The hottest Trials Substack posts right now

Beta-blockers after MI have been a common practice, but recent evidence shows they may not be as crucial as previously thought.
The BHAT and ISIS 1 trials from the 1980s provided insights on the effectiveness of beta-blockers after MI.
These trials highlight the need to reevaluate the use of beta-blockers after MI, as current MI treatment practices have evolved significantly.

The author is in San Diego for a trial, balancing work and enjoying the city.
The author is recording episodes for Serious Trouble during the trial.
The author is updating a classic post about censorship tropes in First Amendment discussions.

In a courtroom, both sides work hard to present their case, highlighting the competition between the defense and prosecution. This can lead to intense moments where one side tries to catch the other off guard.
Even judges are part of this competitive environment. They have to be careful with their instructions because any mistakes can lead to major troubles, like a mistrial.
Competition is everywhere in life, not just in courts. It drives us to improve and set higher standards for ourselves, like how we strive to play music better by observing professionals.

The post discusses a historical figure, Thomas Morton, and his significance in early American history.
The content is a continuation from a previous post titled "The Man Who Told the Puritans 'Up Yours' (1)."
The article is part of a series called An Alt-New England Story.

Forecasting the outcome of the 2024 Presidential campaigns is complex due to numerous variables and uncertainties.
Futurists find it easier to predict the general trends and movements in society rather than specific details.
Developing a 'chunk ahead' phased timeline approach helps in forecasting possible scenarios and making strategic plans for key events.

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Traditional cohort studies and trials are essential in modern medicine and public health for studying the relationship between exposures and outcomes.
Running conventional cohorts and trials can be costly and challenging due to low participation rates, retention issues, and data collection constraints.
Digital cohorts and trials are conducted digitally, collecting data electronically, which helps in remote and siteless studies, making research more accessible and cost-effective.

Vaccines must be evaluated for their ability to prevent people from spreading the virus, not just protecting the individual.
It is crucial to gather information on infectiousness alongside vaccine trials to understand their full impact.
Strategies like frequent testing of early vaccine recipients and vaccinating hard-hit regions first can provide valuable insights on the spread of vaccinated individuals.