The hottest Research Substack posts right now

And their main takeaways
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Multiple Endocrine Neoplasia Type 1

Holodoxa • 119 implied HN points • 15 Jan 24
🏥 Health & Wellness Research
  1. Multiple Endocrine Neoplasia Type 1 (MEN1) is a rare autosomal dominant disorder caused by germline mutations in the tumor suppressor gene MEN1. Menin, encoded by MEN1, is a scaffold protein involved in various cell functions.
  2. Genetic discovery of MEN1 led to a better understanding of the disease and enabled precision medicine strategies for patients with MEN1 mutations.
  3. Therapeutic options for MEN1 include targeted therapies like somatostatin analogues and mTOR inhibitors, as well as chemotherapies; advancements in understanding menin function have opened up potential novel therapeutic approaches.

Does This Study Really Show How To Maintain Weight Loss?

Weight and Healthcare • 439 implied HN points • 05 Nov 22
🏥 Health & Wellness Research
  1. The study on maintaining weight loss analyzed a small sample of participants who were considered 'successes' by Weight Watchers, a fraction of their total enrollment.
  2. The study included participants who had lost weight and maintained it for just one year, even though research shows weight regain within five years is common.
  3. Many responses in the study highlighted motivations like escaping weight stigma and persevering through challenges, raising questions about the effectiveness of weight loss maintenance strategies.

Embarking on the Product Management Journey: Product Research and Discovery

Product Power by Samet Ozkale • 196 implied HN points • 19 Oct 23
💼 Business Research
  1. Product managers can find ideas through user interviews, trend analysis, personal experiences, and input from internal stakeholders.
  2. Criteria for pursuing an idea include satisfying a need, having a unique selling point, being profitable and in demand, and creating value.
  3. Utilizing the Double Diamond framework can guide product discovery and development by focusing on understanding problems before jumping into solutions.

Love, Attention, Patience: The Secrets of Charles Darwin's Scientific Success

Meaning || Matter • 59 implied HN points • 09 Apr 24
🔬 Science Research
  1. Darwin's success was not just about genius; it was about his love for science, his attention to detail, and his patience in observing the world around him. He worked hard to collect data and make sense of it over many years.
  2. His groundbreaking theory of evolution came from his commitment to understanding nature and his experiences during his voyage on the Beagle. He took every opportunity to explore and study different species and their environments.
  3. Even when faced with challenges and doubts, Darwin continued to gather and analyze evidence, showing that persistence and curiosity are key to making important discoveries.

An AI wrote this

antoniomelonio • 99 implied HN points • 23 Jul 25
🕹 Technology Research
  1. It's hard to tell if something was written by a human or an AI. With AI getting better, you might not even know if you're reading real thoughts or generated text.
  2. Many writers on platforms like Substack might not be creating original content anymore. This raises questions about authenticity and what it means to share thoughts.
  3. AI is improving quickly and it's changing the world we know. We need to accept that these changes are real and think about how we'll adapt.
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Platform Papers 2023 Year in Review

Platform Papers • 139 implied HN points • 19 Dec 23
💼 Business Research
  1. 2023 had a record number of articles on platform competition research, with a 16% increase from the previous year.
  2. Marketing articles in platform competition research saw significant growth, accounting for 27% of published articles in 2023.
  3. The main themes in platform competition research covered network effects, platform pricing, winner-takes-all dynamics, and ecosystem governance, highlighting the impact of platforms on their ecosystems.

July Readings

Brain Pizza • 1191 implied HN points • 11 Jul 23
🔬 Science Research
  1. The post discusses various July readings on topics like anger, self-promotion, sleep, loneliness, and more.
  2. The author, Shane O'Mara, is a neuroscientist, psychologist, and writer who provides regular content on Brain Pizza.
  3. Readers can sign up for a 7-day free trial to access more content from Shane O'Mara.

What will we discover by 2050?

Europe in Space • 98 implied HN points • 08 Feb 24
🔬 Science Research
  1. ESA's Voyage 2050 missions will focus on exploring habitability potential, understanding exoplanets, and probing the early universe.
  2. The process of selecting missions involves public submissions, evaluation meetings, and expert committees.
  3. New missions like ARRAKIHS, CALICO, and THESEUS are pushing boundaries in deep imaging and studying high-energy events.

⤴⤵ Up Wing/Down Wing #55

Faster, Please! • 91 implied HN points • 02 Aug 25
🕹 Technology Research
  1. A new fusion power plant is being built, which could provide energy from fusion reactions. This is a big step toward making fusion energy a reality.
  2. The FDA has approved a new HIV prevention shot that only requires two injections a year. This could help reduce new HIV infections significantly.
  3. There's a growing interest in fusion technology, with significant investments being made globally to develop it further.

