Protein sequencing using nanopores is a topic of interest, with a recent study highlighting a large state space of 10^25 and using an Oxford Nanopore's R9.4.1 pore with a range of ~10pA.
Investigating patents can provide insights into the current range for DNA sequencing and can spark further contemplation about the future of protein sequencing using nanopores.
The detailed post on protein sequencing and nanopore current ranges is available for paid subscribers, emphasizing the exclusivity of the content.
Supercritical water can break down organic matter like sewage, paper, plastic, and food into simple molecules, helping in recycling and generating energy.
Using supercritical water can address the issue of a potential future carbon shortage by breaking down carbon present in waste into simple molecules.
Supercritical water enables a wide range of chemical processes like producing green hydrogen, desalination, and supporting different chemical reactions, offering potential for creating sustainable systems.
Calibration of circuits can be a useful solution but it's important to know when it is necessary and when it's not.
Understanding how components like sensors and resistors behave in different conditions is crucial before considering calibration.
Before deciding to calibrate electronic components, a detailed technical and economic analysis should be conducted to ensure it is a suitable solution.
Science can struggle to correct errors from the scientific record, even with healthy reforms in place.
Non-replicable findings can still hold influence and get cited as much as replicable ones.
Natural sciences can swiftly correct mistakes with practical consequences, while social sciences face challenges in self-correction due to less tangible applications and high acceptance of contradictory findings.
The paper introduces an expanded toolbox of reagents for profiling protease substrates and specificity using chemoproteomic methods.
The work demonstrated high N-terminal selectivity with little intrinsic sequence bias beyond a requirement for a backbone amide at position 2.
The 2PCA toolkit enables a broad range of applications in protease biology research by providing selective N-terminal labeling reagents that are easy to implement.
Creating biobased plastics that are both affordable and perform well is a major challenge.
Price, performance, and convincing consumers are the three main hurdles to overcome in promoting biobased plastics.
The success of biobased plastics hinges on their ability to compete with traditional plastics in terms of cost and performance, while also gaining consumer acceptance.
Natural products and drugs have similarities but drugs are a balance between complexity and accessibility for optimization.
Molecular complexity in drugs is increasing to improve IP coverage, binding affinity, and effectiveness for chronic diseases.
Embracing enabling methods, computational modeling, and deep exploration of complex chemical space can revolutionize natural product synthesis for therapeutic goals.
The term 'hallucination' in the context of AI does not imply consciousness, but rather refers to AI systems stating untruths or false information.
AI's ability to 'hallucinate' new proteins opens up possibilities for innovative developments in synthetic biology and drug discovery.
There is speculation about whether AI could one day imagine and create entirely new forms of life based on alternative biochemistries, like synthetic sheep or silicon-based life.
Computer-augmented hypothesis generation is a promising concept that can help uncover new and valuable ideas from existing data.
Looking at old research in a new light can lead to significant breakthroughs, as seen with Don Swanson's and Sharpless' work in different fields.
Tools like LLMs can assist researchers in finding connections between disparate data points, potentially unlocking new avenues for scientific discovery.