The hottest Biotechnology Substack posts right now

And their main takeaways
Top Science Topics
2nd Smartest Guy in the World β€’ 3577 implied HN points β€’ 24 Jan 24
  1. Bill Gates is involved in projects like global tracking tattoos and genetically modified mosquitoes.
  2. There are concerns raised about Bill Gates funding schemes that involve cutting down forests and deploying GMO Frankenmosquitos.
  3. There is skepticism and caution advised regarding Bill Gates' projects to control and monitor the population.
Trevor Klee’s Newsletter β€’ 1119 implied HN points β€’ 05 Feb 24
  1. Karuna Therapeutics achieved a $14 billion sale through drug repurposing.
  2. Drug repurposing can be a highly lucrative business without requiring excessive brilliance or luck.
  3. VCs often prioritize hype and platform-based drug development over drug repurposing success stories.
LatchBio β€’ 268 implied HN points β€’ 07 Mar 24
  1. Elsie Biotechnologies uses computational design tools and high-throughput experimental approaches to develop drugs.
  2. Partnerships with large pharmaceutical companies like GSK can significantly impact the progress of smaller biotech companies.
  3. Oligonucleotide therapies represent the future of drug development, promising safer and more effective treatments.
Not Boring by Packy McCormick β€’ 106 implied HN points β€’ 15 Mar 24
  1. SpaceX successfully launched Starship into orbit, showcasing the power of moonshots to make people feel part of something bigger and optimistic about the future.
  2. Cognition AI, built by gold-medalist coders, can code based on requests, marking a significant advancement in AI technology.
  3. Extropic AI's thermodynamic chips could revolutionize computing by leveraging nature's randomness for energy efficiency, potentially accelerating the next era of computing.
Get a weekly roundup of the best Substack posts, by hacker news affinity:
Asimov Press β€’ 174 implied HN points β€’ 03 Mar 24
  1. Asimov Press is publicly sharing ideas for essays they'd like to publish and inviting writers to contribute by emailing them at [email protected].
  2. Topics in biotechnology range from synthetic blood development to artificial wombs and synthetic nitrogen fixation, showcasing the broad spectrum of innovative research being undertaken.
  3. Biotechnology advancements aim to address a variety of issues, such as animal welfare, predictive growth models for microbes, and challenges in protein structure prediction, highlighting the diverse applications and potential impact of biotechnological research.
ASeq Newsletter β€’ 36 implied HN points β€’ 31 Jan 24
  1. Illumina has a method to potentially double their instruments' throughput, but it may come with a slight decrease in accuracy.
  2. By simultaneously reading both the forward and reverse strands, Illumina can achieve four reads per cluster, doubling the throughput.
  3. Implementing the simultaneous paired-end sequencing approach may be challenging without sacrificing accuracy, but it opens up opportunities for increased throughput in the future.
ASeq Newsletter β€’ 51 implied HN points β€’ 09 Jan 24
  1. Illumina has a variety of sequencing instruments in their lineup, which includes different models and variations.
  2. The cost of production for these instruments varies based on the technology and components used.
  3. Rationalizing the Illumina instrument lineup could involve withdrawing some current models and introducing new, more cost-effective options.
ASeq Newsletter β€’ 21 implied HN points β€’ 17 Feb 24
  1. PPMSeq is a duplex sequencing technique that ensures high accuracy reads by reading both forward and reverse strands of a double-stranded sequence.
  2. Ultima's PPMSeq works by amplifying both strands on the same bead and utilizing a tag to identify their presence, with errors causing radical dephasing which is taken care of by downstream software.
  3. Approaches to implementing PPMSeq on Ultima's platform involve reading both strands in both directions simultaneously or keeping the product on beads in the same orientation, each with its own challenges and considerations.
Everything Is Amazing β€’ 470 implied HN points β€’ 24 Mar 23
  1. The way chameleons change color can inspire future color-changing technology for surfaces and fabrics.
  2. Current advancements in color-changing materials like Fabrican and PhotoChromeleon show promise for future fashion and architectural applications.
  3. The deep meanings and social implications of colors in fashion and pigmentation mean that changing color technology may have complex impacts on society.
Axial β€’ 7 implied HN points β€’ 13 Mar 24
  1. Kidney disease, particularly autosomal dominant polycystic kidney disease (PKD), has been underinvested compared to other conditions like oncology and diabetes.
  2. The development of drugs targeting GPCRs PC-1 and PC-2 in PKD could significantly improve the quality of life for patients by reducing cyst size.
  3. Business models in drug development are shifting towards rare disease candidates like PC-1/2, emphasizing treatments that exceed the current standard of care.
The Century of Biology β€’ 390 implied HN points β€’ 19 Feb 23
  1. The immune system is a major frontier for the future of biotechnology and medicine.
  2. Engineered T cells, like CAR-T therapy, show promise in treating diseases like cancer by programming immune cells.
  3. Immune engineering, especially in combination with the 4-S stack, holds great potential for designing new therapies and advancing genetic engineering technology.
ASeq Newsletter β€’ 14 implied HN points β€’ 14 Feb 24
  1. Ultima has transitioned to using unpatterned flowcells, which are cheaper and possibly work well with minor drawbacks.
  2. Ultima's manufacturing using unpatterned flowcells involves surface treatment and spin coating to attach and shrink beads for better identification and access.
