The hottest Vaccines Substack posts right now

And their main takeaways
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Top Health & Wellness Topics
Your Local Epidemiologist • 1906 implied HN points • 17 Mar 26
  1. A federal judge blocked and reversed the recent vaccine-policy changes, temporarily restoring vaccine access to how it was before June 2025.
  2. The court found the process unlawful because it bypassed the statutorily required ACIP, appointed a committee that wasn’t fairly balanced or expert enough, and made arbitrary administrative changes.
  3. ACIP meetings with the current members are paused and planned votes were cancelled, so rely on established medical society schedules for now while the legal case and future vaccine decisions play out.
Unreported Truths • 34 implied HN points • 26 Mar 26
  1. Flu shots for young children give only partial, short-lived protection against lab-confirmed influenza and usually don't reduce overall respiratory illness, so benefits are limited and require yearly repeats.
  2. Trials have reported rare but serious adverse events and many studies lack true placebo controls, leaving the true short- and long-term risks of repeated annual vaccination starting in infancy unclear.
  3. Given the modest benefits and uncertain risks, strong public-health pressure to vaccinate all healthy kids against flu is questionable and should be re-evaluated to rebuild parental trust.
TK News by Matt Taibbi • 7619 implied HN points • 19 Feb 26
  1. The FDA, led by Vinay Prasad, refused to file Moderna’s mRNA flu vaccine study because the trial didn’t meet the agency’s standards for being “adequate and well‑controlled.”
  2. Moderna’s study compared its shot to Fluarix, a vaccine that performs poorly in people 65+, which could falsely inflate the new vaccine’s benefit and raises ethical questions about informed consent for participants.
  3. Prasad’s move signals a tougher, less pharma‑friendly FDA stance that is drawing industry and media backlash but emphasizes stricter enforcement of trial and safety standards.
Ground Truths • 14172 implied HN points • 22 Jan 26
  1. Multiple large natural experiments across countries show shingles vaccination is consistently linked to lower dementia rates, and the newer Shingrix vaccine may offer even greater protection.
  2. Studies tie the vaccine to slower biological aging and shifts in immune and inflammation markers over years, with bigger benefits seen in women, though blood markers of neurodegeneration haven’t changed and the exact mechanism is still unknown.
  3. Other studies suggest cardiovascular benefits too, so getting Shingrix at 50+ may offer broad protection, but more mechanistic research and replications are needed to confirm these effects.
Your Local Epidemiologist • 1056 implied HN points • 10 Mar 26
  1. Winter respiratory season is finally easing, but spring viruses like HMPV and RSV are on the rise and allergy season is starting earlier and lasting longer, so expect more colds and cranky kids this spring.
  2. The flu vaccine planning for next season is underway, but political interference and leadership turnover could block or delay an updated formula, meaning Americans might receive last year’s vaccine instead of one matched to current strains.
  3. A White House briefing that falsely linked acetaminophen to autism caused a measurable drop in acetaminophen orders for pregnant patients and a big rise in leucovorin prescriptions, showing how misinformation changes clinical care; acetaminophen remains the safest choice for fever and pain in pregnancy, so talk to your clinician if you’re pregnant and sick.
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Popular Rationalism • 574 implied HN points • 16 Oct 24
  1. mRNA vaccines face big challenges because of how fast RNA viruses can change. It's unlikely they'll be able to completely eliminate the virus over time.
  2. These vaccines can push viruses to evolve in ways that make them escape detection and survive better. This means the virus can keep changing and might even become more dangerous.
  3. Natural immunity, from getting the virus instead of a vaccine, can be broader and may help prevent newer variants. This shows how different immune responses can affect how the virus evolves.
Ground Truths • 11197 implied HN points • 14 Dec 25
  1. Two main cure strategies are emerging: a "hard reset" with engineered immune cells (CAR‑T/CAR‑NK) that deplete disease‑causing B cells and is moving toward off‑the‑shelf, in‑body delivery for one‑shot remissions.
