The hottest Biology Substack posts right now

And their main takeaways
Category
Top Science Topics

SNT: Frequently asked questions.

Gordian Knot News • 95 implied HN points • 02 Mar 25
🔬 Science Health Biology Toxicology Radiation Engineering
  1. The SNT model divides radiation exposure into daily doses for better tracking of cancer risk. This helps in understanding how each day's exposure can affect long-term health.
  2. SNT is considered conservative in its estimates, as it tends to predict higher cancer risks compared to other models. This is seen as useful for safety regulations.
  3. There is resistance to SNT in the scientific community, with many experts favoring a different model called LNT. This makes it challenging to implement a new standard for evaluating radiation risks.

AI-generated Anki cards are not to be trusted

De Novo • 121 implied HN points • 13 Jun 25
🚌 Education Learning Memory Technology AI Biology
  1. AI-generated Anki cards can have mistakes that may lead to learning incorrect information. It's important to double-check AI content, especially on complex topics.
  2. Relying on AI for learning new material may not be wise, as it could lead to errors that are not obvious at first glance.
  3. Even when asking different AI systems to review the same content, they can miss errors or indicate correct information as wrong. Human oversight is crucial.

Sex in Biology Signature Campaign

Heterodox STEM • 156 implied HN points • 21 Feb 25
🔬 Science Biology Evolution Ecology Genetics Research
  1. Some biology societies have stated that sex is not simply male or female, which has caused confusion.
  2. A group of biologists has written a letter saying that sex should actually be defined by gamete type, meaning there are two sexes.
  3. They are asking other biologists to sign this letter to support their view and clarify the definition of sex.

Some ants can choose to live 5x as long

Trevor Klee’s Newsletter • 746 implied HN points • 11 Feb 25
🔬 Science Biology Physiology Longevity Insulin
  1. Some ants, like Indian jumping ants, can live much longer lives if they become a pseudoqueen. They can live about five times longer than their worker counterparts after winning a duel for queen status.
  2. The lifespan of these ants can actually change based on their circumstances. If a gamergate is placed in a new colony with an active queen, they revert back to being a normal worker with a shorter lifespan.
  3. This interesting case suggests a different relationship between reproduction and lifespan. In these ants, becoming a reproductive figure seems to extend their life instead of shortening it like it does in many other species.

AI-Designed Enzymes

Asimov Press • 457 implied HN points • 13 Feb 25
🔬 Science Biology Chemistry AI Research Engineering
  1. Researchers are now able to design complex enzymes from scratch using AI. This new ability could help create custom enzymes for various chemical reactions.
  2. The process of designing these enzymes is not easy, as they need to change shape during reactions. Scientists have developed methods to improve their ability to predict how these enzymes will work.
  3. Even though the newly designed enzymes are not as fast as natural ones yet, this work is a big step toward making more effective enzymes for scientific and industrial purposes.
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The Making of a Gene Circuit

Asimov Press • 290 implied HN points • 16 Feb 25
🔬 Science Biology Genetics Mathematics Technology Engineering
  1. The repressilator is a simple gene circuit that helps scientists understand how to control living cells. It's made of three genes that work together in a loop to create a rhythmic 'on-off' signal.
  2. Michael Elowitz and his team proved that you could design circuits in living cells, which opened the door to synthetic biology. This means we can now program cells to perform specific tasks.
  3. Modern advancements have built on the repressilator, allowing us to create complex gene circuits that can mimic computing processes inside cells. This shows how biology can become a tool for engineering and technology.

AI, Cybernetics, and Complexity: unpacking the 2024 Nobel Prizes

Complexity Thoughts • 319 implied HN points • 14 Oct 24
🔬 Science Complexity Cybernetics Artificial Intelligence Physics Biology
  1. The 2024 Nobel Prizes recognized important advances in AI, but these discoveries are also deeply connected to complex systems. This shows that complexity science is becoming a more accepted area in high-level research.
  2. Understanding complex systems requires looking beyond traditional boundaries of science. The future of breakthroughs may rely on merging different scientific fields and using interdisciplinary approaches.
  3. Success in tackling complex challenges, like climate change and health issues, will need both detailed analysis of parts and a broader view of systems. Researchers must balance reductionist methods with insights from complexity science.

