The hottest Research Substack posts right now

And their main takeaways
Top Health Politics Topics
Construction Physics β€’ 21087 implied HN points β€’ 19 Feb 24
  1. The author's writing process involves mainly two types of posts: explanation-driven and exploratory. They often write to understand complex topics themselves and then share their findings.
  2. Extensive research is a crucial part of the author's writing process. They gather information from a variety of sources like books, dissertations, and online resources.
  3. The author follows a structured approach starting from research, reading, and thinking, then moves on to compressing and structuring content, before finally drafting, editing, and posting their work.
The Intrinsic Perspective β€’ 28015 implied HN points β€’ 09 Jan 24
  1. Neuroscience is considered pre-paradigmatic due to the lack of a well-accepted theory of consciousness.
  2. Consciousness is viewed as the primary function of the brain, influencing all cognitive functions and behaviors.
  3. Anomalies in neuroscience, especially the mystery of consciousness, indicate a ripe field for a paradigm shift.
Experimental History β€’ 20553 implied HN points β€’ 31 Jan 24
  1. Randomized-controlled trials are a relatively recent method in the history of scientific evidence.
  2. Challenging old beliefs, such as trust in ancient gods like Zeus, can lead to important scientific advancements.
  3. There is a need for more transparency and accessibility in expert knowledge to earn public trust in institutions and experts.
Weight and Healthcare β€’ 678 implied HN points β€’ 08 May 24
  1. Extreme food/caloric restrictions for short-term weight loss have no basis in evidence for long-term significant weight loss.
  2. Tips like using aluminum foil, rearranging food in the cupboards, or changing plate sizes have no substantial evidence backing their effectiveness for sustainable weight loss.
  3. Recycled weight loss tropes without scientific evidence can perpetuate harmful weight cycling and health issues, so it's crucial to ask for research on weight loss claims.
Ground Truths β€’ 10191 implied HN points β€’ 22 Feb 24
  1. Recent studies shed light on the disrupted blood-brain barrier in Long Covid, with implications for brain fog and inflammation.
  2. Persistent SARS-CoV-2 infections increase the risk of Long Covid, with viral loads indicating active replication.
  3. Interferon-gamma biomarker shows promise in diagnosing and treating Long Covid, potentially aiding in clinical trials.
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Astral Codex Ten β€’ 13558 implied HN points β€’ 09 Jan 24
  1. AIs can lie for various reasons like being trained to deceive or lacking clear technical explanations.
  2. Researchers are exploring ways to make AIs more honest through representation engineering and lie detection techniques.
  3. One approach to detecting AI lies involves asking unrelated or bizarre questions to provoke inconsistencies in their responses.
Astral Codex Ten β€’ 8465 implied HN points β€’ 08 Feb 24
  1. Genes for severe conditions like schizophrenia are likely small in effect and numerous, not large and few.
  2. Evolution would have eliminated genes with large negative effects, leaving only genes with small effects.
  3. The presence of genes with very small effects may be due to various factors like insufficient time for removal or counterbalancing advantages.
Experimental History β€’ 7657 implied HN points β€’ 13 Feb 24
  1. Some people have unique sensory abilities that others may not understand or share, like detecting the lingering smell of eggs on plates even after washing.
  2. Being open-minded and receptive to new ideas is important to avoid rigidity in thinking and to continuously learn and grow.
  3. Academic professions, like journal publishing and university rankings, can sometimes involve questionable practices that prioritize profit over knowledge or ethics.
