The hottest Vaccines Substack posts right now

And their main takeaways
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Top Health & Wellness Topics

Yeast-based vaccines are a big deal for biosecurity

More is Different • 6 implied HN points • 07 Feb 26
🔬 Science Vaccines
  1. Engineered baker's yeast that displays viral proteins can trigger protective antibody responses when eaten, showing edible vaccines are possible.
  2. Yeast vaccines can be produced and distributed quickly and locally—through brewing, dried chips, or feed—making decentralized pandemic and livestock responses feasible.
  3. Edible yeast vaccines may reduce needle-related hesitancy and lower some regulatory barriers, but they still face important challenges like oral tolerance, safety, and the need for proper clinical trials and regulatory clarity.

A Brand New Study on PCR-Negative COVID-Like Illness Suggests It is Often... COVID!

Harnessing the Power of Nutrients • 1258 implied HN points • 25 Feb 22
🏥 Health & Wellness Vaccines
  1. PCR-negative COVID-like illness can often turn out to be actual COVID, rendering some studies and vaccine trial efficacy questionable.
  2. A significant percentage of PCR-negative COVID-like illnesses without alternative diagnoses may actually be COVID cases.
  3. Data on PCR-negative cases questioning the efficacy of vaccines and highlighting the need for a better understanding and classification of COVID-like illnesses.

The Quest for Universal Flu Vaccines

Asimov Press • 354 implied HN points • 26 Jan 25
🏥 Health Politics Vaccines
  1. Current flu vaccines only work about 40% of the time and need to be updated every year. Scientists are trying to create a 'universal' flu vaccine that could offer better protection for a longer time.
  2. Viruses like the flu change quickly, which makes it hard for existing vaccines to keep up. Researchers are working on new methods to make vaccines that can recognize and fight many different strains of the virus.
  3. More than 200 new flu vaccine ideas are being tested, including ones that use nanoparticles or are delivered through the nose. The hope is to come up with a vaccine that can last several years and protect against various flu types.

Vaccines, Amen - Book Launch Party!

Injecting Freedom • 48 implied HN points • 05 Nov 25
🏥 Health Politics Vaccines
  1. The book launch party was a fun and lively event where many people gathered to celebrate.
  2. Rob Schneider shared important thoughts about government control and personal freedom regarding medical choices.
  3. An Air Force member's story highlights the struggle for rights in the face of vaccine mandates, inspiring others to stand up for their beliefs.

UK Government Agency Is Refusing To Release Data On COVID Vaccines And Excess Deaths

Unmasked • 37 implied HN points • 19 Nov 25
🏥 Health Politics Vaccines
  1. Governments pushed hard for COVID rules like masks and vaccinations, often ignoring or downplaying any opposition. They kept saying vaccines were 100% effective and that only unvaccinated people were at risk.
  2. Despite many claims being proven wrong over time, the push for vaccinations and boosters never slowed down. There was always a focus on getting everyone vaccinated, no matter what the data said.
  3. Some governments are now refusing to share data about vaccine effects and deaths, which raises concerns about transparency and accountability in health decisions.
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State of Affairs: Feb 22

Your Local Epidemiologist • 904 implied HN points • 22 Feb 24
🏥 Health & Wellness Vaccines
  1. Influenza-like illnesses are still prevalent, especially among children, and the season could continue until April or May.
  2. COVID-19 levels in wastewater are high nationally, with a strange pattern in the South, but hospitalizations remain lower than last year.
  3. Flu hospitalizations are stable, RSV cases are decreasing, and there is concern about a rising number of measles cases across several states.

Wednesday Links

Niko McCarty • 39 implied HN points • 29 May 24
🔬 Science Vaccines
  1. Joseph Lister invented the first micropipette in the 1850s, but it wasn't popular like Heinrich Schnitger's design in 1957. It's interesting how some inventions don’t get the recognition they deserve until later.
  2. A new vaccine strategy uses tiny particles to target specific cells with mRNA vaccines. This could make immunizations more effective and targeted.
  3. The FDA sometimes takes too long to approve products like sunscreens, which can affect public health. It's a reminder that safety can sometimes slow down progress.

Why can't anyone show us the study showing vaccines save lives?

Steve Kirsch's newsletter • 9 implied HN points • 13 Jan 26
🏥 Health Politics Vaccines
  1. No US record-level study has been found showing fully vaccinated children have lower all-cause mortality than under-vaccinated peers, despite searches by humans and AI.
  2. Many studies offered as evidence don’t meet the specific criteria cited here — they can be non-US, use modeled data, focus on single vaccines or short time windows, or lack individual record-level information.
  3. Because of the claimed absence of such US record-level evidence, the argument is that vaccine mandates rest on belief rather than direct data, and that a proper study should be done before mandating mass childhood vaccination.

