The hottest Research Substack posts right now

And their main takeaways
Category
Top Health Politics Topics

On RFK Jr., Atrazine and WiFi. Plus a puzzle for you!

An Insult to Intuition • 1454 implied HN points • 26 Jun 23
🔬 Science Research
  1. Kennedy discussed the potential effects of Atrazine on organisms like frogs and mammals, sparking a debate on environmental toxins.
  2. The story shared analogies between a hypothetical alien civilization and current human societal challenges, emphasizing the importance of humility and balance.
  3. There was a discussion on the perceived health risks of WiFi radiation, highlighting the need for thoughtful consideration and humility in scientific discourse.

Debunking Pseudoscience: ‘Multimodal Models of Animal Sex’

Reality's Last Stand • 1434 implied HN points • 06 Mar 23
🔬 Science Research
  1. The paper debunks the traditional binary model of biological sex by proposing a multimodal model.
  2. Current efforts in academia are influencing scientific research on sex by incorporating political motivations in the study.
  3. The study fails to provide evidence for more than two sexes and is criticized for misinterpreting sex differences in genetics, endocrinology, morphology, and behavior.

Making Science More Reproducible

Briefly Bio • 158 implied HN points • 18 Jul 24
🔬 Science Research
  1. Reproducibility in science is a big issue, with many experiments failing to be duplicated. This creates a challenge for scientists trying to build on each other's work.
  2. Clear and detailed documentation of scientific processes is crucial. When scientists share their methods well, it helps others replicate results more easily.
  3. Using technology like structured documentation can improve transparency in research. This way, scientists can better understand what happened in an experiment and learn from it.

Statistical AI Analysis Contradicts Bird Flu USDA Lab Leak Claims

Who is Robert Malone • 6 implied HN points • 06 Mar 26
🏥 Health Politics Research
  1. A rigorous Bayesian AI analysis found natural origin far more likely (about 76.8%) than a laboratory escape (about 23.2%), a large reversal from an earlier subjective 65% lab estimate.
  2. A six-layer evidence framework combined with statistical innovations (like power dampening, skepticism factors, and reliability weighting) reduced confirmation bias and produced transparent, reproducible results intended to support AI-enhanced verification systems.
  3. Even with the lower lab-leak probability, the remaining ~23% risk, prior safety incidents, and transparency gaps mean independent genetic testing, full access to records, and stronger international oversight are still warranted.

Introducing the AI Frontier

The AI Frontier • 59 implied HN points • 08 Aug 24
🕹 Technology Research
  1. The blog is now focusing more on specific AI topics instead of a wide range of subjects. This will help them share deeper insights and experiences.
  2. They aim to discuss what they've learned from building their AI product and how technology changes impact AI startups.
  3. Going forward, the blog will highlight useful projects and focus on practical lessons, like data cleaning, rather than generic news about AI.
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We're making diseases more dangerous and they're escaping from labs. But don't worry, it's all for your health & safety.

Break Free with Karen Hunt • 727 implied HN points • 28 Jan 24
🏥 Health & Wellness Research
  1. Mankind is making diseases more dangerous through gain-of-function research, which poses significant risks.
  2. Despite extensive history of studying viruses, humanity has a low success rate in eradicating diseases.
  3. The proliferation of Bio Security Level 4 labs globally and the risks associated with lab accidents highlight the dangers and lack of stringent safety protocols.

February Newsletter

RSS DS+AI Section • 29 implied HN points • 01 Feb 26
🕹 Technology Research
  1. AI misuse and ethical risks are increasing — deepfakes, automated exploit generation, bias, and job impacts mean security, fairness, and regulation need urgent attention.
  2. Research is advancing rapidly across many fronts, including model consistency, memory/lookup mechanisms, test-time training, decentralized and open-source models, and early work on AI systems that can improve themselves.
  3. Practical resources and community activity are abundant, with tutorials, benchmarks, tools, academic outlets, and job opportunities helping practitioners deploy AI responsibly and learn new skills.

Scientific Accuracy and Readability

Scott's Substack • 805 implied HN points • 11 Jan 24
🔬 Science Research
  1. Scientific manuscripts should strike a balance between readability and accuracy.
  2. Clearly state the specific target parameters in research questions to drive methods used.
  3. Different methods in scientific research identify different treatment effects; state target parameters upfront to guide method selection.