Behind the scenes with '24 hours in an invisible epidemic'

Big Charts • 199 implied HN points • 29 Sep 23
🔬 Science Research
  1. The story discusses the correlation between day-to-day activities and happiness, highlighting how social interaction plays a significant role in people's well-being and happiness levels.
  2. Data visualization can sometimes present challenges in clearly conveying findings, emphasizing the importance of ensuring that the visualization aligns with the story being told.
  3. Visualizing individual diaries can make the concept of loneliness feel universal, prompting important conversations about struggles with loneliness in everyday life.

Astronomy and space exploration are shaping our civilization landscape

Space Ambition • 219 implied HN points • 21 Jul 23
🔬 Science Research
  1. Space exploration has greatly influenced our technology and daily lives. From GPS navigation to weather monitoring, many devices we use today were developed because of our quests in space.
  2. Astronomy helped ancient civilizations in navigation and timekeeping. By studying stars, early navigators found their way, and calendars were created to track important agricultural and religious events.
  3. The study of dark matter and other cosmic phenomena might lead to groundbreaking discoveries in the future. These studies could bring about new technologies and a better understanding of our universe.

RDEL #24: How does technical debt impact software engineering morale?

Research-Driven Engineering Leadership • 119 implied HN points • 08 Jan 24
🕹 Technology Research
  1. Technical debt negatively impacts developers' morale by reducing their confidence and hindering their progress
  2. Proper management of technical debt can have a positive influence on developers' morale as it is associated with progress and gratitude
  3. Dealing with technical debt thoughtfully and having a plan to repay it frequently can help minimize its negative impacts on engineering teams

O-Day - Morning, not mourning

Remote View • 196 implied HN points • 12 Feb 23
🔬 Science Research
  1. Discussion on the potential challenges of working technologies
  2. Caution needed when dealing with Fractal Toroidal systems to ensure safety
  3. Respectful treatment of developments in science and technology is essential

Bears, Famine, and Dieting Failure

Weight and Healthcare • 678 implied HN points • 18 May 22
🏥 Health & Wellness Research
  1. Intentional weight loss often results in short-term weight loss followed by long-term weight regain due to the body's biological response to famine-like situations and physical activity.
  2. The body undergoes physiological changes during weight loss attempts to protect against perceived food scarcity and increased physical activity, making long-term weight loss challenging.
  3. Research shows that the majority of intentional weight loss efforts are unsustainable in creating significant long-term weight loss, raising questions about the ethical and evidence-based nature of weight loss interventions.

2023 Kaggle AI Report

Bojan’s Newsletter • 196 implied HN points • 10 Oct 23
🕹 Technology Research
  1. Kaggle is a valuable platform for data science and ML career development
  2. Kaggle solutions often offer innovative insights ahead of research and industry trends
  3. Tabular data ML remains an important area in the field of machine learning

Anomalous Radioactive Variations

Remote View • 196 implied HN points • 29 Mar 23
🔬 Science Research
  1. Joe Parr conducted experiments with pyramids and radioactive sources, noting cyclical variations in radioactive counts possibly linked to moon phases and solar activity.
  2. Parr's hypothesis of a 'hyperspace bubble' forming around the pyramid passing through magnetic fields is based on anomalous events in the data.
  3. The test setups involved rotating pyramids between magnetic fields, with a sophisticated setup to measure radioactive counts and variations.

Open-endedness in Society

Scaling Knowledge • 196 implied HN points • 29 Mar 23
🚌 Education Research
  1. Objectives vs. Open-endedness: Consider if clearly-defined objectives help or hinder impactful discoveries.
  2. Education and Research: Question whether standardized curricula or open-ended curiosity leads to more success in children and scientists.
  3. Novelty Search: Embrace exploration of novel solutions in problem-solving, rather than just following objective-based approaches.

Controversy On Whether Growth Mindset Works Should Strengthen The Theory

The Future of Education • 158 implied HN points • 13 Dec 23
🚌 Education Research
  1. Education research needs to move beyond just identifying 'best practices' and look for nuanced insights that work for specific individuals.
  2. Researchers should focus on deductive research to identify anomalies that can lead to a better understanding of interventions.
  3. Acknowledging anomalies in research can help in providing actionable insights that actually benefit educators and students.

