The hottest Metabolism Substack posts right now

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Your brain 🧠 on exercise: How movement fuels you

Brain Pizza • 1059 implied HN points • 21 Dec 24
🏥 Health & Wellness Exercise Brain health Cognition Metabolism Mental health
  1. Aerobic exercise is great for your brain. It helps improve mood, increases brain volume, and boosts cognitive function.
  2. Resistance training is also important. Regular strength workouts can help maintain brain health, especially as we age.
  3. Metabolism is more complex than just calories in and out. Regular exercise and what we eat play big roles in how our body burns energy.

Understanding Iron

Harnessing the Power of Nutrients • 1997 implied HN points • 01 Jun 24
🏥 Health & Wellness Nutrition Metabolism Disease Regulation
  1. Iron levels inside cells can be misunderstood, leading to confusion between deficiency and overload, especially for those with certain gene variants.
  2. Neurological, psychiatric, and cognitive issues could be linked to iron levels being too low or too high, affecting dopamine and myelin synthesis.
  3. Understanding the complexities of iron metabolism can help in interpreting lab data and making informed decisions to address iron-related problems effectively.

Is Hydrogen Sulfide the New Estrogen?

Harnessing the Power of Nutrients • 1098 implied HN points • 15 Jun 24
🏥 Health & Wellness Nutrition Hormones Research Metabolism
  1. Hydrogen sulfide, a gas with signaling roles, may have estrogenic effects in the body.
  2. High concentrations of hydrogen sulfide can have toxic effects, while lower concentrations are essential for placental function.
  3. Research suggests that hydrogen sulfide could mimic estrogen's effects, potentially leading to various health issues.

Burning questions: Why the ways we think about our metabolism are all wrong

Brain Pizza • 331 implied HN points • 22 Dec 24
🏥 Health & Wellness Metabolism Diet Exercise Nutrition Health Science
  1. Metabolism is more complex than simply burning calories. It’s affected by what we eat, how active we are, and even our age.
  2. The advice to 'eat less and exercise more' doesn’t work for many people and can lead to feelings of guilt. Our bodies just don’t function that way.
  3. Physical activity is still very important for health but doesn’t burn as many calories as commonly believed. Understanding how our metabolism operates can help us use exercise better.

Maybe THIS Is Why You're Hangry

Harnessing the Power of Nutrients • 1817 implied HN points • 19 Mar 24
🏥 Health & Wellness Nutrition Metabolism Genetics Research
  1. Feeling hangry might not always be due to low blood sugar, other factors like S-sulfocysteine levels in your urine could play a role in overstimulation symptoms.
  2. Elevated S-sulfocysteine, a neurostimulant, can result from breakdown of protein when hungry for glucose and may lead to various overstimulation symptoms like anxiety and muscle tension.
  3. Testing for S-sulfocysteine levels in urine should be more widely implemented to understand its potential impact on psychological traits and neuro-psychiatric diseases.
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Are Seed Oils Behind Your Oxalate Problem?

Harnessing the Power of Nutrients • 1777 implied HN points • 29 Feb 24
🏥 Health & Wellness Nutrition Detoxification Antioxidants Metabolism Genetics
  1. High oxalate levels might be due to seed oils leading to glyoxal production which is a major source of oxalate.
  2. Reducing consumption of seed oils in favor of tropical oils, olive oil, and grass-fed animal fats might help lower oxalate production.
  3. Nutrients like biotin, B12, and folate play roles in detoxifying oxalate, and checking for energetic bottlenecks through comprehensive screenings can help address oxalate issues.

How I Found My Health “Super Unlock” After 20 Years of Research and 20,000 Genes Tested

Harnessing the Power of Nutrients • 4034 implied HN points • 21 Sep 23
🏥 Health & Wellness Metabolism Diet Nutrition
  1. Each person has unique health unlocks that are specific to them and can be found through whole genome sequencing.
  2. Identifying rare metabolic disease genes through personalized testing can lead to targeted health improvements.
  3. Addressing individual genetic mutations related to energy metabolism can result in significant health benefits and improved overall wellness.