The Autism Surge: Lies, Conspiracies, and My Own Kids

Common Sense with Bari Weiss • 7776 implied HN points • 20 Jul 23
🏥 Health & Wellness Research
  1. Autism diagnoses in California have increased significantly over the past few decades, with a 50-fold surge in cases over 33 years.
  2. The rise in autism cases cannot solely be explained by better or broader diagnostics, indicating a real and concerning increase in the disorder.
  3. The lack of clear understanding of the causes of autism and the increasing rates point towards a pressing need for better research, support, and services for individuals with autism.

AwakeNotWoke again is over the target as this is explained in response to my substack: "So the vaccine mRNA not only does not remain at the injection site but, contrary to the bullshit conclusions of

Alexander News Network -Dr. Paul Elias Alexander's substack • 628 implied HN points • 12 Feb 24
🏥 Health Politics Research
  1. Vaccine mRNA doesn't stay at the injection site but can spread to placenta and umbilical cord blood, which may have biological benefits but also risks for the fetus.
  2. Research shows that COVID vaccine content can affect babies in the womb, highlighting the lack of information from vaccine makers in studies involving pregnant women.
  3. The study underlines the importance of providing critical information for pregnant women to make informed decisions regarding COVID vaccination.

The Utter Ridiculousness of the 5-10% Weight Loss Recommendation

Weight and Healthcare • 1318 implied HN points • 04 Oct 23
🏥 Health & Wellness Research
  1. The recommendation for 5-10% weight loss to improve health is widespread but may not have significant impact on individuals' health conditions.
  2. The weight loss recommendation is based on flawed BMI categories, often leading to unrealistic goals for individuals, especially those with obesity.
  3. The focus on weight loss overlooks the importance of evidence-based, individualized medical interventions for all patients, regardless of size.

Tyler Cowen: Does AI Make Us Stupid?

Common Sense with Bari Weiss • 774 implied HN points • 23 Jun 25
🕹 Technology Research
  1. Using AI tools like ChatGPT can make some tasks easier but may reduce our ability to think deeply. It's similar to how relying on GPS makes people less familiar with routes.
  2. A new research paper suggests that using AI could lower our cognitive effort for tasks, leading to concerns about long-term thinking skills.
  3. Despite the fears about AI making us 'stupid,' the writer believes we're not in a worse situation than before—just be aware of how we use these tools.

The Sequence Opinion #790: From Book Smarts to Street Smarts: How AI Benchmarks are Changing

TheSequence • 70 implied HN points • 15 Jan 26
🕹 Technology Research
  1. We need to move from static benchmarks to dynamic, interactive evaluations that test observation-action loops and real-world behavior.
  2. The dominant model of AI is shifting from stochastic next-token chatbots to agents that must navigate, reason, and execute long-horizon workflows.
  3. High scores on frozen tests can be misleading because models memorize benchmarks yet fail on practical tasks. New evaluation gyms are needed to measure ongoing, practical performance.

Links For May 2023

Astral Codex Ten • 8396 implied HN points • 01 Jun 23
🕹 Technology Research
  1. The Nisean horse was highly regarded by ancient civilizations and fought over in wars
  2. UNAM university in Mexico is operating an octopus farm disguised as a research center
  3. Research shows that the Success Sequence may not accurately measure outcomes due to various factors

Data Science Weekly - Issue 528

Data Science Weekly Newsletter • 799 implied HN points • 05 Jan 24
🕹 Technology Research
  1. Data Science Weekly shares curated news and articles each week related to data science, AI, and machine learning. This helps readers stay updated on important trends and topics.
  2. Deepnote emphasizes using its own platform for building data infrastructure, showcasing how versatile tools can simplify data tasks. It highlights the importance of a universal computational medium.
  3. A reliable A/B testing system is essential for businesses to make informed decisions and optimize performance. Companies that use effective experimentation platforms can significantly improve their outcomes and reduce manual work.

Please don't sue the scientists who exposed your papers for containing bad data

The Intrinsic Perspective • 6981 implied HN points • 07 Aug 23
🔬 Science Research
  1. Scientists accused of misconduct may face damaging consequences like losing their careers and facing lawsuits.
  2. Intent matters when judging data fabrication, and public condemnation is not always the best approach.
  3. Challenges arise when individuals expose scientific fraud by prominent researchers and face potential legal repercussions.

What Are Virtual Cells?

The Century of Biology • 644 implied HN points • 29 Jun 25
🔬 Science Research
  1. AI is changing biology by making it easier to model things like proteins and cells. Instead of trying to write down every detail, researchers can use data to train models that can predict how cells behave.
  2. The concept of 'Virtual Cells' is about building computer models that can simulate how real cells function. This can help scientists understand complex biological processes and test experiments without needing a lab.
  3. Using AI to learn from large amounts of biological data could lead to breakthroughs in medicine and biology, allowing researchers to predict outcomes and design better experiments more efficiently.

