The hottest Clinical Research Substack posts right now

The brain has a vital connection with the immune system, challenging the old belief that the brain is cut off from it. New studies show that brain immune cells can help prevent and treat diseases.
Recent research has discovered ways to program T cells to respond to brain issues, which may aid in treating brain tumors and autoimmune diseases. This could lead to better therapies by specifically targeting brain conditions.
There is a newly understood communication path between the body and brain that controls inflammation and immune responses. Understanding this connection can improve treatments for autoimmune diseases and conditions like Long Covid.

Yale's Integrity Project has been criticized for spreading misinformation about youth gender medicine and the Cass Review. Many argue that their claims are not based on solid evidence.
Critics of the Integrity Project highlight that their arguments often lack proper context or are misleading. They suggest that the project's authors are prioritizing a legal narrative over accurate scientific discourse.
The debate around gender medicine for youth is complicated and filled with differing opinions. It's important to critically evaluate sources and claims to understand the real effects of treatments like puberty blockers.

Lark Health is primarily a weight loss program marketed as a diabetes prevention and overall health coaching service, but its actual effectiveness in sustainable weight loss is questionable.
Results from a study on Lark Health showed that only a small percentage of participants completed the program and the average weight loss achieved was minimal, raising concerns about the program's real impact.
Despite claims of 'clinically proven results,' Lark Health's focus on weight loss rather than holistic health raises ethical questions, especially as it is backed by the CDC and marketed through insurance companies and employers.

Alzheimer's clinical trials still use outdated paper-based tools like the CDR scale, hindering progress in drug development
Industry experts push for novel digital tools to improve clinical trials, aiming for more efficient, reliable, and cost-effective drug development
The shift towards neurotech and digital tools in Alzheimer's research shows promise for advancing diagnostics and treatments, challenging the status quo of reliance on paper-based measures

N-of-1 trials focus on understanding individual patient responses to interventions.
N-of-1 trials are valuable for rare diseases, chronic pain, and long-term treatments.
Using N-of-1 trials can help in predicting response to medications and improve drug development for rare conditions.

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