Thiamin Supplements: Not For Everyone

Harnessing the Power of Nutrients • 1697 implied HN points • 19 Feb 24
🏥 Health & Wellness Nutrition Supplementation Metabolism Mitochondria Toxicity
  1. Thiamin is crucial for various functions like stable blood glucose, calmness, tissue health, detoxification, and athletic performance.
  2. Thiamin deficiency can lead to issues such as mitochondrial dysfunction, nerve problems, and eyesight deterioration.
  3. Excessive thiamin supplementation may cause adverse effects and stress on metabolic pathways, so it's important to be mindful of when to supplement thiamin and when to stop.

CoQ10 Deficiency Is Sulfur Toxicity

Harnessing the Power of Nutrients • 1358 implied HN points • 12 Mar 24
🏥 Health & Wellness Nutrition Toxicity Supplementation Metabolism Genetics
  1. CoQ10 deficiency is linked to sulfur toxicity, impacting various bodily functions and potentially causing issues like anxiety after eating meat or taurine consumption.
  2. Hydrogen sulfide, a necessary gasotransmitter, can turn toxic at high concentrations, affecting the body's ability to convert food energy to ATP.
  3. Taurine can help counteract the effects of sulfur toxicity by suppressing the trans-sulfuration pathway, which can prevent the overproduction of hydrogen sulfide and sulfite.

How Vinegar Can Kick You Into And Out of Ketosis

Harnessing the Power of Nutrients • 1637 implied HN points • 17 Feb 24
🏥 Health & Wellness Ketosis Biochemistry Diet Metabolism
  1. The dose of vinegar is crucial for its impact on ketosis - too little may not kick you into ketosis, and too much can kick you out
  2. Vinegar works by influencing the balance of acetyl CoA to oxaloacetate, which is important for ketogenesis
  3. Careful moderation is key - excessive consumption of vinegar can lead to metabolic abnormalities and kick you out of ketosis

Is Vitamin C Destroying Your Mitochondria?

Harnessing the Power of Nutrients • 1617 implied HN points • 17 Feb 24
🏥 Health & Wellness Nutrition Supplements Mitochondria Oxidative stress Metabolism
  1. High doses of Vitamin C can inhibit CoQ10 synthesis and decrease copper status, affecting mitochondrial function.
  2. Excessive Vitamin C intake can lead to the generation of oxalate, a mitochondrial toxin, causing potential mitochondrial damage.
  3. While high doses of Vitamin C can have benefits in specific cases, for general use, it's safer to stick to doses from a Vitamin C-rich diet.

ex_rice review: Didn't lose any weight, Non-24 gone

Experimental Fat Loss • 198 implied HN points • 16 Dec 24
🏥 Health & Wellness Nutrition Weight Loss Diets Metabolism Health Conditions
  1. A rice-only diet was tested, but it didn’t lead to weight loss. Instead, there was an increase in body fat and lean mass, which was disappointing.
  2. The individual’s sleep cycle disorder, called Non-24, seemed to improve during the rice diet, suggesting a potential link between carb intake and circadian rhythms.
  3. The experiment highlighted that feeling full doesn't always mean being satisfied; the body knows when it has the energy it needs, regardless of how much food is consumed.

Will Eating Protein Wreck Your Arteries?

Harnessing the Power of Nutrients • 1298 implied HN points • 21 Feb 24
🏥 Health & Wellness Nutrition Research Atherosclerosis Metabolism Risk Factors
  1. A new paper claims that the amino acid leucine can stimulate atherosclerosis by stimulating mTOR in immune cells, in a manner similar to its role in muscle growth.
  2. Higher protein intake may lead to adverse effects on vascular health, especially in terms of atherosclerosis development.
  3. The study highlights a potential downside of excessive mTOR stimulation due to leucine intake, emphasizing the importance of cycling through feeding and fasting states for optimal health.

The Food Group You May Be Missing

Are You Okay? • 2236 implied HN points • 10 Jul 23
🏥 Health & Wellness Nutrition Metabolism Healthy Eating Meal Planning
  1. Protein is crucial for our body's functioning - for fullness, energy, weight management, muscle mass, and more. Aim for 0.7 to 1.0 grams of protein per kilogram of body weight daily.
  2. A healthy diet is sustainable and includes protein sources like chicken, fish, eggs, yogurt, lentils, and more to fulfill metabolic needs.
  3. Prioritize meeting basic biological needs first, like hunger cues and metabolic requirements, before focusing solely on vegetables or restrictive diets.

