The hottest Substack posts of Christian Bonanno

And their main takeaways
1 HN point 12 Jun 24
  1. The author discovered through genetic testing that they had a homozygous carrier of minor alleles in the Purine Nucleoside Phosphorylase gene, affecting their immune system and mental health.
  2. Partial Purine Nucleoside Phosphorylase Deficiency can manifest with mild-moderate immune abnormalities in the third decade of life, impacting immune function and typical development.
  3. Having excess GTP due to the gene deficiency could lead to over activation of serotonin and dopamine receptors, potentially causing symptoms of Bipolar Mania and Schizophrenia, and zinc supplementation might help counteract these effects.
0 implied HN points 10 Jun 24
  1. The author faced a multitude of physical and mental health challenges, from chronic illness to rare disorders, impacting their life significantly.
  2. Their main health concern was Schizoaffective Disorder Bipolar Type, but it was just one part of a larger array of health issues they dealt with.
  3. Despite experiencing severe health struggles and setbacks that led to homelessness, the author retains hope of rebuilding their life now that their disorder seems to be under control.
0 implied HN points 11 Jun 24
  1. Autoimmune disorders may not be the body attacking itself, but a protective response to certain conditions.
  2. High levels of hydrogen peroxide (H2O2) might be a key factor in autoimmune thyroiditis (AT), and reducing H2O2 levels could potentially cure it.
  3. Genetic defects in enzymes like GPX1 can lead to higher AT risk, and boosting enzyme activity with nutrients like selenium may offer a solution.