The hottest Metabolism Substack posts right now

And their main takeaways
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Top Science Topics

ex150-9 review: Down 4lbs, broke through 220lbs

Experimental Fat Loss • 106 implied HN points • 18 Mar 24
🏥 Health & Wellness Weight Loss Nutrition Fitness Metabolism Healthy Eating
  1. Decision-making dilemma: stick to what works or explore new options. It's tricky to find the balance.
  2. Balancing exploitation and exploration in weight loss experiments is key to progress. Trying new things can build confidence, but sticking to what's known to work is crucial for consistent results.
  3. It's important to evaluate the success of experiments and prioritize proven methods. Understanding mechanisms behind weight loss can lead to more effective strategies.

Torricelli's Law for Fat Loss

Experimental Fat Loss • 127 implied HN points • 10 Mar 24
🏥 Health & Wellness Weight Loss Metabolism Diet Sleep Predictions
  1. Torricelli's Law for Fat Loss explains how weight loss can slow down as you approach your normal weight, similar to a bucket draining liquid with decreasing speed.
  2. Weight loss projections can be influenced by dietary changes and external factors, like daylight savings time affecting circadian rhythms and potentially affecting weight loss plateaus.
  3. Testing multiple weight loss projections, such as following a fitted curve and intuition-based predictions, can help in anticipating weight loss outcomes and adjusting dietary strategies.

The Food Group You May Be Missing

Are You Okay? • 2236 implied HN points • 10 Jul 23
🏥 Health & Wellness Nutrition Metabolism Healthy Eating Meal Planning
  1. Protein is crucial for our body's functioning - for fullness, energy, weight management, muscle mass, and more. Aim for 0.7 to 1.0 grams of protein per kilogram of body weight daily.
  2. A healthy diet is sustainable and includes protein sources like chicken, fish, eggs, yogurt, lentils, and more to fulfill metabolic needs.
  3. Prioritize meeting basic biological needs first, like hunger cues and metabolic requirements, before focusing solely on vegetables or restrictive diets.
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Fuel-Partitioning causes Obesity

Experimental Fat Loss • 169 implied HN points • 14 Jan 24
🏥 Health & Wellness Nutrition Weight Loss Fitness Metabolism Diet
  1. Mainstream CICO/EBM and Fuel Partitioning/low-carb are two paradigms about what causes obesity.
  2. CICO views calories as the cause of fat gain, while Fuel Partitioning sees excess calories as a result of other issues.
  3. CICO doesn't work for everyone, and there are diets like low-carb or keto that work better for some due to Fuel Partitioning.

Why Are We Getting Fatter? | Part II: Decomposing Fats & Carbs

Mind & Matter • 157 implied HN points • 28 Dec 23
🏥 Health & Wellness Nutrition Diet Obesity Metabolism
  1. Calories are not interchangeable; different types of foods with the same caloric content can have distinct metabolic consequences.
  2. Total calories alone cannot account for the rise in obesity and diabetes rates; the macronutrient composition of diets has changed over time.
  3. Carbohydrate and fat intake have shifted over the years, with varying trends in protein, saturated fats, monounsaturated fats, and polyunsaturated fats consumption.

Why Are We Getting Fatter? | Part I: Diet Advice, Health Trends & Informational Obesity

Mind & Matter • 157 implied HN points • 12 Dec 23
🏥 Health & Wellness Obesity Diet Metabolism Nutrition Exercise
  1. The rise in obesity rates continues despite no increase in calorie consumption or decrease in physical activity.
  2. There is a lot of conflicting diet advice and information overload, leading to confusion and misinformation.
  3. Metabolic health can be affected by various factors like body fat, food intake, and specific macronutrient composition of the diet.

We Used To Eat A Lot More Without Becoming Obese

Unfashionable • 15 implied HN points • 14 Mar 24
🏥 Health & Wellness Nutrition Metabolism Obesity Diet Research
  1. Historically, people used to eat more without becoming obese, challenging the 'calories in, calories out' theory.
  2. Studies show that children in the past consumed significantly more calories than recommended today, even without modern concept of workouts.
  3. The Ray Peat community suggests that historically, people had faster metabolisms, which could explain the paradox of declining calorie intake and rising obesity rates.

Reversing obesity != getting shredded

Experimental Fat Loss • 141 implied HN points • 21 Oct 23
🏥 Health & Wellness Obesity Metabolism Diet Nutrition Fitness
  1. Reversing obesity is not the same as achieving a shredded body like bodybuilders do.
  2. Starving yourself to extreme levels, like bodybuilders do, is not a sustainable or healthy method to reverse obesity.
  3. Using a strategy meant for bodybuilders, such as extreme dieting, to reverse obesity can be detrimental to your health in the long run.

