The hottest Research Substack posts right now

And their main takeaways
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Top Health Politics Topics

Edge 442: If You Thought DeepMind's AlphaFold was Impressive, Wait Until You Learn About AlphaProteo

TheSequence • 77 implied HN points • 24 Oct 24
🕹 Technology Research
  1. DeepMind has developed a new AI model called AlphaProteo, which focuses on designing proteins that can interact with specific targets. This is important for advancing drug development.
  2. Proteins are crucial for many biological processes and their interactions can be manipulated for various applications, such as treating diseases or improving diagnostics.
  3. With AlphaProteo, scientists can create protein binders that may help block harmful interactions in the body, leading to better therapies and health outcomes.

Science writing update, August 2023 edition

Science Fictions • 229 implied HN points • 09 Aug 23
🔬 Science Research
  1. LK-99, the 'room-temperature superconductor', turned out not to be true despite initial social media hype and extravagant claims.
  2. Transparency in scientific publication processes, like preprints and peer review at eLife, can lead to challenges like circulating false claims.
  3. The approval of new drugs for Alzheimer's disease may not always mean groundbreaking results, highlighting the importance of critically analyzing scientific breakthrough claims.

RDEL #29: Besides coding, how do software engineers contribute to the agile development process?

Research-Driven Engineering Leadership • 19 implied HN points • 12 Feb 24
🕹 Technology Research
  1. Software engineers in Agile development contribute beyond just coding.
  2. Non-technical tasks such as process improvement, goal setting, and meeting attendance are crucial for software engineers in Agile development.
  3. Engineers play a vital role in correctly scoping, communicating, and completing projects in Agile development processes.

Walk in the Pines #149

Pinecone Weekly Brief • 19 implied HN points • 11 Feb 24
💼 Business Research
  1. The post features weekly recommendations for readings, podcasts, and videos related to finance and leadership.
  2. Various links are provided for further exploration, including articles from WSJ and podcast episodes discussing diverse topics.
  3. Disclosure at the end explains that the content is for informational and educational purposes, not as direct investment advice.
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Don't Overlook China's Open Source LLMs

TheSequence • 154 implied HN points • 11 Feb 24
🕹 Technology Research
  1. Smaug-72B, an open-source Chinese model, leads the open LLM leaderboard.
  2. Chinese innovation in open-source generative AI is noteworthy with models like Yi family, DeepSeek Chat, and Qwen LLMs.
  3. Chinese open-source LLMs like Smaug demonstrate impressive quality, showcasing contributions to the AI space.

Making the First Transgenic Ants

Asimov Press • 154 implied HN points • 05 Feb 24
🔬 Science Research
  1. Engineered ants are used to study neuroscience of pheromone signaling
  2. Creating transgenic ants involved precise genetic engineering and long, meticulous work
  3. Transgenic ants provided insights into the brain's response to communication signals, aiding in understanding insect behavior

Calibrating circuits

Only Wonder Knows • 19 implied HN points • 09 Feb 24
🔬 Science Research
  1. Calibration of circuits can be a useful solution but it's important to know when it is necessary and when it's not.
  2. Understanding how components like sensors and resistors behave in different conditions is crucial before considering calibration.
  3. Before deciding to calibrate electronic components, a detailed technical and economic analysis should be conducted to ensure it is a suitable solution.

Trusted - AI/Cyber News and Notes, 2023-04-13

Trusted • 39 implied HN points • 13 Apr 23
🕹 Technology Research
  1. NTIA is seeking public input on AI accountability policies to establish trust in AI systems.
  2. FTC Commissioner Bedoya emphasizes that generative AI is already regulated by existing laws.
  3. Various developments in AI technology are highlighted, from finetuned versions of LLaMA to simulations controlled by LLMs.

🥟 Chao-Down #79 Leaked Google memo says the company "has no moat" in AI, Khan Academy launches personal AI tutor

Chaos Theory • 39 implied HN points • 05 May 23
🕹 Technology Research
  1. An anonymous Google memo suggests the company lacks a competitive advantage in AI compared to other tech giants.
  2. The rise of open-source AI communities has proven to produce competitive AI models against big tech firms.
  3. The value in AI lies in tapping into the global mindshare of human intelligence rather than the strength of individual models.