Mechanisms too simple for humans to design

Telescopic Turnip • 274 implied HN points • 22 Jan 25
🔬 Science Biology Evolution Genetics Technology Artificial Intelligence
  1. Living organisms, like butterflies and bacteria, are incredibly complex, yet humans struggle to replicate them fully because they are surprisingly simple in construction. It's like trying to build a working insect but only using a few basic parts.
  2. The information contained in the genomes of living beings is often much less than what we assume. For example, the human genome contains less useful information than what fits on a CD, showcasing how nature efficiently packs information.
  3. Natural evolution leads to a balance where simpler designs can survive better, while human-made technologies often have complex specifications and high error rates. This means some amazing designs in nature might be too bizarre for humans to create intentionally.

A Search for Sick Animals

Asimov Press • 186 implied HN points • 05 Feb 25
🔬 Science Biology Medical Research Neuroscience Animal studies Genetics
  1. Animal models are really important for studying diseases like Parkinson's because they can show how conditions develop and help test new treatments.
  2. Researchers have looked for animals with naturally occurring Parkinson's, but finding them is hard. A recent study claims to have found a monkey with the disease indicating there may be others we just haven't discovered yet.
  3. If scientists can identify more animals with Parkinson's, it could lead to better understanding and treatment options for humans. It's important to keep searching for these models.

We’re entering a golden age of engineering biology

Noahpinion • 16647 implied HN points • 18 Feb 24
🔬 Science Biology AI Genetics Automation Medicine
  1. The advancements in deep learning, cost-effective data collection through lab automation, and precision DNA editing with technologies like CRISPR are converging to transform biology from a scientific field to an engineering discipline.
  2. Historically, biology has been challenging due to its immense complexity, requiring costly trial-and-error experiments. However, with current advancements, we are now at a critical point where predictability and engineering in biological systems are becoming a reality.
  3. The decreasing cost of DNA sequencing, breakthroughs in deep learning models for biology, sophisticated lab automation, and precise genetic editing tools like CRISPR are paving the way for a revolutionary era in engineering biology, with vast potential in healthcare, agriculture, and industry.

The Case for 2 mSv/day. 2.0.

Gordian Knot News • 139 implied HN points • 04 Feb 25
🔬 Science Radiation Health Biology Environment Nuclear
  1. The historical dose limit for radiation exposure was set at 2 mSv per day, based on a time when no harmful effects were clearly detected. This suggests that at this level of exposure, there might not be significant health risks.
  2. Our body has a strong system for repairing DNA damage caused by radiation and natural processes. Most DNA issues are fixed quickly, which means low-level radiation may not lead to serious health problems.
  3. If we accept that 2 mSv per day is safe, it could change how we manage nuclear power. It may allow for safer operations and reduce unnecessary evacuations, ultimately making energy cheaper and more sustainable.

Genomic prediction of IQ is modern snake oil

The Infinitesimal • 1298 implied HN points • 06 Jul 24
🔬 Science Genetics Biology Psychology Mathematics Research
  1. Genetic tests claiming to predict IQ are not reliable. They often rely on complex methods that mostly just lead to guesswork.
  2. The accuracy of these genetic predictions is very low, explaining only a tiny fraction of variations in IQ scores. In fact, other factors like age and social environment play a much bigger role.
  3. Many of these predictions confuse people about how genetics really work. It's important to understand that these scores should be treated more like entertainment than serious assessments.

Pikas Hit the Trail

Street Smart Naturalist: Explorations of the Urban Kind • 399 implied HN points • 08 Aug 24
🔬 Science Biology Ecology Evolution Climate Biodiversity
  1. Pikas are cute animals that have traveled a long way from Asia to North America over millions of years. They didn't just hop across in one go; it took many generations to spread out.
  2. Pikas have a unique relationship with their parasites, which helps scientists understand their history better. These tiny creatures help tell the story of the pikas and how they adapted over time.
  3. Climate change is a big threat to pikas today. As their homes warm up, they may struggle to find suitable places to live, especially since they can't go any higher into the mountains.

