The hottest Genetics Substack posts right now

And their main takeaways
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Top Health & Wellness Topics

We need to talk about astrology

Granted • 18608 implied HN points • 10 Mar 24
🔬 Science Astrology Personality Traits Genetics Research Findings Cognitive Biases
  1. Astrology does not have scientific backing and can lead to harmful stereotypes and discrimination.
  2. Studies have shown that zodiac signs do not correspond to personality traits, and astrology cannot predict life outcomes.
  3. Belief in astrology may indicate a lack of critical thinking skills and could lead to acceptance of other unfounded beliefs.

We’re entering a golden age of engineering biology

Noahpinion • 16647 implied HN points • 18 Feb 24
🔬 Science Biology AI Genetics Automation Medicine
  1. The advancements in deep learning, cost-effective data collection through lab automation, and precision DNA editing with technologies like CRISPR are converging to transform biology from a scientific field to an engineering discipline.
  2. Historically, biology has been challenging due to its immense complexity, requiring costly trial-and-error experiments. However, with current advancements, we are now at a critical point where predictability and engineering in biological systems are becoming a reality.
  3. The decreasing cost of DNA sequencing, breakthroughs in deep learning models for biology, sophisticated lab automation, and precise genetic editing tools like CRISPR are paving the way for a revolutionary era in engineering biology, with vast potential in healthcare, agriculture, and industry.

Who Does Polygenic Selection Help?

Astral Codex Ten • 11562 implied HN points • 23 Feb 24
🔬 Science Genetics Medical Ethics Biology Healthcare
  1. Polygenic selection can help prevent genetic diseases like schizophrenia by choosing embryos with lower risk during IVF, leading to healthier children
  2. Despite the complex nature of genetic selection, it can have positive effects on individuals and society by preventing diseases and improving overall health outcomes
  3. Analogies like preventing fetal alcohol syndrome through prenatal care or choosing healthier IVF embryos demonstrate the ethical and practical benefits of polygenic selection

It's Fair To Describe Schizophrenia As Probably Mostly Genetic

Astral Codex Ten • 13077 implied HN points • 01 Feb 24
🏥 Health & Wellness Mental health Genetics
  1. Schizophrenia is likely mostly genetic but may not be described as a genetic disease based on heritability estimates.
  2. Genes play a crucial role in schizophrenia, serving as a risk factor and potentially a cause for the condition.
  3. Despite the complex interplay of genetic and environmental factors, schizophrenia can be colloquially referred to as genetic due to the significant genetic contribution in its development.

Some Unintuitive Properties Of Polygenic Disorders

Astral Codex Ten • 14247 implied HN points • 24 Jan 24
🔬 Science Genetics Simulation
  1. Schizophrenia, considered 80% genetic, shows varied risk in identical twins, proving genetics' complex role.
  2. Nazi eugenics program didn't reduce schizophrenia rates in Germany, showcasing environmental influences.
  3. Simplistic simulations demonstrate the nuanced interplay between genetic and environmental factors in polygenic disorders.
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Evolution Explains Polygenic Structure

Astral Codex Ten • 8465 implied HN points • 08 Feb 24
🔬 Science Evolution Genetics Mental health Research
  1. Genes for severe conditions like schizophrenia are likely small in effect and numerous, not large and few.
  2. Evolution would have eliminated genes with large negative effects, leaving only genes with small effects.
  3. The presence of genes with very small effects may be due to various factors like insufficient time for removal or counterbalancing advantages.

Polygenic Risk Scores: Ready for Prime Time?

Ground Truths • 3980 implied HN points • 19 Feb 24
🏥 Health & Wellness Genetics Risk Assessment Prevention Data Analysis
  1. Polygenic risk scores can provide valuable information on high genetic risk for diseases like heart disease and cancer, beyond traditional clinical risk factors.
  2. The use of polygenic risk scores is advancing thanks to efforts like the eMERGE consortium, incorporating multi-ancestry data and rigorous validation.
  3. Actionable polygenic risk scores have the potential to reduce health disparities and enhance preventive strategies in medical practice.

