The hottest Obesity Substack posts right now

And their main takeaways
Top Health & Wellness Topics
Unsettled Science β€’ 772 implied HN points β€’ 15 Mar 24
  1. Harvard longevity expert David Sinclair faced challenges in his career due to questions about the science behind his longevity claims for resveratrol, affecting his reputation and leading to his resignation.
  2. Recent dietary guidelines in Germany emphasizing less meat and dairy in favor of grains and vegetables have raised concerns among experts, including questioning the soundness of these plant-based recommendations.
  3. A study using data from the influential Nurses Health Study at Harvard School of Public Health revealed that even those who followed U.S. dietary guidelines on fat consumption still gained weight, shedding doubt on the effectiveness of these dietary recommendations.
Unsettled Science β€’ 675 implied HN points β€’ 08 Mar 24
  1. FDA approved an over-the-counter glucose monitor, making it easier for people to track blood sugar levels, important for weight loss and managing diabetes
  2. Labrador retrievers with a specific gene mutation struggle with obesity, showing lower metabolic rate and greater hunger, shedding light on genetic factors affecting weight
  3. FDA permitted a qualified health claim that yogurt 'may' prevent type 2 diabetes, based on limited scientific evidence, raising concerns about potential health risks of promoting foods high in added sugars
Ground Truths β€’ 7742 implied HN points β€’ 24 Sep 23
  1. The expanding GLP-1 drug family shows potential for treating obesity with new triple agonist drugs.
  2. Clinical trials with G-agonists reveal reductions in major cardiovascular events and heart failure symptoms.
  3. GLP-1 drugs have shown promise in treating early type 1 diabetes, cognitive function, alcohol use disorder, and more.
Unsettled Science β€’ 818 implied HN points β€’ 16 Feb 24
  1. Ketogenic diet can help reduce alcohol cravings based on a small study, which also showed benefits in mice and humans.
  2. NIH is investing $190 million in short-term nutrition studies with questionable value, sparking concerns about meaningful data and focus.
  3. Weight-loss prescriptions among U.S. service members, along with rising obesity rates in military, raise questions about the effectiveness of current dietary guidelines and the impact on national security.
The Next Brand β€’ 609 implied HN points β€’ 02 Feb 24
  1. Ozempic, a GLP-1 agonist, is being hyped as a solution to obesity, but it may not address the real issues of metabolic health in America.
  2. Ozempic, despite its weight loss claims, may result in serious side effects, including muscle and bone loss, gastrointestinal events, and more.
  3. The push to fund drugs like Ozempic with taxpayer money raises concerns about cost, corruption, and missed opportunities to address root causes of health issues.
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Unsettled Science β€’ 675 implied HN points β€’ 22 Jan 24
  1. Nutrition researchers caution against using individual or small sample experiences as evidence in clinical practice.
  2. Physicians believe in the effectiveness of carbohydrate restriction based on their observations of patient outcomes.
  3. There is a conflict between doctors and academics regarding the best approach for treating obesity and diabetes.
Are You Okay? β€’ 439 implied HN points β€’ 24 Nov 23
  1. Mounjaro and Ozempic are medications for treating type 2 diabetes; Mounjaro also has a version for obesity, Zepbound. Both types of drugs improve insulin sensitivity, reduce blood sugar levels, and promote weight loss.
  2. Forgetfulness about simple things like names of familiar items could be a part of normal aging rather than a sign of dementia. However, if there are persistent concerns, it's best to consult a healthcare provider.
  3. Maintaining a balanced lifestyle with a healthy diet, regular exercise, and realistic expectations is essential for the effective use of medications like Mounjaro, Ozempic, and related drugs.
Mind & Matter β€’ 196 implied HN points β€’ 06 Jan 24
  1. The type of fats we are consuming now is different from what our ancestors ate.
  2. Consuming high levels of omega-6 PUFAs while being deficient in omega-3s can promote inflammation and metabolic dysfunction.
  3. Changes in dietary fat consumption trends, such as a shift towards more plant-based fats, have influenced the balance of fatty acids we consume.
Mind & Matter β€’ 157 implied HN points β€’ 28 Dec 23
  1. Calories are not interchangeable; different types of foods with the same caloric content can have distinct metabolic consequences.
  2. Total calories alone cannot account for the rise in obesity and diabetes rates; the macronutrient composition of diets has changed over time.
  3. Carbohydrate and fat intake have shifted over the years, with varying trends in protein, saturated fats, monounsaturated fats, and polyunsaturated fats consumption.