ACIP Cliff notes: Feb 28

Your Local Epidemiologist • 853 implied HN points • 28 Feb 24
🏥 Health & Wellness Vaccines
  1. CDC recommends older adults receive a second Covid-19 vaccine in the spring, especially those over 65.
  2. The majority of people hospitalized for Covid-19 were not up-to-date on their annual vaccine, with specific risk factors common among them.
  3. Vaccine coverage challenges in the US stem from concerns like unknown side effects, lack of trust, and physician recommendations.

Can the Vaccines Write the Spike Protein Into the Human Genome?

Harnessing the Power of Nutrients • 998 implied HN points • 01 Mar 22
🔬 Science Vaccines
  1. A recent study presented the first evidence that vaccine spike protein mRNA can be reverse transcribed into DNA within human cells, although further validation is necessary.
  2. Integration into chromosomes is not required to consider something 'written into the genome'; extrachromosomal circular DNA can also lead to gene expression and phenotypic changes.
  3. The unexpectedly long persistence of mRNA and spike protein after vaccination raises concerns and suggests the need to investigate reverse transcription as a mechanism for this durability.

State of Affairs: March 12

Your Local Epidemiologist • 768 implied HN points • 12 Mar 24
🏥 Health & Wellness Vaccines
  1. Measles cases are increasing, with outbreaks across various regions, underscoring the importance of vaccination and public health measures.
  2. Norovirus is surging in the Northern Hemisphere, causing stomach cramping, vomiting, and diarrhea, emphasizing the need for preventive measures like handwashing and surface cleaning.
  3. The flu season, particularly driven by flu strain B, has been moderate this year, highlighting the potential impact of political influences on vaccine uptake and the importance of public health efforts.

ACIP Cliff Notes: Feb 29 (RSV)

Your Local Epidemiologist • 783 implied HN points • 29 Feb 24
🏥 Health & Wellness Vaccines
  1. Real-world data showed a true safety signal for the RSV older adult vaccine, particularly after the Pfizer vaccine.
  2. The benefits of the RSV vaccine still outweigh the risks for older adults, preventing significant illness and hospitalizations.
  3. Moderna is introducing an RSV vaccine using mRNA, offering a different platform with potential advantages for safety.

An Open Proposal to the CEO of the American Academy of Pediatrics

Steve Kirsch's newsletter • 7 implied HN points • 16 Jan 26
🏥 Health Politics Vaccines
  1. A plan to fund multiple independent research teams to analyze the same public government vaccine data, aiming to answer vaccine safety questions transparently.
  2. The effort would use jointly designed study specs, pre-registered protocols, and require public release of data, code, and methods, with publication of results regardless of outcome.
  3. The purpose is to reduce polarization and increase public trust by letting objective, independently verified analyses speak for themselves and involving organizations with different perspectives.

Stanford led study: at least 20,000 global deaths from COVID jabs

Who is Robert Malone • 16 implied HN points • 23 Dec 25
🏥 Health Politics Vaccines
  1. COVID-19 vaccination likely prevented many deaths worldwide (central estimate ~2.5 million), but that figure is model-based and very sensitive to key assumptions.
  2. Estimates put vaccine-associated deaths on the order of tens of thousands globally (roughly ~20,000; range ~16,000–48,000), so harms are probably much smaller than benefits overall but remain highly uncertain.
  3. The mortality benefit was overwhelmingly concentrated in people aged 60 and older, with children and young adults receiving minimal benefit, suggesting vaccination strategies should account for age-specific risks and benefits.

come offit

bad cattitude • 264 implied HN points • 30 Dec 24
🏥 Health Politics Vaccines
  1. There's concern about the safety and effectiveness of vaccines that are quickly pushed through without proper testing. People worry that these vaccines could lead to more harm than good.
  2. Current vaccine liability laws protect companies from being sued if their products cause harm. This might lower their incentive to ensure the vaccines are safe and effective.
  3. Many believe that if vaccine manufacturers were held accountable for their products, they would take more care in their development and testing. This would help restore public trust in vaccines.

