The hottest Methylation Substack posts right now

Methylation is crucial for many body processes, with signs of imbalance like fatty liver disease, cardiovascular risks, fatigue, and more.
Simply testing homocysteine, folate, and B12 isn't enough to assess methylation levels accurately. More in-depth tests like the Genova Methylation Panel are recommended.
The interpretive section of the Genova Methylation Panel report provides helpful insights, but it may not cover all relevant patterns. Supplementing with genetic testing like StrateGene is also suggested.

Methylation is crucial for physical, mental, and emotional health. It involves the transfer of methyl groups and plays a role in synthesizing important molecules like creatine and phosphatidylcholine.
Balancing methylation is vital; too much can have negative consequences. Proper nutrition, including methionine, vitamins B12 and folate, betaine, and glycine, is essential.
To optimize MTHFR status, focus on foods and supplements that support methylation. Searchable databases and related articles provide valuable information on this topic.

Energy deficiency can be a primary issue affecting methylation patterns.
Patterns on the Genova Methylation Panel are showing energy deficiency as a key problem.
Consulting practice has revealed energy deficiency impacting methylation more than nutrient-related issues.

The MTHFR Protocol offers a quick guide to optimizing and personalizing methylation through foods and supplements.
The protocol is available to Masterpass members through paid subscription plans.
To access the guide, subscribe via the provided link and choose a paid option to receive immediate access.

Lipoic acid can deplete methyl groups, potentially affecting methylation in the body.
Methyl groups can be sapped by excess lipoic acid that isn't used as an enzymatic cofactor.
When taking lipoic acid, consider using the R-form, spreading doses evenly, and monitoring for any signs of undermethylation.

Get a weekly roundup of the best Substack posts, by hacker news affinity:

MTHFR is an important enzyme involved in methylation, and deficiencies can lead to various health issues. Common genetic variations like C677T and A1298C can impair MTHFR activity.
The solution starts with ensuring an adequate intake of riboflavin, which plays a crucial role in supporting MTHFR function. This requires a dietary adjustment and potentially exploring a specific protocol.
Beyond riboflavin, addressing other nutrient deficiencies and genetic impairments related to energy metabolism is crucial for optimizing MTHFR activity. Comprehensive screenings can help identify these underlying issues for effective solutions.

The Genetic Choline Calculator can help determine how much choline you should aim for based on your genetic data.
The calculator considers specific genetic variations related to choline metabolism and folate utilization to provide personalized recommendations.
Utilize the calculator to understand your choline requirements better and explore resources to meet them through diet and supplementation.