The hottest Gene Therapy Substack posts right now

The judiciary, influenced by eugenicists, normalized forced genetic therapy as a societal condition.
Utilitarianism, used for 'the greater good,' erodes individual rights and can lead to tyranny.
The next step from gene therapy is CRISPR gene editing, aiming for genetic perfection for the elite.

Delivering gene therapies safely and specifically inside the body is a challenging problem.
Using viruses for gene therapy presents challenges due to lack of specificity and immune response.
Dyno Therapeutics aims to revolutionize gene therapy through AI-powered capsid design solutions.

Chris Dixon writes a book about blockchain's future impact on the internet.
Gene therapy successfully restores hearing for an 11-year-old using innovative treatments.
Researchers develop CAR T cells targeting senescent cells and Bridge RNAs for genetic modifications.

Gene therapy can partially restore color vision in those with a hereditary disease
Gene editing in trees can lead to more sustainable paper production
Winning a Nobel Prize may reduce scientific productivity due to increased obligations

Decreased cost of R&D in biotech may lead to more academics starting startups.
Biotech is transitioning from analog to digital with the help of AI and computation.
New infrastructure and technologies are lowering the cost of starting and running biotech companies.

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Forge Biologics is a gene therapy manufacturing company in Ohio led by Tim Miller.
They have one of the largest AAV manufacturing facilities with collaborations with other companies.
Forge Biologics aims to increase biomanufacturing capacity and focuses on treating Krabbe Disease.

Gene therapy has the potential to treat and cure genetic diseases, but it is a complex process requiring expertise in biology and manufacturing.
The gene therapy value chain involves steps like target identification, payload design, delivery vehicle design, translation development, manufacturing, and clinical trials.
Companies are working on breakthroughs in gene therapy technology, such as improving AAV vectors and refining CRISPR-Cas9 systems, but face challenges in experimental processes and data availability.

DNA storage in hydrogels can last 1000 years, showing potential for efficient information storage.
Mapping the human pangenome with 47 people aids in understanding genetic diversity and phenotypes.
A single genetic mutation in ants created a 'supergene' impacting social organization, hinting at collective behavior research possibilities.