  2. A "soft reset" uses inverse or tolerogenic vaccines and Treg/dendritic‑cell approaches to retrain the immune system to tolerate self‑antigens instead of attacking them.
  3. Advances in cancer immunotherapy (CAR‑T, checkpoint modulation, in‑vivo delivery, gene editing) are accelerating autoimmune cures, but challenges remain with cost, safety (e.g., cytokine release, neurotoxicity, vector risks) and equitable access.
Popular Rationalism • 1069 implied HN points • 03 Oct 24
  1. Replicon mRNA vaccines have the ability to replicate inside the body, which could lead to unknown risks and side effects. This uncontrolled replication raises concerns about overstimulating the immune system or causing mutations.
  2. Protests in Japan highlight public fear and skepticism surrounding self-replicating vaccines. Many people are worried about the lack of long-term safety data and want more transparency from health officials.
  3. How Japan handles this new vaccine could influence other countries' decisions. Regulatory bodies worldwide need to balance innovation with public safety and trust to avoid backlash and promote acceptance.
Your Local Epidemiologist • 1472 implied HN points • 18 Feb 26
  1. The FDA initially refused to file Moderna’s mRNA flu vaccine application, highlighting how shifting regulatory decisions could slow or deter long-term vaccine innovation and investment.
  2. Colorectal cancer rates are rising in younger adults, so screening now starts at 45 and people should watch symptoms at any age while focusing on healthier diets, more fiber, and regular activity to lower risk.
  3. Winter respiratory illnesses are lingering (flu B, RSV, colds) and measles cases have surged past 1,000, plus a small outbreak of drug-resistant Salmonella linked to moringa capsules—stay current on vaccines, heed outbreak warnings, and check supplement lot codes if you own the product.
Unmasked • 29 implied HN points • 19 Mar 26
  1. New leaders are running major public health agencies now, with Dr. Jay Bhattacharya in an interim leadership role and Dr. Marty Makary taking a lead at the FDA.
  2. Public health experts have strongly pushed getting both the flu and COVID shots—often at the same visit—and the public health establishment continues to promote those recommendations.
  3. CDC’s latest estimates show this year’s flu vaccine had extremely low effectiveness against the dominant strain.
Cremieux Recueil • 199 implied HN points • 05 Mar 26
  1. A single study claiming that hepatitis B vaccination in early infancy causes autism is statistically fragile, underpowered, and its positive finding disappears after proper multiple-comparison corrections.
  2. The study’s result depended on questionable analytic choices—like excluding girls, omitting important control variables, and running inappropriate specificity tests—which made the finding misleading.
  3. Reanalyses produce inconsistent and biologically implausible associations with other conditions, indicating confounding rather than causation, and there is no credible evidence that hepatitis B vaccination causes autism.
Injecting Freedom • 37 implied HN points • 16 Mar 26
  1. An advocacy group asked the federal autism committee to review possible links between infant vaccines and autism and submitted related materials for consideration.
  2. The claim that vaccines do not cause autism is framed as a belief rather than settled science, and the group is calling for more research on the issue.
  3. They publicly shared a chapter and a comment letter to push the committee and the public to re-examine the topic and attract broader attention.
Your Local Epidemiologist • 1065 implied HN points • 30 Jan 26
  1. Trust in government and institutions is fragile, and doing things the old way isn't enough. Institutions often miss what they don't know, so listening to people on the ground is essential.
  2. Good policy can fail if planners don't anticipate on-the-ground confusion — nothing changes if nothing changes. The corn masa flour folate fortification shows how well-intended rules can go sideways without prior listening and clear communication.
  3. Tracking new science and providing practical resources helps trusted messengers respond better. Recent studies (like therapies for damaged neurons and vaccines) and downloadable guides for clinicians and educators show the value of pairing evidence with usable tools.
Steve Kirsch's newsletter • 2 implied HN points • 12 Mar 26
  1. She treated thousands of COVID patients with early outpatient protocols and publicly challenged hospital vaccine mandates, which led to suspension of her privileges and legal action that influenced FDA messaging on ivermectin.
