The hottest Pharmaceuticals Substack posts right now

And their main takeaways
Category
Top Science Topics

With Kennedy on Board, This is What a Trump Win Will Mean for Democrats

Popular Rationalism • 1367 implied HN points • 01 Nov 24
🇺🇸 U.S. Politics Elections Public Health Political parties Pharmaceuticals Vaccine Safety
  1. A Trump win could force the Democratic Party to rethink its ties with the pharmaceutical industry. This may lead to more transparency and accountability in health policies.
  2. Robert F. Kennedy Jr. is seen as a potential leader who could push for a health agenda focused on questioning the status quo and prioritizing public health over profit.
  3. The public is becoming more aware of vaccine safety issues, and this awareness may change how health policies are formed and implemented in the future.

Ensitrelvir (Xocova®): Japanese Company Shionogi & Co., Ltd. Sets a Model for Success in Translational Research for the Coming Future of Ethical Science

Popular Rationalism • 455 implied HN points • 29 Oct 24
🏥 Health Politics Pharmaceuticals Drug Development Clinical Trials Public Health
  1. Ensitrelvir, also known as Xocova, is a new antiviral pill that is 30 times more effective than a placebo. It was developed by a Japanese company called Shionogi & Co., which worked closely with researchers.
  2. This medication targets a key enzyme the virus needs to replicate, making it effective against COVID-19 symptoms, especially those caused by Omicron variants. It has shown a strong safety profile and fewer side effects compared to some other treatments.
  3. Xocova is easier to take than some alternatives because it requires only a once-daily dose and has fewer interactions with other medications. This makes it a more convenient option for many patients.

Anaphylaxis, allergens, immunogenicity, vaccines.

Bailiwick News • 3269 implied HN points • 16 Oct 24
🏥 Health Politics Vaccination Public Health Pharmaceuticals Regulations Allergies
  1. Vaccines and many biological products can cause allergic reactions like anaphylaxis. This means they can intentionally harm people while claiming to protect them.
  2. There are laws that make it hard to hold companies accountable for the negative effects of vaccines. These laws allow harmful practices to continue under the guise of vaccination programs.
  3. Congress is more focused on how effective these vaccines are at causing harm, rather than their safety. This reflects a deeper concern about managing public health costs rather than protecting individuals.

Reading List 12/28/24

Construction Physics • 11065 implied HN points • 28 Dec 24
🕹 Technology Manufacturing Pharmaceuticals Engineering Infrastructure Aerospace
  1. China is planning to build the world's largest hydroelectric dam, which could produce a huge amount of electricity and help meet its environmental goals.
  2. Chinese manufacturing is becoming very competitive not just in cars, but also in pharmaceuticals, with Chinese companies now creating many new drugs.
  3. In manufacturing, new startups often struggle financially at first, facing a tough phase called the 'valley of death' before they start making profits.

When the Sackler Brothers studied LSD

Res Obscura • 2799 implied HN points • 29 Jan 25
💾 History Psychedelics Medical Ethics Pharmaceuticals Mental health Scientific research
  1. The Sackler brothers, known for their later role in the opioid crisis, initially explored the potential of LSD and other psychedelic treatments in the 1950s. They even attended early scientific discussions about LSD.
  2. Despite their good intentions to improve mental health treatments, the Sacklers also recognized the financial gains from pharmaceuticals. This shift in focus highlights how idealistic motives can change when wealth is involved.
  3. The ongoing debate about psychedelics mirrors this historical pattern. As society cautiously opens up to these substances for therapy, there are concerns about commercialization, addiction, and the potential for harm.
Get a weekly roundup of the best Substack posts, by hacker news affinity:

Your top 10 FAQ on drug prices

Your Local Epidemiologist • 1591 implied HN points • 15 May 25
🏥 Health Politics Drug Pricing Healthcare policy Pharmaceuticals Public Health Patient Advocacy
  1. Drug prices in the U.S. are much higher than in other countries because drug companies set their own prices, and patents keep competition away for many years. This results in Americans paying more for medications.
  2. High drug prices lead people to skip doses or avoid taking medicine altogether, which can result in serious health issues. Many people can't afford their medications, causing preventable health problems.
  3. There are possible solutions to lower drug prices, like the government negotiating prices and reforming patents to allow generics more quickly. However, it requires public pressure and political will to make these changes happen.

Sleep, Diet, Exercise and GLP-1 Drugs

Don't Worry About the Vase • 2688 implied HN points • 21 Jan 25
🏥 Health & Wellness Nutrition Diet Exercise Pharmaceuticals Mental health
  1. GLP-1 drugs can be very effective for weight loss, and many people are seeing good results from them. They have contributed to a noticeable drop in obesity rates among those who use them, especially college graduates.
  2. Willpower plays an important role in personal fitness and dieting. While using willpower can be tough, it also has positive effects on self-discipline and can lead to healthier habits over time.
  3. It's vital to find joy in exercising and maintaining a healthy lifestyle. Enjoyable activities make it easier to stick to fitness routines and achieve overall well-being.

