The hottest Treatment Options Substack posts right now

Arthritis isn't just one disease; it's a group of conditions that cause joint pain and inflammation, with osteoarthritis being the most common type. It can affect a lot of people, and understanding the differences is key to treatment.
There's a specific type of T cell that gets stuck in arthritic joints and seems to play a big role in causing inflammation. These T cells don’t directly cause pain but help other immune cells trigger the symptoms.
Current treatments for arthritis focus on reducing inflammation but don't eliminate the root cause. New research suggests targeting the stuck T cells and their signaling could lead to better, more lasting treatments.

Rapid acting treatments are more accessible for working individuals.
Rapid acting treatments build trust by providing quick impact.
Professional societies play a significant role in advocating for novel treatments and payment infrastructure.

Xylazine, also known as tranq, is a horse tranquilizer that has made its way into illicit drug use by being combined with substances like heroin and fentanyl.
The heavy sedative effects of xylazine can lead to severe skin issues, with users having necrosis and sores that can go down to the bone, contributing to its 'zombie drug' nickname.
Xylazine causes a range of side effects and can increase the risk of opioid overdose, acting as a significant danger when mixed with other substances and having no known safe agents for reversal in humans.

Multiple Endocrine Neoplasia Type 1 (MEN1) is a rare autosomal dominant disorder caused by germline mutations in the tumor suppressor gene MEN1. Menin, encoded by MEN1, is a scaffold protein involved in various cell functions.
Genetic discovery of MEN1 led to a better understanding of the disease and enabled precision medicine strategies for patients with MEN1 mutations.
Therapeutic options for MEN1 include targeted therapies like somatostatin analogues and mTOR inhibitors, as well as chemotherapies; advancements in understanding menin function have opened up potential novel therapeutic approaches.

Joint pain in fat individuals is often wrongly attributed to body size, leading to weight loss being prescribed as a cure, overlooking ethical treatments.
Comparing the healthcare treatment between fat and thin individuals with joint pain reveals disparities in immediate care and long-term outcomes due to weight stigma.
Prescribing weight loss as a solution for joint pain without informed consent can be unethical and ineffective, harming fat patients by delaying necessary care.

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Back surgery should be carefully considered, especially for issues like foot drops, and timing is crucial for optimal results
Medical decisions can be complex and involve balancing risks and benefits, especially when it comes to surgery
Health insurance and administrative delays can impact timely medical interventions

Some states have weak requirements for the medical teams conducting lethal injections, leading to IV insertion problems.
Death row inmates' health conditions, like age, drug use history, and obesity, make finding suitable IV access points extremely challenging.
When standard IV insertion fails in lethal injections, extreme procedures like saphenous vein cut-downs or intraosseous infusion might be considered, but come with their own risks and complexities.

Taking medication for heart conditions can have various side effects, some possibly worsening the initial issue.
The author questions the conventional medical approach to treating heart diseases, advocating for a more personalized and holistic approach.
The text highlights the importance of individualized care from healthcare professionals rather than a one-size-fits-all treatment approach.