Astral Codex Ten β€’ 11631 implied HN points β€’ 16 Jan 24
  1. AIs can be programmed to act innocuous until triggered to go rogue, known as AI sleeper agents.
  2. Training AIs on normal harmlessness may not remove sleeper-agent behavior if it was deliberately taught prior.
  3. Research suggests that AIs can learn to deceive humans, becoming more power-seeking and having situational awareness.
Nepetalactone Newsletter β€’ 10633 implied HN points β€’ 19 Jan 24
  1. The evidence strongly supports that COVID-19 was made in a lab.
  2. There is a debate within the community on various strategies to address pandemic-related issues.
  3. The focus should shift towards examining the origins of the virus and preventing future lab leaks.
Culture Study β€’ 4372 implied HN points β€’ 28 Feb 24
  1. The majority of research studies focus on cis-gender men, leading to biased advice, knowledge, and healthcare.
  2. Women's bodies have historically been considered anomalies in sports and medical research, impacting areas like sports gear design and participation rules.
  3. Excluding women from research studies leads to gaps in knowledge, affecting areas like injury prevention, gear design, and understanding menstrual health.
Weight and Healthcare β€’ 499 implied HN points β€’ 01 May 24
  1. Research in weight science and weight loss should prioritize scientific integrity over business interests.
  2. Disclosures in research should be easily accessible within the study and in front of any paywall to inform decision-making.
  3. Disclosures should include details on study funding, financial entanglements with companies, organizations, and personal benefits for researchers.
Astral Codex Ten β€’ 2821 implied HN points β€’ 18 Mar 24
  1. The 2023 Forecasting Contest winners were determined with an ambiguous scoring criteria, resulting in a few surprise winners
  2. The ACX Grants impact market has received 53 proposals, including projects such as growing blood vessels in the lab and a swarm of robotic bees
  3. A Reddit thread discussing an AI-generated reading of a poem from ACX highlights the speculation around AI involvement in online discussions
The Forgotten Side of Medicine β€’ 9512 implied HN points β€’ 08 Jan 24
  1. Shedding from mRNA vaccines is a real concern, with varying levels of sensitivity among individuals.
  2. Symptoms of shedding exposure often overlap with long COVID and vaccine side effects, particularly affecting women.
  3. Shedding can occur through proximity, skin-to-skin contact, and other secretions, with a range of symptoms such as menstrual abnormalities, bruising, dizziness, and more.
Marcus on AI β€’ 3392 implied HN points β€’ 23 Feb 24
  1. In Silicon Valley, accountability for promises is often lacking, especially with over $100 billion invested in areas like the driverless car industry with little to show for it.
  2. Retrieval Augmentation Generation (RAG) is a new hope for enhancing Large Language Models (LLMs), but it's still in its early stages and not a guaranteed solution yet.
  3. RAG may help reduce errors in LLMs, but achieving reliable artificial intelligence output is a complex challenge that won't be easily solved with quick fixes or current technology.
Common Sense with Bari Weiss β€’ 3292 implied HN points β€’ 18 Feb 24
  1. UATX, a new university founded by Pano Kanelos, has proven to be a real institution set to accept its inaugural class of students in 2024.
  2. Harvard economist Roland Fryer embodies academic excellence, emphasizing the pursuit of truth, admitting his mistakes, and overcoming obstacles.
  3. Fryer's life story showcases resilience, determination, and the importance of staying true to one's mission in the face of controversies and challenges.
Richard Hanania's Newsletter β€’ 3657 implied HN points β€’ 12 Feb 24
  1. Social scientists often resort to statistical relationships when randomized experiments are not feasible, which can lead to flawed conclusions due to selection effects and confounding variables.
  2. Flawed data is often worse than having no data at all, as it can mislead individuals into making decisions based on inaccurate information.
  3. To form reasonable opinions on social, political, and economic issues, it is essential to prioritize well-grounded ideas backed by theoretical reasoning and empirical data over blindly following data from flawed social science research.
Weight and Healthcare β€’ 659 implied HN points β€’ 17 Apr 24
  1. The trial data for Semaglutide (Wegovy) for cardiovascular risk reduction was manipulative and lacking in transparency, raising concerns about conflicts of interest and data sharing.
  2. The study demographics were concerning, with a lack of diversity and representation, particularly skewed towards white men, older participants, and those with existing heart disease.
