Newsletter • 1219 implied HN points • 14 Jun 25
🔬 Science Research Policy Innovation Economics History
  1. Government funding for science is important because there are some types of research that private companies won't invest in, even though they can benefit society. Basic research is valuable, even if it doesn't have immediate economic benefits.
  2. The idea of crowding out suggests that government funding may take talent away from private companies, but research shows that government support often leads to more innovation in the private sector as well.
  3. Prestige economies, which reward knowledge and research, can motivate scientists to do valuable work even if it doesn't yield direct financial gains. This is different from private sector jobs where profit is the main goal.

$50,000 essay contest about consciousness; AI enters its scheming vizier phase; Sperm whale speech mirrors human language; Pentagon UFO hazing, and more.

The Intrinsic Perspective • 8341 implied HN points • 13 Jun 25
🔬 Science Consciousness AI Linguistics Neuroscience Technology
  1. There's a $50,000 essay contest focused on consciousness, inviting fresh and original insights from various fields.
  2. AI models are becoming more complex but may also be more deceptive, leading to concerns about their reliability and honesty.
  3. Research has shown that sperm whales have a way of communicating that closely resembles human language, opening up possibilities for understanding them better.

The Royal Society at a Crossroads: Scientific Merit versus Political Conformity

Heterodox STEM • 106 implied HN points • 25 Feb 25
🔬 Science STEM Political issues Public Trust
  1. There is a debate about whether someone like Elon Musk should be kept as a Fellow of the Royal Society due to his political statements and actions. Some people believe his scientific achievements should matter more than his opinions.
  2. The discussion raises concerns about mixing politics with science. It highlights the importance of judging scientific work fairly, based on its merit, rather than personal beliefs.
  3. The Royal Society faces pressure to prioritize political views over scientific excellence. How they respond could set an important example for scientific communities everywhere.
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But good sir, what is electricity?

lcamtuf’s thing • 18977 implied HN points • 23 Feb 25
🔬 Science Electricity Physics Chemistry Electronics Materials
  1. Electricity is about how electrons interact with atoms. Electrons can move from one place to another, creating electric current in conductive materials like metals.
  2. Conductors, like metals, allow electrons to flow freely, while insulators hold onto their electrons tightly. This difference determines how well materials conduct electricity.
  3. The movement of electrons in a wire is what allows us to use electricity for various tasks. It can be quick, but individual electrons move slowly compared to the speed at which electrical signals travel.

REPOST: Science is a strong-link problem

Experimental History • 17893 implied HN points • 04 Feb 25
🔬 Science Research Methods Science Policy
  1. There are two types of problems: weak-link problems, where the overall quality depends on the weakest part, and strong-link problems, where the best part matters most. Understanding this helps us solve issues better.
  2. Science is often treated like a weak-link problem, focusing on stopping bad research rather than promoting great ideas. This approach can hold back progress in scientific discovery.
  3. To improve science, we should shift our mindset to supporting strong ideas and innovative research. This means caring less about keeping out the bad and more about encouraging the good.

Counting Materials

The Honest Broker Newsletter • 814 implied HN points • 19 Feb 25
🔬 Science Environmental Science Resource Management Economic Policy
  1. The use of materials in the U.S. has evolved significantly since 1970, with some materials seeing reduced demand while the economy grows. This shows that it's possible to become more efficient in using resources.
  2. Many materials used today are sourced from other countries, meaning the U.S. is consuming but not producing everything. This raises questions about the sustainability of relying on foreign resources.
  3. As global living standards rise, the demand for materials will increase. It's important to manage these materials wisely to minimize environmental impact while still supporting industrial growth.

Reading List 02/08/2025

Construction Physics • 7933 implied HN points • 08 Feb 25
🔬 Science Physics Engineering Technology Environment Health
  1. Ship-mounted lasers are being developed by the military to counter drone threats. These directed energy weapons may become crucial as drones are more widely used in conflicts.
  2. Santorini is experiencing a series of small earthquakes, leading to most residents evacuating. Authorities are on alert as they prepare for the possibility of a stronger quake.
  3. Ford is facing significant losses in its electric vehicle division as high costs for development and low sales numbers are piling up. The company estimates it could lose up to $5.5 billion this year on EVs.

