The hottest Research Substack posts right now

And their main takeaways
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Top Health Politics Topics

Building Relationships Through Research

Tippets by Taps • 12 implied HN points • 25 Aug 23
💼 Business Research
  1. Preparation is key to success in building relationships
  2. Making a strong first impression by doing research on the person before a meeting is crucial
  3. Levels of researching individuals before meetings can vary based on importance, time available, and online presence

Interesting Links and News: 30-July-2025

FutureIQ • 1 implied HN point • 30 Jul 25
🔬 Science Research
  1. Frog pregnancy tests were once common, where urine from a woman was injected into a frog. If the frog ovulated, that meant the woman was pregnant.
  2. Boring things can lead to success if we pay attention to them. For example, detailed reports can uncover important truths like the Boston Globe's investigation into priest misconduct.
  3. The way we view competition can affect decisions. Zero-sum thinking makes us see others' gains as our losses, leading to protective policies like tariffs and reduced funding for education.

Quant Letter: August 2023, Week 1

The Parlour • 12 implied HN points • 02 Aug 23
💰 Finance Research
  1. The featured papers discussed in the newsletter are 'Displaced by Big Data,' 'Deep Learning for Corporate Bonds,' and 'Exploiting the dynamics of commodity futures curves.'
  2. The newsletter highlights research on whether new data diminishes the advantages of active fund managers with industry expertise.
  3. Readers are encouraged to subscribe for a 7-day free trial to access the full post archives.
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Things That Caught My Eye #7

Natural Selections • 4 implied HN points • 15 Oct 24
🔬 Science Research
  1. Scientists found that a dye in Doritos can make mice's skin transparent, helping to study them while alive. It's a strange but useful discovery for research.
  2. Written language and the alphabet took a long time to develop, with alphabetical order coming much later than the letters themselves.
  3. Boys and girls react differently to poor teaching, and this may influence how schools approach education for each gender.

Agent Sources

Perspective Agents • 9 implied HN points • 30 Nov 23
🕹 Technology Research
  1. Agents in AI are rapidly evolving and have the potential to change how we access and interact with information.
  2. The emergence of personalized AI agents like GPTs can provide customized, insightful perspectives in contrast to traditional media sources.
  3. Creating trust markets with GPTs as virtual experts offers a new way to monetize expertise and deliver high-quality information.

Roche's neurology strategy

Axial • 7 implied HN points • 13 Mar 24
🏥 Health & Wellness Research
  1. Roche is focusing on developing therapies for neurological diseases like Alzheimer's, with a new drug called trontinemab showing potential for rapid clearance of amyloid plaques in the brain.
  2. Roche's neurology strategy includes a diverse pipeline of treatments for various conditions like multiple sclerosis, neuromuscular disorders, and gene therapies for muscle-related illnesses.
  3. The company's commitment to Alzheimer's research is driven by the amyloid hypothesis, societal impact, and economic burden, aiming to improve patient outcomes and address the growing need for effective treatments in the aging population.

GPCRs in kidney disease

Axial • 7 implied HN points • 13 Mar 24
🔬 Science Research
  1. Kidney disease, particularly autosomal dominant polycystic kidney disease (PKD), has been underinvested compared to other conditions like oncology and diabetes.
  2. The development of drugs targeting GPCRs PC-1 and PC-2 in PKD could significantly improve the quality of life for patients by reducing cyst size.
  3. Business models in drug development are shifting towards rare disease candidates like PC-1/2, emphasizing treatments that exceed the current standard of care.

Is The Revio A Single Color System?

ASeq Newsletter • 7 implied HN points • 11 Mar 24
🔬 Science Research
  1. The Revio possibly uses a single color system for sequencing, which could lead to improved efficiency and simplification of the fabrication process.
  2. The SNR (signal-to-noise ratio) varies significantly between nucleotides in the Revio, indicating potential differences in brightness.
  3. There is ongoing exploration to determine if the Revio sequencing system utilizes a one or two-color system, with a focus on experimental support and additional evidence.

Whatever happened to the industrial R&D lab?

The Works in Progress Newsletter • 10 implied HN points • 28 Sep 23
🕹 Technology Research
  1. In the past, industrial R&D labs within large corporations led to a surge in innovation, but this trend declined over time.
  2. The decline of industrial R&D labs has shifted innovation towards small companies, startups, and academic teams.
  3. Current trends show a resurgence of large firm R&D labs, particularly in Big Tech, driven by factors like anti-tech antitrust enforcement and innovation investments.

