The hottest Enzymes Substack posts right now

All living things are made up of enzymes that catalyze chemical reactions in our bodies
Enzymes play a crucial role in maintaining balance and homeostasis within our bodies
Evolution has shaped enzymes to help organisms adapt to changing environments and survive

Lignin can be a valuable source of aromatic structures for creating synthetic polymers and other materials.
MetGen's enzyme-based technology allows for efficient depolymerization and refining of lignin in alkaline conditions.
MetGen's advancements in lignin processing could make it a viable alternative to petroleum-based feedstocks for creating chemicals and materials.

Gene therapy can partially restore color vision in those with a hereditary disease
Gene editing in trees can lead to more sustainable paper production
Winning a Nobel Prize may reduce scientific productivity due to increased obligations

Enzymes evolve through mutations in DNA that lead to changes in proteins.
Proteins define traits, and understanding their evolution helps us comprehend life's diversity.
Evolutionary biology provides a framework for understanding genetic changes in organisms, including the origin of antibiotic resistance.

LOVPLD is a new optogenetic tool to control PA production with high precision in cells.
LOVPLD has lower background activity compared to previous optogenetic approaches.
LOVPLD allows for studying organelle-specific PA metabolism and AMPK regulation.

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Hba1c is a useful test, but it has limitations due to factors like red blood cell turnover and variations in deglycating enzymes; it should be used in conjunction with other information for a complete understanding.
Higher levels of the deglycating enzyme FN3K coupled with lower downstream metabolism of 3-deoxyglucosone can lead to lower Hba1c, which might not accurately reflect glycation levels.
Insulin signaling and consumption of polyphenol-rich fruits and vegetables may help protect against the accumulation of harmful substances like 3-deoxyglucosone, which contribute to diabetes complications.

Acetyl CoA is a key product in the biosynthesis of cholesterol, derived from various energy sources.
Statin drugs hinder the synthesis of mevalonate, which is crucial for generating cholesterol, squalene, and coenzyme Q10.
Understanding the flow chart of cholesterol biosynthesis helps comprehend the creation of vitamin D, bile acids, and steroid hormones.

Autoimmune disorders may not be the body attacking itself, but a protective response to certain conditions.
High levels of hydrogen peroxide (H2O2) might be a key factor in autoimmune thyroiditis (AT), and reducing H2O2 levels could potentially cure it.
Genetic defects in enzymes like GPX1 can lead to higher AT risk, and boosting enzyme activity with nutrients like selenium may offer a solution.

Enzymes play crucial roles in converting sugar into energy
Hexokinase, Phosphoglucose isomerase, and Phosphofructokinase-1 are key enzymes in the process
The glycolysis pathway involves multiple steps and enzymes to produce ATP