The hottest Biomedical Research Substack posts right now

And their main takeaways
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Reforming the NIH’s Intramural Program

The Good Science Project • 29 implied HN points • 15 Jan 25
🏥 Health Politics Health Policy Biomedical Research Government oversight Public Health
  1. The NIH's Intramural Research Program (IRP) needs major changes to better support innovative research. It was meant for high-risk projects, but now resembles traditional university grant-funded research.
  2. There's a call for more transparency and less bureaucracy in the IRP to help scientists focus on their research. Right now, unnecessary paperwork and spending limits reduce their ability to innovate.
  3. To boost true high-risk research, the IRP should evaluate its ongoing projects compared to other research being done outside the NIH. This way, they can ensure they are doing unique work that couldn’t be done elsewhere.

Some Candid and Scathing Opinions from a Former NIH Insider

The Good Science Project • 48 implied HN points • 16 Dec 24
🏥 Health Politics Public Health Government Policy Biomedical Research Health Reform
  1. NIH has many institutes, but their setup often comes from political pressure, not careful planning. This can create issues when trying to reorganize for better efficiency.
  2. The Scientific Management Review Board (SMRB) was meant to help with changes at NIH, but it lost effectiveness under pressure from leadership, showing the challenges of making serious reforms.
  3. Collins, as the NIH director, was seen as domineering and sometimes pushed decisions without considering others’ views. This behavior can lead to problematic decisions and lack of support within the organization.

Orbital Biolabs: Unleashing Cosmic Potential for Earth's Scientific Progress

Space Ambition • 199 implied HN points • 26 May 23
🔬 Science Biomedical Research Gene-editing Pharmaceuticals
  1. Space labs help scientists learn about biology in unique ways. In microgravity, they can see how living things react differently than on Earth.
  2. New technologies, like 3D printing and gene editing, are being tested in space. This could lead to cool advances in medicine and health back on Earth.
  3. There's a growing trend of private companies joining space research. This means more opportunities for innovative experiments and discoveries.

Vial: Reimagining Clinical Trials

The Century of Biology • 308 implied HN points • 30 Jul 23
🏥 Health & Wellness Clinical Trials Drug Discovery Medical Technology Healthcare system Biomedical Research
  1. Vial is working to reduce the cost of clinical trials by innovating new technology.
  2. Vial's Act I focuses on structuring, digitizing, and automating the clinical trial process to drive efficiency.
  3. Vial's Act II, Battery Bio, aims to revolutionize drug discovery by integrating software and advanced technologies in a vertically integrated approach.

Dashing Data Viz - Issue 234

Dashing Data Viz • 98 implied HN points • 19 Apr 23
🕹 Technology Data Visualization Biomedical Research
  1. Consider ways to find freelance data visualization work through various platforms or lead-generation services.
  2. Explore different data visualization tools and seek resources to understand them better.
  3. Learn how to enhance your data visualization skills by creating appealing and interactive visualizations using tools like Vega-Lite and ggplot2.
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Axial Discovery - Phenotypic screening

Discovery by Axial • 3 implied HN points • 27 Mar 23
🔬 Science Drug Discovery Genomics Drug Development Biomedical Research
  1. Phenotypic screening focuses on identifying specific physical or biochemical traits of interest for drug discovery.
  2. Key rules for effective phenotypic screens include selecting relevant cell models, designing disease-specific assays, and defining clinical-like endpoints.
  3. Advancing phenotypic screening requires improving throughput of complex models, developing translational disease models, enhancing proteomic tools, and integrating phenotypic and target-based screening.