Upcoming Webinar: Introducing A New Spatial Analysis Platform

LatchBio • 1 implied HN point • 15 Jul 25
🔬 Science Research
  1. The webinar will showcase a new easy-to-use platform for analyzing spatial and single-cell data. Anyone can join to see how it works, even if they have no coding skills.
  2. Participants will learn various techniques like identifying important genes and creating visualizations to explore their data. This makes complex analyses more accessible.
  3. The platform allows interactive exploration of data through a friendly interface, helping scientists work more efficiently and effectively.

Nyhetsbrev steigan.no 07.03.2024

steigan.no • 7 implied HN points • 07 Mar 24
🏥 Health & Wellness Research
  1. Ukrainian special forces are reportedly fighting in the civil war in Sudan, raising questions about the motives and implications of their involvement.
  2. A Croatian pathologist discovered a 52% increase in carcinoma cancer cases among mRNA-vaccinated individuals aged 15-59, raising concerns about potential risks associated with COVID-19 vaccines.
  3. Financial aid provided to Ukraine seems to mostly benefit American defense manufacturers, raising suspicions of ulterior motives behind the aid package.

An Fc engineering approach that modulates antibody-dependent cytokine release without altering cell-killing functions

Axial • 7 implied HN points • 17 Feb 24
🔬 Science Research
  1. An innovative Fc engineering approach can adjust antibody-dependent cytokine release without impacting cell-killing functions. This shows that manipulating cytokine release independently is possible.
  2. Different IgG isotypes have varying abilities to stimulate proinflammatory cytokine release. This indicates the importance of isotype selection beyond just cytotoxicity.
  3. Engineering antibodies to selectively engage FcγRs can potentially enhance immune responses. This opens up new possibilities for optimizing antibody immunotherapies against cancer.

Together by a tether

Joshua Gans' Newsletter • 19 implied HN points • 05 Aug 20
🏥 Health & Wellness Research
  1. New research indicates that implementing better employment policies and creating staff bubbles in nursing homes can reduce Covid-19 outbreaks by 44%.
  2. Covid-19 spreads through contacts in nursing homes, amplified by staff moving between facilities; increasing network connections increases Covid cases significantly.
  3. Creating staff bubbles in nursing homes to eliminate inter-facility connections can potentially reduce infections by 44 per cent.

July Newsletter

RSS DS+AI Section • 11 implied HN points • 03 Jul 23
🕹 Technology Research
  1. The newsletter features updates on industrial strength data science, including committee activities and upcoming events.
  2. Ethics, bias, and diversity remain hot topics in data science and AI, with examples of generative AI misuse and intentional misuse.
  3. The newsletter includes practical tips, developments in research, and fun projects in the data science and AI field.

037: Living With MTHFR

Harnessing the Power of Nutrients • 59 implied HN points • 12 Aug 17
🏥 Health & Wellness Research
  1. MTHFR enzyme affects vital processes like methylation, gene expression, and neurotransmitter metabolism.
  2. Supplementing with methyl-folate is just a small part of managing MTHFR polymorphisms; focus on a diet rich in natural food folate and incorporating choline, creatine, and glycine.
  3. Key tests for MTHFR mutations include measuring homocysteine levels and evaluating plasma methionine, glycine, and sarcosine.

Data Science Weekly - Issue 374

Data Science Weekly Newsletter • 19 implied HN points • 21 Jan 21
🕹 Technology Research
  1. Controlled experiments are important for understanding the impact of new features in software. They help ensure that changes actually improve user experience and metrics.
  2. Deep learning is being used in various scientific fields, making tools like DeepChem important for democratizing access to advanced technologies. This helps researchers across disciplines like chemistry and bioinformatics.
  3. There are innovative methods for diagnosing diseases like prostate cancer using AI. These techniques can offer high accuracy and reduce the need for invasive procedures.

Hypothetical Side Effects of High-Dose Vitamin K

Harnessing the Power of Nutrients • 139 implied HN points • 28 Apr 13
🏥 Health & Wellness Research
  1. High doses of vitamin K could potentially contribute to vitamin E deficiency by activating common receptors that break down both vitamins in a similar pathway.
  2. High doses of vitamin K have the potential to deplete glutathione, the master antioxidant, impairing detoxification and antioxidant activity.
  3. Pharmacological doses of vitamin K, although considered safe and effective, could inhibit bone resorption and potentially impact blood sugar control, insulin sensitivity, metabolic rate, and testosterone production.

