The hottest Clinical Trials Substack posts right now

And their main takeaways
Category
Top Health & Wellness Topics

Lighting up Long Covid

Ground Truths • 15222 implied HN points • 19 Jan 24
🏥 Health & Wellness Long Covid Vaccination Clinical Trials
  1. A new study on Long Covid analyzed 6,600 proteins to identify potential biomarkers like complement activation.
  2. Vaccination offers substantial protection against Long Covid, especially in those not at risk of severe illness.
  3. Recent reports highlight potential neurologic damage from Covid and call for more research on effective treatments.

Defense of Dr. Charles Hoffe Vs. The BC College of Physicians and Surgeons - Part 4

Pierre Kory’s Medical Musings • 4835 implied HN points • 28 Jan 24
🏥 Health & Wellness Clinical Trials
  1. Dr. Hoffe advocates for the safety and effectiveness of ivermectin as a Covid treatment.
  2. Extensive data supports the unparalleled safety profile of ivermectin for Covid and parasitic diseases.
  3. Comparisons show that ivermectin is safer than other approved Covid treatments like Remdesivir, Paxlovid, and Molnupiravir.

Forensic analysis of 38 subject deaths shared by Corinne Michels Writer Science Rules by Corinne Michels, found evidence of an over 3.7-fold increase in number of deaths due to cardiovascular events

Alexander News Network -Dr. Paul Elias Alexander's substack • 1572 implied HN points • 25 Jan 24
🏥 Health Politics Vaccine Safety Clinical Trials
  1. Forensic analysis found a 3.7-fold increase in deaths due to cardiovascular events in Pfizer vaccinated individuals compared to placebo.
  2. The adverse event signal was not reported by Pfizer/BioNTech.
  3. Inconsistencies were found in subject data reported in the study and publications by Pfizer/BioNTech trial site administrators.

Karuna Therapeutics, a drug repurposing effort, sold for about $14 billion. This is their story.

Trevor Klee’s Newsletter • 1119 implied HN points • 05 Feb 24
🔬 Science Biotechnology Drug Development Pharmaceuticals Clinical Trials Innovation
  1. Karuna Therapeutics achieved a $14 billion sale through drug repurposing.
  2. Drug repurposing can be a highly lucrative business without requiring excessive brilliance or luck.
  3. VCs often prioritize hype and platform-based drug development over drug repurposing success stories.
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LabGenius - the long slow road to faster drug discovery

Rory’s Always On Newsletter • 530 implied HN points • 07 Feb 24
🔬 Science Biotech AI Drug Discovery Machine Learning Clinical Trials
  1. AI and machine learning are revolutionizing drug discovery by speeding up the identification of potential treatments, leading to big rewards for those in the industry.
  2. Building a successful biotech company requires patience, determination, and significant funding, often with a focus on research and development before revenue generation.
  3. Investors in biotech companies must be prepared for a long journey of constant failures and successes, akin to the process of drug discovery, with potential acquisitions being key outcomes.

The Potential of Psychedelics

The Last Bear Standing • 43 implied HN points • 15 Mar 24
🏥 Health & Wellness Psychedelics Mental health Therapeutics Clinical Trials FDA Approval
  1. There has been a resurgence of interest in the medical potential of psychedelics, with ongoing research and clinical trials exploring their efficacy in treating mental health conditions.
  2. Despite the challenges and market fluctuations, there is increasing regulatory support for psychedelic drug trials, potentially leading to FDA approvals and breakthrough therapy designations for conditions like PTSD.
  3. Psychedelic treatments involve controlled drug administration in conjunction with therapy, aiming to address the root causes of mental health disorders by stimulating new perspectives and thought patterns.

Sonia Gandhi's mission to change Parkinson's trials

Rory’s Always On Newsletter • 727 implied HN points • 05 Sep 23
🏥 Health & Wellness Clinical Trials Neuroscience
  1. Professor Sonia Gandhi leads a mission to improve Parkinson's trials by implementing ACT PD initiative for more efficient drug testing.
  2. The UK aims to become a hub for clinical trials like the multi-arm system to find disease-modifying therapies for Parkinson's faster.
  3. Funding is crucial for scientists like Professor Gandhi to advance technology and trial designs for breakthroughs in Parkinson's research.