How Many Calories Does Sulfur Have?

Harnessing the Power of Nutrients • 878 implied HN points • 04 Mar 24
🏥 Health & Wellness Nutrition Metabolism
  1. Calories do not only come from carbohydrate, fat, and protein, but also from sulfur through a complex metabolic process involving sulfur amino acids
  2. The caloric yield of sulfur can vary depending on how it is metabolized, ranging from 0.15 to 0.45 Calories per gram
  3. Most sulfur intake is from cruciferous and alliaceous vegetables, but the caloric value of sulfur in these foods is complex and can be quite low

Your "MTHFR" Is One of 26 Nutrient Deficiencies

Harnessing the Power of Nutrients • 1218 implied HN points • 14 Dec 23
🏥 Health & Wellness Nutrition Genetics Metabolism Screening
  1. MTHFR is just one of 26 nutrient deficiencies that can impact your health.
  2. Low MTHFR activity can lead to various health issues, but can usually be addressed through dietary modifications.
  3. To address MTHFR issues effectively, consider optimizing riboflavin intake, comprehensive nutritional screening, and screening for energy metabolism.

Stop Measuring Glucose Without Measuring Lactate

Harnessing the Power of Nutrients • 1338 implied HN points • 12 Nov 23
🏥 Health & Wellness Nutrition Metabolism Medical Technology Biochemistry Testing
  1. Measuring glucose alone is not rational; it should also be measured along with lactate and ketones for better understanding of metabolic changes.
  2. BCAAs can impact glucose levels through multiple pathways, highlighting the importance of context in interpreting metabolic markers.
  3. Having a home test for pyruvate could provide more valuable insights into metabolic health, along with glucose and lactate measurements.

Is Keto just a Band-Aid?

Experimental Fat Loss • 176 implied HN points • 12 Nov 24
🏥 Health & Wellness Dieting Nutrition Weight Loss Metabolism Health trends
  1. Keto can help some people lose weight initially, but it often doesn't lead to long-term success. Many people may gain the weight back after stopping the diet.
  2. People can do keto in many different ways, but not all methods work for everyone. It's important to find what suits your body and lifestyle best.
  3. Keto isn't the only option for weight loss; other diets, like those focused on potatoes or rice, can also be effective. Choose a diet that you enjoy to make it easier to stick to.

A PhD's Secret Weapon: The Four Biomarkers Every Expert Should, But Doesn’t, Analyze

Harnessing the Power of Nutrients • 1977 implied HN points • 28 Apr 23
🏥 Health & Wellness Nutrition Metabolism Supplements Biomarkers Medical Advice
  1. Tests ordered in health space often don't go deep enough to uncover root causes.
  2. When analyzing health biomarkers, considering the main fuels of mitochondria is crucial.
  3. Understanding the ratios and interactions of biomarkers like lactate, pyruvate, and ketones can reveal important insights for mitochondrial function.

Hormones Are Never In Charge

Harnessing the Power of Nutrients • 1018 implied HN points • 26 Oct 23
🏥 Health & Wellness Hormones Nutrition Metabolism Supplements Medical Advice
  1. Hormones are not the primary cause of problems and are simply messengers between tissues.
  2. Hormones can be affected by factors like nutrient deficiencies, body fat levels, and energy metabolism issues.
  3. Addressing the root causes of hormonal imbalances through optimizing body composition, correcting nutrient deficiencies, and managing energy metabolism can be more effective than relying solely on hormone treatments.

Can B12 and Folate Help Detoxify Oxalate?

Harnessing the Power of Nutrients • 998 implied HN points • 15 Jun 23
🏥 Health & Wellness Nutrition Detoxification Supplementation Testing Metabolism
  1. B12 and folate can help detoxify oxalate by converting it to formate and joining it to tetrahydrofolate in a two-step process.
  2. The rate of the first detoxification step exceeding the rate of the second step can lead to oxalate dumping symptoms.
  3. Nutritionally supporting the two detoxification steps requires biotin, manganese, tetrahydrofolate, B12, and various other nutrients.

Questions on NAC, biofilms, vitamin C and brain fog, energy metabolism driving autoimmune disorders.