Walk in the Pines #107

Pinecone Weekly Brief • 39 implied HN points • 05 Mar 23
💰 Finance Research
  1. The post shares best reads, listens, and watches of the week
  2. It includes links to articles about macroeconomics, biocomputers, and podcasts
  3. The content is focused on providing diverse educational resources for subscribers

(My) shallow thoughts about deep learning, I

Silicon Reckoner • 39 implied HN points • 27 Jun 23
🔬 Science Research
  1. The workshop on 'AI to Assist Mathematical Reasoning' involved sessions with mathematicians and professionals discussing the role of institutions in adapting to AI.
  2. Panelists highlighted the importance of collaborations, new publication models, and the need for changes in teaching to incorporate new technologies in mathematics.
  3. There was a discussion about the potential impact of AI on mathematical reasoning, with a focus on automation, creating an ecosystem for accessibility, and the implications for democratizing decisions.

RDEL #1: What’s the best way for eng teams to communicate via Slack?

Research-Driven Engineering Leadership • 39 implied HN points • 17 Jul 23
🕹 Technology Research
  1. Effective communication in engineering teams via Slack involves 'burstiness', quick and synchronous messaging followed by periods of silence.
  2. Research shows that 'bursty' communication styles correlate with higher team performance in distributed software engineering teams.
  3. To improve team 'burstiness', managers can observe current communication styles, consider time zone overlaps, and foster a culture of synchronous collaboration.

The language of command

Nick Merrill • 39 implied HN points • 28 Jul 23
🕹 Technology Research
  1. In bureaucratic contexts, commands are linguistically coded, associated with power relations.
  2. Computers operate on commands, reflecting cultural stories about labor discipline and efficiency.
  3. AI challenges the traditional power dynamics associated with commanding computers, raising existential questions for users.

About the Extrasolar Times

Extrasolar Times • 39 implied HN points • 30 May 23
🔬 Science Research
  1. The Extrasolar Times is a newspaper focused on news from beyond our solar system.
  2. The question of whether we are alone in the universe remains unanswered.
  3. The editor of The Extrasolar Times is Dr. Vincent Van Eylen, an expert in exoplanets.

Walk in the Pines #132

Pinecone Weekly Brief • 39 implied HN points • 17 Sep 23
💰 Finance Research
  1. The post shares various recommended reads, listens, and watches of the week.
  2. It includes links to interesting articles, podcasts, and videos for further exploration.
  3. The content seems focused on macroeconomic research and investment-related topics.

Compilation Post #3

Extropic Thoughts • 39 implied HN points • 15 Apr 23
🔬 Science Research
  1. Child mortality rates have drastically decreased over centuries, signifying significant progress in global healthcare.
  2. America's GDP and economic dominance have continued to grow, especially when compared to its developed peers like in 1990.
  3. AI advancements like ChatGPT's 'iPhone moment' and BloombergGPT are reshaping industries with their capabilities.

Action Potentials for May

Neurobiology Notes • 39 implied HN points • 19 May 23
🔬 Science Research
  1. Scanning electron microscopy in the mouse hippocampus allows for 3D reconstructions with synaptic annotations.
  2. Neural circuitry in zebrafish shows persistent representations for head orientation.
  3. Goldfish boundary neurons selectively fire at the edge of a water tank.

First letters found in new scroll

Vesuvius Challenge • 62 implied HN points • 27 Nov 24
💾 History Research
  1. A new scroll called PHerc. 172 has been discovered, and it was buried during the eruption of Mount Vesuvius around 79 AD.
  2. Scientists are excited because they clearly see ink in the scroll for the first time, allowing them to start reading its Greek text.
  3. The team is looking for help to further analyze the scroll and unlock more of its content, as many words are already close to being readable.

A Benchmark for Verifying Chain-Of-Thought

Cobus Greyling on LLMs, NLU, NLP, chatbots & voicebots • 19 implied HN points • 07 Feb 24
🕹 Technology Research
  1. A new dataset called REVEAL helps check if reasoning used in answers is correct or logical. It assesses whether each part of the reasoning leads to the final answer.
  2. REVEAL focuses on verifying claims based on provided evidence. It does not check how the evidence was found, but how well the reasoning uses it.
  3. Creating detailed datasets like REVEAL is complex and time-consuming. It requires skilled annotators to carefully evaluate the logic and relevance in each reasoning step.

Christmas Special: 20% Off Forever

The Algorithmic Bridge • 63 implied HN points • 02 Dec 24
🕹 Technology Research
  1. The subscription to The Algorithmic Bridge is currently 20% off, and this discount will stay with you forever once you claim it. This offer is available until January 1st.
  2. There are three key reasons to subscribe: honesty, commitment, and humanity. The creator avoids ads, works full-time on this project, and focuses on how AI affects people.
  3. Starting January 1st, the subscription price will increase to $10 per month or $100 per year for new subscribers. Current subscribers will keep their original pricing.

