The hottest CRISPR Substack posts right now

CRISPR technology has revolutionized biology with its programmable gene editing capabilities, leading to rapid advancements and commercial interest.
New tools like HACE for targeted genetic variation and technologies for RNA writing are expanding the toolkit for programming biology.
Exploration of retrons as a tool for DNA production and genome editing reveals the potential for diverse applications in genome engineering.

Researchers are using CRISPR technology to fix a genetic mutation that causes a type of blindness in mice. This mutation is in the rhodopsin gene, which is important for vision.
Timing is really important for the treatment to be effective. Treating mice earlier resulted in better preservation of their eyesight compared to treating them later.
Despite progress, there are challenges in translating this therapy for humans. The mutation is rare, making it tough to conduct clinical trials, and the therapy needs further development for success.

Gene therapy can partially restore color vision in those with a hereditary disease
Gene editing in trees can lead to more sustainable paper production
Winning a Nobel Prize may reduce scientific productivity due to increased obligations

Biology is unique because it allows measuring designs in real experiments at massive scales.
AI and machine learning are driving breakthroughs in biology including genome editing prediction and antimicrobial peptide discovery.
Advancements in neurotech include brain-computer interface speed records and LED implants for vision stimulation.

Nicole Gaudelli and Alexis Komor are scientists who invented CRISPR Base Editing.
Axial partners with founders and invests in early-stage life sciences companies.
Axial is interested in supporting rare inventors in life sciences and potentially investing in their visions.

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Gene therapy has the potential to treat and cure genetic diseases, but it is a complex process requiring expertise in biology and manufacturing.
The gene therapy value chain involves steps like target identification, payload design, delivery vehicle design, translation development, manufacturing, and clinical trials.
Companies are working on breakthroughs in gene therapy technology, such as improving AAV vectors and refining CRISPR-Cas9 systems, but face challenges in experimental processes and data availability.