Harnessing the Power of Nutrients • 918 implied HN points • 30 May 23
🏥 Health & Wellness Nutrition Autoimmune Metabolism Supplements
  1. N-acetylcysteine (NAC) can disrupt biofilms at specific doses but may harm gut health with chronic use.
  2. Vitamin C can lead to muscle pain, joint pain, and brain fog due to oxalate crystals and energy metabolism issues.
  3. Autoimmune conditions might be linked to deficiencies in vitamins A and D impacting energy metabolism, potentially causing vitamin A activation issues.

Erythritol and Blood Clotting

Harnessing the Power of Nutrients • 1258 implied HN points • 14 Mar 23
🏥 Health & Wellness Nutrition Supplements Research Metabolism Biochemistry
  1. Erythritol may contribute to cardiovascular disease by increasing blood clotting propensity, especially in individuals with high erythritol levels.
  2. Understanding the polyol pathway and pentose phosphate pathway is crucial for comprehending how erythritol metabolism affects thiamin deficiency and oxidative stress.
  3. Plasma erythritol likely serves as a marker of pentose phosphate pathway activation, indicating NADPH depletion and suboptimal thiamin status.

Why Would Citrate or Malate Cause Insomnia?

Harnessing the Power of Nutrients • 659 implied HN points • 18 Aug 23
🏥 Health & Wellness Nutrition Insomnia Metabolism Supplements
  1. Citrate and malate in supplements can cause insomnia for different people, suggesting individual differences in energy metabolism.
  2. The opposite reactions to citrate and malate indicate underlying idiosyncrasies in energy metabolism.
  3. Consider exploring metabolic issues or mold contamination as possible reasons for experiencing insomnia from citrate or malate supplements.

The Anti-PUFA Elevator Pitch

The Heart Attack Diet • 239 implied HN points • 02 Feb 24
🏥 Health & Wellness Nutrition Metabolism Weight management Medical Myths
  1. Animal fats are considered more natural for humans to eat than polyunsaturated fats
  2. Polyunsaturated fats, though essential in small amounts, may pose risks as a staple food due to their chemical complexity and potential impact on metabolism
  3. The modern diet high in polyunsaturated fats may be linked to metabolic issues and health conditions, potentially impacting weight, body composition, and overall well-being

In case you missed my mitochondrial energy talk...

Harnessing the Power of Nutrients • 459 implied HN points • 30 Jun 23
🏥 Health & Wellness Metabolism Nutrition Genetics Energy Health
  1. The Mitochondrial Energy Summit is hosting an 'Encore Weekend' event starting at 6 PM eastern time tonight, allowing those who missed the original airing to catch up.
  2. Attendees have praised the talk for its valuable insights on energy metabolism and nutrition, sparking discussions on lifestyle changes like consuming superfoods more regularly.
  3. Chris Masterjohn's talk has received glowing reviews, with attendees expressing appreciation for his knowledge, dedication, and balanced approach to discussing the intersection of genetics and nutrition.

When to Consider Inborn Errors of Metabolism

Harnessing the Power of Nutrients • 459 implied HN points • 21 Jun 23
🏥 Health & Wellness Metabolism Nutrition Genetics Diseases Medical care
  1. Inborn errors of metabolism are rare but often go undiagnosed because they are not actively sought out.
  2. Even though these errors are rare individually, collectively they can affect a significant portion of the population.
  3. Symptoms of inborn errors of metabolism can vary widely in terms of onset, presentation, and age group affected.

Adventures in Zone 2 Cardio Training | Part 1

Harnessing the Power of Nutrients • 1118 implied HN points • 29 Sep 22
🏥 Health & Wellness Fitness Training Metabolism Endurance Measurement
  1. Zone 2 cardio training is essential for metabolic health and involves moderate intensity fat-burning exercise that can be sustained for an hour.
  2. Training in Zone 2 can improve endurance, fat oxidation, and lactate clearance in slow-twitch muscle fibers, benefiting overall fitness and potentially impacting fasting tolerance.
  3. Measuring lactate levels using a meter provides precise feedback for optimal training intensity in Zone 2, leading to rapid progress and efficient workouts.

