Trevor Klee’s Newsletter

Trevor Klee's Newsletter explores a wide array of topics primarily focusing on the intersection of biology, philosophy, and the impact of historical and contemporary societal transformations. It delves into personal anecdotes to illustrate broader themes, discusses scientific advancements, and critiques various aspects of culture, science, and ethics.

Philosophy and Society Biological Sciences Personal Anecdotes Cultural Critique Scientific Advancements Ethical Philosophy Societal Transformations

The hottest Substack posts of Trevor Klee’s Newsletter

And their main takeaways
2910 implied HN points β€’ 20 Feb 24
  1. As people grow older, they tend to spend less time with their parents and siblings, shifting towards spending more time with friends, kids, and spouse.
  2. Due to limited time spent with family, individuals may feel like inverse strangers, knowing intimate details yet unable to rely on each other for everyday support.
  3. Memories and interactions within a family become fragmented snapshots over time, creating a sense of distance and unfamiliarity among family members.
1119 implied HN points β€’ 05 Feb 24
  1. Karuna Therapeutics achieved a $14 billion sale through drug repurposing.
  2. Drug repurposing can be a highly lucrative business without requiring excessive brilliance or luck.
  3. VCs often prioritize hype and platform-based drug development over drug repurposing success stories.
373 implied HN points β€’ 29 Feb 24
  1. Success in biotech often involves licensing and developing existing molecules, rather than creating completely new ones.
  2. To thrive in biotech, it's crucial to strategically select candidates and navigate clinical trials efficiently with the available resources.
  3. Viking Therapeutics' success was built on wisely choosing profitable indications, selecting the right molecules, and executing their development program effectively.
1865 implied HN points β€’ 19 Oct 23
  1. Life is precious and should be valued
  2. Taking unnecessary risks can have serious consequences
  3. As we grow older, we tend to appreciate life more and see the importance of safety
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3283 implied HN points β€’ 18 Mar 23
  1. The Catholic Church venerated Aristotle and opposed Galileo because they trusted ancient philosophy over new scientific ideas.
  2. Living in a world where science evolves, we give more weight to current evidence than ancient texts or philosophers.
  3. Lessons from history remind us of the importance of valuing empirical evidence over established theories.
2611 implied HN points β€’ 05 Apr 23
  1. Tulsa, Oklahoma is experiencing positive transformations due to the efforts of wealthy individuals and community foundations.
  2. The Tulsa Tomorrow program aims to attract young Jewish individuals to Tulsa by offering job opportunities, social events, and resources to fulfill their dreams.
  3. Wealthy individuals in Tulsa have made significant investments to improve the city, showing visible impact in contrast to certain bureaucratic challenges faced by other cities.
1044 implied HN points β€’ 11 Jun 23
  1. Qualifying for MassHealth requires being low income and a Massachusetts resident.
  2. The application process for MassHealth can be complicated and time-consuming.
  3. Accessing and completing the application may require navigating challenges and inconsistencies in the system.
447 implied HN points β€’ 22 Aug 23
  1. Some dogs are deeply fulfilled by tasks ingrained in their nature, like fetching.
  2. Understanding a dog's behavior should consider their innate instincts and not just human-like comparisons.
  3. The bond between humans and dogs involves mutual shaping of behaviors and needs.
671 implied HN points β€’ 13 Jun 23
  1. When searching for something, we tend to look where it is easiest to see, even if it might not be the best place to find it.
  2. This behavior can lead to wasting time and effort on ineffective or inefficient search strategies.
  3. It is important to be mindful of not getting stuck looking in familiar or visible places, but to explore all possibilities.
522 implied HN points β€’ 20 May 23
  1. Queen Elizabeth I and her sister Bloody Mary had misleading sobriquets.
  2. The label of being 'bloody' is often applied based on who is killed, not just the act of killing.
  3. Throughout history, rulers have been considered tyrants based on who they oppress or kill, rather than the number of victims.
597 implied HN points β€’ 28 Feb 23
  1. Definitions can have significant consequences, especially when redefined in academic contexts.
  2. The term 'artificial general intelligence' can be misleading due to unclear definitions of 'intelligence' and 'general'.
  3. Understanding the consequences of how terms are defined is crucial in avoiding misunderstandings and panic.