  2. She now treats people who report injuries after COVID-19 mRNA shots and is publicly calling for those vaccines to be taken off the market pending a full safety investigation.
  3. She wrote a book about misinformation in medicine during the pandemic and is actively pursuing legal battles with medical boards while participating in health freedom advocacy.
Igor’s Newsletter • 12618 implied HN points • 21 Jan 24
  1. IgG4 antibodies caused by mRNA technology may lead to immune tolerance and reduced ability to fight infections.
  2. A study showed that mRNA vaccines resulted in much higher IgG4 levels compared to Novavax, indicating a dysfunctional immune response.
  3. The use of mRNA technology in vaccines has been linked to a faulty immune response, potentially worsening the pandemic.
Injecting Freedom • 26 implied HN points • 16 Mar 26
  1. A federal Task Force for Safer Childhood Vaccines was recently reinstated, restoring a government body to address vaccine safety.
  2. A 9-page letter urges immediate reforms across seven HHS agencies, calling for VAERS and VICP changes, elimination of conflicts of interest, more vaccine data transparency, and stricter approval standards.
  3. The task force has a large, urgent workload and should quickly adopt these recommendations to strengthen vaccine safety oversight.
Injecting Freedom • 186 implied HN points • 25 Feb 26
  1. A prominent vaccine expert recontacted a longtime critic after a contentious deposition, focusing on procedural complaints and insisting he should be credited for protecting children while blaming the critic for harm to unvaccinated kids.
  2. The expert pushed post-deposition actions to defend vaccine orthodoxy—urging WHO/FDA/CDC changes and holding private meetings—but those efforts didn’t erase the admissions made in the deposition.
  3. The critic offered a redo deposition and constructive steps to help vaccine-injured children, received no engagement, and published the correspondence to push for transparency and public debate about vaccinology.
The DisInformation Chronicle • 290 implied HN points • 03 Feb 26
  1. Bioweapons are presented as a serious and underprepared threat that requires creating a new security apparatus and refocusing or reorganizing public health agencies.
  2. The COVID pandemic is portrayed as likely originating from a lab, and mRNA COVID vaccines are characterized as gene therapy with safety concerns for children, prompting calls for manufacturers to disclose how long, how much, and where spike protein is produced.
  3. Masks are claimed not to prevent people from catching viruses, and some Long COVID patients may not clear the virus or spike protein, raising treatment and public health concerns.
The Forgotten Side of Medicine • 8824 implied HN points • 12 Jan 24
  1. The author dissects a modern vaccine propaganda piece and reveals tactics used to defend unchallenged arguments.
  2. Peter Hotez is highlighted as drawing the ire of the vaccine safety community by defending the vaccine narrative and attacking critics.
  3. Hotez's suggestions to silence opposition and his rhetoric are critiqued for their implications on free speech and public debate.
Igor’s Newsletter • 7409 implied HN points • 27 Jan 24
  1. Male infants and male rat pups show disproportionate effects from mRNA COVID vaccines given to pregnant mothers.
  2. Studies demonstrate a mysterious sex difference arising from COVID vaccine exposure during pregnancy.
  3. Boys born to vaccinated mothers have more negative outcomes compared to girls, especially when the vaccination occurs in the first trimester.
uTobian • 7252 implied HN points • 22 Jan 24
  1. Higher education failed in responding to Covid, showing weaknesses and flaws.
  2. Climate change movement shifted focus to target small farmers and families, losing sight of its original goals.
  3. Advocating for 'freedom of choice' in allowing toxic products can lead to harmful consequences and is not a viable solution.
The Forgotten Side of Medicine • 6800 implied HN points • 21 Jan 24
  1. Over the past years, data suggests that unvaccinated individuals may become ill when in close contact with vaccinated individuals; mechanisms for this transmission involve exosome shedding, COVID-19 shedding, and potentially transfected bacterial shedding.
