The hottest Methods Substack posts right now

And their main takeaways
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Meta-rational practices: Overview 2

Meaningness • 119 implied HN points • 16 Mar 24
🚌 Education Methods Exercises Ontology Learning
  1. Opportunities for meta-rational improvement can be categorized in different sites for enhancing rationality
  2. Improving circumrational practice involves methods like better material supports, skills training, and proceduralization
  3. Enhancing the ontology includes steps like merging categories, splitting distinctions, and reassigning cases

Synthetic data: Anthropic’s CAI, scaling, OpenAI’s Superalignment, tips, and open-source examples

Democratizing Automation • 332 implied HN points • 29 Nov 23
🕹 Technology AI Data Models Methods Applications
  1. Synthetic data is becoming more important in AI, with a focus on removing human involvement.
  2. Proponents believe that using vast amounts of synthetic data can lead to breakthroughs in AI models.
  3. Open and closed communities are both utilizing synthetic data for different end goals.
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An N terminomics toolbox combining 2-pyridine carboxaldehyde probes and click chemistry for profiling protease specificity

Axial • 37 implied HN points • 12 Dec 23
🔬 Science Chemistry Biology Research Proteins Methods
  1. The paper introduces an expanded toolbox of reagents for profiling protease substrates and specificity using chemoproteomic methods.
  2. The work demonstrated high N-terminal selectivity with little intrinsic sequence bias beyond a requirement for a backbone amide at position 2.
  3. The 2PCA toolkit enables a broad range of applications in protease biology research by providing selective N-terminal labeling reagents that are easy to implement.