The hottest Medication Substack posts right now

And their main takeaways
Top Health & Wellness Topics
Freddie deBoer • 5659 implied HN points • 15 Mar 24
  1. The author started taking a medication called Rybelsus due to metabolic problems caused by long-term use of psychiatric medications and physical limitations.
  2. The author's struggles with weight management, loss of control due to inability to lift weights, and the significant cost of medication highlight the challenges they face in trying to maintain their health.
  3. Regular monitoring and support from professionals are essential for the author's well-being, despite concerns about societal judgment around medication use.
Sasha's 'Newsletter' • 2451 implied HN points • 14 Mar 24
  1. Happiness is not a fixed state; significant increases in happiness are achievable through various factors like medication, career growth, physical activities, and personal growth.
  2. Factors contributing to increased happiness include therapy, meditation, improved social connections, financial stability, and positive life changes.
  3. Belief in static happiness levels may limit people from realizing their potential for significant happiness increases, preventing them from actively working towards a happier life.
Are You Okay? • 3095 implied HN points • 19 Feb 24
  1. Self-compassion is a crucial element for overall health, often more important than medication for certain symptoms.
  2. Non-pharmacologic interventions are commonly prescribed alongside medications to address complex health problems like weight gain, insomnia, and chronic pain.
  3. Self-compassion, forgiveness, and love for oneself can be the most effective remedies for inner struggles and health issues, often more powerful than medication.
Are You Okay? • 1737 implied HN points • 18 Mar 24
  1. Mental health is a crucial aspect of overall health, affecting our thoughts, feelings, and behaviors, as well as our physical health. It is not just about happiness but about acknowledging and working on our fears, moods, habits, and relationships.
  2. Being aware of our mental health, accepting the things we cannot change, and taking action over the things we can control are important steps in managing mental health.
  3. Addressing mental health issues is a nuanced process that may involve a combination of medication, therapy, lifestyle changes, and self-discovery. It requires a holistic approach considering bio-psycho-social elements.
Get a weekly roundup of the best Substack posts, by hacker news affinity:
2nd Smartest Guy in the World • 3832 implied HN points • 21 Jan 24
  1. Ivermectin, known as 'horse dewormer,' is now proving to be a powerful cancer treatment protocol.
  2. Combining Ivermectin with Fenbendazole creates a potent anti-cancer, anti-parasitic, and anti-viral therapy.
  3. Doctors suggest cancer may be related to intracellular parasites and Ivermectin may help in treating it.
2nd Smartest Guy in the World • 2555 implied HN points • 06 Feb 24
  1. A synergistic pairing of ivermectin and fenbendazole is highly effective at preventing and treating cancer.
  2. Both ivermectin and fenbendazole show promise in inhibiting the growth and spread of cancerous tumors.
  3. Combining ivermectin and fenbendazole with other anti-cancer nutrients like quercetin, vitamins C and D, and curcumin can enhance their effects.
Weight and Healthcare • 659 implied HN points • 17 Apr 24
  1. The trial data for Semaglutide (Wegovy) for cardiovascular risk reduction was manipulative and lacking in transparency, raising concerns about conflicts of interest and data sharing.
  2. The study demographics were concerning, with a lack of diversity and representation, particularly skewed towards white men, older participants, and those with existing heart disease.
  3. The actual cardiovascular risk reduction with Semaglutide was much lower than claimed, highlighting issues with study design, data presentation, and potential overemphasis on specific demographics in the results.
Sensible Medicine • 2948 implied HN points • 15 Jan 24
  1. Beta-blockers after MI have been a common practice, but recent evidence shows they may not be as crucial as previously thought.
  2. The BHAT and ISIS 1 trials from the 1980s provided insights on the effectiveness of beta-blockers after MI.
  3. These trials highlight the need to reevaluate the use of beta-blockers after MI, as current MI treatment practices have evolved significantly.
Weight and Healthcare • 798 implied HN points • 06 Apr 24
  1. Be cautious of the concept of 'food noise' promoted by weight loss drug makers as a rebranding of normal hunger or a way to profit off people's broken relationships with food.
  2. Some weight loss drugs aim to manipulate hunger signals through impacting the brain and gut, with unclear long-term effects and potential risks.
  3. The weight loss industry's push for drugs like GLP-1 agonists raises concerns about informed consent, lack of long-term research, and prioritizing short-term weight loss over potential health consequences.
Maryanne Demasi, reports • 1906 implied HN points • 29 Jan 24
  1. Rosuvastatin (Crestor®) quickly became a popular cholesterol-lowering drug due to an aggressive marketing campaign.
  2. In Australia, rosuvastatin is the most prescribed drug, with over 14 million prescriptions written in a financial year.
  3. Rosuvastatin was found to be the most potent statin in lowering cholesterol, but this higher potency also led to greater toxicity.