AI keeps getting better at talking about consciousness

The Intrinsic Perspective • 13599 implied HN points • 13 Mar 24
🔬 Science AI Consciousness Philosophy Neurotechnology Biology
  1. Artificial Intelligence is advancing in discussing consciousness, raising questions about its implications
  2. There is a scientific imbalance between the understanding of creating AI and understanding consciousness
  3. Debates on AI consciousness highlight challenges in defining consciousness and its relation to AI capabilities

Invisible feedback loops: How the body shapes the brain

Brain Pizza • 662 implied HN points • 27 Nov 24
🔬 Science Neuroscience Cognition Health Biology Philosophy
  1. The brain is not separate from the body; they work together in complex ways. Understanding how they interact can give us better insights into health and disease.
  2. Various bodily factors like gut health, muscle activity, and fat can influence how our brain functions. This shows the importance of considering the whole body when studying the brain.
  3. Topics like cancer cachexia and the gut-brain axis highlight specific connections between body signals and brain function, which can impact cognitive health.

If langurs can drink seawater, can humans do so as well?

Trevor Klee’s Newsletter • 895 implied HN points • 14 Nov 24
🔬 Science Biology Zoology Evolution Physiology Genetics
  1. Cat Ba langurs can drink seawater and survive in dry conditions due to their diet and unique adaptations. They mainly get water from the leaves they eat, which helps them thrive on an isolated island.
  2. Humans cannot drink seawater without serious health issues. Consuming saltwater leads to dehydration because our bodies can't remove the excess salt fast enough.
  3. Research suggests that Cat Ba langurs have special genetic traits that allow them to manage salt and calcium better than most mammals. This helps them live in their harsh environment.

Gregor Mendel's Vanishing Act

Asimov Press • 232 implied HN points • 12 Jan 25
🔬 Science Genetics Botany History Research Biology
  1. Gregor Mendel, known as the father of genetics, did much more than just his famous pea experiments. He worked across various scientific fields and made important discoveries about inheritance long before it was fully understood.
  2. Sadly, many of Mendel's notes and findings were destroyed after his death, leaving behind an incomplete representation of his life’s work. This loss means we might never fully appreciate the depth of his contributions.
  3. Mendel's educational journey was filled with challenges, including health issues that impacted his ability to become a teacher. Ironically, these struggles led him to his groundbreaking research in genetics, which changed biology forever.

Cracking biological emergence with mechanistic interpretability

Trevor Klee’s Newsletter • 597 implied HN points • 26 Nov 24
🔬 Science Biology Emergence Deep Learning
  1. Emergent properties in biology can be hard to connect, kind of like trying to understand a car by randomly taking it apart. Even as we learn about proteins and genes, connecting them to actual biological traits remains a challenge.
  2. Deep learning models like Alpha Fold are changing the game by revealing connections between micro and macro biological features, even if we don't fully understand how they do it. It's like having a model that can assemble a car based on its parts without exactly knowing how all those parts work together.
  3. Recently, there's been exciting work in mechanistic interpretability, which helps us understand how these deep learning models make sense of biology. This could lead to new insights and even virtual experiments that help us learn about cell behavior and gene interactions.

Who Does Polygenic Selection Help?

Astral Codex Ten • 11562 implied HN points • 23 Feb 24
🔬 Science Genetics Medical Ethics Biology IVF Healthcare
  1. Polygenic selection can help prevent genetic diseases like schizophrenia by choosing embryos with lower risk during IVF, leading to healthier children
  2. Despite the complex nature of genetic selection, it can have positive effects on individuals and society by preventing diseases and improving overall health outcomes
  3. Analogies like preventing fetal alcohol syndrome through prenatal care or choosing healthier IVF embryos demonstrate the ethical and practical benefits of polygenic selection

The Dangers of Mirrored Life

Asimov Press • 444 implied HN points • 12 Dec 24
🔬 Science Biology Synthetic Biology Ecology Bioethics Genetics
  1. Creating mirrored organisms could be very dangerous. They might spread quickly, infect humans, and even cause extinctions of vulnerable species.
  2. Scientists worry that mirrored cells could escape labs and evade our immune systems. This means they could thrive and multiply without us even knowing.
  3. Most experts believe we should be cautious and avoid creating these mirrored life forms. It's better to discuss the risks now than to face the consequences later.

