Seven Powers in Life Sciences 58 implied HN points • 13 Mar 23 💼 Business Strategy Power Dynamics Branding Resources Operations Scale Economies in business help reduce costs as production volume increases Network Economies create value as more customers join, creating barriers for new entrants Counter-Positioning involves pursuing a business model that incumbents cannot copy without damaging their existing business
Digest 5/23/23 39 implied HN points • 23 May 23 💼 Business Innovation Investment Science Entrepreneurship Axial partners with inventors in early-stage life sciences. Syntex pioneered the birth control pill and shifted focus to oral contraceptives. ReNAgade Therapeutics raised $300M to develop RNA medicines.
Digest 5/22/23 39 implied HN points • 22 May 23 💼 Business Venture Capital Biotechnology Genomics Axial invests in early-stage life sciences companies Rondo Therapeutics founded in 2019, developing bispecifics for solid tumors Kathleen Keough leads research on three-dimensional genome rewiring
Digest 5/21/23 39 implied HN points • 21 May 23 💼 Business Investing Entrepreneurship Life Sciences Axial partners with inventors in life sciences for early-stage investments Nimbus Therapeutics has successfully sold assets for significant amounts Scientist David Ross focuses on integrating neuroscience into psychiatry
Digest 5/20/23 39 implied HN points • 20 May 23 💼 Business Startups Investing Science Axial partners with great inventors and invests in early-stage life sciences companies Be Biopharma focuses on developing engineered B-cells for cancer & rare diseases Scientist Stories highlight the role of nature in solving environmental challenges through new enzymes
Cryoport 39 implied HN points • 11 Apr 23 💼 Business Biotech Logistics Investing Supply Chain Healthcare Axial partners with great founders and inventors in early-stage life sciences companies. Cryoport is a leading biotech logistics company for cell therapies and more, with over $200M in annual sales. Cryoport's IntegriCell platform streamlines distribution with strategic locations across the US.
Brammer Bio 39 implied HN points • 06 Apr 23 💼 Business Startups Investing Biotechnology Axial partners with inventors and invests in early-stage life sciences companies Brammer Bio was formed through a merger and acquired by Thermo Fisher Structured finance is crucial for building successful biomanufacturing startups
Digest 6/20/23 19 implied HN points • 19 Jun 23 💼 Business Venture Capital Biotech Science Axial partners with inventors in life sciences for early-stage investments Octave Bioscience focuses on MS care management with a blood test Immunology discoveries rely heavily on experimental research
Digest 5/26/23 19 implied HN points • 26 May 23 💼 Business Investing Biotech Innovation Research Axial partners with inventors and founders in early-stage life sciences companies. Carbon Biosciences is focused on expanding the gene therapy toolbox, especially for cystic fibrosis. Scientist David Schaffer focuses on evolving next-gen AAV vectors for gene therapy.
Digest 5/19/23 19 implied HN points • 20 May 23 💼 Business Innovation Investment Biotechnology Healthcare Axial invests in early-stage life sciences companies with great founders and inventors Doximity was founded to create a LinkedIn for doctors and now covers over 80% of physicians in the US Regeneron's formula focuses on having the best science and following it diligently for success
Forge Biologics 19 implied HN points • 05 Apr 23 💼 Business Biotechnology Investing Manufacturing Gene Therapy Collaborations Forge Biologics is a gene therapy manufacturing company in Ohio led by Tim Miller. They have one of the largest AAV manufacturing facilities with collaborations with other companies. Forge Biologics aims to increase biomanufacturing capacity and focuses on treating Krabbe Disease.
Oxford Nanopore 19 implied HN points • 17 Mar 23 🕹 Technology Biotech Genomics Startups Innovation Oxford Nanopore sequences DNA with a nanopore technology. ONT has made advancements in base-calling and chemistry for improved accuracy. The company has created a new genomics category and is exploring various applications beyond COVID surveillance.
GreenLight Biosciences 19 implied HN points • 03 Apr 23 🔬 Science Agriculture Axial partners with early-stage life sciences companies to invest in their vision and help them grow. GreenLight Biosciences uses cell-free RNA manufacturing for human health and agriculture, bringing down costs and expanding applications. GreenLight is transitioning their manufacturing scale from dsRNA to mRNA for vaccines and gene therapies.
LatchBio 19 implied HN points • 23 Mar 23 🕹 Technology Life Sciences Bioinformatics Software Development Axial invests in early-stage life sciences companies and supports rare inventors. LatchBio offers a platform for scientists to store, process, and visualize data and is hiring. Users can run different workflows and access popular tools in life sciences through Latch.
Axial Daily #1 (Biotech Exits) 2 HN points • 17 Mar 23 💼 Business Biotech Investing Startups Acquisitions Pharmaceuticals Important theme in biotech exits: Selling to large companies like Sanofi early on can be valuable. On average, biotech companies took about 13.8 years from founding to exit, with a valuation of $5.6B at acquisition. Success stories in biotech highlight the value of innovative technologies and focusing on unmet medical needs.