The Infinitesimal

Thinking about genetics in a world where every variant is causal but only a tiny bit.

The hottest Substack posts of The Infinitesimal

And their main takeaways
719 implied HN points β€’ 09 Aug 24
  1. Twin heritability models can produce different estimates of how much traits are influenced by genetics versus environment. This can lead to confusion about what is truly inherited and what is shaped by upbringing.
  2. Cultural factors along with genetic factors play a significant role in shaping traits. Sometimes, what seems genetic can actually be environmental influences like parenting styles, which complicate our understanding of inheritance.
  3. Recent studies suggest that assumptions made in traditional twin studies might not be entirely accurate. By including more family relationships and considering cultural impacts, researchers can get a clearer picture of what really contributes to traits.
1298 implied HN points β€’ 06 Jul 24
  1. Genetic tests claiming to predict IQ are not reliable. They often rely on complex methods that mostly just lead to guesswork.
  2. The accuracy of these genetic predictions is very low, explaining only a tiny fraction of variations in IQ scores. In fact, other factors like age and social environment play a much bigger role.
  3. Many of these predictions confuse people about how genetics really work. It's important to understand that these scores should be treated more like entertainment than serious assessments.
359 implied HN points β€’ 21 Aug 24
  1. Gene-environment interactions (GxE) are common but hard to identify in humans. They show how genetic traits can change in different environments, affecting how we understand traits like obesity or education.
  2. There are different models to explain how genes and environments work together. Some models show that environments can amplify or change the effects of multiple genetic variants on traits.
  3. Research has found that environmental factors, like socioeconomic status or education quality, can significantly influence how genetic variations are expressed, meaning genetics alone doesn't tell the whole story about traits.
539 implied HN points β€’ 27 Jul 24
  1. Education seems to improve specific skills rather than overall intelligence. This means going to school might help you get better at certain subjects instead of making you smarter in a general way.
  2. The study raising these points had some issues in how it was set up. This makes us wonder about the validity of its conclusions regarding education and intelligence.
  3. A strong theory behind how education impacts intelligence is important for clear understanding. Without it, we might misinterpret results and make broad claims that don’t hold up.
479 implied HN points β€’ 13 Jul 24
  1. Polygenic embryo selection may not improve outcomes significantly for complex traits like IQ or education, as gains from such selections are often minimal.
  2. Screening for diseases may also have limited results, especially when those diseases are defined by arbitrary thresholds rather than clear biological mechanisms.
  3. There may be unintended consequences from embryo selection, such as increased risk for other traits, due to complex genetic correlations that are not fully understood.
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499 implied HN points β€’ 05 Jul 24
  1. Human traits are influenced by many tiny genetic factors, making understanding them complex. This means small changes in genetics can impact our traits in different ways.
  2. Talking about nature versus nurture isn't simple; both genetics and environment play big roles. There's often a mix of many genes working together rather than clear-cut definitions.
  3. The concept of heritability is tricky and often debated. Different studies can show very different results about how much genetics affect things like intelligence or behavior.
339 implied HN points β€’ 23 Jul 24
  1. Assortative mating happens when partners select each other based on certain traits, like height or education, making their children more genetically similar over generations.
  2. This type of mating can lead to increased genetic variance in the population, but does not change the genetic variance within families because the parent's traits balance out among the children.
  3. When estimating heritability or variance, it’s important to use the right approach. Population-level estimates can be misleading if based on family data, and vice versa.
319 implied HN points β€’ 19 Jul 24
  1. The Million Veteran Program's study looked at genetic data from 600,000 people, revealing that diversity in ancestry helped identify genetic traits linked to diseases.
  2. Most genetic differences between groups were due to allele frequency changes rather than real differences in how genes affect health.
  3. Fewer than 1% of significant genetic associations showed differences between populations, indicating that many genetic effects are quite similar across different ancestry groups.
62 HN points β€’ 26 Aug 24
  1. Intelligence is not predicted by genetics in the same way height is. Studies show genetics only account for a small part of IQ scores compared to height.
  2. IQ is more influenced by environmental factors and cultural background. This means the way we measure intelligence might be impacted by things like access to education.
  3. The meaning of IQ and what it actually measures is still not clear. Unlike height, which is easy to measure, intelligence testing doesn’t have a simple or consistent method of measurement.