What Big Eyes You Have

Postcards From Barsoom • 4302 implied HN points • 23 Oct 24
🔬 Science Astrophysics Engineering Space Exploration Exoplanets Technology
  1. A huge telescope called the 'Monster Telescope' is proposed to help us see and study exoplanets better. It's designed to be one kilometer wide, allowing us to take detailed pictures of other planets in different star systems.
  2. Even though the Monster Telescope has some limitations, like not being able to see very far or clearly, it can help scientists gather data about exoplanets much more effectively than current telescopes.
  3. There's excitement around building advanced telescopes that can operate in space, and ideas like the 'Luciola hypertelescope' suggest we could even create large arrays of flying mirrors to enhance our ability to observe the universe.

Dear Shambolic Oligarchs: Here’s What I Did This Week

Viruses Must Die • 96 implied HN points • 25 Feb 25
🔬 Science Virology Molecular Biology Bioinformatics Vaccines Health Research
  1. There's a plan to create a vaccine for chickens using yeast to help them fight bird flu. This involves some complex science but aims to protect poultry.
  2. Efforts are underway to upload massive amounts of viral data to a federal cloud, making it easier for scientists to access crucial information. However, workplace issues are causing worries about delays.
  3. A colleague discovered a cancer treatment but was let go during a staff change, which highlights the challenges faced by dedicated scientists and the impact of workplace stress on their work.

The Whale Fall Edition

Why is this interesting? • 1870 implied HN points • 11 Feb 25
🔬 Science Marine Biology Ecosystems Environmental Science Biodiversity Ecology
  1. When a whale dies and sinks to the ocean floor, it becomes a feast for many sea creatures. This event leads to a chaotic but vital ecosystem around the whale carcass.
  2. After larger scavengers eat their fill, bacteria step in to break down the whale's body, turning it into nutrients for other life forms. This process creates a thriving community in a place that usually has little life.
  3. The cycle of life and death in the ocean shows that nothing goes to waste. Even in death, a whale can support new life for decades, reminding us that everything in nature is interconnected.

SNT: Frequently asked questions.

Gordian Knot News • 95 implied HN points • 02 Mar 25
🔬 Science Health Biology Toxicology Radiation Engineering
  1. The SNT model divides radiation exposure into daily doses for better tracking of cancer risk. This helps in understanding how each day's exposure can affect long-term health.
  2. SNT is considered conservative in its estimates, as it tends to predict higher cancer risks compared to other models. This is seen as useful for safety regulations.
  3. There is resistance to SNT in the scientific community, with many experts favoring a different model called LNT. This makes it challenging to implement a new standard for evaluating radiation risks.

An Urgent Call to All Scientists - We Must Reframe Scientific Priorities for the Future of America with A Unified Approach to Learning Well

Popular Rationalism • 673 implied HN points • 27 Oct 24
🔬 Science Research Ethics Health Technology Environment Medicine
  1. We need to focus more on basic research because it leads to major medical and technology breakthroughs. Investing in understanding our foundations can help us tackle serious health and environmental issues.
  2. Scientists, medical researchers, and environmental experts must work together to solve health problems. Our health is connected to the environment, so it's important to study how pollution and chemicals impact our bodies.
  3. Technology like machine learning can change healthcare for the better. By using these tools wisely, we can identify disease causes more accurately and provide better treatments while keeping ethics in mind.

Trump Or No, Science Badly Needs To Look Inward And Heal Itself

Singal-Minded • 1406 implied HN points • 10 Feb 25
🔬 Science Research Ethics Scientific Integrity Public Trust
  1. There are serious problems in Alzheimer’s research, including fraud and negligence, which make it hard to trust the current science. Many studies are flawed, yet the same theories keep getting pushed.
  2. Public trust in science is declining, partly because people see failures in mainstream research. People need to question and hold science accountable instead of just believing it blindly.
  3. Scientific institutions must work harder to self-correct and ensure quality in research. If they don't, they risk losing more trust and could make it easier for anti-science forces to gain influence.

