The hottest Genomics Substack posts right now

And their main takeaways
Category
Top Science Topics

The Pet Theory Economy

Nepetalactone Newsletter • 1965 implied HN points • 28 Jan 24
🔬 Science Genomics Virology Health Policy
  1. In the Pet Theory Economy, people defend and promote their theories as if their livelihoods depend on it, driven by the need for traffic and novelty.
  2. Challenging someone's theory is seen as interference with their ability to make a living, leading to a circular logic where blame is shifted.
  3. Focusing on various aspects of issues is valid; one should not be limited to a single perspective or group and should question narratives that feed into a narrow Pet Theory economy.

Nvidia Illumina Acquisition? The AI Foundry for Healthcare – The Hardware of Life

SemiAnalysis • 7576 implied HN points • 27 Sep 23
🕹 Technology Healthcare Genomics AI Compute Data Analysis
  1. Eroom's Law and Moore's Law are critical in Semiconductors and Drug Research, analyzing time, money, and output.
  2. Healthcare, a $4 trillion industry, lags behind in technological progress driven by Moore's Law.
  3. Illumina acquisition by Nvidia could bridge the gap in genomics, addressing bottlenecks and enabling full-stack healthcare solutions.

My review of THE COMING WAVE

Ground Truths • 7567 implied HN points • 09 Sep 23
🕹 Technology AI Genomics Large Language Models
  1. AI is on the brink of transforming our lives with the majority of interactions being with AIs, not people.
  2. The book 'THE COMING WAVE' by Mustafa Suleyman discusses the future of AI integrating life science and digital applications.
  3. The book offers a balanced perspective on AI's potential, historical context, and the challenges and opportunities it presents.
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The Genetic Time Machine: Neanderthals, genomics and hybridization priors

ideassleepfuriously • 982 implied HN points • 16 Jan 24
🔬 Science Genomics Evolutionary biology Anthropology Genetics
  1. 200 thousand years of isolation may not be enough for genetic incompatibilities to develop
  2. Genomics has revolutionized evolutionary biology by providing precise insights with massive amounts of data
  3. The mixing of Neanderthal and modern human lineages led to genetic incompatibilities and selection against Neanderthal-origin DNA in modern humans

Genetic Justice

Parrhesia • 799 implied HN points • 11 Nov 23
🔬 Science Genomics Human nature Social justice
  1. Polygenic scores can predict genetic traits but work better for populations they are 'trained' on.
  2. Social justice advocates stigmatizing genetic research may hinder opportunities for certain ethnic groups.
  3. Taboos around genetic research on traits like intelligence can limit the use of polygenic scores for reproductive decisions.

A Dark Horse.

News Items • 216 implied HN points • 31 Jan 24
🔬 Science Genomics
  1. Ultima Genomics is launching a machine that can read a human genome for as little as $100.
  2. The Human Genome Project was a significant scientific effort that initially cost ~$3 billion, but now it's only $100.
  3. Advances in technology have greatly reduced the cost of sequencing a human genome.

Illumina: The Measurement Monopoly

The Century of Biology • 535 implied HN points • 17 Sep 23
🕹 Technology Biotech Genomics Market dominance Business strategy
  1. DNA sequencing technology has rapidly advanced, transforming biology into an information science.
  2. Illumina emerged as a dominant force in genomics by inventing a new measurement technology and establishing enduring differential returns over time.
  3. Illumina's strategic business properties like cornered resources, switching costs, network economies, scale economies, and branding have enabled its market dominance and recurring revenue from consumables.

What The H*ll Is PPMSeq?

ASeq Newsletter • 21 implied HN points • 17 Feb 24
🔬 Science Biotechnology Genomics Sequencing Bioinformatics
  1. PPMSeq is a duplex sequencing technique that ensures high accuracy reads by reading both forward and reverse strands of a double-stranded sequence.
  2. Ultima's PPMSeq works by amplifying both strands on the same bead and utilizing a tag to identify their presence, with errors causing radical dephasing which is taken care of by downstream software.
  3. Approaches to implementing PPMSeq on Ultima's platform involve reading both strands in both directions simultaneously or keeping the product on beads in the same orientation, each with its own challenges and considerations.

PacBio Market Cap <$1B

ASeq Newsletter • 7 implied HN points • 18 Mar 24
🕹 Technology Market Analysis Genomics Competitors Sequencing
  1. PacBio's market cap drops below $1B, making it potentially attractive for acquisition.
  2. Despite some positives like new instruments and competitive specs, PacBio faces challenges in gaining traction for long-read sequencing in clinical settings.
  3. The majority of PacBio's IP expires in 2029, raising concerns that competitors could enter the market in the near future.

Some Thoughts On 10X Genomics

ASeq Newsletter • 36 implied HN points • 18 Jan 24
🔬 Science Genomics Competitors Market Growth
  1. Spatial revenue for 10X Genomics is increasing, while single cell revenue growth is slowing down.
  2. There may not be much growth expected in single cell applications for 10X Genomics, but spatial sequencing shows potential for growth.
  3. 10X Genomics faces competition in the single cell market, but may retain a significant market share.