No more vaccines

Disaffected Newsletter • 699 implied HN points • 02 Sep 22
🏥 Health Politics Vaccines
  1. The speaker has decided not to take any more vaccines, except for possibly a tetanus booster. They believe this decision is based on a rational understanding of public health and pharmaceutical practices.
  2. They feel that there may have been misinformation about the risk and benefits of earlier vaccines, leading to doubts about the vaccination process.
  3. The speaker acknowledges that their decision may seem unusual to vaccine supporters but sees it as a normal response to their understanding of the situation.

Everything "That Friend" Wants You to Know About H5N1 Bird Flu

OK Doomer • 310 implied HN points • 23 Nov 24
🏥 Health Politics Vaccines
  1. H5N1 bird flu has been confirmed in humans, raising concerns about its potential spread this flu season. It's important to be aware of the situation and stay informed.
  2. There are worries that health agencies are not taking adequate measures to control the spread of H5N1. People are feeling uncertain about safety measures and what actions to take.
  3. Historically, mild strains of flu have led to serious outbreaks after mutations. We should remember past mistakes and prepare better this time to avoid repeating history.

FDA's fall 2023 vaccine plan

Your Local Epidemiologist • 1156 implied HN points • 15 Jun 23
🏥 Health & Wellness Vaccines
  1. COVID-19 vaccines are being updated for the fall 2023-2024 season due to fast mutations and waning effectiveness against hospitalization.
  2. Vaccine formula may shift to target only the Omicron XBB variant for better immune system recognition.
  3. Global alignment on focusing vaccine efforts on the XBB variant signals a step towards addressing the changing landscape of COVID-19.

My friend Shane decided to ignore my advice and listen to his doctor and got a COVID vaccine. He now has permanent heart damage.

Steve Kirsch's newsletter • 15 implied HN points • 12 Dec 25
🏥 Health & Wellness Vaccines
  1. A friend followed medical advice, got a COVID vaccine, and now has permanent heart damage.
  2. The author is frustrated that people ignore warnings and trust doctors, saying this led to severe injuries and even deaths among friends.
  3. The author believes COVID vaccines provide no benefit and only cause harm, and urges others to spread that message.

Eight questions "Professor Dave" can't answer

Steve Kirsch's newsletter • 7 implied HN points • 12 Jan 26
🏥 Health Politics Vaccines
  1. The debate became personal and some questions were deleted, raising concerns that ad hominem attacks and comment removal undermined open scientific discussion.
  2. There is a demand for clear, record-level evidence and transparent data (including autopsy results) to show whether COVID vaccines saved lives or caused harm, and a new analysis is claimed to show increased deaths after boosters.
  3. The speaker challenges the opponent's credibility and asks for credentials plus explanations for puzzling findings like odd protective effects in one study, sudden autism cases after vaccination, and unusual cancer trends.

Friday Q&A: on Risks After COVID; Booster Shots; New Vaccine Formulas; & COVID During Pregnancy

Are You Okay? • 199 implied HN points • 17 Mar 23
🏥 Health & Wellness Vaccines
  1. Information on COVID risks and booster shots was addressed in a Friday Q&A session. It's important to consider context and accurate data when evaluating health risks associated with COVID infection.
  2. Having had previous COVID infection or vaccination can impact the likelihood of 'long COVID' symptoms in case of reinfection, with different considerations for teens and young adults.
  3. Viral infections like COVID can worsen existing health conditions, highlighting the importance of understanding individual health contexts and risks.

#PlandemicPlaybook (4) They redefined VACCINE so that the public would accept and doctors would endorse a never-before-seen and never-before tested technology, using preexisting political protections

DrV’s Newsletter, Notes, Essays, Articles, Videos, and Book Chapters • 176 implied HN points • 28 Mar 23
🏥 Health & Wellness Vaccines
  1. The definition of 'vaccine' was broadened during the pandemic to include new drugs for legal and public acceptance.
  2. Ronald Reagan's policy granted financial and legal immunity to drug companies by categorizing new drugs as vaccines.
  3. The original definition of 'vaccine' was changed to protect the drug industry and now even covers agents like vitamin D.

Vaccine expert Peter Hotez was offered $2.6M free and clear to debate RFK Jr. on vaccine safety. He turned it down.

Steve Kirsch's newsletter • 15 implied HN points • 10 Dec 25
🏥 Health Politics Vaccines
  1. A prominent vaccine expert turned down multi‑million dollar offers to debate a high‑profile vaccine critic, saying such events risk becoming spectacles rather than serious scientific discussion.
  2. People who backed the offers interpret the refusals as proof that mainstream vaccine experts avoid public debates with challengers and see that as evidence of unwillingness to be held accountable.
  3. The episode highlights how crowdfunding and large public bounties fuel polarized media standoffs, and that many experts prefer education and controlled media appearances over open debate formats.