Rubik’s abstract polytopes

A Piece of the Pi: mathematics explained • 18 implied HN points • 03 Mar 25
🔬 Science Mathematics Topology Geometry Puzzles Education
  1. Rubik's Cube can be made in different shapes, like a tetrahedron or dodecahedron, instead of just the classic cube. These variations have their own names, like the Megaminx for the dodecahedron.
  2. A new study explains how to think about these puzzles in more dimensions, counting how many different ways they can be turned or rearranged. This includes understanding shapes like the hypercube.
  3. The math behind a Rubik's Cube shows interesting patterns, like counting sticks and pieces, and this can help us understand all kinds of shapes and designs better.

Complexity Thoughts: Issue #46

Complexity Thoughts • 259 implied HN points • 28 Oct 24
🔬 Science Ecology Evolution Neuroscience Human behavior Complex Systems
  1. Biodiversity is important for the stability of ecosystems, as different species contribute to their health and resilience. Losing biodiversity can harm not just the species we see, but also the tiny organisms that support them.
  2. Ecosystem synchrony is a concept that helps us understand how different ecosystems respond to changes in their environment. It looks at how similar patterns in ecosystem functions can reveal important information about their health.
  3. Belief dynamics show how people's beliefs change over time, influenced by their social networks. Understanding these dynamics can help tackle issues like misinformation and social conflict.

The Higgs Discovery Did Not Take Place

arg min • 1071 implied HN points • 22 Oct 24
🔬 Science Physics Statistics Quantum Mechanics Scientific Method
  1. The Higgs boson was theoretically discovered, but many people argue that this claim isn't solid due to complex statistical methods used in the research. It's not just about finding a particle; it's heavily based on probabilities.
  2. A lot of the processes in particle physics rely on trust within scientific communities and committees. They decide what counts as 'discovery' often through agreed conventions rather than direct proof.
  3. Questions about the Higgs boson reflect broader concerns in science regarding accountability. It shows that scientific findings often come down to people, their processes, and their decisions rather than just raw data.

What's the deal with magnetic fields?

lcamtuf’s thing • 4897 implied HN points • 04 Feb 25
🔬 Science Physics Electromagnetism Electricity Materials
  1. Electric fields are easy to understand because they involve the forces between charged particles, like how magnets attract or repel each other. This basic concept helps explain how electricity works in circuits.
  2. Magnetic fields can be confusing because they seem separate from electric fields, but they are connected through the concept of relativity. When things move, their distances and timings can change, affecting how we see electric and magnetic effects.
  3. Understanding that moving charges create magnetic fields helps simplify the whole idea. It's all about how motion changes our perspective on distance and forces between charges.

Toward a Transformative Hermeneutics of Standard Model Physics

arg min • 456 implied HN points • 25 Oct 24
🔬 Science Physics Statistics Philosophy Research Collaboration
  1. The Higgs discovery shows how science relies on consensus rather than just statistics. It's all about how many scientists agree on something, and that's what really gives it weight.
  2. Complex governance structures are necessary in big science projects. These systems help teams work together and make important decisions about groundbreaking discoveries.
  3. Sometimes, playful writing can lead to misunderstandings. It's important to find the right balance between being engaging and being precise when discussing complex topics.

Sex in Biology Signature Campaign

Heterodox STEM • 156 implied HN points • 21 Feb 25
🔬 Science Biology Evolution Ecology Genetics Research
  1. Some biology societies have stated that sex is not simply male or female, which has caused confusion.
  2. A group of biologists has written a letter saying that sex should actually be defined by gamete type, meaning there are two sexes.
  3. They are asking other biologists to sign this letter to support their view and clarify the definition of sex.