3.4.8 Maxwell's Methods and Views

Fields & Energy • 219 implied HN points • 22 May 24
🔬 Science Research
  1. Maxwell used physical analogies and models to understand complex electrical and magnetic behaviors. This helped him discover important concepts like the displacement current.
  2. He believed that energy is linked to electromagnetic fields, not just to electric charges. This was a key part of his theory of electromagnetism.
  3. Despite his great contributions, some of Maxwell's ideas were not recognized during his time. His work on gases faced rejection, showing how science can overlook important discoveries.

Aldén et al. showed us that SARS-CoV-2 (COVID) mRNA (RNA) can be reverse-transcribed & integrated into the genome of human cells; shit, did Malone know this? I know he knew but was silent! Can he be

Alexander News Network -Dr. Paul Elias Alexander's substack • 569 implied HN points • 11 Feb 24
🏥 Health Politics Research
  1. SARS-CoV-2 (COVID) mRNA can be reverse-transcribed and integrated into the genome of human cells, leading to potential implications and questions regarding the knowledge of certain individuals.
  2. The up-take of BNT162b2 into human liver cells can result in changes in genetic expression, potentially suggesting rapid effects of mRNA exposure.
  3. Studies have shown that mRNA from vaccines can be reverse transcribed into DNA within human cells in as fast as 6 hours, indicating a swift biological process.

Whose Bodies Get Studied

Culture Study • 4373 implied HN points • 28 Feb 24
🏥 Health & Wellness Research
  1. The majority of research studies focus on cis-gender men, leading to biased advice, knowledge, and healthcare.
  2. Women's bodies have historically been considered anomalies in sports and medical research, impacting areas like sports gear design and participation rules.
  3. Excluding women from research studies leads to gaps in knowledge, affecting areas like injury prevention, gear design, and understanding menstrual health.

10 pm tonight---Disaffected, Episode 161

Disaffected Newsletter • 479 implied HN points • 02 Mar 24
🎙 Podcasts Research
  1. A Democratic city council candidate in Burlington is facing backlash for an accusation related to a racial slur. This shows how political struggles can become intense, especially within the party.
  2. There is a debate about a man who set himself on fire to protest Israel. Some see him as a martyr, while others believe he was struggling with personal issues.
  3. A UK researcher claims that female psychopaths are just as common as male ones. This challenges the stereotype that we often have about violent behavior being mostly male.

Planarian: The Immortal Flatworm

Solve Cancer in 365 days • 19 implied HN points • 03 Sep 24
🔬 Science Research
  1. Planarians are unique flatworms that can regenerate any part of their body, even after being cut into many pieces. This shows amazing capabilities, as they can grow back perfectly.
  2. These worms also challenge our ideas about intelligence. They can transfer learned information across their bodies, suggesting that intelligence might not just reside in the brain.
  3. Scientists are exploring how the electrical patterns in planarians can guide regeneration and influence cellular behavior. Understanding this could lead to advances in human healing and possibly control over our own biology.

The Bitter Pipeline

Abstraction • 39 implied HN points • 28 Jan 26
🕹 Technology Research
  1. Frontier models scale better than human-designed forecasting pipelines, so the structured process that helped smaller models often adds no value with larger models.
  2. Empirical tests show spending compute on polling and ensembling big models improves forecast skill more than token-heavy steps like classification or decomposition, with ensembling giving measurable uplift while the pipeline did not.
  3. The practical move is to simplify: ensemble aggressively, validate empirically, and keep experimenting with ways to elicit latent model knowledge instead of adding complex hand-crafted processes.

⤴⤵ Up Wing/Down Wing #54

Faster, Please! • 548 implied HN points • 26 Jul 25
🕹 Technology Research
  1. AI has made big progress by solving complex math problems at an international competition without human help. This shows how smart AI can get and how it might help in research.
  2. Japan is building a new nuclear reactor, its first since a big disaster in 2011. This move is part of a plan to rely less on energy imports and use more nuclear power.
  3. Public opinion in Japan is changing, allowing for a gradual increase in nuclear energy use. The government wants nuclear power to provide more electricity to reduce energy costs.

Open Thread 310

Astral Codex Ten • 4749 implied HN points • 08 Jan 24
🔬 Science Research
  1. Weekly open thread for sharing anything or asking questions.
  2. Seeking volunteers in different expertise areas for reviewing proposals.
  3. Discussion on the impact of distinctively black names on job interviews and life outcomes.