The Mysterious Case of Outlier 17

Experimental Fat Loss • 106 implied HN points • 07 Oct 23
🏥 Health & Wellness Weight Loss Diet Nutrition Metabolism
  1. Outlier 17 lost a significant amount of weight on the Half-Tato diet, which was only 50% potatoes and 50% regular food, with the main focus on how her approach ties into eliminating PUFAs, limiting protein intake, and focusing on a specific macronutrient.
  2. The Half-Tato diet study compared to other experiments led to observations that avoiding PUFAs, keeping protein intake low, and following a specific macro balance might contribute significantly to weight loss.
  3. Outlier 17's success might be due to factors like avoidance of PUFAs, low protein intake, and focus on a specific macro balance, indicating potential keys to effective weight loss.

Seed Oils explain the 8 Mysteries of Obesity

Experimental Fat Loss • 176 implied HN points • 22 Jul 23
🏥 Health & Wellness Obesity Nutrition Metabolism Diet Wellness
  1. Obesity is caused by long-term dysfunction of mitochondrial energy metabolism, mainly due to changes in food intake starting in the late 1800s and increased seed oil consumption since the 1930s and 1970s.
  2. The drastic increase in obesity rates since the mid-1970s can be attributed to the rise in seed oil consumption, such as the introduction of canola oil in the 1970s.
  3. The ongoing obesity crisis, even since 2010, has seen a massive increase due to a 50% rise in seed oil consumption like soybean oil.

Friday Q&A: Diet Coke; Stomach Woes; Strength Training for Beginners; & Finding the Right Doctor for Menopause

Are You Okay? • 219 implied HN points • 03 Mar 23
🏥 Health & Wellness Nutrition Fitness Supplements Metabolism
  1. Consuming Diet Coke daily doesn't completely negate healthy eating habits, but it's worth considering the potential downsides such as caffeine content and artificial sweeteners.
  2. Individual responses to gas, bloating, and irregular bowel movements can vary, and there isn't one-size-fits-all advice for using probiotics to address these issues.
  3. Health is about balancing risks and rewards, and making choices that work best for your body and well-being, whether it's enjoying certain habits or deciding to make changes for better health.

Not losing fat on Keto/Carnivore? Try eating less protein.

Experimental Fat Loss • 141 implied HN points • 27 May 23
🏥 Health & Wellness Nutrition Weight Loss Metabolism Diet Medical Research
  1. Eating high protein might hinder fat loss on Keto/Carnivore diets; consider reducing protein intake.
  2. Popular Keto/Carnivore diets emphasize high protein, but excessive protein intake may not be suitable for everyone.
  3. Moderating protein intake and focusing on adequate fat consumption is essential for maintaining a balanced diet on Keto/Carnivore.

Kraft test results: still insulin resistant

Experimental Fat Loss • 77 implied HN points • 30 Aug 23
🏥 Health & Wellness Nutrition Fitness Metabolism
  1. Insulin resistance can exist with normal glucose levels, especially after years on a ketogenic diet.
  2. Measuring fasting insulin levels can be a better indicator of insulin resistance than glucose levels.
  3. The Kraft test, which measures insulin response over time after a meal, can provide more insights into metabolic health than traditional glucose tests.

The Role of Microbiome in Disease Prevention ( Part 6.1/11)

Gutsphere - Your Ultimate Guide to Optimal Gut Health • 0 implied HN points • 15 Jan 24
🏥 Health & Wellness Microbiome Disease Prevention Immune System Inflammation Metabolism
  1. A healthy gut microbiome helps regulate the immune system, reducing the risk of autoimmune diseases and enhancing the body's ability to fight infections.
  2. Balanced gut microbiota can help regulate inflammation, preventing diseases like arthritis, heart disease, and Alzheimer's.
  3. The gut microbiome influences metabolic health, reducing the risk of conditions such as obesity and type 2 diabetes in older adults.

2 Science-Backed Insights to Help Remote Workers Lose Weight

Austin's Analects • 0 implied HN points • 20 Apr 23
🏥 Health & Wellness Weight Loss Metabolism Nutrition
  1. Not all calories are equal: Fats and proteins keep you full longer than carbs. Choose high-quality, satiating foods like fats and proteins for weight loss.
  2. Metabolism matters: High-fat, high-protein diets help maintain a higher metabolism. Weight loss involves both calorie restriction and choosing the right types of calories.
  3. Quality over quantity: While calorie restriction is key to weight loss, the type of calories consumed also matters. Opting for high-quality foods makes it easier to stick to a calorie limit and lose weight.