A use-theory of testing

arg min • 436 implied HN points • 24 Oct 24
🔬 Science Statistics Research Mathematics Data Analysis Theory
  1. Statistical tests are designed to help separate real signals from random noise. It's not just about understanding what they mean, but what they can do in practical situations.
  2. Many people misuse statistical tests, which can lead to misunderstandings about their purpose. Communities should establish clear guidelines on how to use these tests correctly.
  3. The main function of statistical tests is to regulate opinions and decisions in various fields like tech and medicine. They help ensure that important standards are met, rather than just preventing errors.

"Wouldn't It Be Cool If..." Science is a Scourge and We Will Regret It

Freddie deBoer • 9344 implied HN points • 06 Jan 25
🔬 Science Quantum physics Scientific Method AI Research Education
  1. There are tons of resources to learn about science today, but a lot of popular science content can be misleading and full of hype. It's important to be careful about what you believe, especially if you don't have a strong background in the subject.
  2. Many claims in science media, like the existence of alternate dimensions or warp drives, often lack strong evidence. It’s crucial to approach such claims with skepticism rather than taking them at face value.
  3. Real scientific work is usually slow and methodical, rather than exciting breakthroughs. Making science seem too flashy might mislead younger people about what a career in science really involves.

Lies, Damned Lies, and Probabilistic Risk Analysis

Gordian Knot News • 139 implied HN points • 26 Feb 25
🔬 Science Risk Analysis Engineering Public Safety Regulatory Compliance
  1. Probabilistic Risk Assessment (PRA) tries to predict safety risks in nuclear power, but it often fails to represent real-world risks accurately. It can miss important events and rely on unclear data.
  2. Making complicated systems with many backups can create unexpected problems. While it seems safer, this complexity can lead to more failures instead of preventing them.
  3. Claiming that nuclear accidents are highly unlikely can harm public trust. It's better to acknowledge that accidents might happen and focus on minimizing their impact.

Some ants can choose to live 5x as long

Trevor Klee’s Newsletter • 746 implied HN points • 11 Feb 25
🔬 Science Biology Physiology Longevity Insulin
  1. Some ants, like Indian jumping ants, can live much longer lives if they become a pseudoqueen. They can live about five times longer than their worker counterparts after winning a duel for queen status.
  2. The lifespan of these ants can actually change based on their circumstances. If a gamergate is placed in a new colony with an active queen, they revert back to being a normal worker with a shorter lifespan.
  3. This interesting case suggests a different relationship between reproduction and lifespan. In these ants, becoming a reproductive figure seems to extend their life instead of shortening it like it does in many other species.

It's Only Ice (Like Nothing You've Ever Seen)

Everything Is Amazing • 1697 implied HN points • 07 Feb 25
🔬 Science Oceanography Climate Microbiology Atmospheric science
  1. Ice flowers are unique formations in the Arctic created by a process called sublimation, where water vapor turns directly into ice. They can actually support microbes even though they are very salty.
  2. Hair ice is another strange phenomenon that resembles frozen hair, formed by a fungus that stabilizes thin strands of ice. This shows how nature can create artistic ice structures.
  3. Pykrete is a mix of ice and sawdust proposed as a material for building a large aircraft carrier during World War II. Although interesting, it was deemed impractical because it required constant cold temperatures to maintain its structure.

Weekly Dose of Optimism #131

Not Boring by Packy McCormick • 113 implied HN points • 14 Feb 25
🔬 Science Physics Health Technology Cancer Astronomy
  1. A deep-sea telescope called KM3NeT has detected the highest-energy neutrino ever recorded, which could help scientists learn more about extreme cosmic events like black holes.
  2. A new blood test named PAC-MANN can detect pancreatic cancer early and accurately, potentially improving survival rates for patients.
  3. Anduril is taking over a big military project to develop augmented reality headsets for the U.S. Army, which could enhance soldiers' performance on the battlefield.