I Say Thank You to Big Pharma

In My Tribe • 455 implied HN points • 01 Jun 25
🏥 Health Politics Pharmaceuticals Medical Research Drug policy Healthcare systems
  1. It's important to keep encouraging medical research because it brings a lot of benefits to society. We rely on a mix of private and government support for this research.
  2. Cutting drug prices without considering the negative effects might hurt medical research and innovation. We should think about the long-term impact of such changes.
  3. Using prizes instead of patents could lead to fairer rewards for drug developers and might reduce some issues in the research funding system.

FDA approves Pfizer drugs with inadequate safety and efficacy data, and then regulators work for Pfizer

Vinay Prasad's Observations and Thoughts • 180 implied HN points • 24 Feb 25
🏥 Health Politics Regulation Public Health Corruption Pharmaceuticals
  1. FDA approvals for Pfizer drugs may not have enough safety and effectiveness data. This raises concerns about the reliability of the drugs available to the public.
  2. There is a pattern of FDA regulators moving to jobs at pharmaceutical companies after approving their products. This can create a conflict of interest and lead to questions about transparency.
  3. The system seems designed to favor big pharmaceutical companies rather than prioritize patient safety and well-being. This indicates a troubling relationship between regulators and the companies they oversee.

Rep. Chip Roy: Why I’m Backing RFK Jr.

Common Sense with Bari Weiss • 741 implied HN points • 01 Feb 25
🇺🇸 U.S. Politics Health Policy Public Health Pharmaceuticals Government Appointments
  1. Chip Roy supports RFK Jr. for Health and Human Services despite having different opinions with others. He believes RFK Jr. knows how to improve America's health.
  2. Both Roy and Erick Erickson have had life-threatening health issues, and they credit innovative drugs by Big Pharma for their recoveries.
  3. Roy shares his personal story of overcoming cancer with a revolutionary drug, showcasing the importance of medical advancements.

Big Pharma Saved My Life

Common Sense with Bari Weiss • 653 implied HN points • 31 Jan 25
🏥 Health & Wellness Healthcare Pharmaceuticals Medical treatment Personal Stories Chronic Illness
  1. The American healthcare system has many problems but still plays a crucial role in saving lives.
  2. Personal experiences highlight the importance of pharmaceutical advancements in treating serious health conditions.
  3. Faith and medical technology together can have a profound impact on survival and recovery from critical illnesses.

I went to the world's biggest Cancer conference

That Damn Optimist • 29 implied HN points • 09 Jun 25
🏥 Health & Wellness Cancer Research Pharmaceuticals Patient Care
  1. The conference was huge, with around 50,000 people attending, making it a bustling environment with a lot to navigate. It was easy to get lost while trying to find my way among oncologists, researchers, and exhibitors.
  2. Pharmaceutical companies had a huge presence, advertising their products everywhere and showcasing impressive booths. This made it hard to separate scientific information from marketing, but the food and snacks provided became a fun topic of conversation.
  3. The talks were really informative and focused on new scientific advancements, which was refreshing. Presenters openly discussed the limitations of their studies, making the discussions feel more honest and engaging compared to other conferences.

Regulators almost killed biotech before it began

Trevor Klee’s Newsletter • 970 implied HN points • 07 Jan 25
🕹 Technology Biotechnology Regulation Innovation Pharmaceuticals History
  1. Genentech is seen as the start of the biotech field because it combined new technology with business and research. This company pioneered how biotech operates today.
  2. Regulations nearly stopped Genentech from forming, creating fears about safety and ethics in biotechnology. However, Genentech managed to navigate around these regulations and succeed.
  3. Unlike big companies, Genentech used private funding and worked in less regulated spaces. This allowed them to develop human insulin without the heavy regulatory burden faced by larger firms.

Technology indistinguishable from magic

Wrong Side of History • 470 implied HN points • 31 Dec 24
🏥 Health & Wellness Pharmaceuticals Gene Therapy Chronic Illness Public Health
  1. Medical technology has advanced a lot recently. Many serious diseases, like diabetes and HIV, are now much easier to treat than before.
  2. New treatments for conditions such as schizophrenia and allergies are being developed, showing promise for better ways to help people who suffer from these issues.
  3. Innovations like gene therapy and cancer vaccines are changing how we approach some of the most challenging health problems, potentially offering cures or significantly improved treatments.

