The hottest Biology Substack posts right now

And their main takeaways
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Top Science Topics

AI keeps getting better at talking about consciousness

The Intrinsic Perspective • 13599 implied HN points • 13 Mar 24
🔬 Science AI Consciousness Philosophy Neurotechnology Biology
  1. Artificial Intelligence is advancing in discussing consciousness, raising questions about its implications
  2. There is a scientific imbalance between the understanding of creating AI and understanding consciousness
  3. Debates on AI consciousness highlight challenges in defining consciousness and its relation to AI capabilities

We’re entering a golden age of engineering biology

Noahpinion • 16647 implied HN points • 18 Feb 24
🔬 Science Biology AI Genetics Automation Medicine
  1. The advancements in deep learning, cost-effective data collection through lab automation, and precision DNA editing with technologies like CRISPR are converging to transform biology from a scientific field to an engineering discipline.
  2. Historically, biology has been challenging due to its immense complexity, requiring costly trial-and-error experiments. However, with current advancements, we are now at a critical point where predictability and engineering in biological systems are becoming a reality.
  3. The decreasing cost of DNA sequencing, breakthroughs in deep learning models for biology, sophisticated lab automation, and precise genetic editing tools like CRISPR are paving the way for a revolutionary era in engineering biology, with vast potential in healthcare, agriculture, and industry.

Who Does Polygenic Selection Help?

Astral Codex Ten • 11562 implied HN points • 23 Feb 24
🔬 Science Genetics Medical Ethics Biology Healthcare
  1. Polygenic selection can help prevent genetic diseases like schizophrenia by choosing embryos with lower risk during IVF, leading to healthier children
  2. Despite the complex nature of genetic selection, it can have positive effects on individuals and society by preventing diseases and improving overall health outcomes
  3. Analogies like preventing fetal alcohol syndrome through prenatal care or choosing healthier IVF embryos demonstrate the ethical and practical benefits of polygenic selection

Links For February 2024

Astral Codex Ten • 7433 implied HN points • 29 Feb 24
🔬 Science Psychology Medicine Technology History Biology
  1. Blind mathematicians often work in geometry and topology, suggesting unique perceptions.
  2. The Basilica of the Holy House in Italy intriguingly ties angelic folklore with historical architecture.
  3. Starting a journey from Seattle and heading east ends in Russia, the first country reached while traversing the Atlantic Ocean.
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Why It Might Not Sink In Until You've Written It Down

Everything Is Amazing • 1477 implied HN points • 18 Feb 24
🔬 Science Memory Note Taking Biology Inspiration
  1. Writing something down helps you remember it better, so it's not just about typing but also about physically writing.
  2. Observing nature can lead to interesting discoveries, like how birds charm worms using vibrations to catch them.
  3. Unexpected collaborations and interactions can lead to exciting outcomes, like gaining exposure to a wider audience through social media.

Epistemic Hell

Secretum Secretorum • 1768 implied HN points • 27 Jan 24
🔬 Science Health Physics Medicine Biology Research
  1. Through history, reasoning based on limited information has led to dangerous outcomes, like chronic cyanide poisoning and scurvy.
  2. Some scientific problems, like understanding heredity, have been challenging due to complexity and the need for exceptional datasets.
  3. To escape epistemic hells, radical ideas, serendipity, unlearning prior knowledge, and persistence are vital.

MASHUP: Aboriginal Smokeless Nicotine, Quinine & Caffeine Therapy, African G6PD Deficiency

Grey Goose Chronicles • 786 implied HN points • 29 Jan 24
🔬 Science Biology Medicine Genetics History
  1. Aboriginal Australians have a unique way of consuming tobacco with varying effects and health benefits.
  2. Quinine has a rich history in colonial expansion and fighting malaria, while caffeine might hold potential as an antimalarial drug.
  3. Genetic conditions like G6PD deficiency in sub-Saharan Africans show adaptations to malaria, impacting medical treatments and outcomes.

New tools for programming biology

The Century of Biology • 472 implied HN points • 18 Feb 24
🔬 Science Biology Genetics CRISPR
  1. CRISPR technology has revolutionized biology with its programmable gene editing capabilities, leading to rapid advancements and commercial interest.
  2. New tools like HACE for targeted genetic variation and technologies for RNA writing are expanding the toolkit for programming biology.
  3. Exploration of retrons as a tool for DNA production and genome editing reveals the potential for diverse applications in genome engineering.

Numlock News: January 18, 2024 • Stellar Streams, Tetrapods, Richard Feynman

Numlock News • 766 implied HN points • 18 Jan 24
🔬 Science Space Biology Data Privacy Astronomy Physics
  1. The National Baseball Hall of Fame faced a significant financial decline in revenue and attendance in 2022.
  2. Walmart's financial services became a target for scammers, leading to billions of dollars in fraud.
  3. Biologists are concerned about the extinction of tetrapod species, with around 856 currently missing and presumed extinct.

Fast Biology

Asimov Press • 270 implied HN points • 20 Feb 24
🔬 Science Biology Physics Mathematics Experimentation
  1. The concept of viewing time differently through the lens of the Minute Man and the Millennium Man prompts questions about our understanding of speed and time in the world.
  2. Biological processes at the cellular level can occur at astonishing speeds, with enzymes performing millions of chemical reactions per second and protein 'motors' spinning thousands of times a minute.
  3. Scientists use innovative experiments to directly observe rapid biological processes, such as watching ATP synthase spin or tracking ribosomes moving along messenger RNA strands, to gain a deeper understanding of the intricate workings of life.