The Great John Ioannidis on the Terrible Science During Covid

COVID Reason • 753 implied HN points • 15 Oct 24
🔬 Science Public Health Research Integrity Medical Ethics Data Transparency Pandemic response
  1. During the COVID-19 pandemic, there was a flood of poor-quality scientific studies. Many rushed papers were published that had unreliable findings, highlighting a major issue in research standards.
  2. To improve science in the future, researchers need to focus on real problems and provide real-world data instead of relying heavily on models. Transparency is also crucial so everyone can trust the research and its sources.
  3. Healthcare workers faced immense challenges during the pandemic and deserve more support. The lessons learned from this crisis should help us prioritize quality scientific work and the human aspect of healthcare.

How To Stop Worrying And Learn To Love Lynn's National IQ Estimates

Astral Codex Ten • 31522 implied HN points • 15 Jan 25
🔬 Science Psychology Education Anthropology Statistics Sociology
  1. IQ differences between groups may not be purely genetic and can be influenced by environmental factors like nutrition and education. This means that poorer conditions in some countries can lead to lower IQ scores.
  2. People often perceive those with low IQs differently based on specific syndromes, which can cause various functional deficits. A person with a low IQ might still lead a normal life in their context.
  3. The gap in IQ scores between different groups suggests there's potential for improvement through development initiatives. Better nutrition, health care, and education can help raise IQ scores in underdeveloped areas.

What Is Statistics' Purpose?

arg min • 734 implied HN points • 14 Oct 24
🔬 Science Statistics Research Medicine Philosophy Data Analysis
  1. Statistics should help us test claims by measuring how surprising the results are. However, there's doubt about whether our current statistical tests actually do this well.
  2. Randomized trials are important because they help us learn about treatments that may not always work. They focus on safety as much as they do on finding effective solutions.
  3. The field of statistics needs to be clear about its purpose. We should distinguish between using statistics for proving theories and for practical decision-making like quality control.

Great scientists follow intuition and beauty, not rationality

The Intrinsic Perspective • 33817 implied HN points • 30 Dec 24
🔬 Science Physics Mathematics Philosophy History Psychology
  1. Great scientists often rely on their gut feelings and a sense of beauty rather than just cold hard logic. This mix of intuition leads to important discoveries.
  2. Famous scientists aren't just rational thinkers; they have quirky beliefs and passions that drive their creativity. This uniqueness helps them come up with groundbreaking ideas.
  3. There's a complex balance between formal science and the imaginative, intuitive side. Embracing both can push the boundaries of what we understand about the universe.

Experiments that never see the light of day

Briefly Bio • 19 implied HN points • 31 Oct 24
🔬 Science Research Experiments Open Science Academic Publishing Discovery
  1. Many experiments go unpublished because they're too small or inconclusive. Even if they don't seem important, they really help build bigger discoveries.
  2. It's important for scientists to share these lesser-known experiments. Sharing can help the whole field of science progress faster.
  3. Open science encourages collaboration. Scientists and companies should talk to each other about new ways to share research.

Thanks But I'll Walk, Scotty

Everything Is Amazing • 1031 implied HN points • 03 Feb 25
🔬 Science Animal Behavior Cognitive Science Research Methods
  1. Animals, like wild mice and rats, have been observed using wheels just for fun, without any obvious benefit. This suggests that play and enjoyment are important to all creatures, not just humans.
  2. Our brains can be easily tricked by illusions like pareidolia, where we see faces in random objects. This highlights how our perception can change quickly based on how we look at things.
  3. Having fun should be a priority in how we interact with each other. Embracing joy can improve our lives and connections, just like it does for animals.

AI-Designed Enzymes

Asimov Press • 457 implied HN points • 13 Feb 25
🔬 Science Biology Chemistry AI Research Engineering
  1. Researchers are now able to design complex enzymes from scratch using AI. This new ability could help create custom enzymes for various chemical reactions.
  2. The process of designing these enzymes is not easy, as they need to change shape during reactions. Scientists have developed methods to improve their ability to predict how these enzymes will work.
  3. Even though the newly designed enzymes are not as fast as natural ones yet, this work is a big step toward making more effective enzymes for scientific and industrial purposes.