  2. Efforts to unravel the mysteries of mRNA vaccine shedding have revealed concerns such as shedding's impact on sexual shedding, odor emission, blood transfusions, cancer, and mitigation methods.
  3. Various factors can influence shedding reactions, such as sensitivity levels, timing post-vaccination, symptoms experienced, and potential links to the gut microbiome and pheromones.
Your Local Epidemiologist • 1372 implied HN points • 03 Dec 25
  1. The U.S. vaccine meeting will focus on the Hepatitis B vaccine and the childhood immunization schedule. The only vote will be about maintaining the birth dose of the Hepatitis B vaccine for infants.
  2. Many misleading claims about vaccines might arise during the meeting, but there's a lot of solid evidence supporting the current vaccination schedule's safety and effectiveness. Knowing the facts can help people respond to misinformation.
  3. It's important to understand how the vaccine schedule was created and why children receive vaccines at specific times. This schedule helps protect children from serious infections when they are most vulnerable.
uTobian • 8667 implied HN points • 01 May 23
  1. The study on autism prevalence and costs shows the rising financial burden of autism over the years.
  2. The model presented in the study reveals the alarming increase in autism rates, especially for certain demographics.
  3. The study highlights the shift in costs from parents to government as the first generation of autism epidemic children age, emphasizing the need for prevention strategies.
Ground Truths • 10148 implied HN points • 14 Feb 25
  1. There are now 6 different nasal vaccines in clinical trials in the US aimed at preventing COVID-19 and blocking its transmission. These vaccines are promising because they might work better than traditional shots.
  2. Two major challenges facing these new vaccines are the low current levels of the virus, which make it harder to gather data from trials, and the uncertainty about ongoing government support for these projects.
  3. Successful nasal vaccines could provide a convenient way to protect people from COVID-19, but it will take time to find out if they really work well in humans.
The Dossier • 8372 implied HN points • 11 Oct 23
  1. A Canadian detective is on trial for investigating a potential link between infant deaths and mRNA vaccines.
  2. The detective faced misconduct charges for inquiring about COVID-19 vaccination status of deceased infants' parents.
  3. The detective's trial was complicated by a leaked investigation, wiretap controversy, and allegations of a cover-up.
uTobian • 8195 implied HN points • 14 Apr 23
  1. Psychopaths who fit in are more dangerous than the stereotypical crazy ones because they are harder to spot.
  2. The American public health establishment includes individuals who seem well-adjusted but are responsible for significant harm, like downplaying vaccine safety concerns.
  3. The public health system is run by individuals who are well-adjusted to an insane society, perpetuating harm while appearing normal.
Pierre Kory’s Medical Musings • 4422 implied HN points • 21 Jan 24
  1. Dr. Hoffe's statements on the efficacy of ivermectin in treating Covid-19 are supported by a large body of scientific evidence, including numerous positive meta-analyses and health ministry reports.
  2. Dr. Corneil's expert report ignored significant positive evidence on the effectiveness of ivermectin, focusing on selective negative studies and flawed trials.
  3. The exclusion of key studies, manipulation of trial data, and reliance on questionable criteria suggest a biased and disingenuous approach in evaluating the efficacy of ivermectin for Covid-19 treatment.
Injecting Freedom • 69 implied HN points • 26 Feb 26
  1. A double-board-certified neurologist says he has seen acute vaccine adverse events firsthand that are quietly acknowledged but rarely reported.
  2. He argues there is deep cognitive dissonance in medicine, with flawed vaccine surveillance systems and many neurologists staying silent about suspected vaccine harms.
  3. He calls for more transparency, better reporting, recognition of genetic susceptibility, and stronger informed consent and parental choice around vaccinations.
Emerald Robinson’s The Right Way • 4602 implied HN points • 24 Jan 24
  1. Bill Gates revealed plans for global tracking tattoos with micro-needle patches at the World Economic Forum in Davos.
  2. Four years after initial reports, Bill Gates confirmed development of a digital ID system using vaccines.
  3. Support for independent and fearless journalists is crucial in facing legal battles and silencing tactics.