The hottest Alzheimer's Substack posts right now

Our world is getting older as life expectancy increases, leading to a significant demographic shift with implications for society.
As we age, changes in mental abilities are natural, with factors like brain tissue flexibility diminishing and communication speed between nerve cells slowing down.
Dementia is a complex condition, not a normal part of aging, and it is essential to recognize signs early for timely interventions and support.

Alzheimer's can cause cognitive decline and memory loss, leading to confusion and agitation
Playing music or engaging in familiar activities can help Alzheimer's patients feel connected and recognized
Despite the challenges of mental illness, love and joy can still prevail

Alzheimer's is a major problem in the US, affecting millions and expected to double in the next 25 years.
Inequality plays a significant role in Alzheimer's, with different communities and demographics being impacted differently.
More focus is needed on training caregivers, analyzing data on minority communities, and educating about new drugs to address Alzheimer's inequalities.

Obesity during middle age can increase the risk of Alzheimer's disease and other serious health conditions like heart disease and type 2 diabetes.
Genes associated with obesity, especially those inherited through the maternal lineage, can play a role in the risk of developing Alzheimer's disease.
Understanding the impact of altered adipokines, potential treatments like Ozempic, and the interplay between obesity and Alzheimer's disease is crucial for public health challenges.

Roche is focusing on developing therapies for neurological diseases like Alzheimer's, with a new drug called trontinemab showing potential for rapid clearance of amyloid plaques in the brain.
Roche's neurology strategy includes a diverse pipeline of treatments for various conditions like multiple sclerosis, neuromuscular disorders, and gene therapies for muscle-related illnesses.
The company's commitment to Alzheimer's research is driven by the amyloid hypothesis, societal impact, and economic burden, aiming to improve patient outcomes and address the growing need for effective treatments in the aging population.

Get a weekly roundup of the best Substack posts, by hacker news affinity:

The Physical Activity Guidelines should focus more on high-intensity exercise to combat Alzheimer's.
Reducing sedentary behavior is crucial for preventing Alzheimer's, not just increasing physical activity.
Alzheimer's is not just a medical issue but also a social and economic crisis that requires a proactive approach.