The hottest Toxicity Substack posts right now

Rosuvastatin (Crestor®) quickly became a popular cholesterol-lowering drug due to an aggressive marketing campaign.
In Australia, rosuvastatin is the most prescribed drug, with over 14 million prescriptions written in a financial year.
Rosuvastatin was found to be the most potent statin in lowering cholesterol, but this higher potency also led to greater toxicity.

PhD research can be challenging but can lead to unexpected and serendipitous discoveries
The stability of certain compounds is crucial in preventing toxicity, as observed in experiments with aluminium and silicic acid in fish
Understanding the chemistry behind experimental outcomes is key, as seen in the success of a PhD research project despite initial doubts

Ozempic, a GLP-1 agonist, is being hyped as a solution to obesity, but it may not address the real issues of metabolic health in America.
Ozempic, despite its weight loss claims, may result in serious side effects, including muscle and bone loss, gastrointestinal events, and more.
The push to fund drugs like Ozempic with taxpayer money raises concerns about cost, corruption, and missed opportunities to address root causes of health issues.

Despite changes over time, some problems, like toxic leadership, persist unchanged.
Ignoring toxic leadership allows it to continue and negatively impact organizations.
Toxic leadership isn't just about overt hostility, but also subtle influences that harm teams.

Antibiotics are poisons that target bacteria more than humans.
Metronidazole, a 5-nitroimidazole antibiotic, damages cellular molecules by reactive compounds.
Metronidazole is effective against bacteria, parasites, and cancer due to its action in reducing environments.

Get a weekly roundup of the best Substack posts, by hacker news affinity:

A recent study highlighted the toxicity and degradation of graphene, raising concerns about its broad applications and potential hazards on the environment and human health.
Further research is needed on the degradation of graphene-based nanomaterials to understand their environmental impact and health risks. Some compounds like humic acid and specific enzymes play a role in the biodegradation process.
Graphene is a trending material in various industries, but there are growing concerns about its safety, likening it to the new asbestos or Glyphosate 2.0. Monitoring industry trends and applications of graphene is important for understanding its impact.

Solar and wind generate less waste compared to coal
Studies project that solar and wind waste will be relatively small in the future
Moving to renewable or nuclear energy reduces waste significantly compared to coal

Online discourse has remained consistently toxic over the past 30 years, challenging the belief that it has worsened.
Toxicity in conversations tends to increase the longer they go on, involving fewer but more active participants.
Platforms exhibit similar levels of toxic comments, and moderation policies have the potential to influence the spread of toxic content.

Chemicals sector is crucial for our modern world and economy.
Our reliance on chemicals is often unnoticed until accidents or disasters occur.
Understanding the interconnectedness of materials like salt and PVC can help us address environmental challenges.

Verification on Twitter has lost its value in identifying valuable people.
Content creators are responsible for cultivating a healthy community on platforms.
Having a checkmark on Twitter can lead to visibility and potential echo chambers.

Gender madness is driven by taboos around sex and sublimation of western sex taboos.
Men and women bond differently due to hormonal differences, impacting behavior and relationships.
Understanding sex complementarity can help navigate societal views on masculinity and femininity.