Open Thread 313

Astral Codex Ten • 2202 implied HN points • 29 Jan 24
🔬 Science Research Genetics Psychology Fiction Education
  1. Genes matter 2x as much as the environment in schizophrenia, not 4x as previously thought
  2. A study on political reasoning errors failed to replicate, questioning a larger literature on the topic
  3. Humans merging with AI may not be unprecedented, as evidenced by a medieval Italian man merging with a knife

Recommended Reading, Part II: Anthrophysiocracy

Contemplations on the Tree of Woe • 1040 implied HN points • 28 Feb 24
📖 Philosophy Human nature Political Ideologies Genetics
  1. Anthrophysiocracy explores the idea that there are objectively better social structures for human flourishing based on human nature, which varies across populations.
  2. The concept of constrained and unconstrained viewpoints on human nature influences political ideologies and social debates, with implications for societal structures and governance.
  3. Biological differences among human populations impact behavior and societal organization, challenging the notion of a universal governing system and emphasizing the importance of diverse self-governance.

Beyond the Pale: Irish cultural uniqueness past Rome's reach

Razib Khan's Unsupervised Learning • 463 implied HN points • 17 Mar 24
💾 History Europe Genetics
  1. Irish cultural uniqueness is deeply rooted in their historical resistance to aligning with Roman norms, particularly in the realm of religion and organization.
  2. The genetic analysis shows that the Irish share close genetic ties with the British populations, highlighting their shared ancestry and debunking the notion of a significant genetic difference between them.
  3. The distinctiveness of Irish culture, including practices like polygyny, and their gradual integration of Christianity at their own pace, sets them apart in the European context.

The longer I live, the wronger I get to be

Razib Khan's Unsupervised Learning • 674 implied HN points • 02 Mar 24
🔬 Science Genetics Evolution Data Analysis
  1. In the field of human population genetics, interesting times can lead to significant advancements and significant shifts in understanding.
  2. The concept of intelligence as influenced by single 'IQ genes' has been refuted in favor of the understanding that intelligence involves thousands of genes with small effects.
  3. Historical inaccuracies regarding the ancestry of European Jews, the dynamics of human evolution out of Africa, and the role of natural selection in human evolution have been corrected with new scientific discoveries and insights.

Quibbling with Cofnas: I

Not On Your Team, But Always Fair • 1690 implied HN points • 21 Jan 24
🌍 World Politics Ideology Genetics Race relations
  1. The hereditarian thesis acknowledges that different human groups have varied traits, but using the term 'race realism' may not be the best way to describe this concept.
  2. Social outcomes are influenced by both genetic differences and cultural patterns, making 'race' a limited descriptor for these variations.
  3. While genes play a role in social outcomes, factors like culture and social circumstances also significantly impact these outcomes, suggesting that a broader perspective than 'race realism' is needed.

Contra the ACMG on Polygenic Embryo Screening

Parrhesia • 494 implied HN points • 09 Mar 24
🏥 Health & Wellness Genetics Ethics Medical Research Reproductive Rights
  1. Several scientists and professional organizations criticize polygenic embryo screening for polygenic disorders due to concerns like lack of validation and utility.
  2. The article argues that the recommendation against polygenic embryo screening is flawed because it doesn't compare the method to other acceptable alternatives like selection based on embryo morphology.
  3. The authors suggest that the critique against polygenic embryo screening lacks consideration of the ethical implications and does not provide a comprehensive cost-benefit analysis.

Hans, are we…. the admixed ones?

Razib Khan's Unsupervised Learning • 446 implied HN points • 28 Feb 24
🔬 Science Genetics Population Ancestry History
  1. There is a lack of definitive research on the genetic history of Germany compared to other European countries like Britain or Estonia.
  2. Germany's past with race science, notable figures like Hans Günther, and the overshadowing of the Nazi era, has impacted the nation's exploration of human population genetics.
  3. Historical migrations, such as those of Corded Ware populations, have contributed significantly to the genetic makeup of Northern Europe, with influences from Neolithic farming populations.

Hereditarian Hypotheses Aren't More Harmful

ideassleepfuriously • 1238 implied HN points • 11 Jan 24
🔬 Science Genetics Bioethics Technology Research Health
  1. The blank slate perspective can lead to conflict, totalitarianism, and rejection of genetic enhancement technology.
  2. We should value understanding the role of genes in socioeconomic outcomes for accurate policy-making.
  3. Attributing group disparities to genes can reduce blame, control, and punishment, fostering compassion and reducing social conflict.