This week: Bacteria anticipate the seasons! Placebos activate the same neurons as anesthesia! And don’t touch radio towers with hot dogs.

Niko McCarty • 79 implied HN points • 07 Sep 24
🔬 Science Biology Neuroscience Physics Mathematics Environmental Science
  1. Bacteria can sense changes in seasons and adapt to prepare for colder weather. This helps them survive better when temperatures drop.
  2. Placebos work by activating the same brain neurons as pain relief drugs like anesthesia. This shows how our mind can influence our body’s responses.
  3. A fun fact: touching a hot dog to a radio tower can turn it into a speaker. Just a quirky reminder to be careful with food and electronics!

Mitochondria Are Alive

Asimov Press • 735 implied HN points • 08 Nov 24
🔬 Science Biology Evolution Molecular Biology Genetics
  1. Mitochondria are more than just cell parts; they are alive and have their own functions. They carry their own DNA and replicate just like bacteria.
  2. Thinking of mitochondria as living beings can help us understand their role better in our health and in biology. Many diseases are linked to problems with mitochondria.
  3. Mitochondria can interact with their environment and even move between cells, which shows they can adapt and play important roles in complex biological systems.

How To 'See' The World Like Daredevil

Everything Is Amazing • 610 implied HN points • 12 Nov 24
🔬 Science Biology Research Psychology Environment Technology
  1. Some recent science suggests that it's possible for people to see the world in a unique way, similar to characters like Daredevil. It hints at untapped human abilities that we might not even know we have.
  2. There is a fascinating tree in Utah called Pando, which is actually one single tree made up of many clones. It's estimated to be between 16,000 and 80,000 years old, making it one of the oldest living organisms on Earth.
  3. It's important to focus on positive stories and support the art and media that inspire us. Finding and sharing things we love can help create a better world.

Links For February 2024

Astral Codex Ten • 7433 implied HN points • 29 Feb 24
🔬 Science Psychology Medicine Technology History Biology
  1. Blind mathematicians often work in geometry and topology, suggesting unique perceptions.
  2. The Basilica of the Holy House in Italy intriguingly ties angelic folklore with historical architecture.
  3. Starting a journey from Seattle and heading east ends in Russia, the first country reached while traversing the Atlantic Ocean.

Francis Crick Was Misunderstood

Asimov Press • 386 implied HN points • 01 Dec 24
🔬 Science Biology Genetics Molecular Biology Evolution Research
  1. The Central Dogma explains that information in cells flows mainly from DNA to RNA to proteins, but it's more complex than just that. It actually includes several other information transfers that many people don't realize.
  2. Francis Crick named his idea the Central Dogma, but it’s not an unchangeable belief; it's a scientific hypothesis based on evidence. Even though people often misunderstand it, he believed in testing ideas with experiments.
  3. Recent discoveries show that some processes in biology may seem to contradict the Central Dogma, but they don't actually break its rules. The essential point is that information can only flow from nucleic acids to proteins, never the other way around.

The Total Dose Cult

Gordian Knot News • 124 implied HN points • 06 Jan 25
🔬 Science Radiation Health Risk Assessment Nuclear Biology
  1. Total dose of radiation can be misleading. It's not just about how much radiation someone gets, but also how quickly they receive it.
  2. People exposed to radiation over a long time can have different health risks compared to those who are exposed quickly. The way their body processes radiation can vary.
  3. When discussing radiation harm, it's important to consider the rate at which people are exposed. This helps to get a clearer understanding of potential risks.

