The hottest Pharma Industry Substack posts right now

And their main takeaways
Category
Top Health Politics Topics
Don't Worry About the Vase • 2374 implied HN points • 17 Mar 26
  1. The FDA is acting inconsistently and retroactively on approvals, and that behavior is chilling investment and innovation in vaccines and other drug development.
  2. Clinical trials and oversight are inefficient and expensive—practices like 100% source data verification and rigid IRB processes waste resources and slow progress, so risk-based monitoring, standardized trial infrastructure, and more flexible accredited reviews could help.
  3. Medical and market developments are moving care forward—AI can improve cancer screening, GLP-1 competition is driving down prices, and simple habits like daily walking give big health benefits—but regulatory and cultural barriers risk limiting their impact.
Unreported Truths • 34 implied HN points • 26 Mar 26
  1. Flu shots for young children give only partial, short-lived protection against lab-confirmed influenza and usually don't reduce overall respiratory illness, so benefits are limited and require yearly repeats.
  2. Trials have reported rare but serious adverse events and many studies lack true placebo controls, leaving the true short- and long-term risks of repeated annual vaccination starting in infancy unclear.
  3. Given the modest benefits and uncertain risks, strong public-health pressure to vaccinate all healthy kids against flu is questionable and should be re-evaluated to rebuild parental trust.
Unreported Truths • 27 implied HN points • 29 Jan 26
  1. More Americans now list affording medical care as their top financial worry, even above housing and transportation.
  2. Concern about healthcare costs crosses party lines and many voters distrust both major parties to fix it, making the issue politically potent.
  3. Democrats favor expanding subsidies and coverage while Republicans face hard choices, and entrenched health-industry power makes big reform risky even though a simple, bold message could win voter support.
Viruses Must Die • 52 implied HN points • 27 Dec 25
  1. Talk to vaccine skeptics with empathy and without sneering; listening and explaining things simply helps conversations go much better.
  2. Distrust of institutional scientists and Big Pharma fuels skepticism, but independent scientists also deserve critical scrutiny—avoid reflexive tribalism on either side.
  3. Vaccine beer might appeal to some skeptics if it’s transparent, clearly not coercive (for example, visibly colored), and developed with feedback from skeptical communities beyond one’s family.
Unreported Truths • 75 implied HN points • 11 Dec 25
  1. Some mainstream outlets and officials have finally acknowledged that mRNA COVID vaccines may have caused deaths among children, years after the shots were rolled out.
  2. Vaccine makers and some journals reportedly withheld or downplayed negative trial results and side effects, delaying proper scrutiny of mRNA vaccine risks.
  3. That handling has eroded public trust in medicine and prompted calls for accountability and stricter vaccine approval standards.
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