My guess why potatoes creates weight loss

Metabolic Repair • 8 HN points • 24 Aug 24
🏥 Health & Wellness Nutrition Dieting Metabolism Weight Loss Health Science
  1. Eating a lot of potatoes may help you lose weight because they can reduce your appetite and cravings. This might be similar to how some weight-loss medications work.
  2. Potatoes might also increase your body temperature and metabolism, making you burn more calories just by being active. The effects can vary from person to person depending on their unique body and genetics.
  3. A mostly potato diet is low in fat and iron, which may also contribute to weight loss. This combination can change how your body feels about food and potentially help you eat less.

An Entirely Unnecessary Mom Test

The Heart Attack Diet • 119 implied HN points • 04 Mar 24
🏥 Health & Wellness Weight management Metabolism Nutrition
  1. The author is noticing a rise in weight and is exploring the impact of their diet choices and set-point on this increase.
  2. They plan to take a break from focusing on weight, let their mom feed them generously, and see how it affects their weight over the next month.
  3. The author is prepared for their weight to continue rising but is also considering the possibility of a new set point for their weight.

Questions on plant compounds and heart disease, balancing omega-3 and omega-6 fatty acids, food intolerances, nutrient cofactors for genetic defects in branched-chain amino acid metabolism.

Harnessing the Power of Nutrients • 519 implied HN points • 02 Feb 23
🏥 Health & Wellness Nutrition Genetics Supplementation Metabolism Weight Loss
  1. Plant foods and their phytochemicals can help reduce arterial plaque.
  2. Balancing omega-3 and omega-6 fatty acids is crucial for health; consider arachidonic acid intake and cumulative EPA over years.
  3. Branched-chain amino acid metabolism requires B vitamins, calcium, magnesium, and more; extra support may be needed during weight loss.

The Signal And The Noise

The Heart Attack Diet • 119 implied HN points • 12 Feb 24
🏥 Health & Wellness Diet Weight Loss Metabolism
  1. Measure your weight and waking temperature daily at the same time, and focus on the trend of the seven-day average for better insights.
  2. Avoid influencing measurements that do not impact your main goal, listen to your body's signals of hunger, and be cautious of using willpower for weight management.
  3. Be mindful of the effects of circadian rhythms, weekly variations, and water weight on your body measurements, and strive to minimize noise by staying consistent.

Why Are We Getting Fatter? | Part II: Decomposing Fats & Carbs

Mind & Matter • 157 implied HN points • 28 Dec 23
🏥 Health & Wellness Nutrition Diet Obesity Metabolism Carbohydrates
  1. Calories are not interchangeable; different types of foods with the same caloric content can have distinct metabolic consequences.
  2. Total calories alone cannot account for the rise in obesity and diabetes rates; the macronutrient composition of diets has changed over time.
  3. Carbohydrate and fat intake have shifted over the years, with varying trends in protein, saturated fats, monounsaturated fats, and polyunsaturated fats consumption.

Vitamins and Minerals 101 Premium

Harnessing the Power of Nutrients • 778 implied HN points • 27 Jun 22
🏥 Health & Wellness Nutrition Vitamins Minerals Metabolism
  1. The course 'Vitamins and Minerals 101 Premium' is designed to take learners from beginner to intermediate level in understanding vitamins, minerals, and essential fatty acids.
  2. The course offers the first three lessons for free, with the remaining reserved for Masterpass members.
  3. Vitamins play diverse and crucial roles in the body, from supporting immunity and brain health to energy metabolism and skin health.

Lab Tests

Harnessing the Power of Nutrients • 219 implied HN points • 14 Oct 23
🏥 Health & Wellness Nutrition Metabolism Testing
  1. Comprehensive lab tests can help identify nutritional deficiencies and energy metabolism issues.
  2. A simple DIY home test for molybdenum deficiency can be done with basic equipment and a supplement.
  3. Interpreting the Genova Methylation Panel requires going beyond the report's interpretive section to uncover patterns.

Why Are We Getting Fatter? | Part I: Diet Advice, Health Trends & Informational Obesity

Mind & Matter • 157 implied HN points • 12 Dec 23
🏥 Health & Wellness Obesity Diet Metabolism Nutrition Exercise
  1. The rise in obesity rates continues despite no increase in calorie consumption or decrease in physical activity.
  2. There is a lot of conflicting diet advice and information overload, leading to confusion and misinformation.
  3. Metabolic health can be affected by various factors like body fat, food intake, and specific macronutrient composition of the diet.