Sunday Roundup 12/3/23

Silent Lunch, The David Zweig Newsletter • 8 implied HN points • 03 Dec 23
📰 News Research
  1. The post covers topics like DEI and Jews, a study on vegan twins, and a comparison of death rates between Florida and California.
  2. The post is by David Zweig and was published on December 3, 2023.
  3. To keep reading the post and get access to full archives, a subscription to Silent Lunch, The David Zweig Newsletter, is required. A 7-day free trial is available.

✅ Monday Briefing #20: UK obesity ad consultation, comms conspiracy, Guinness recall, PDR tool, productivity apps, Parler boom and more…

Wadds Inc. newsletter • 19 implied HN points • 16 Nov 20
💼 Business Research
  1. The UK Government is consulting on new rules to limit online ads for unhealthy food products. This aims to tackle obesity issues, especially among children.
  2. Many influencers are seen the same way as journalists by the public, which raises questions about the trustworthiness of news and information sources.
  3. There has been a surge in popularity for the app Parler, especially among conservatives, following the US elections and changes in how Twitter manages disinformation.

Why I'm allergic to AI hype

More is Different • 7 implied HN points • 06 Jan 24
🕹 Technology Research
  1. Data science jobs may not be as glamorous as they seem, often involving mundane tasks and not much intellectual excitement.
  2. Efforts to create AGI have faced challenges, with ambitious projects like Mindfire encountering skepticism and practical difficulties.
  3. AI in healthcare, such as for radiology, has seen startups struggle and face issues like lack of affordability, deployment challenges, and unpredictability in performance.

Poor regions suffer more from extreme weather

Klement on Investing • 1 implied HN point • 16 Jun 25
🌞 Climate & Environment Research
  1. Poor regions are hit harder by extreme weather because they often lack the resources to recover. This is due to their location and economic status.
  2. Research shows that even in wealthier areas, like parts of Europe, countries with lower GDP are more affected by weather extremes than richer countries.
  3. A small increase in extreme weather events can significantly lower average income in struggling regions, making it important to consider these risks when investing in such areas.

In-Context Learning, In Context + Author Q&As

The Gradient • 11 implied HN points • 29 Apr 23
🕹 Technology Research
  1. In-context learning involves large language models learning new tasks at inference time with prompts.
  2. Authors Hattie Zhou and Sewon Min share insights on in-context learning in Q&A sessions.
  3. In-context learning helps model better infer concepts learned during pretraining without gradient updates.

Update #48: Generative AI in Law & Art and Promptable Vision Models

The Gradient • 11 implied HN points • 25 Apr 23
🕹 Technology Research
  1. Generative AI is transforming fields like Law and Art, raising ethical and legal questions about ownership and bias.
  2. Recent models allow users to specify vision tasks through flexible prompts, enabling diverse applications in image segmentation and visual tasks.
  3. Advances in promptable vision models and generative AI pose challenges and opportunities, from disrupting professions to potential ethical and legal implications.

🥊 The Google vs OpenAI boxing match continues

Year 2049 • 6 implied HN points • 16 Feb 24
🕹 Technology Research
  1. OpenAI and Google are continuously surprising with new AI advancements like Gemini 1.5 Pro and Sora.
  2. Google's Gemini 1.5 Pro features a 1 million token context window and uses innovative architecture for improved performance.
  3. OpenAI's Sora introduces text-to-video capabilities with impressive video generation but still faces challenges in certain scenarios.

Notes on Progress: The world that has never been

The Works in Progress Newsletter • 12 implied HN points • 15 Feb 23
🕹 Technology Research
  1. Ben Reinhardt announces his new ARPA-style lab, Speculative Technologies, to create the world that has never been.
  2. Academia, NASA, and startups each have limitations in fostering novel technologies and scaling them for impact.
  3. Building a nonprofit research organization like DARPA could support groundbreaking technologies with a focus on societal impact and scale.

🛰️ Your guide to AI: February 2024

Guide to AI • 6 implied HN points • 04 Feb 24
🕹 Technology Research
  1. The newsletter covers important developments in AI policy, research, industry, and startups
  2. The geopolitics of AI, including international cooperation and challenges with foundation model providers
  3. Updates on hardware advancements in AI, such as new chip restrictions and AI infrastructure investments by big tech companies

🌊 Ocean Financing, Algal Biorefineries, and Wild vs Cultivated Seaweed...

paxtier • 6 implied HN points • 07 Feb 24
🔬 Science Research
  1. Significant challenges in financing the blue economy persist due to the gap between required funding and actual investment.
  2. Algal biorefineries are attracting investors with reduced energy requirements and beneficial partnerships.
  3. Debate between wild and cultivated seaweed continues, with different regions presenting arguments for each method of harvesting.