  3. The occupancy and loading efficiency of Ultima's unpatterned flowcells suggest a potential capacity for 8 billion reads per run, showing advancements since their 2022 preprints.
The Century of Biology β€’ 272 implied HN points β€’ 26 Mar 23
  1. Multiple important technological paradigms are converging in the life sciences, impacting life on various scales.
  2. Synthetic biology focuses on designing new genetic circuits to program cells for new tasks.
  3. Using a platform like CLASSIC, genetic circuits can be systematically tested to learn composition-to-function relationships.
The Polymerist β€’ 215 implied HN points β€’ 25 Apr 23
  1. Lignin can be a valuable source of aromatic structures for creating synthetic polymers and other materials.
  2. MetGen's enzyme-based technology allows for efficient depolymerization and refining of lignin in alkaline conditions.
  3. MetGen's advancements in lignin processing could make it a viable alternative to petroleum-based feedstocks for creating chemicals and materials.
Axial β€’ 7 implied HN points β€’ 17 Feb 24
  1. MoonLake Immunotherapeutics is developing a tri-specific nanobody therapy called Sonelokimab (SLK) that has shown significant efficacy in treating inflammatory diseases like HS, PsA, and PsO.
  2. SLK offers unique benefits like blocking all IL-17 pro-inflammatory dimers, enabling tissue penetration, and maintaining high response rates in patients with moderate-to-severe conditions.
  3. MoonLake's SLK has the potential to become a best-in-class IL-17 inhibitor in a multibillion-dollar market, with its innovative structure, clinical success, and competitive advantages over existing treatments.
Splitting Infinity β€’ 39 implied HN points β€’ 30 Oct 23
  1. Yeast, especially in precision fermentation, can be genetically modified to produce a wide range of chemicals, biologics, and medicines by augmenting their genes.
  2. The main challenge in precision fermentation is reducing costs, particularly in the purification process where proteins are separated from complex solutions.
  3. Novel techniques like self-cleaving tags and self-aggregating proteins offer promising solutions for purifying proteins in a cost-effective and efficient manner, potentially eliminating the need for expensive purification methods like column chromatography.
Erika’s Newsletter β€’ 137 implied HN points β€’ 18 Apr 23
  1. It's important to keep good track of custom DNA programs in biology for engineering purposes.
  2. Current DNA management lacks clear nomenclature and annotation, making it challenging to work with DNA sequences.
  3. Challenges in DNA management highlight the complexity of biological functions and the importance of handling sequences carefully and thoughtfully.
Axial β€’ 37 implied HN points β€’ 20 Oct 23
  1. New optimized prime editors called PE6 variants improve editing outcomes in mammalian cells
  2. Phage-assisted continuous evolution enhances the efficiency of compact reverse transcriptases
  3. Combining evolved Cas9 domains with engineered RTs creates efficient prime editors for installing DNA sequences in vivo
Extropic Thoughts β€’ 78 implied HN points β€’ 12 Jul 23
  1. The essay discusses amending the human constitution to overcome limitations like aging and death.
  2. It proposes expanding human perceptual abilities and enhancing intelligence through biotechnology and neural improvements.
  3. The amendments aim to move humanity towards a posthuman condition, integrating technology into individuals for unprecedented innovation.
Asimov Press β€’ 90 implied HN points β€’ 16 Apr 23
  1. GPT-4 controlled a lab robot to conduct chemical reactions, showcasing the potential of using natural language to automate experiments.
  2. Skin microbes were engineered to activate the immune system to fight tumors when applied to the skin, offering a novel cancer treatment approach.
  3. Tobacco plants were genetically modified to produce moth sex pheromones, providing a natural way to repel male moths from crops and protect them.
LatchBio β€’ 39 implied HN points β€’ 29 Aug 23
  1. Storing and transferring large sequencing files in biology can be challenging due to the lack of user-friendly storage solutions like AWS S3.
  2. Integrating and tracking sample metadata in biology is vital but often hindered by unintuitive systems and lack of system integrations.
  3. Setting up data pipelines and computational workflows for biology data analysis is labor-intensive, requiring user-friendly interfaces and tools.
ASeq Newsletter β€’ 14 implied HN points β€’ 06 Dec 23
  1. Bought an old MiSeq on eBay, faced issues like getting reagents from Illumina and shipping to Japan but managed to resolve them
  2. Had to reset the password for the MiSeq, managed it by using a Linux system to reset and configure passwords
  3. Prepped PhiX control, ran a sequencing run with over-clustered results, but was able to get 20+ bases aligned to PhiX
paxtier β€’ 1 implied HN point β€’ 18 Mar 24
  1. There has been a 200% increase in investments in the blue economy between 2018 and 2022, signifying a growing interest and momentum.
  2. Challenges in the sector include a massive global unmet financing gap, concentration of investments at market launch phase, and investor hesitancy.
  3. Recent developments highlight collaborations in seaweed cultivation, funding raises for startups like KAS, and advancements in sustainable aquafeeds.
paxtier β€’ 2 implied HN points β€’ 25 Feb 24
  1. An algae domestication program won a Seaweed Ideathon, focusing on sustainable agriculture practices and biostimulant production.
  2. Investors are showing interest in aquaculture technology, with significant funding rounds announced for seaweed-derived products and sustainability initiatives.
  3. Job opportunities in the seaweed and microalgae industry are on the rise, with companies like PhycoWorks and GreenWave actively recruiting for various positions.