Mind & Matter β€’ 157 implied HN points β€’ 12 Dec 23
  1. The rise in obesity rates continues despite no increase in calorie consumption or decrease in physical activity.
  2. There is a lot of conflicting diet advice and information overload, leading to confusion and misinformation.
  3. Metabolic health can be affected by various factors like body fat, food intake, and specific macronutrient composition of the diet.
Unfashionable β€’ 15 implied HN points β€’ 14 Mar 24
  1. Historically, people used to eat more without becoming obese, challenging the 'calories in, calories out' theory.
  2. Studies show that children in the past consumed significantly more calories than recommended today, even without modern concept of workouts.
  3. The Ray Peat community suggests that historically, people had faster metabolisms, which could explain the paradox of declining calorie intake and rising obesity rates.
Second Opinion β€’ 511 implied HN points β€’ 30 May 23
  1. Obesity is a complex chronic disease that needs to be treated seriously.
  2. New weight loss drugs are effective and show promising results, but they are costly and come with side effects.
  3. It's important to consider a variety of evidence-based solutions, including lifestyle interventions, in tackling the obesity epidemic.
Neuro Athletics β€’ 50 implied HN points β€’ 09 Jan 24
  1. Obesity during middle age can increase the risk of Alzheimer's disease and other serious health conditions like heart disease and type 2 diabetes.
  2. Genes associated with obesity, especially those inherited through the maternal lineage, can play a role in the risk of developing Alzheimer's disease.
  3. Understanding the impact of altered adipokines, potential treatments like Ozempic, and the interplay between obesity and Alzheimer's disease is crucial for public health challenges.
Experimental Fat Loss β€’ 141 implied HN points β€’ 21 Oct 23
  1. Reversing obesity is not the same as achieving a shredded body like bodybuilders do.
  2. Starving yourself to extreme levels, like bodybuilders do, is not a sustainable or healthy method to reverse obesity.
  3. Using a strategy meant for bodybuilders, such as extreme dieting, to reverse obesity can be detrimental to your health in the long run.
The Frontier Psychiatrists β€’ 353 implied HN points β€’ 21 Apr 23
  1. Obesity can be considered an illness, impacted by factors like medications, lifestyle changes, and health conditions.
  2. Medical treatments like semaglutide (Ozempic) can help improve metabolic health in individuals with obesity and related conditions like diabetes.
  3. It's important to consider the risks of inaction in managing obesity and related health issues, alongside the risks of treatments, with a focus on improving quality of life.
Experimental Fat Loss β€’ 176 implied HN points β€’ 22 Jul 23
  1. Obesity is caused by long-term dysfunction of mitochondrial energy metabolism, mainly due to changes in food intake starting in the late 1800s and increased seed oil consumption since the 1930s and 1970s.
  2. The drastic increase in obesity rates since the mid-1970s can be attributed to the rise in seed oil consumption, such as the introduction of canola oil in the 1970s.
  3. The ongoing obesity crisis, even since 2010, has seen a massive increase due to a 50% rise in seed oil consumption like soybean oil.
Unsettled Science β€’ 3 HN points β€’ 20 Feb 24
  1. Eating plant-based diets tends to be healthier than consuming a lot of meat, especially processed meat, which is linked to heart disease and diabetes.
  2. The controversy lies in the differing levels of evidence - observational studies show plant-based diets may be healthier, but randomized controlled trials do not strongly support this.
  3. The GRADE methodology challenges the reliability of evidence from observational studies in nutrition, raising questions about long-standing dietary advice.
SatPost by Trung Phan β€’ 69 implied HN points β€’ 11 Mar 23
  1. A new drug developed for one purpose, treating diabetes, is proving to be very effective for treating obesity.
  2. The drug class GLP-1 agonists, with active ingredient semaglutide, shows promise for weight loss with potential market growth.
  3. Despite the promising results, there are drawbacks to consider, such as side effects, cost, and the need for continuous treatment.
semaglutide β€’ 39 implied HN points β€’ 16 Mar 23
  1. Be wary of potential deadly side effects of popular weight loss drugs like Ozempic and Wegovy.
  2. Weight Watchers and NHS are incorporating weight loss drugs like Wegovy into their programs.
  3. The high costs and potential health risks associated with weight loss medications raise concerns about accessibility and effectiveness.
semaglutide β€’ 0 implied HN points β€’ 16 Nov 23
  1. Zepbound, a new weight loss drug, is approved by the FDA and competes with established drugs like Wegovy.
  2. Zepbound may lead to a price war in the weight loss drug market, potentially resulting in lower prices for consumers.
  3. Zepbound's unique combination of hormones helps with weight loss and Eli Lilly is already working on even more potent drugs in the future.