Vial: Reimagining Clinical Trials

The Century of Biology • 308 implied HN points • 30 Jul 23
🏥 Health & Wellness Clinical Trials Drug Discovery Medical Technology Healthcare system
  1. Vial is working to reduce the cost of clinical trials by innovating new technology.
  2. Vial's Act I focuses on structuring, digitizing, and automating the clinical trial process to drive efficiency.
  3. Vial's Act II, Battery Bio, aims to revolutionize drug discovery by integrating software and advanced technologies in a vertically integrated approach.

COVID-19 vaccines’ effectiveness and safety exaggerated in clinical trials & observational studies, academics find

Who is Robert Malone • 15 implied HN points • 06 Mar 24
🏥 Health & Wellness Vaccines Clinical Trials Safety Effectiveness
  1. Claims about COVID-19 vaccines' effectiveness and safety were exaggerated in clinical trials and observational studies, impacting risk-benefit analyses.
  2. Observational studies exhibited biases like case-counting window bias, affecting estimates of vaccine effectiveness.
  3. Studies showed issues with safety estimates, short counting windows, and potential negative effectiveness of COVID-19 vaccines.

What the “Casual Cruelty” of Dr. Paul Offit Reveals

Injecting Freedom • 137 implied HN points • 03 Aug 23
🏥 Health & Wellness Vaccines Childhood Clinical Trials Safety Informed consent
  1. Dr. Paul Offit's article raises concerns about vaccine clinical trials and the lack of placebo controls.
  2. There is a debate about the safety and efficacy of childhood vaccines and the importance of proper clinical trials.
  3. The ethical considerations of vaccine trials and the need for valid safety profiles are highlighted.

MoonLake Immunotherapeutics

Axial • 7 implied HN points • 17 Feb 24
🏥 Health & Wellness Biotechnology Clinical Trials Drug Development
  1. MoonLake Immunotherapeutics is developing a tri-specific nanobody therapy called Sonelokimab (SLK) that has shown significant efficacy in treating inflammatory diseases like HS, PsA, and PsO.
  2. SLK offers unique benefits like blocking all IL-17 pro-inflammatory dimers, enabling tissue penetration, and maintaining high response rates in patients with moderate-to-severe conditions.
  3. MoonLake's SLK has the potential to become a best-in-class IL-17 inhibitor in a multibillion-dollar market, with its innovative structure, clinical success, and competitive advantages over existing treatments.

Clinical Trial to License RotaTeq, Like Almost All Childhood Vaccines, Did Not Use a Placebo Control

Injecting Freedom • 80 implied HN points • 25 Jun 23
🏥 Health Politics Vaccines Clinical Trials FDA
  1. Most childhood vaccines were licensed without using a placebo control in their clinical trials.
  2. The clinical trial for RotaTeq did not use a true placebo as the control group, but included bioactive ingredients.
  3. Robert F. Kennedy, Jr. advocates for vaccine safety and freedom of choice without restricting access to vaccines.

The Anatomy of a Clinical Trial

Superfluid • 26 implied HN points • 19 Apr 23
🏥 Health & Wellness Clinical Trials Logistics Data Analytics Future Trends
  1. Clinical trials are expensive and crucial for determining the efficacy and safety of new drugs.
  2. There are multiple stakeholders involved in running a clinical trial, each with important roles to play.
  3. Challenges in clinical trials include patient recruitment, trial logistics, and data analytics, but there are innovative startups working on solutions.

Axial Discovery - Clinical trial statistical analysis

Discovery by Axial • 1 implied HN point • 08 Sep 23
🔬 Science Clinical Trials Statistical Analysis Software Development Data Integration Data Visualization
  1. Clinical trial statistical analysis involves collecting and interpreting data to evaluate new treatments.
  2. Startups have opportunities to develop software for automating and streamlining statistical analysis processes due to increasing data complexity.
  3. Software development for data integration, visualization, and communication can improve efficiency in clinical trial statistical analysis.