The Mantis Shrimp Edition

Why is this interesting? • 241 implied HN points • 20 Nov 24
🔬 Science Biology Zoology Marine life Animal Behavior Ecology
  1. Mantis shrimp can punch very fast, making them the fastest strikers in the animal world. It's incredible how quickly they can hit their targets.
  2. These shrimp are very protective of their territory and will aggressively defend their space against intruders.
  3. Their powerful punches are so strong that they can even break glass, showing just how strong these small creatures really are.

Collective Intelligence and Emergence

Solve Cancer in 365 days • 59 implied HN points • 30 Aug 24
🔬 Science Biology Medicine Technology Research Collective Intelligence Emergence
  1. Collective intelligence in biology means that groups of cells work together to solve problems that individuals can't. Each level of organization, like cells and organs, solves specific issues that contribute to the whole.
  2. Emergence happens when the combined actions of simpler parts create complex behaviors. This can be seen in things like how cells coordinate to form organs or how flocks of birds move together.
  3. Understanding collective behaviors in cells could lead to big advancements in medicine. This includes helping treat cancer by changing how cells behave or improving tissue engineering and organ regeneration.

Inside Job: Secret Histories in the National Museum

Asimov Press • 186 implied HN points • 08 Dec 24
🔬 Science Biology History Research Environment Military
  1. The Smithsonian National Museum of Natural History holds millions of specimens, including a secret history of bioweapons experiments conducted by the U.S. military.
  2. Many animal specimens collected during military conflicts reveal connections between warfare and biological research programs, showing how these historical events influenced scientific endeavors.
  3. The presence of everyday specimens in the museum, like insects and rodents, can unveil hidden stories about government actions and ecological research, suggesting that even small details can have significant implications.

Biology is not Bigotry

Critical Mass • 77 implied HN points • 31 Dec 24
🔬 Science Biology Philosophy Gender Studies Human Rights Social justice
  1. Biological sex is generally defined by the type of reproductive cells, making it binary in nature. This means there are typically only two sexes: male and female.
  2. Self-identity does not change biological sex; feelings and gender roles are different from biological facts. Someone can express their gender in various ways, but that does not alter their biological sex.
  3. Discussions around sex and gender should not overshadow the primary mission of organizations focused on free thought and secularism. It's important to separate scientific understanding from ideology.

The origins of power dynamics, or why chimps can't play baseball

The Garden of Forking Paths • 2122 implied HN points • 05 Jul 23
🔬 Science Evolution Biology Psychology Anthropology Human behavior
  1. Humans can throw objects accurately and at high speeds, shaping our modern power dynamics in society.
  2. Our unique shoulder adaptations allow for precise and fast throwing, giving us a competitive advantage over other species.
  3. The ability to use ranged weapons and throw projectiles from a distance has influenced human social structures and power dynamics.

Constructing space-filling curves

A Piece of the Pi: mathematics explained • 90 implied HN points • 30 Dec 24
🔬 Science Mathematics Physics Biology Chemistry Engineering
  1. Space-filling curves, like the Hilbert curve, can fill a whole area by connecting points in a specific way through iterations. They start small and grow by adding more points and connections at each step.
  2. Different seeds can lead to different types of curves. Each seed can be developed using two choices for how to connect the points, leading to many possible variations.
  3. The process used to create these curves can also be reversed. By looking at a curve and breaking it down, you can see how it was made step by step.

Bioelectric Signalling and Cellular Communication

Solve Cancer in 365 days • 39 implied HN points • 28 Aug 24
🔬 Science Biology Cell Biology Genetics Medical Research
  1. Bioelectricity is how cells communicate using tiny electrical signals. Think of it as the way cells send messages to each other in the body.
  2. Cells have gate-like structures called ion channels that control the movement of charged particles, creating bioelectric signals. These signals help in many processes such as healing and development.
  3. Manipulating bioelectric signals could potentially change how cells behave, which might lead to new ways to treat diseases like cancer by changing unhealthy cells back to normal ones.