Investing 101

Investing 101 • 59 implied HN points • 03 Jan 26
💼 Business Research
  1. Build a compounding engine of reading, research, writing, and investing that converts broad exposure to ideas into concrete actions and bets.
  2. Adopt concrete daily and weekly habits to feed that engine — aim for steady reading across categories, a nightly short story/poem/essay routine, and weekly micro essays to capture emerging ideas.
  3. Make investing an explicit output of the process by widening conversational reach, documenting thinking in an investing journal, and publishing portfolio updates, Requests for Startups, and idea notes to strengthen conviction.

Common Terminology and Statistics Issues- Part 2

Weight and Healthcare • 738 implied HN points • 27 Dec 23
🏥 Health & Wellness Research
  1. Using percentages without proper context can be misleading, it's crucial to provide a full picture for accurate interpretation.
  2. Understanding the difference between relative and absolute risk in statistics can prevent manipulation and provide a clearer view of the data.
  3. Different methods for handling dropouts in trials, like LOCF and BOCF, can impact outcomes significantly and need careful consideration in research.

Increased risk of 20%? Dr. JimThorp, obstetrician/gynecologist who led the fight against the COVID mRNA technology gene injections as to harms on the fetus, mother, newborn, as has Dr. Naomi Wolf, are

Alexander News Network -Dr. Paul Elias Alexander's substack • 530 implied HN points • 11 Feb 24
🏥 Health Politics Research
  1. A new study suggests a 20% increased risk of severe bleeding post-mRNA vaccination in women hospitalized for heavy menstrual bleeding.
  2. The study focused on women aged 15-50 who experienced heavy menstrual bleeding post-mRNA vaccination in France between May 2021 and August 2022, with 99.8% receiving Comirnaty (Pfizer) or Spikevax (Moderna).
  3. Primary vaccination doses showed a 20% increased risk, particularly in socially disadvantaged municipalities and among women not using hormonal contraception, but this increased risk was not found for booster doses.

The Food Safety Impact of Food Fraud: What 795 Food Fraud Cases Tell Us About Real Risk

The Rotten Apple • 42 implied HN points • 26 Jan 26
🍲 Food & Drink Research
  1. Food fraud creates food safety risks. New research has measured how often fraud incidents also pose safety hazards by analyzing 795 cases.
  2. Not all fraud is equally dangerous: the study categorizes which types of fraud, which hazards, and which foods are most likely to cause safety problems.
  3. The findings give practical guidance for industry to prioritize monitoring and prevention so resources target the fraud types and food products that pose the biggest safety risk.

Biotech

ChinaTalk • 681 implied HN points • 09 Jun 25
🕹 Technology Research
  1. China's biotech industry has transformed from copying foreign drugs to developing innovative medications that compete globally. This shift shows that they are now making significant progress in drug discovery.
  2. Companies like BeiGene and Legend Biotech have successfully created cancer therapies that are approved internationally, demonstrating China's growing capability in biopharmaceuticals and bringing new options to cancer patients worldwide.
  3. New drugs from Chinese companies like Akeso are showing promise in clinical trials, potentially leading to breakthroughs in cancer treatment. This trend attracts global attention and investments, signaling a bright future for China's biotech sector.

The Sequence Radar #803: Last Week in AI: Anthropic and OpenAI’s Battle for the Long Horizon, Goodfire and LayerLens Push AI Accountability

TheSequence • 28 implied HN points • 08 Feb 26
🕹 Technology Research
  1. AI is moving from conversational assistants to agentic systems that can plan, act, and self-manage across long time horizons, with new models built to reason over huge contexts and even help in their own development.
  2. Interpretability and accountability are rising to the top of the agenda, as companies build tools to map model internals and run agent-as-a-judge evaluations that verify complex, multi-step behaviors.
  3. A fast-growing ecosystem of research, platforms, hardware moves, and big funding rounds is racing to operationalize and scale verifiable autonomous agents across industries like coding, cloud ops, audio, and healthcare.

The Evidence is in: Masks DO NOT WORK

COVID Reason • 1586 implied HN points • 08 Aug 23
🏥 Health & Wellness Research
  1. The Cochrane Review found little evidence that masks are effective against viral transmission
  2. A new study focused on dozen research to determine the impact of masks on spread of infectious respiratory diseases
  3. Confidence intervals in the report show a relative paucity in the effectiveness of masking