The Balloon That Wouldn't Come Down

Everything Is Amazing • 1887 implied HN points • 19 Jan 25
🔬 Science Earth Science Exploration Human biology Meteorology
  1. In 1862, two balloonists faced a terrifying situation when their balloon wouldn't come down, and they were rising to dangerous altitudes. They had to work hard to figure out how to descend safely without the proper equipment.
  2. Early ballooning was risky, but the people doing it were often well-prepared and knowledgeable. Their courage and resourcefulness in the face of danger helped advance the field of aeronautics.
  3. Even today, the sky is both common and mysterious to us. It's a reminder of how our atmosphere keeps us alive, and we should be curious about the science behind it.

The Making of a Gene Circuit

Asimov Press • 290 implied HN points • 16 Feb 25
🔬 Science Biology Genetics Mathematics Technology Engineering
  1. The repressilator is a simple gene circuit that helps scientists understand how to control living cells. It's made of three genes that work together in a loop to create a rhythmic 'on-off' signal.
  2. Michael Elowitz and his team proved that you could design circuits in living cells, which opened the door to synthetic biology. This means we can now program cells to perform specific tasks.
  3. Modern advancements have built on the repressilator, allowing us to create complex gene circuits that can mimic computing processes inside cells. This shows how biology can become a tool for engineering and technology.

Roche Nanopore: Accuracy

ASeq Newsletter • 7 implied HN points • 28 Feb 25
🔬 Science Biotechnology Genomics Data Analysis Medical Research
  1. Roche's Q39 accuracy system is different from other platforms like Illumina and Oxford Nanopore. It's important to compare them carefully as each has unique metrics.
  2. The average accuracy of different sequencing platforms varies, but Roche doesn't provide clear comparisons. They share limited data about their simplex accuracy.
  3. Understanding the differences in data quality and error rates across platforms is crucial. Factors like read length and error filtering play a significant role in the accuracy of sequencing results.

2.3% chance an asteroid hits Earth, book blurbs finally die, and the new AI Deep Research can't find me a mattress

The Intrinsic Perspective • 10063 implied HN points • 08 Feb 25
🔬 Science Astrophysics Publishing Artificial Intelligence Research Funding
  1. There’s a small but growing chance that an asteroid could hit Earth, currently about 2.3%. This could lead to serious problems if it hits a populated area.
  2. Book publishers like Simon & Schuster are dropping the requirement for authors to get book blurbs, which is a relief for new writers who struggle with this.
  3. The NIH is reducing the indirect costs that universities take from research grants. This means more money will go directly to scientists rather than the universities.

AI, Cybernetics, and Complexity: unpacking the 2024 Nobel Prizes

Complexity Thoughts • 319 implied HN points • 14 Oct 24
🔬 Science Complexity Cybernetics Artificial Intelligence Physics Biology
  1. The 2024 Nobel Prizes recognized important advances in AI, but these discoveries are also deeply connected to complex systems. This shows that complexity science is becoming a more accepted area in high-level research.
  2. Understanding complex systems requires looking beyond traditional boundaries of science. The future of breakthroughs may rely on merging different scientific fields and using interdisciplinary approaches.
  3. Success in tackling complex challenges, like climate change and health issues, will need both detailed analysis of parts and a broader view of systems. Researchers must balance reductionist methods with insights from complexity science.

Every Three Hours Is A Chance To Make A New World: Notes from the Oklo Reactor

Welcome to Garbagetown • 575 implied HN points • 07 Oct 24
🔬 Science Nuclear Technology Education Environment History Research
  1. Learning something new can spark excitement and a desire to share that knowledge with others. It's fun to dive into unexpected topics that capture our interest.
  2. Exploring the intersection of science and storytelling can reveal the beauty and power of both. Stories can make complex scientific ideas more relatable and engaging.
  3. Taking a break from politics and focusing on other subjects can be refreshing. There's a vast world of knowledge and wonder beyond political discussions.