The hottest Genomics Substack posts right now

And their main takeaways
Category
Top Science Topics

Everything Wrong With: "Illumina: The Measurement Monopoly" Part 8/8

ASeq Newsletter • 7 implied HN points • 14 Mar 24
🔬 Science Genomics
  1. The misconception that the author is independently wealthy is addressed, highlighting the need for funding for their content creation activities.
  2. The discussion covers the vertical integration strategies of AffyMetrix and Illumina in the genomics industry.
  3. There is a desire for a less vertically integrated future in the sequencing industry, focusing on filling sequencers with reagents like qPCR machines.

Axial Discovery - Phenotypic screening

Discovery by Axial • 3 implied HN points • 27 Mar 23
🔬 Science Genomics
  1. Phenotypic screening focuses on identifying specific physical or biochemical traits of interest for drug discovery.
  2. Key rules for effective phenotypic screens include selecting relevant cell models, designing disease-specific assays, and defining clinical-like endpoints.
  3. Advancing phenotypic screening requires improving throughput of complex models, developing translational disease models, enhancing proteomic tools, and integrating phenotypic and target-based screening.

Axial Discovery - Kidney disease

Discovery by Axial • 3 implied HN points • 06 Mar 23
🏥 Health & Wellness Genomics
  1. Kidney disease affects over 30 million people in the US with high healthcare costs.
  2. New tools like genomics, proteomics, and metabolomics show promise in understanding kidney biology and drug development.
  3. CKD is a big opportunity for new treatments, focusing on new MoAs like loss of podocytes, chemokines, JAK inhibitors, and ECM deposition.

Classical-to-Quantum Sequence Encoding in Genomics

Quantum Formalism • 0 implied HN points • 13 Apr 23
🔬 Science Genomics
  1. A special webinar on classical-to-quantum sequence encoding in genomics will take place tomorrow at 4 pm GMT with key insights presented by the team working on QF's data encoding challenge.
  2. The webinar abstract highlights innovative methods that combine diverse fields like Electrical Engineering, Information Theory, and Neural Networks to create efficient data encoding schemes for genomics.
  3. The research explores utilizing lossless compression, wavelet-based encoding, and information entropy in developing classical-to-quantum data encoding methods, offering implications for the future of bioinformatics and quantum computing.

Zaiku Digest | February Newsletter.

Deep-Tech Newsletter • 0 implied HN points • 28 Feb 24
🕹 Technology Genomics
  1. Zaiku Group is establishing a network for quantum genomics research
  2. The Quantum House of Cards paper by Xavier Waintal sparks diverse reactions within the quantum computing community
  3. Zaiku Group advocates for open dialogue between skeptics and optimists in quantum computing for productive discourse
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Yes, Carrots Really Are Orange Because of Orangists

Outlandish Claims • 0 implied HN points • 08 Jun 24
🍲 Food & Drink Genomics
  1. Carrots have a long history and were mostly cultivated for their leaves and seeds initially, with their roots later being consumed by the Roman Empire.
  2. Genomic studies have shown that orange carrots were likely deliberately bred and cultivated in the 16th century, possibly in honor of the House of Orange.
  3. It's important to be aware of overconfidence and skepticism, as historical beliefs can be supported or refuted by emerging evidence, like in the case of the orange carrot's origins.

Biotech Needs Its Hydrogen Atom

Niko McCarty • 0 implied HN points • 25 May 24
🔬 Science Genomics
  1. Biotechnology needs a common foundation, much like how hydrogen is essential to physics. This foundation would help scientists work together more effectively and share their findings.
  2. If scientists could collaborate and understand life better, they could design solutions for diseases and other challenges. This could lead to a future where we have more control over creating living organisms for our needs.
  3. Focusing on studying a simple organism like Mycoplasma genitalium could be key to building this foundation. By deeply understanding it, we could create models that help us predict how other cells function.

ONT Not Suing MGI?

ASeq Newsletter • 0 implied HN points • 04 Nov 24
🔬 Science Genomics
  1. ONT has decided not to sue MGI after all. This means there won't be legal issues between these companies right now.
  2. The decision was reported by GenomeWeb, highlighting a significant change in ONT's approach.
  3. This could impact the business relationship between ONT and BGI, since they are linked in some way.

Roche Nanopore: First Thoughts (pt2)

ASeq Newsletter • 0 implied HN points • 20 Feb 25
🕹 Technology Genomics
  1. Roche is developing a new duplex approach that improves sequencing accuracy significantly, moving from Q20+ to around Q39. This is a big upgrade for DNA sequencing.
  2. The company aims to launch their product in 2026, but early access is expected in 2025. There's a chance they could face challenges during execution.
  3. While Roche's reads are shorter and competitive with other platforms, they will need to handle pricing and compete with long-read technologies from companies like Oxford and PacBio.

Nanopore Sequencing Companies: Geneus

ASeq Newsletter • 0 implied HN points • 15 Feb 25
🕹 Technology Genomics
  1. Geneus is a nanopore sequencing company claiming 99% accuracy in their technology. They use special features that allow many sequencing units to fit on a tiny chip.
  2. Their sequencing method seems to be different from others, focusing on synthesizing a complementary strand with unique tags. This method helps identify the sequence of DNA more effectively.
  3. The advancements in size and technology from Geneus might be huge, but details on how they achieved this remain unclear.

PromethION 84Gb/Flowcell

ASeq Newsletter • 0 implied HN points • 09 Jun 25
🕹 Technology Genomics
  1. The PromethION flowcell has an average output of about 84Gb per run. This is important for understanding how much data you can expect.
  2. In comparison, the PacBio flowcell seems to produce higher quality data with around 120-150Gb. This could make it a better option for some users.
  3. Cost per gigabyte is lower for PacBio, making it potentially more affordable when analyzing large amounts of data.

SemiConBio - Roswell Reboot

ASeq Newsletter • 0 implied HN points • 28 Nov 25
🕹 Technology Genomics
  1. The old Roswell company appears to be rebooting as SemiConBio with a new CEO (Mike Aicher) and a small team still active, which is surprising given expectations they were out of cash.
  2. Recent successful demonstrations of DNA expansion by companies like Roche could lower the technical bar for solid‑state readout technologies, making such sensors more attractive as alternatives to bilayer nanopores.
  3. SemiConBio’s specific sequencing approach probably isn’t a direct fit for reading expanded DNA, but some of its components or techniques might be repurposed to build a high‑speed, solid‑state readout.

QuantumDx

ASeq Newsletter • 0 implied HN points • 10 Feb 26
🕹 Technology Genomics
  1. QuantumDx has shifted from researching FET nanowire DNA sequencing to developing sample-to-answer qPCR platforms.
  2. This represents a big technological pivot toward a more conservative, near-term, market-ready diagnostics strategy instead of experimental sequencing hardware.
  3. The latest update about the company is published as paid, subscriber-only content.

Biotech Week in Review - 05-12-2023

Engineering the Future • 0 implied HN points • 15 May 23
🔬 Science Genomics
  1. DNA storage in hydrogels can last 1000 years, showing potential for efficient information storage.
  2. Mapping the human pangenome with 47 people aids in understanding genetic diversity and phenotypes.
  3. A single genetic mutation in ants created a 'supergene' impacting social organization, hinting at collective behavior research possibilities.