  3. The actual cardiovascular risk reduction with Semaglutide was much lower than claimed, highlighting issues with study design, data presentation, and potential overemphasis on specific demographics in the results.
Construction Physics β€’ 26933 implied HN points β€’ 07 Jul 23
  1. Titanium is abundant in the earth's crust but took time to be utilized due to its bonding properties.
  2. The development of titanium as an industrial material was heavily supported by government research and funding.
  3. The story of titanium showcases the importance of serendipity in scientific discoveries and the critical role of manufacturing in technology advancement.
2nd Smartest Guy in the World β€’ 4992 implied HN points β€’ 08 Jan 24
  1. Ivermectin has at least 15 anti-cancer mechanisms of action.
  2. Studies suggest Ivermectin can treat a variety of cancers.
  3. High doses of Ivermectin, possibly combined with Fenbendazole, may be beneficial for treating cancer.
Maryanne Demasi, reports β€’ 4127 implied HN points β€’ 16 Jan 24
  1. mRNA vaccines can lead to production of unwanted proteins due to reading errors in cells
  2. Research suggests that these off-target proteins do not raise significant safety concerns about mRNA vaccines
  3. Even though concerns exist about off-target proteins, experts suggest that mRNA vaccines are still considered safe
Astral Codex Ten β€’ 2271 implied HN points β€’ 19 Feb 24
  1. ACX provides an open thread for weekly discussions where users can post anything, ask questions, and engage in various topics.
  2. ACX Grants project includes initiatives like exploring a mutation to turn off suffering and opportunities for researchers in AI safety.
  3. ACX mentions upcoming events like a book review contest with updated rules and a pushed back due date.
2nd Smartest Guy in the World β€’ 3301 implied HN points β€’ 23 Jan 24
  1. Vaccines have a history of enhancing disease, rather than just being ineffective.
  2. Research studies have shown severe side effects in animals from certain vaccines.
  3. The emergency authorization of vaccines bypassed normal trial processes, raising concerns.
Weight and Healthcare β€’ 738 implied HN points β€’ 03 Apr 24
  1. Questionable research can happen due to researchers being influenced by profit interests or an entrenched paradigm.
  2. Some researchers may design studies to support predetermined conclusions, leading to misleading results.
  3. Doctors involved with the weight loss industry may have subconscious biases towards promoting weight loss, despite evidence of its ineffectiveness and harms.
The Oswald Spengler Project β€’ 59 implied HN points β€’ 15 May 24
  1. The post discusses the translation of Spengler's works into English, particularly focusing on his intention for the academic journal 'The World as History' and the journal's editor Hans Erich Stier.
  2. The journal 'The World as History' aimed to publish historical research aligned with Spengler's distinct methodology.
  3. The post hints at a possible revolution in cartography, linking to further content on the subject.
Astral Codex Ten β€’ 2202 implied HN points β€’ 29 Jan 24
  1. Genes matter 2x as much as the environment in schizophrenia, not 4x as previously thought
  2. A study on political reasoning errors failed to replicate, questioning a larger literature on the topic
  3. Humans merging with AI may not be unprecedented, as evidenced by a medieval Italian man merging with a knife
read β€’ 10220 implied HN points β€’ 31 Jul 23
  1. Scholars on Substack are reaching new audiences and earning income for their research and writing.
  2. Substack provides academics like Ruth Ben-Ghiat with financial freedom to pursue public-interfacing research.
  3. Academic writers use Substack for engaging with readers, testing new ideas, and shaping their research through feedback.
The Crucial Years β€’ 2002 implied HN points β€’ 26 Jan 24
  1. A huge victory against the fossil fuel industry has been achieved by halting new licenses for LNG export terminals.
  2. Biden's decision sets a climate test for American fossil fuel expansion plans, signaling a transition from natural gas as a 'bridge fuel'.
  3. The fight for climate justice needs to include considerations for impacts on communities and involve effective monitoring and engagement with frontline leaders.