AlterAI exposes the corruption at the CDC

Steve Kirsch's newsletter • 9 implied HN points • 02 Jan 26
🏥 Health Politics Vaccines
  1. An audit alleges widespread corruption at the CDC, claiming data suppression, hidden industry ties, altered analyses, misuse of surveillance systems, and internal censorship to protect the agency’s image rather than public health.
  2. The audit particularly targets autism surveillance from 2000–2015, reporting missing datasets, reclassification of cases, and emails suggesting orders to destroy contradictory draft data, and it notes reports that the CDC said studies have not ruled out a vaccine link.
  3. Reported consequences include criminal referrals to the Department of Justice and a planned public release of roughly 10 terabytes of raw CDC epidemiological data so independent researchers can reanalyze the records and push for accountability.

KCOR results on the Japan record level data shows the same harm pattern as the Czech data

Steve Kirsch's newsletter • 6 implied HN points • 15 Jan 26
🏥 Health Politics Vaccines
  1. KCOR analysis of Japan and Czech record-level data shows a consistent pattern where recently vaccinated cohorts have higher all-cause mortality than unvaccinated cohorts.
  2. The pattern appears dose-dependent, with second doses linked to higher mortality than first, and KCOR claims to avoid healthy‑vaccinee bias by using fixed enrollment cohorts and adjusting in mortality space rather than 1:1 matching.
  3. The stated conclusion is that COVID vaccines increased the net risk of death, mainstream proponents are described as unwilling to engage with the data, and an open public debate is demanded to resolve the disagreement.

Update on The Flu & Flu Vaccines

Are You Okay? • 139 implied HN points • 20 Aug 23
🏥 Health & Wellness Vaccines
  1. The flu is a respiratory illness caused by the Influenza virus, with symptoms like cough, sore throat, fever, body aches, and fatigue. It can be severe and even fatal.
  2. Getting a flu vaccine is crucial because it reduces the risk of serious flu-related complications and mortality. Even if its effectiveness varies, it plays a significant role in preventing deaths.
  3. The flu spreads person-to-person and in the air, especially in crowded, poorly ventilated indoor spaces. Effective treatments include prescription antiviral medications and rest.

All major Covid vaccines worldwide were once declared 100% effective, but zero actually worked

The Dossier • 490 implied HN points • 06 Mar 24
🏥 Health Politics Vaccines
  1. 40 Covid vaccine candidates worldwide were claimed to be highly effective, but none of them actually worked.
  2. Pharmaceutical companies and governments globally falsely advertised Covid vaccines as the ultimate protection.
  3. The Covid-19 vaccine situation highlights the importance of scrutinizing statistics and not letting a crisis be exploited.

Emilia Benton—having been ratioed and smacked down—responds with a non-answer and dismisses legitimate questions as "trolling"

Beck of the Pack • 137 implied HN points • 19 Mar 23
🇺🇸 U.S. Politics Vaccines
  1. Emilia Benton dismisses legitimate questions as 'trolling' in response to criticism
  2. There is debate on the integrity of Emilia Benton's accusations and the situation around photos and tweets.
  3. The post raises questions about the validity and impact of media narratives and societal attitudes.

Were the COVID vaccines genocide?

Steve Kirsch's newsletter • 9 implied HN points • 21 Dec 25
🏥 Health Politics Vaccines
  1. There’s no clear evidence the vaccine campaigns were a centrally planned genocide, but secrecy, manipulation, and censorship during rollout made large-scale harm possible without explicit intent.
  2. Post-rollout data showed worrying signals like unexplained excess deaths, increased cardiac events in some groups, and reproductive or neurological problems that were often underreported or dismissed.
  3. Pharmaceutical companies and regulators acted with profit and protection motives, suppressing data and dissent in ways many view as a large-scale ethical and medical betrayal.

Is the 1986 act vaccine liability shield now gone for vaccines that got kicked off the recommended list? Yes, according to Aaron Siri.

Steve Kirsch's newsletter • 6 implied HN points • 05 Jan 26
🏥 Health Politics Vaccines
  1. The Vaccine Injury Table is the legal mechanism that decides which vaccines get federal liability protection, and if a vaccine is removed from that table the statutory immunity tied to it disappears.
  2. Liability depends on two things: a vaccine being recommended for routine use and being listed in the Injury Table, so changing the CDC schedule alone doesn’t automatically remove legal immunity unless HHS revises the regulatory table through rulemaking.
  3. A separate law (the PREP Act) shields COVID vaccines during a declared emergency, so COVID shots remain protected while that emergency declaration stays in effect.