MASHUP: Aboriginal Smokeless Nicotine, Quinine & Caffeine Therapy, African G6PD Deficiency

Grey Goose Chronicles • 786 implied HN points • 29 Jan 24
🔬 Science Biology Medicine Genetics History
  1. Aboriginal Australians have a unique way of consuming tobacco with varying effects and health benefits.
  2. Quinine has a rich history in colonial expansion and fighting malaria, while caffeine might hold potential as an antimalarial drug.
  3. Genetic conditions like G6PD deficiency in sub-Saharan Africans show adaptations to malaria, impacting medical treatments and outcomes.

The Genetic Time Machine: Neanderthals, genomics and hybridization priors

ideassleepfuriously • 982 implied HN points • 16 Jan 24
🔬 Science Genomics Evolutionary biology Anthropology Genetics
  1. 200 thousand years of isolation may not be enough for genetic incompatibilities to develop
  2. Genomics has revolutionized evolutionary biology by providing precise insights with massive amounts of data
  3. The mixing of Neanderthal and modern human lineages led to genetic incompatibilities and selection against Neanderthal-origin DNA in modern humans

New tools for programming biology

The Century of Biology • 472 implied HN points • 18 Feb 24
🔬 Science Biology Genetics CRISPR
  1. CRISPR technology has revolutionized biology with its programmable gene editing capabilities, leading to rapid advancements and commercial interest.
  2. New tools like HACE for targeted genetic variation and technologies for RNA writing are expanding the toolkit for programming biology.
  3. Exploration of retrons as a tool for DNA production and genome editing reveals the potential for diverse applications in genome engineering.

Genetiken förändrar vår syn på ras

Rak höger med Ivar Arpi • 589 implied HN points • 07 Feb 24
🌍 World Politics Genetics Race Migration Archaeology History
  1. Genetics has revealed greater differences between people than previously thought, challenging both racist and politically correct beliefs.
  2. Historical migrations and cultural exchanges are being reevaluated in light of DNA research, overthrowing old theories.
  3. Recent genetic studies have shed light on demographic movements, such as the Indo-European migrations, significantly impacting our understanding of human history.

Autism diagnoses are rising, yes, but autism, probably not

Just Emil Kirkegaard Things • 923 implied HN points • 09 Jan 24
🔬 Science Autism Diagnosis Mental health Genetics Bioethics
  1. Autism diagnoses are increasing due to more liberal diagnostic criteria and shifts in categorization.
  2. There is a trend of decreasing thresholds for autism diagnoses, including reclassifying individuals previously diagnosed with other conditions.
  3. The prevalence of autism is influenced by genetic factors, and options for reducing autism risk may raise ethical questions.

The Goldilocks zone between inbreeding and outbreeding

ideassleepfuriously • 884 implied HN points • 10 Jan 24
🔬 Science Genetics Evolution Psychology Fertility
  1. The risk of producing abnormal embryos is highest in siblings, lower in first cousins, and lowest in third or fourth cousins.
  2. Inbreeding can lead to shared defective alleles and recessive disorders, causing inbreeding depression.
  3. Outbreeding can lead to genetic incompatibilities and higher rates of miscarriage, causing outbreeding depression.

The two Indo-European revolutions and Germania’s rise

Razib Khan's Unsupervised Learning • 274 implied HN points • 29 Feb 24
💾 History Ancient Civilizations Genetics Archaeology
  1. The rise and fall of different cultures in pre-Roman Germany was influenced by successive trends in artifacts and genetics, highlighting a transition from Bronze Age patriarchies to new ruling elites.
  2. The Beaker revolution in Central Europe saw the replacement of Corded Ware male lineages dominated by R1a with a rise in the R1b haplogroup, indicating a shift in ruling elite and population dynamics.
  3. The Beaker people's expansion from western Germany led to genetic subsuming of previous populations in Britain and Ireland, contributing to the formation of proto-Germanic tribes in antiquity.

Why Does COVID-19 Impact People Differently?