💊💉 The future of weight loss drugs: A Quick Q&A with … analyst (and superforecaster) Greg Justice

Faster, Please! • 548 implied HN points • 07 Jan 25
🏥 Health Politics Pharmaceuticals Healthcare access Regulations Affordability
  1. GLP-1 medications like Ozempic and Wegovy are changing how obesity is treated. They might also help with other health issues, making them seem like wonder drugs.
  2. While these drugs are becoming more popular, there are challenges in getting them to the people who need them, mainly about their costs and healthcare regulations.
  3. It looks like prices for GLP-1s may drop slightly due to competition, but significant price control changes are not expected anytime soon.

💊💉 Will the anti-obesity wonder drugs work wonders for the US economy?

Faster, Please! • 1553 implied HN points • 30 Oct 24
🏥 Health Politics Healthcare Economic Impact Pharmaceuticals Obesity Chronic diseases
  1. GLP-1 drugs like Ozempic and Wegovy could change the way we treat obesity and have a huge positive impact on health. They work by helping individuals lose weight and may also lower the risk of serious diseases like diabetes and Alzheimer's.
  2. These medications could boost the US economy significantly. Estimates suggest that by improving health and productivity, they might help increase the GDP by about 0.5 to 1 percent in rich countries.
  3. The overall benefits of health innovations, including GLP-1 drugs, aren't fully captured in traditional economic measures. They can lead to a better quality of life and longer life expectancy, which is valuable beyond just the numbers.

come offit

bad cattitude • 264 implied HN points • 30 Dec 24
🏥 Health Politics Vaccines Public Health Government Policy Pharmaceuticals Health Safety
  1. There's concern about the safety and effectiveness of vaccines that are quickly pushed through without proper testing. People worry that these vaccines could lead to more harm than good.
  2. Current vaccine liability laws protect companies from being sued if their products cause harm. This might lower their incentive to ensure the vaccines are safe and effective.
  3. Many believe that if vaccine manufacturers were held accountable for their products, they would take more care in their development and testing. This would help restore public trust in vaccines.

Are drugs good? Are side effects bad? It depends on what you're trying to do.

Trevor Klee’s Newsletter • 895 implied HN points • 01 Nov 24
🏥 Health Politics Drug policy Mental health Medical Ethics Psychedelics Pharmaceuticals
  1. The good or bad nature of drugs really depends on what you're trying to achieve with them. It's important to consider the purpose behind using any drug.
  2. Different drugs can have different effects. For example, psychedelics can be helpful for depression but dangerous for someone who is unstable. It's all about context.
  3. Drugs should be viewed as tools that work in specific ways. We need to determine if those effects match what we want for our health or goals.

Drug regulators - the revolving door keeps revolving

Maryanne Demasi, reports • 2692 implied HN points • 22 Jan 24
🏥 Health Politics Pharmaceuticals mRNA technology
  1. A former TGA boss has been appointed to the board of Medicines Australia to advance mRNA technology in Australia.
  2. John Skerritt, previously with TGA, reflects on his achievements in speeding up drug approvals during his time there.
  3. Concerns are raised about the 'revolving door' practice where agency officials end up working for industries they once regulated.

Johnson & Johnson to acquire $2 billion drug developer "Ambrx Biopharma" to treat Turbo Cancers with same tech as Pfizer's $43 billion Seagen acquisition. Both set their sights on 2025 Cancer TSUNAMI

COVID Intel - by Dr.William Makis • 2731 implied HN points • 17 Jan 24
🏥 Health & Wellness Medicine Cancer Pharmaceuticals
  1. Johnson & Johnson is acquiring a $2 billion drug developer to focus on treating aggressive cancers.
  2. This acquisition uses technology similar to Pfizer's $43 billion purchase of Seagen.
  3. Both companies are aiming to address the anticipated increase in cancer cases by 2025.

The Medicare Price Caps are the Moral Equivalent of Genocide

Something to Consider • 239 implied HN points • 01 Jul 24
🏥 Health Politics Healthcare policy Pharmaceuticals Public Health Economic Impact Regulation
  1. Medicare price caps could lower investment in new drugs, as they cut profits for pharmaceutical companies. Less investment might mean fewer new medicines in the future.
  2. Reducing drug prices could result in significant loss of life, as fewer new drugs mean fewer treatments for diseases. This effect is not just for the U.S., but could impact people globally.
  3. Instead of cutting prices, the focus should be on finding ways to help people afford medications. It's important to invest in pharmaceuticals to save lives rather than trying to cut costs at the expense of future health advancements.

Links in Progress: Snakebites, Pig Hearts, and More

The Works in Progress Newsletter • 19 implied HN points • 03 Feb 25
🔬 Science Biotechnology Medicine Genetics Public Health Pharmaceuticals
  1. An AI tool has been developed to create a new kind of antivenom that can work without refrigeration. This could help save many lives, especially in areas where snakebites are common.
  2. A study showed that a vaccine for Ebola had an 84% effectiveness in preventing the disease in high-risk groups. This is good news for controlling future outbreaks.
  3. New technologies in gene editing and drug development are rapidly evolving, with Chinese companies making significant strides in creating new treatments.