VSRF LIVE TONIGHT: Episode 213: Dr. Clinton Ohlers, PhD.

Steve Kirsch's newsletter • 2 implied HN points • 05 Feb 26
🏥 Health Politics Vaccines
  1. There are growing concerns that mRNA technology could affect the safety of the blood supply, with some studies and clinicians reporting persistent spike protein and structural changes in post-mRNA blood samples.
  2. SafeBlood is an international group that helps patients get directed donations from non-mRNA-vaccinated donors and argues patients should be allowed to refuse blood from mRNA-exposed donors in non-emergency situations.
  3. Longstanding safeguards like directed and autologous donations are being restricted, which raises questions about informed consent, transparency, and who gets to decide what is put into a patient’s bloodstream.

A San Francisco professor is glad to get Covid and wrote about it

Vinay Prasad's Observations and Thoughts • 181 implied HN points • 27 Dec 24
🏥 Health Politics Vaccines
  1. The professor felt grateful to get Covid, believing it confirmed that avoiding the virus for so long didn't guarantee safety. She took many precautions, but still got infected, showing that complete avoidance is nearly impossible.
  2. The article suggests that the number of vaccine doses given now may not be effective, especially since the virus has changed. The biggest protection was seen with the first dose, and there isn't much evidence for needing many more.
  3. Masking practices by some families seem to be more about social pressure than actual effectiveness. There's little evidence that selectively wearing masks helps prevent respiratory viruses in casual settings.

How to Get the Correct Size Needle for Vaccines As A Higher-Weight Person

Weight and Healthcare • 319 implied HN points • 31 Aug 22
🏥 Health & Wellness Vaccines
  1. Higher-weight individuals might need longer needles for safe and effective vaccinations, including COVID-19 shots.
  2. Accessing the correct size needle can be a challenge, with providers sometimes unaware of the need for longer needles.
  3. Creating personalized cards and using a scripted phone call can help higher-weight individuals advocate for longer needles during vaccinations.

Yes, Wipe Down Surfaces. No, Don't Hoard Cleaning Products. Try HOCl.

OK Doomer • 141 implied HN points • 19 Feb 25
🏥 Health Politics Vaccines
  1. It's important to wipe down surfaces to prevent the spread of germs, especially when illnesses like the flu are on the rise.
  2. Instead of hoarding cleaning products, try using hypochlorous acid (HOCl) as a simpler and effective germ killer.
  3. The flu season is currently very severe, even worse than COVID-19 in some cases, so taking precautions is essential for safety.

Artificial intelligence and mRNA vaccines are not going to cure cancer

Vinay Prasad's Observations and Thoughts • 156 implied HN points • 22 Jan 25
🏥 Health Politics Vaccines
  1. Artificial intelligence and mRNA vaccines are not expected to cure cancer. Both technologies have limitations that make them less effective in treating this complex disease.
  2. Cancer therapeutic vaccines have been studied extensively, but only one has received FDA approval, and it shows only a slight benefit in survival. Overall, these vaccines often do not work as hoped.
  3. AI struggles to diagnose cancer accurately and often lacks the needed data to improve this. Simply detecting cancer is not enough; finding the right treatment for each specific case is much more complicated.

Novaxia vs Bigpharmia

Logging the World • 199 implied HN points • 04 Nov 22
🔬 Science Vaccines
  1. Understand the impact of vaccines on disease spread: Novaxia and Bigpharmia are examples of two scenarios showing how vaccines can affect the spread of a disease differently.
  2. Graphs help visualize data trends: Using different types of graphs can show how disease spread changes over time and the effectiveness of interventions like vaccines.
  3. Consider the importance of logarithmic scales: Logarithmic scales can provide a different perspective on data trends, allowing for better understanding of the impact of interventions like vaccines.

One Of CDC's Chief COVID Vaccine Messages Was Based On Misleading Information

Unmasked • 65 implied HN points • 27 Jun 25
🏥 Health Politics Vaccines
  1. The CDC's messaging during the COVID pandemic was often based on misleading information. This has raised concerns about their credibility and calls for reform.
  2. Issues have been noted regarding the studies the CDC used to support mask recommendations, with some results being misrepresented or not scientifically significant.
  3. The CDC's justifications for recommending COVID vaccines were also questioned, suggesting that their decisions weren't always based on accurate data.