The hottest Immunotherapy Substack posts right now

And their main takeaways
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Top Health & Wellness Topics

Metastatic Cancer Treatment Since 2010: The Success Stories

Rough Diamonds • 19 implied HN points • 04 Nov 24
🏥 Health & Wellness Cancer Research Immunotherapy Patient Care
  1. Metastatic cancer is often very serious and many people diagnosed don't survive long. However, some treatments are making progress in helping patients achieve long-term remission.
  2. New treatments, especially immunotherapies, are showing promise in making metastatic cancer disappear in some patients. This is a big deal because it used to be very rare.
  3. There's still a lot of potential to improve cancer treatments. Researchers are exploring many different strategies, and exciting possibilities are on the horizon to help more patients.

A Century-Long Saga of Familial Colorectal Cancer

Holodoxa • 79 implied HN points • 14 Nov 23
🏥 Health & Wellness Genetics Cancer Immunotherapy Prevention
  1. The study of Michigan and Nebraskan families led to the discovery of mutated mismatch repair genes causing hereditary colorectal cancers like Lynch syndrome.
  2. Mismatch repair genes play a crucial role in maintaining DNA integrity and preventing cancer development. Defects in these genes can lead to conditions like microsatellite instability.
  3. Individuals with Lynch syndrome have higher cancer risks associated with certain genes like MLH1 and MSH2, but a relatively good clinical outcome is observed with improved survival rates.

A Dormant Army Within

Holodoxa • 2 HN points • 03 Jul 24
🏥 Health & Wellness Immunotherapy Cancer Treatment Immune System Drug Development
  1. The immune system has key components like T cells which play a crucial role in fighting cancer by harnessing latent immunity.
  2. Researchers like James Allison and Tasuku Honjo have made significant contributions in understanding how cancer evades the immune system and how immune checkpoints like CTLA-4 and PD-1 can be targeted to enhance immune response against cancer.
  3. Cellular immunotherapy, particularly immune checkpoint inhibitors targeting PD-(L)1, has shown great potential in treating various cancers, with some patients showing long-term remissions and ongoing innovative developments in this field.

An Fc engineering approach that modulates antibody-dependent cytokine release without altering cell-killing functions

Axial • 7 implied HN points • 17 Feb 24
🔬 Science Research Engineering Antibodies Immunotherapy
  1. An innovative Fc engineering approach can adjust antibody-dependent cytokine release without impacting cell-killing functions. This shows that manipulating cytokine release independently is possible.
  2. Different IgG isotypes have varying abilities to stimulate proinflammatory cytokine release. This indicates the importance of isotype selection beyond just cytotoxicity.
  3. Engineering antibodies to selectively engage FcγRs can potentially enhance immune responses. This opens up new possibilities for optimizing antibody immunotherapies against cancer.

Unleashing Our Immune Response to Quash Cancer

Ground Truths • 3 HN points • 10 Feb 24
🏥 Health & Wellness Immunotherapy Vaccines
  1. Cancer cells have various tricks to evade targeted therapies like changing their driver mutation and cell identity, stealing the mitochondria from T cells, and spreading predominantly during sleep.
  2. Immune response strategies like immune checkpoint inhibitors, therapeutic cancer vaccines, antibody-drug conjugates, and oncolytic viruses are being developed to combat cancer.
  3. Combining different immunotherapy strategies and approaches like engineering T cells show promise in overcoming the challenges of treating cancer and improving patient outcomes.
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