Trying Too Hard or Not Hard Enough?

Psych • 19 implied HN points • 07 Feb 24
🏥 Health & Wellness Research
  1. Effort to become wealthy gains more status than being effortlessly wealthy.
  2. Effort to become cool earns less status than being effortlessly cool.
  3. Effort that clearly benefits the group increases status, while disregarding the group decreases it.

The Impact of AI on the Environment: A Critical Analysis

Rod’s Blog • 19 implied HN points • 05 Feb 24
🔬 Science Research
  1. AI has both direct and indirect impacts on the environment. It can lead to high energy consumption and carbon emissions due to the computational complexity and rapid innovation cycle of AI systems.
  2. The way AI is used can either help or harm the environment. It can optimize energy efficiency and support sustainable development, but it can also increase resource demand, pollution, and disrupt ecosystems.
  3. To lessen the negative environmental effects of AI, collaborative efforts are essential. This includes implementing ethical guidelines, promoting green AI research, educating about AI's environmental impact, and incentivizing energy-efficient AI solutions.

The Counterfactual's poll #2

The Counterfactual • 19 implied HN points • 05 Feb 24
🕹 Technology Research
  1. Subscribers can vote each month on research topics. This helps decide what the writer will explore next based on community interest.
  2. The upcoming projects mostly focus on how Large Language Models (LLMs) can measure or modify readability. Some topics might take more than a month to research thoroughly.
  3. One of the suggested studies looks at whether AI responses vary by month, testing if it seems 'lazier' in December compared to other months.

Achieving Government Efficiency Requires More, Not Less, Investment

The Good Science Project • 44 implied HN points • 18 Feb 25
🇺🇸 U.S. Politics Research
  1. Government efficiency means getting more value from every dollar spent, not just cutting costs. Investing wisely can help achieve better results.
  2. To make government work better, we need to invest in research and development. This can help find smarter ways to deliver public services that benefit everyone.
  3. Cutting government spending isn't the answer to making it more efficient. We need to assess which programs work best and invest in them to create more social value.

Intel Foundry Event: Press Q&A

More Than Moore • 140 implied HN points • 21 Feb 24
🕹 Technology Research
  1. A 30-minute press Q&A was held during the Intel Foundry event with key executives, allowing for open discussions and questions.
  2. The post includes details on upcoming content, such as an interview with Intel CEO Pat Gelsinger and a brief overview from a Twitter thread.
  3. The publication, More Than Moore, offers paid subscriber-exclusive content and engages with various high-tech companies in the industry for research and analysis.

Unsolved Problems in Biosafety

A Biologist's Guide to Life • 5 implied HN points • 25 Nov 25
🔬 Science Research
  1. Biosafety faces ongoing challenges that need attention. It's crucial to keep exploring these issues to find solutions.
  2. Understanding and managing risks from biological agents is complex. We need clear strategies to handle those risks effectively.
  3. Engaging in open discussions about biosafety is important. Sharing ideas can help us tackle these scientific puzzles better.

New Beginnings

New World Same Humans • 58 implied HN points • 11 Dec 24
🕹 Technology Research
  1. Starting in 2025, there will be weekly notes sharing thoughts on technology and society. These will help us understand the ongoing tech changes and their impact on our lives.
  2. Community engagement is being reintroduced through monthly discussions where readers can share their thoughts on the topics addressed. This is a space for conversation and connection.
  3. An exciting new project called Chief AI Officer will launch, focusing on how AI affects businesses and professionals. This community aims to provide knowledge and strategies for navigating the AI revolution.

Psychology Findings You Can Bank On

Unsafe Science • 54 implied HN points • 24 Dec 24
🔬 Science Research
  1. Psychological research has produced valuable insights that can enhance our understanding of human behavior. It's important to pay attention to these findings.
  2. Some claims made in the social sciences are questionable and need to be critically evaluated. Not everything that is published is reliable.
  3. There's ongoing debate about the quality of psychological studies, so it's good to be skeptical and look for well-supported evidence.

Future of Gut Health and Longevity( Part 10/11)

Gutsphere - Your Ultimate Guide to Optimal Gut Health • 19 implied HN points • 01 Feb 24
🏥 Health & Wellness Research
  1. Advancements in microbiome research have uncovered the importance of gut health in overall well-being and disease prevention.
  2. Personalized medicine based on individual microbiome profiles is a promising frontier that could revolutionize healthcare treatments.
  3. Microbiome-based therapies show potential in redefining treatment approaches for various diseases, particularly those common in aging populations.