January Newsletter

RSS DS+AI Section • 11 implied HN points • 01 Jan 26
🕹 Technology Research
  1. AI and large language models are advancing rapidly, with major companies and open-source projects pushing innovations in long-context reasoning, memory, and generative capabilities. Competition is driving frequent releases and new research on foundation models and video/world-models.
  2. Ethics, bias, interpretability, and regulation remain central concerns as real-world uses expand, prompting debates, lawsuits, and calls for better safety research. Work on interpretability is seen as especially important for progressing AI more safely.
  3. The community is focusing on practical adoption and professionalisation through tutorials, production tips, projects, workshops, a new journal, and competency frameworks. There are also learning opportunities, internships, and calls for volunteers to help shape best practices and careers.

Quick Guide: Will Weight Loss Improve/Cure This Health Condition?

Weight and Healthcare • 379 implied HN points • 03 Dec 22
🏥 Health & Wellness Research
  1. Weight loss may not necessarily improve health conditions; health changes may stem from behavior changes instead.
  2. Unintentional weight loss or weight loss through methods like liposuction may not lead to the same health benefits as intentional weight loss.
  3. The presence of a health issue in thin individuals suggests that weight loss might not always be the solution; alternative treatments beyond weight loss exist.

"Now...Where Was I?"

Everything Is Amazing • 868 implied HN points • 04 Dec 23
🔬 Science Research
  1. Memories and the science behind them are fascinating and much stranger than we think.
  2. Some sea creatures, like the leaf sheep, perform photosynthesis just like plants.
  3. Learning about memory can involve tricks to store and retrieve information in our brains.

The Sequence Opinion #694: From Proof Engines to Polymaths: How AI Conquered the International Math Olympiad

TheSequence • 91 implied HN points • 30 Jul 25
🕹 Technology Research
  1. AI has advanced significantly, now able to solve complex math problems at an Olympiad level. This shows how much smarter and capable AI has become.
  2. Recent competition results indicate that general AI models can perform creative problem-solving, moving beyond just following rules.
  3. The evolution of AI from specialized models to general-purpose ones highlights the rapid growth in technology and its potential applications.

New Science January 2024 Updates

New Science • 98 implied HN points • 01 Feb 24
🔬 Science Research
  1. New Science is focusing on creating an institution of science for an ever-changing world.
  2. They are working on deliverables like a playbook for fellowship programs and collaborating with new team members.
  3. The organization is under new leadership, with Sasha Targ becoming the Executive Director.

Evaluating LLMs is a minefield

AI Snake Oil • 955 implied HN points • 04 Oct 23
🕹 Technology Research
  1. Evaluating LLMs can be highly challenging.
  2. Current methods for evaluating chatbots and large language models need improvement, especially regarding societal impact.
  3. Research is essential to enhance evaluation techniques for LLMs.

Edu-Snippets

The Science of Learning • 219 implied HN points • 24 Jul 23
🚌 Education Research
  1. Retrieval practice helps all students remember what they learned better, whether they know a lot or a little about a topic. It involves recalling information, like through quizzes, and boosts memory retention.
  2. Studying over spaced intervals is more effective than cramming all at once. Mixing up different subjects or topics during study sessions can also improve learning by making it more engaging.
  3. Many college students don't realize how beneficial spacing and mixing subjects can be for their studying. Teaching them about these techniques can help them study smarter and remember better.

DeepSeek: Frequently Asked Questions

Artificial Ignorance • 243 implied HN points • 28 Jan 25
🕹 Technology Research
  1. DeepSeek is a new AI company that has made a big impact by focusing on research instead of just selling products. It started quietly but became popular with its recent models that work well and are cheaper than competitors.
  2. Their latest products, DeepSeek V3 and R1, perform similarly to big names like ChatGPT but at much lower prices, making AI more accessible. People can even use their chatbot for free on their website.
  3. DeepSeek's success has raised questions about the future of AI development, suggesting that state-of-the-art systems can be built without spending billions. This shift in the industry has attracted significant attention and worry from major tech companies.

Last Week in AI #245: OpenAI Dev Day, Gen AI's impact on white-collar jobs, EU's AI Act negotiations stall, Humane's wearable AI assistant, and more!

Last Week in AI • 178 implied HN points • 13 Nov 23
🕹 Technology Research
  1. OpenAI introduced new features like GPT-4 Turbo and custom GPT bots without coding at their developer event.
  2. Generative AI like ChatGPT is impacting freelance jobs, but assisting consultants in productivity and quality.
  3. Negotiations for the EU's AI Act stalled over regulating foundation models, posing a risk to the entire law.