Alexander News Network -Dr. Paul Elias Alexander's substack • 1395 implied HN points • 05 Feb 24
  1. Sedation of elderly patients with toxic drugs can worsen their breathing and health.
  2. Some medical professionals neglected and mistreated elderly patients during the COVID-19 crisis.
  3. It's important to have an emergency preparedness kit with essential medications.
The Vajenda • 1139 implied HN points • 07 Feb 24
  1. Reproductive hormones can have different effects on women, such as premenstrual syndrome and postpartum depression.
  2. Progesterone/progestins in menopausal hormone therapy can impact mood and may have complex interactions in the brain.
  3. Options to consider if progesterone/progestins negatively affect quality of life include switching dosage or trying alternative medications.
Are You Okay? • 1238 implied HN points • 22 Jan 24
  1. Depression is a medical condition, not a flaw. Seeing your doctor is crucial.
  2. Treatment options for depression vary and can include therapy, lifestyle changes, or medication like Prozac, Lexapro, and Zoloft.
  3. Pharmacotherapy, like antidepressants, can be beneficial in managing depression when used as part of a holistic treatment plan.
Are You Okay? • 439 implied HN points • 22 Mar 24
  1. During the pandemic, many experienced heightened anxiety, including fears around COVID, leading to mental health challenges that may persist post-pandemic. It's crucial to validate experiences, offer empathy, and seek professional help to address anxiety disorders effectively.
  2. Examine potential side effects of medications like GLP1 agonists such as Ozempic, Wegovy, and others, which may cause mild hair loss. Healthcare providers should consider these effects when prescribing and monitor patients accordingly.
  3. The approach to addressing health-related anxiety is multi-faceted, involving psychotherapy, medication, trauma therapy, or even exposure to the feared illness under professional guidance, emphasizing the importance of a comprehensive approach to treatment.
Weight and Healthcare • 439 implied HN points • 20 Mar 24
  1. Eli Lilly and other pharmaceutical companies are focused on lobbying for insurance coverage of weight loss drugs, pushing for the idea of higher-weight bodies as a 'disease' worth medicating.
  2. The FDA approval for weight loss drugs like Zepbound requires different criteria based on BMI, raising concerns about the risk assessments being tied to body size.
  3. Pharmaceutical companies like Eli Lilly prioritize shareholder interests over customer concerns, raising questions about the true motivations behind their actions.
Weight and Healthcare • 1118 implied HN points • 10 Jan 24
  1. Ozempic and Wegovy are different brand names for the same drug used for weight loss.
  2. Wegovy is not just a weight loss drug but a megadose of a diabetes drug with weight loss as a side effect.
  3. Wegovy has serious side effects including complications when going off the drug and the need for continuous use to maintain weight loss.
Weight and Healthcare • 818 implied HN points • 03 Feb 24
  1. Tirzepatide, known as Zepbound for weight loss, was initially a Type 2 diabetes medication by Eli Lilly that got FDA approval for weight loss due to its side effect of weight loss. It works by interfering with normal digestion processes and hunger signals.
  2. There are dosing differences between the diabetes and weight loss applications of Tirzepatide. For weight loss, patients are encouraged to continuously increase the dosage to the highest tolerable level, potentially facing side effects that impact their quality of life.
  3. The side effects of Tirzepatide/Zepbound can range from mild discomfort to serious conditions like thyroid C-Cell tumors, gastrointestinal diseases, and pancreatic issues. Patients need to be aware of potential risks, like drug interactions and impact on pregnancy.
Are You Okay? • 499 implied HN points • 26 Jan 24
  1. Premenstrual Dysphoric Disorder (PMDD) is a real and potentially debilitating condition that affects many women. Managing it can involve tracking symptoms, regular exercise, a nutritious diet, adequate sleep, hormonal treatments, SSRIs, psychotherapy, and stress reduction techniques.
  2. When considering tapering off antidepressants, it's important to discuss this process with a healthcare provider. Psychotherapy can be a valuable tool for retraining the brain during this transition.
  3. Individualized treatment plans are crucial for addressing specific symptoms and needs when managing hormonal mood swings, tapering antidepressants, or dealing with other health concerns. Working closely with a doctor can help in developing a suitable plan.
Are You Okay? • 619 implied HN points • 29 Dec 23
  1. Engaging in weight-bearing exercises like yoga can improve bone density and reduce the risk of osteoporosis, along with a calcium-rich diet and vitamin D supplements.
  2. For older adults, incorporating simple weight-bearing exercises into routines, like wearing a weighted vest while walking, can significantly enhance muscle strength and overall health.
  3. Decisions on medications for osteoporosis should be personalized, considering the effectiveness of lifestyle changes and the potential benefits of prescriptions like Fosamax, which may be complemented by habits like yoga.
Curing Addiction • 99 implied HN points • 05 Apr 24
  1. Addiction might be curable by modifying addictive drive biologically, shifting treatment significantly.
  2. Evidence supports the idea that addiction can be biologically changed, opening doors for potential cures.
  3. New medications like GLP-1 drugs show promise in reducing addictive behaviors, offering hope for addiction treatment advancement.
Break Free with Karen Hunt • 1454 implied HN points • 02 Jul 23
  1. Psychologists can label non-compliance during COVID as psychopathy, justifying 'fixing' individuals as they see fit.
  2. The power dynamics post-COVID have allowed for the manipulation and control of citizens, using psychology as a weapon.