LIL Science • 943 implied HN points • 24 Dec 23
🏥 Health & Wellness COVID-19 Genetics Immune System Vaccination
  1. COVID-19 affects people differently, with factors like age, comorbidities, and exposure to the virus playing a role
  2. Genetics, such as blood type and HLA genotype, can impact susceptibility to severe COVID-19
  3. Research is ongoing to uncover genetic factors that influence COVID-19 severity, but prevention through vaccination, masks, and distancing remains key

Eggs and scrambled chromosomes

De Novo • 121 implied HN points • 15 Mar 24
🔬 Science Biology Genetics Research
  1. Growth of eggs from stem cells is challenging, but a new research approach involving injecting adult cell nucleus into a donor egg may offer an alternative.
  2. Chromosomes' proper segregation during meiosis II seems more efficient in inbred mice compared to hybrid mice, indicating the importance of genetic similarity in the process.
  3. Understanding the mechanism that aids proper segregation in inbred chromosomes could potentially lead to advancements in using the nuclear transfer method for human oocytes, though challenges like aneuploidy and efficiency still need to be addressed.

Stories We’d Like to Publish

Asimov Press • 174 implied HN points • 03 Mar 24
🔬 Science Biotechnology Genetics Microbiology Predictive Models Animal Welfare
  1. Asimov Press is publicly sharing ideas for essays they'd like to publish and inviting writers to contribute by emailing them at [email protected].
  2. Topics in biotechnology range from synthetic blood development to artificial wombs and synthetic nitrogen fixation, showcasing the broad spectrum of innovative research being undertaken.
  3. Biotechnology advancements aim to address a variety of issues, such as animal welfare, predictive growth models for microbes, and challenges in protein structure prediction, highlighting the diverse applications and potential impact of biotechnological research.

RKUL: Time Well Spent 03/03/2024

Razib Khan's Unsupervised Learning • 171 implied HN points • 04 Mar 24
🔬 Science Evolutionary biology Genetics Anthropology Ancient History Podcasts
  1. Parents can now screen embryos during IVF using whole genome sequencing to check for hundreds of conditions, keeping families safe.
  2. The presence of maternal grandmothers has been linked to higher survivorship among grandchildren, showing the evolutionary importance of menopause.
  3. Research on ancient DNA and AI may offer valuable insights into human history, potentially surpassing the impact of ancient DNA studies.

Schizophrenia: a coda

Wyclif's Dust • 1751 implied HN points • 23 Sep 23
🏥 Health & Wellness Mental health Research Genetics
  1. There are significant differences in schizophrenia polygenic scores between ethnic groups, which can impact diagnosis and treatment.
  2. Genetic research on different ethnic groups can lead to improved medical outcomes and understanding disparities.
  3. Studying gene-environment interactions in intergroup context can provide insights into causal pathways for social and medical outcomes.

The Vector Zoo

Asimov Press • 96 implied HN points • 07 Mar 24
🔬 Science Diseases Genetics Vaccines
  1. The Vector Zoo showcases humanity's battle to eradicate zoonotic and vector-borne diseases, emphasizing the challenges faced in diseases like malaria due to shifting parasites and vectors.
  2. The Last Mile Labyrinth in the Vector Zoo symbolizes the choice between collaborative efforts towards disease eradication or reverting to isolated living, highlighting the complexities and costs involved in disease elimination.
  3. The Temple of Political Will in the Vector Zoo underscores the critical role of social and political commitment in disease eradication, demonstrating the impact of funding and investments in public health initiatives.

Interracial Dating Paper FAQ

sebjenseb • 196 implied HN points • 10 Feb 24
🔬 Science Research Genetics Data Analysis Psychology Relationships
  1. Assortative mating occurs between races, with individuals who date outside their race being more similar to each other in terms of intelligence, height, and risk-taking behaviors.
  2. Current literature suggests that interracial relationships may have a higher likelihood of ending or experiencing domestic violence issues, and mixed-race children might be more prone to mental/behavioral problems, possibly due to self-selection rather than social factors.
  3. Attractiveness was a weak predictor of interracial dating across all races, indicating that mate value or race exchanges based on mate value were not significant factors in interracial dating.