Coming Soon! Science & Scientism

Fields & Energy • 139 implied HN points • 05 Dec 23
🔬 Science Research
  1. The discussion will explore the differences between science and scientism, which refers to an excessive reliance on scientific methods or claims.
  2. Francis Bacon is a key historical figure in the development of modern science, particularly with his influence on the Royal Society.
  3. A livestream event featuring experts will dive deeper into these topics, highlighting the philosophical aspects of science.

Barcoding Brains

Asimov Press • 225 implied HN points • 09 Feb 25
🔬 Science Research
  1. Connectomics is a method that maps connections in the brain, helping scientists understand how these connections affect our behavior and brain function. However, it's really slow and expensive to do.
  2. A non-profit called E11 Bio is developing new tools to make brain mapping faster and cheaper. They aim to create a complete map of a mouse's brain in just five years for a fraction of the current cost.
  3. Understanding the brain's connections can improve treatments for various brain diseases and potentially lead to advanced technologies like brain-computer interfaces. This could really change how we approach brain health and artificial intelligence.

The Sequence Radar #684: AI Browsers are Coming

TheSequence • 98 implied HN points • 13 Jul 25
🕹 Technology Research
  1. AI browsers are becoming popular and may change how we use the internet. They offer smart features like conversational search and real-time content help.
  2. New AI browsers, like Perplexity's Comet and the upcoming OpenAI browser, aim to make online research faster and easier by summarizing information and managing tasks.
  3. Traditional browsers are also adding AI features to stay competitive, suggesting that the future of browsing will focus on smart technology rather than just layout and speed.

Misinformation Researcher Sander van der Linden Caught Lying and Spreading Misinformation

The DisInformation Chronicle • 670 implied HN points • 22 Feb 24
🇺🇸 U.S. Politics Research
  1. Misinformation researcher Sander van der Linden was caught lying and spreading misinformation, tarnishing his credibility.
  2. The incident sheds light on the concern that 'misinformation research' might be used for political purposes to silence dissent on controversial topics.
  3. Van der Linden's behavior on social media and Wikipedia highlights potential manipulation to create a false image of credibility and promote personal research.

Here's how to stop the harmful content before it's posted

techandsocialcohesion • 59 implied HN points • 29 Mar 24
🕹 Technology Research
  1. Researchers are exploring using AI to prevent toxic content before it's posted online by prompting users as they type messages.
  2. Users appreciated the concept of receiving alerts about potentially harmful language but had concerns about privacy and disruptions to natural conversation flow.
  3. Implementing proactive measures like AI-based content moderation prompts not only eases the burden on moderation systems but also enhances the quality of online interactions by promoting empathy and understanding.

Top 50 Space Conferences to Propel Your Space Ambition

Space Ambition • 279 implied HN points • 05 May 23
🕹 Technology Research
  1. There are many global space conferences where people can network and share ideas. These events are great for anyone interested in space, from CEOs to scientists.
  2. The conferences cover a range of topics, including business, technology, and academic research. Each event offers chances to meet professionals and learn about the latest developments in space.
  3. Attending these conferences can help spark new ideas and connect people who may become future partners or clients in the space industry.

The Sequence Engineering #661: Create Your Own Deep Research Agent with DeerFlow

TheSequence • 119 implied HN points • 11 Jun 25
🕹 Technology Research
  1. DeerFlow is an open-source tool that helps automate research tasks. It uses multiple agents to make research faster and easier.
  2. The framework can do many tasks, like searching the web and creating reports, with little help from people. This makes it very efficient.
  3. It's designed for developers and engineers who want to build research systems that can grow and adapt easily.

Orange peels, human tests, and LLMs

The Counterfactual • 139 implied HN points • 28 Nov 23
🕹 Technology Research
  1. It's tricky to know what Large Language Models (LLMs) can really do. Figuring out how to measure their skills, like reasoning, is more complicated than it seems.
  2. Using tests designed for humans might not always work for LLMs. Just because a test is good for people doesn't mean it measures the same things for AI.
  3. We need to look deeper into how LLMs solve tasks, not just focus on their test scores. Understanding their inner workings could help us assess their true capabilities better.

'Science Fictions' by Stuart Ritchie is a stupid, confused book, polluted with ideology

Heterodox STEM • 85 implied HN points • 23 Jul 25
🔬 Science Research
  1. The book highlights major issues in science, like fraud and poor management, but also fails to address the real problems caused by centralization and prestige within scientific institutions.
  2. There's a strong critique of being selectively skeptical about certain scientific areas while promoting others without question, suggesting a bias in the author's approach.
  3. A call for a new role of science critics is made, emphasizing the need for independent reviewers who can help evaluate and communicate scientific ideas better.