Eggs and scrambled chromosomes

De Novo • 121 implied HN points • 15 Mar 24
🔬 Science Biology Genetics Research
  1. Growth of eggs from stem cells is challenging, but a new research approach involving injecting adult cell nucleus into a donor egg may offer an alternative.
  2. Chromosomes' proper segregation during meiosis II seems more efficient in inbred mice compared to hybrid mice, indicating the importance of genetic similarity in the process.
  3. Understanding the mechanism that aids proper segregation in inbred chromosomes could potentially lead to advancements in using the nuclear transfer method for human oocytes, though challenges like aneuploidy and efficiency still need to be addressed.

The origins of power dynamics, or why chimps can't play baseball

The Garden of Forking Paths • 2122 implied HN points • 05 Jul 23
🔬 Science Evolution Biology Psychology Anthropology Human behavior
  1. Humans can throw objects accurately and at high speeds, shaping our modern power dynamics in society.
  2. Our unique shoulder adaptations allow for precise and fast throwing, giving us a competitive advantage over other species.
  3. The ability to use ranged weapons and throw projectiles from a distance has influenced human social structures and power dynamics.

Making the Micropipette

Asimov Press • 322 implied HN points • 02 Jan 24
🔬 Science Biology Innovation Technology Research History
  1. The development of the micropipette was driven by the hazards and limitations of mouth pipetting.
  2. Innovators from different parts of the world each contributed to the modern micropipette's design and features.
  3. The history of the micropipette highlights the importance of simple tools and incremental improvements in scientific breakthroughs.

But Seriously, Why The F*ck Do Giraffes Have Long Necks?

Insight Axis • 612 implied HN points • 12 Nov 23
🔬 Science Biology Genetics Evolution Knowledge Environment
  1. Giraffes have long necks to better reach food on tall trees, increasing their chances of survival and passing on their genes.
  2. In the true story of giraffes' evolution, genes are the main characters that hold knowledge for survival in their environment.
  3. Humans, unlike giraffes, can create their own knowledge using their minds, allowing them to survive in diverse environments and even outer space.

On RFK Jr., Atrazine and WiFi. Plus a puzzle for you!

An Insult to Intuition • 1454 implied HN points • 26 Jun 23
🔬 Science Technology Medicine Research Biology Physics
  1. Kennedy discussed the potential effects of Atrazine on organisms like frogs and mammals, sparking a debate on environmental toxins.
  2. The story shared analogies between a hypothetical alien civilization and current human societal challenges, emphasizing the importance of humility and balance.
  3. There was a discussion on the perceived health risks of WiFi radiation, highlighting the need for thoughtful consideration and humility in scientific discourse.

Why wasn't preservation with the goal of potential future revival started earlier in history?

Neurobiology Notes • 176 implied HN points • 16 Jan 24
🔬 Science Biology Technology History Neuroscience Cryonics
  1. Despite preservation with the goal of future revival not being proposed for most of human history, in 1962, Evan Cooper and Robert Ettinger independently introduced the concept of cryonics.
  2. Factors influencing the delay in proposing preservation with future revival include a need for optimism in technological progress, willingness to take risks, and advances in preservation technology.
  3. Other possible reasons for the delayed start include societal restrictions, advancements in information theory, and the idea that preservation does not need to be perfect to be pursued.

Why The Sky Smells Great

Everything Is Amazing • 1255 implied HN points • 25 May 23
🔬 Science Nature Health Biology Psychology Weather
  1. The smell of fresh air can impact our mood and health, like boosting immune cells when exposed to aromatic forest scents.
  2. Weather changes can create distinct smells, like the pre-storm smell of ozone or the earthy petrichor after rain.
  3. Our sense of smell may have deeper cultural and biological connections that we are still exploring.

Debunking Pseudoscience: ‘Multimodal Models of Animal Sex’

Reality's Last Stand • 1434 implied HN points • 06 Mar 23
🔬 Science Biology Gender Research Evolution Critique
  1. The paper debunks the traditional binary model of biological sex by proposing a multimodal model.
  2. Current efforts in academia are influencing scientific research on sex by incorporating political motivations in the study.
  3. The study fails to provide evidence for more than two sexes and is criticized for misinterpreting sex differences in genetics, endocrinology, morphology, and behavior.

Graphene: New Comprehensive Study, Degradation, and Industry Trends

Tessa Fights Robots • 43 implied HN points • 06 Mar 24
🔬 Science Research Toxicity Applications Biology Industry
  1. A recent study highlighted the toxicity and degradation of graphene, raising concerns about its broad applications and potential hazards on the environment and human health.
  2. Further research is needed on the degradation of graphene-based nanomaterials to understand their environmental impact and health risks. Some compounds like humic acid and specific enzymes play a role in the biodegradation process.
  3. Graphene is a trending material in various industries, but there are growing concerns about its safety, likening it to the new asbestos or Glyphosate 2.0. Monitoring industry trends and applications of graphene is important for understanding its impact.

Chemistry sets and the old-fashioned childhood

Demodexio • 132 implied HN points • 04 Jan 24
🚌 Education Chemistry Biology
  1. Chemistry sets used to be more dangerous, now they are heavily regulated for children's safety.
  2. We should invest more in structured education for kids in subjects like chemistry and biology to provide similar experiences.
  3. Children today have more limited freedom to explore outdoors, so it's important to offer structured outdoor education in schools.