The hottest Medical Studies Substack posts right now

Dr. Hoffe advocates for the safety and effectiveness of ivermectin as a Covid treatment.
Extensive data supports the unparalleled safety profile of ivermectin for Covid and parasitic diseases.
Comparisons show that ivermectin is safer than other approved Covid treatments like Remdesivir, Paxlovid, and Molnupiravir.

Study claimed hearing aids could reduce death rate by 24%, which is unexpected.
Critics pointed out issues like imbalanced groups and unmeasured differences in the study.
This study highlights problems with incentives in science research and publication.

Small trials may show larger treatment effects, but we should be skeptical of these results.
Large trials are valuable in confirming or refuting the findings of small trials.
Trials with composite endpoints can make it challenging to communicate treatment efficacy to patients.

When evaluating medical studies, focus on patient-oriented evidence that looks at outcomes meaningful to real people.
Disease-oriented evidence is more common but may not provide helpful insights into patient outcomes.
Be cautious of drawing conclusions about patient-oriented outcomes from disease-oriented evidence.

Healthcare practitioners rely on study conclusions for information, but they may be misleading and harmful if not thoroughly examined.
Prescribing weight loss has a high failure rate and negative health impacts, leading to unrealistic expectations for patients and blame if goals are not met.
Research misleading patients and healthcare providers can result in missed diagnoses, incorrect treatments, and patient disengagement, especially in mental health care.

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Studies conducted in isolated human cells or tissues are not direct human studies, but can help generate hypotheses, explain existing data, and provide molecular details.
To confirm that a phenomenon occurs in humans, a double-blind, controlled trial is necessary, like the study conducted by Dr. Fasano's group in celiac patients.
Existing evidence suggests that non-celiac gluten-sensitive patients do not have leaky guts, but there may be subsets of non-celiac subjects who react to gluten; further research is needed.