  3. Psychiatry and psychology have a history of coercion, drugging, and inhumane treatments towards those deemed non-compliant or ill.
Are You Okay? • 459 implied HN points • 15 Dec 23
  1. It's important to balance the risks associated with COVID-19 with the desire for social interaction and living a fulfilling life.
  2. Protecting against serious COVID outcomes involves getting vaccinated and optimizing health, while preventing infection means avoiding sick individuals and wearing masks in crowded indoor spaces.
  3. Decisions regarding COVID risk mitigation should be personalized, taking into account individual vulnerabilities and risk tolerance, and it's advised to consult with a healthcare provider for tailored advice.
Weight and Healthcare • 579 implied HN points • 04 Nov 23
  1. Wegovy is a weight-loss drug that has not been around for a long time, as it is a repurposed version of another drug called semaglutide, with evolving risks and warnings.
  2. Wegovy and Ozempic differ in dosage and treatment purpose, with Wegovy aiming to maximize weight loss side effects at a high dose that exceeds the maximum dose of Ozempic.
  3. Informed consent conversations with healthcare practitioners are essential, especially when considering drugs like Wegovy with significant side effects and dosage differences.
The Frontier Psychiatrists • 294 implied HN points • 15 Jan 24
  1. Antipsychotic medications can increase the risk of metabolic syndrome and other adverse outcomes in individuals with depression.
  2. Youth treated with higher-dose antipsychotic medications are at risk of increased mortality, especially among vulnerable children.
  3. Treating young adults with high-dose antipsychotic medications can result in significantly more deaths compared to fentanyl, emphasizing the need for better options for vulnerable youth.
Are You Okay? • 439 implied HN points • 24 Nov 23
  1. Mounjaro and Ozempic are medications for treating type 2 diabetes; Mounjaro also has a version for obesity, Zepbound. Both types of drugs improve insulin sensitivity, reduce blood sugar levels, and promote weight loss.
  2. Forgetfulness about simple things like names of familiar items could be a part of normal aging rather than a sign of dementia. However, if there are persistent concerns, it's best to consult a healthcare provider.
  3. Maintaining a balanced lifestyle with a healthy diet, regular exercise, and realistic expectations is essential for the effective use of medications like Mounjaro, Ozempic, and related drugs.
Are You Okay? • 539 implied HN points • 20 Oct 23
  1. When caring for aging loved ones, it's crucial to prioritize your own mental and physical health to prevent caregiver burnout.
  2. Shift your perception of control to restore agency and self-determination in your life, especially while taking care of others.
  3. In caregiving, meeting your basic biological needs like sleep, talking to someone, eating healthily, and moving your body is essential for long-term wellbeing.
Thing of Things • 176 implied HN points • 09 Feb 24
  1. If you have occasional insomnia, believing that lying down with your eyes closed can be almost as beneficial as sleeping might help.
  2. For chronic insomnia, consider trying antidepressants or other sleeping medications under your doctor's guidance. Cognitive behavioral therapy for insomnia is also effective.
  3. Cognitive behavioral therapy for insomnia involves following a strict routine, including tracking sleep patterns, setting a consistent wake-up time, and avoiding napping during the day.
Are You Okay? • 439 implied HN points • 10 Nov 23
  1. The Galleri cancer test is a non-FDA-approved blood test that claims to detect over 50 types of cancer, but has limitations in accuracy with false negatives and false positives.
  2. When it comes to cancer screening, it is crucial to follow evidence-based recommendations such as mammography for breast cancer, colonoscopy for colon cancer, and other specific tests for high-risk individuals.
  3. For those concerned about cancer risk, focusing on known preventive measures like maintaining a healthy lifestyle, limiting alcohol and processed food intake, and regular exercise is important, alongside consulting with a healthcare provider for personalized screening recommendations.
The Frontier Psychiatrists • 117 implied HN points • 09 Feb 24
  1. Remeron, also known as Mirtazapine, has unique side effects like making you sleepy and increasing appetite due to its histamine effects.
  2. While Remeron may not differ significantly in its antidepressant effects from other drugs, it could work slightly faster and be more favorable in treating depression compared to SSRIs.
  3. A meta-analysis suggests that overall, Remeron might have a slight edge over SSRIs in treating depression, making it potentially a better option for some individuals.
The Frontier Psychiatrists • 117 implied HN points • 08 Feb 24
  1. Bupropion is a versatile antidepressant with different brand names for various uses like depression, smoking cessation, and weight loss.
  2. Bupropion works differently than most antidepressants by affecting dopamine and norepinephrine, leading to no sexual side effects.
  3. Through meta-analysis, studies have shown that Bupropion is more effective than a placebo in treating depression.
The Microdose • 589 implied HN points • 05 Jun 23
  1. Psychedelic clinical trials often exclude participants taking SSRIs to isolate the effects of the single drug being studied.
  2. The main risk of mixing SSRIs and psychedelics is serotonin toxicity, but in healthy volunteers, the risk seems low.
  3. Tapering off SSRIs can have risks, including the return of depression or anxiety symptoms and serotonin discontinuation syndrome.