The hottest Therapeutics Substack posts right now

And their main takeaways
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Top Science Topics

Cancer Science in On a Tear

Ground Truths • 7436 implied HN points • 10 Nov 24
🏥 Health & Wellness Cancer Research Medical Science Therapeutics Biotechnology Genomics
  1. Recent research has made great progress in understanding cancer, revealing that many cancer cells may come from multiple clones. This helps explain how cancer develops and spreads.
  2. Studies are showing how powerful visual mapping of tumors can be, especially for identifying how different immune responses affect the growth of cancers like breast and ovarian cancer.
  3. New insights into circular DNA in cancer cells are revealing its role in tumor growth and resistance to treatments. There is even potential for new therapies targeting this DNA to combat cancer.

The best psychedelic (survey results)

Knowingless • 1890 implied HN points • 26 Nov 24
🏥 Health & Wellness Psychedelics Mental health Substance Use Therapeutics Addiction
  1. Different people value different effects of drugs. Some want deep life changes, while others prefer milder experiences.
  2. Ayahuasca is often seen as the most intense option, but MDMA is highly rated for pleasure and social experiences.
  3. It's important to consider the risks and benefits when choosing a drug, as different ones can impact your life in various ways.

The role of Claudin-1 in fibrotic disease

Axial • 14 implied HN points • 05 Jan 25
🔬 Science Health Biology Medicine Research Therapeutics
  1. Claudin-1 is a protein that plays a key role in fibrotic diseases. When it gets exposed outside its normal area in tissues, it can trigger harmful processes that lead to excessive scarring.
  2. Research shows that targeting Claudin-1 could be a promising way to treat fibrosis in different organs. Approaches like using specific antibodies have shown positive results in reducing fibrosis in animal studies.
  3. Future studies need to focus on understanding how Claudin-1 works in detail and testing these new treatments in humans. This could lead to better options for people suffering from fibrotic diseases.
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Covid, Contagion, and Looking Forward

Risk Musings • 401 implied HN points • 28 Oct 23
🏥 Health & Wellness Disease Public Health Therapeutics Immunity Research
  1. Covid has become a global experience with waning immunity and increased contagiousness.
  2. Understanding Covid's spread involves looking beyond R0 numbers to factors like effective reproduction rate and incubation period.
  3. To combat Covid, focus on reducing susceptibility through therapeutics, policy changes like banning gain-of-function research, and investing in public health infrastructure.

The Potential of Psychedelics

The Last Bear Standing • 43 implied HN points • 15 Mar 24
🏥 Health & Wellness Psychedelics Mental health Therapeutics Clinical Trials FDA Approval
  1. There has been a resurgence of interest in the medical potential of psychedelics, with ongoing research and clinical trials exploring their efficacy in treating mental health conditions.
  2. Despite the challenges and market fluctuations, there is increasing regulatory support for psychedelic drug trials, potentially leading to FDA approvals and breakthrough therapy designations for conditions like PTSD.
  3. Psychedelic treatments involve controlled drug administration in conjunction with therapy, aiming to address the root causes of mental health disorders by stimulating new perspectives and thought patterns.

Human Immunology Biosciences

Axial • 7 implied HN points • 03 Mar 24
🔬 Science Biosciences Therapeutics Genetics
  1. Human Immunology Biosciences (HI-Bio) is a clinical-stage biotech company focused on precision medicines for immune-mediated diseases, with the aim to target specific cellular drivers of disease with therapeutics.
  2. HI-Bio's assets include felzartamab and HIB210, targeting dysfunctional plasma cells and other immune system components to potentially provide more effective treatments for diseases like membranous nephropathy and IgA nephropathy.
  3. The company utilizes a platform that integrates human genetics, immunophenotyping, data sciences, and therapeutic engineering to advance its clinical pipeline in understanding and addressing immune-mediated diseases.

Natural Product Synthesis in the 21st Century: Beyond the Mountain Top

Axial • 7 implied HN points • 17 Feb 24
🔬 Science Chemistry Biology Prediction Automation Therapeutics
  1. Natural products and drugs have similarities but drugs are a balance between complexity and accessibility for optimization.
  2. Molecular complexity in drugs is increasing to improve IP coverage, binding affinity, and effectiveness for chronic diseases.
  3. Embracing enabling methods, computational modeling, and deep exploration of complex chemical space can revolutionize natural product synthesis for therapeutic goals.

We Are Not Done

Are You Okay? • 0 implied HN points • 14 Mar 22
🏥 Health & Wellness COVID-19 Vaccines Immunity Public Health Therapeutics
  1. High school and college students are experiencing mixed emotions about removing masks, ranging from excitement to worry and empathy for others.
  2. As mask mandates are lifted, individuals are responsible for assessing their own risks and decisions about wearing masks.
  3. Key lessons learned in the age of Omicron include the evolving role of vaccines, the importance of ventilation, the legitimacy of infection-acquired immunity, and the increasing population immunity compared to last year.

Spread Facts

Are You Okay? • 0 implied HN points • 06 Jul 20
🏥 Health & Wellness Medical Updates Prevention Therapeutics Public Health
  1. COVID-19 cases are surging in 39 states across the U.S. due to people ignoring public health advice and gathering in crowded spaces without masks.
  2. Wearing masks, practicing social distancing, and washing hands are crucial in preventing the spread of the virus and can help shut it down and reopen the economy.
  3. Face shields plus masks are recommended for those with regular, close contact indoors with others, while N95 masks are in short supply and should be reserved for healthcare workers.

Trust Science

Are You Okay? • 0 implied HN points • 14 Apr 20
🏥 Health & Wellness Medicine Mental health Treatment Research Therapeutics
  1. Trust science for COVID-19 treatments: It's crucial to rely on scientific methods like randomized controlled trials and emergency use authorizations for drug approvals.
  2. Current drug treatments: Hydroxychloroquine, chloroquine, azithromycin, and convalescent plasma are being explored for COVID-19, but careful monitoring is needed due to potential risks and uncertainties.
  3. Mental and behavioral health impact: Patience with drug development processes is important, collaboration among researchers is key, and humor can play a role in maintaining mental well-being during uncertain times.