Everything Wrong With: "Illumina: The Measurement Monopoly" Part 8/8

ASeq Newsletter • 7 implied HN points • 14 Mar 24
🔬 Science Genomics Biology Technology Business Analysis
  1. The misconception that the author is independently wealthy is addressed, highlighting the need for funding for their content creation activities.
  2. The discussion covers the vertical integration strategies of AffyMetrix and Illumina in the genomics industry.
  3. There is a desire for a less vertically integrated future in the sequencing industry, focusing on filling sequencers with reagents like qPCR machines.

Ultima Unpatterned Flowcells

ASeq Newsletter • 14 implied HN points • 14 Feb 24
🔬 Science Biotechnology Genomics Technology Research Innovation
  1. Ultima has transitioned to using unpatterned flowcells, which are cheaper and possibly work well with minor drawbacks.
  2. Ultima's manufacturing using unpatterned flowcells involves surface treatment and spin coating to attach and shrink beads for better identification and access.
  3. The occupancy and loading efficiency of Ultima's unpatterned flowcells suggest a potential capacity for 8 billion reads per run, showing advancements since their 2022 preprints.

Real-time Spatial Sequencing

ASeq Newsletter • 21 implied HN points • 25 Jan 24
🔬 Science Biology Technology Research Innovation Genomics
  1. Real-time spatial sequencing involves obtaining a full time course of RNA as it's transcribed and cleared from cells.
  2. Challenges include releasing RNA from cells without damaging them, determining porous array density, and developing a sequencing method.
  3. Potential solutions include using electroporation or biological nanopores, adjusting array density, and utilizing real-time sequencing approaches.

The Future of Sequencing

ASeq Newsletter • 29 implied HN points • 04 Jan 24
🔬 Science Genomics Automation
  1. Sequencers should be as boring and simple as qPCR machines for easy use and accessibility.
  2. Automation in sequencing should focus on sample-to-answer approaches like the GeneXpert in diagnostics.
  3. Broader adoption of sequencing in clinical applications may require a cultural shift towards valuing diagnosis even without immediate treatment options.

DNA Tubes - The HiSeq X Fluidic System

ASeq Newsletter • 29 implied HN points • 13 Dec 23
🔬 Science Genomics
  1. The HiSeq X DNA sequencer contains about 100 meters of tubing inside for its fluidics system.
  2. The majority of the tubing in the HiSeq X appears to be around 1.5mm OD and 1mm ID, possibly made of PTFE.
  3. The fluidic path of the HiSeq X is structured similarly to the Solexa Genome Analyzer and uses components from the same vendors.

Axial Discovery - Kidney disease

Axial • 29 implied HN points • 06 Mar 23
🏥 Health & Wellness Genomics Drug Development
  1. Over 30 million people in the US are affected by kidney disease, leading to high healthcare costs and lowered quality of life.
  2. New tools like genomics, proteomics, and metabolomics are transforming drug development for kidney diseases.
  3. Companies like Goldfinch Bio and Chinook Therapeutics are developing medicines for rare kidney diseases with defined clinical milestones.

Oxford Nanopore

axialdaily • 19 implied HN points • 17 Mar 23
🕹 Technology Biotech Genomics Startups Innovation
  1. Oxford Nanopore sequences DNA with a nanopore technology.
  2. ONT has made advancements in base-calling and chemistry for improved accuracy.
  3. The company has created a new genomics category and is exploring various applications beyond COVID surveillance.

Axial Discovery - Phenotypic screening

Discovery by Axial • 3 implied HN points • 27 Mar 23
🔬 Science Drug Discovery Genomics Drug Development
  1. Phenotypic screening focuses on identifying specific physical or biochemical traits of interest for drug discovery.
  2. Key rules for effective phenotypic screens include selecting relevant cell models, designing disease-specific assays, and defining clinical-like endpoints.
  3. Advancing phenotypic screening requires improving throughput of complex models, developing translational disease models, enhancing proteomic tools, and integrating phenotypic and target-based screening.

Axial Discovery - Kidney disease

Discovery by Axial • 3 implied HN points • 06 Mar 23
🏥 Health & Wellness Genomics Treatment
  1. Kidney disease affects over 30 million people in the US with high healthcare costs.
  2. New tools like genomics, proteomics, and metabolomics show promise in understanding kidney biology and drug development.
  3. CKD is a big opportunity for new treatments, focusing on new MoAs like loss of podocytes, chemokines, JAK inhibitors, and ECM deposition.

Classical-to-Quantum Sequence Encoding in Genomics

Quantum Formalism • 0 implied HN points • 13 Apr 23
🔬 Science Genomics Quantum Computing Bioinformatics Machine Learning
  1. A special webinar on classical-to-quantum sequence encoding in genomics will take place tomorrow at 4 pm GMT with key insights presented by the team working on QF's data encoding challenge.
  2. The webinar abstract highlights innovative methods that combine diverse fields like Electrical Engineering, Information Theory, and Neural Networks to create efficient data encoding schemes for genomics.
  3. The research explores utilizing lossless compression, wavelet-based encoding, and information entropy in developing classical-to-quantum data encoding methods, offering implications for the future of bioinformatics and quantum computing.