The hottest Oxidative stress Substack posts right now

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Is Vitamin C Destroying Your Mitochondria?

Harnessing the Power of Nutrients • 1617 implied HN points • 17 Feb 24
🏥 Health & Wellness Nutrition Supplements Mitochondria Oxidative stress Metabolism
  1. High doses of Vitamin C can inhibit CoQ10 synthesis and decrease copper status, affecting mitochondrial function.
  2. Excessive Vitamin C intake can lead to the generation of oxalate, a mitochondrial toxin, causing potential mitochondrial damage.
  3. While high doses of Vitamin C can have benefits in specific cases, for general use, it's safer to stick to doses from a Vitamin C-rich diet.

Manganese Toxicity Is a CoQ10 Deficiency

Harnessing the Power of Nutrients • 998 implied HN points • 11 Mar 24
🏥 Health & Wellness Nutrition Supplementation Toxicity Oxidative stress
  1. Excess manganese can lead to mitochondrial dysfunction by hindering CoQ10 synthesis.
  2. Manganese toxicity disrupts ATP production, causes oxidative stress, and hampers CoQ10 levels, impacting energy generation.
  3. CoQ10 supplementation, along with managing manganese levels and ensuring adequate iron, may help address issues related to CoQ10 synthesis and toxicity.

Jinfiniti "Total Antioxidant Capacity" -- Worth It?

Harnessing the Power of Nutrients • 399 implied HN points • 18 Dec 23
🏥 Health & Wellness Antioxidants Oxidative stress Energy metabolism
  1. Jinfiniti's 'Total Antioxidant Capacity' test is not precise and may not be worth investing in.
  2. The commonly used FRAP and ORAC assays for antioxidant status assessment are non-specific and may not provide meaningful information.
  3. A more effective approach involves a comprehensive screening for energy metabolism and antioxidant components to identify specific areas for optimization.

025: Why You Need to Manage Your Iron Status and How to Do It

Harnessing the Power of Nutrients • 159 implied HN points • 27 Jan 17
🏥 Health & Wellness Nutrition Supplements Oxidative stress Diet
  1. Managing iron status is crucial as both deficiencies and excesses can lead to health issues.
  2. Iron from plant-based foods is less bioavailable than from animal-based sources, but vitamin C can help improve absorption.
  3. Supplements like iron-saturated lactoferrin, liposomal iron, and heme iron can be beneficial for improving iron status without causing significant side effects.

When Glucose Makes a Mess

Harnessing the Power of Nutrients • 19 implied HN points • 19 Jan 10
🏥 Health & Wellness Nutrition Oxidative stress Proteins Research
  1. Oxidative stress caused by sugars can be similar to other types of stress like nitrative and carbonyl stress
  2. Methylglyoxal, a compound from sugar breakdown, can damage proteins by forming harmful imidazole rings
  3. Methylglyoxal's reaction with lysine can lead to crosslinking of proteins, potentially disrupting protein function and structure
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