Disease X - Turns Out Death Is Profitable

AND Magazine • 1061 implied HN points • 15 Jan 24
🏥 Health & Wellness Pandemics Prevention Research Pharmaceuticals Healthcare systems
  1. Lab leaks and mishaps involving dangerous viruses are increasing worldwide post COVID-19 pandemic.
  2. Scientists are creating highly lethal viruses through experiments, raising concerns about potential future pandemics.
  3. There is a focus on preparing for 'Disease X' which may lead to profit-making opportunities and increased restrictions.

A simple suggestion for RFK Jr to end corruption in medicine

Vinay Prasad's Observations and Thoughts • 189 implied HN points • 23 Nov 24
🏥 Health Politics Medical Ethics Pharmaceuticals Public Health Government Policy Healthcare Reform
  1. RFK Jr. wants to fight corruption in medicine, especially the money doctors take from pharmaceutical companies. It's important to have honest practices to benefit patients.
  2. A proposed change is to limit the number of doctors in advisory groups who have received money from drug companies. This could start at no more than 60% in 2025 and end with 0% by 2028.
  3. By having fewer conflicts of interest, doctors might focus more on what's best for patients rather than just following drug company interests. This could lead to better healthcare decisions.

The PBM-insurer mafia comes for community pharmacies

HEALTH CARE un-covered • 579 implied HN points • 20 Mar 24
🏥 Health Politics Pharmaceuticals Healthcare Reform Insurance Regulations Public Health
  1. Big Pharmacy Benefit Managers (PBMs) like UnitedHealth and Cigna are pushing independent pharmacies out of business. They drop reimbursement rates, making it harder for these smaller pharmacies to survive.
  2. The financial troubles for independent pharmacies are linked to complex fees and lack of transparency from PBMs. Many pharmacies are struggling with fees that keep rising unexpectedly.
  3. Without independent pharmacies, people might face longer waits for medications and less personalized care. It's important for lawmakers to step in and make changes to support these community pharmacies.

What does RFK Jr mean for healthcare?

Vinay Prasad's Observations and Thoughts • 176 implied HN points • 13 Nov 24
🏥 Health Politics Healthcare policy Public Health Pharmaceuticals Vaccine Mandates Regulatory issues
  1. RFK Jr. could be pushed out of the healthcare conversation because he is anti-corporation. Many pharmaceutical companies might not want him involved due to his stance.
  2. He wants to change how vaccine makers are protected from lawsuits, suggesting they should face accountability like other drug companies. This could lead to better safety practices in vaccines.
  3. The current healthcare system is seen as corrupt and ineffective. There's a need for deeper reforms and better studies to ensure drug and vaccine safety.

Get Ready for Pfizer's "TURBO-CHARGED GUIDED MISSILE" Cancer Drugs

Break Free with Karen Hunt • 1395 implied HN points • 06 May 23
🏥 Health & Wellness Pharmaceuticals Mental health Holistic health Chronic diseases Preventive Healthcare
  1. Our leaders often benefit from wars without considering the consequences for ordinary citizens.
  2. Big Pharma's greed for profits drives the creation of drugs that may not address the root causes of diseases.
  3. People should focus on healthy habits instead of relying solely on medications for their well-being.

Current Pfizer Board Member and Former Trump Appointed FDA Commissioner, Dr. Scott Gottlieb

Injecting Freedom • 116 implied HN points • 02 Dec 24
🏥 Health Politics Vaccines Public Health Pharmaceuticals Health Policy Medical Ethics
  1. Dr. Scott Gottlieb made claims about vaccines that were proven to be false. It's important to double-check facts, especially when discussing health topics.
  2. Gottlieb's connection to Pfizer raises questions about conflicts of interest when he criticizes others in the vaccine debate. It shows that personal interests can affect public statements.
  3. There is a call for more open discussions about vaccines and health issues. Honest debates can help clarify misunderstandings and improve public knowledge.

We Must Pay More for Drugs

Something to Consider • 79 implied HN points • 27 Jul 24
🏥 Health Politics Drug Pricing Pharmaceuticals Consumer Rights Health economics
  1. Patents help inventors protect their ideas, but they alone can't ensure fair profits from innovations. We need more support to make sure inventors get what they deserve.
  2. In a monopoly, the price of goods reflects production costs, not research costs. This can lead to less innovation if prices don't encourage investment.
  3. To encourage more drug discoveries, we might need to pay higher prices or create subsidies and prizes for medical breakthroughs. It’s a tough choice, but necessary for progress.

Centessa Pharmaceuticals: Asset-Centric Business Model

Axial • 7 implied HN points • 31 Jan 25
💼 Business Startups Investing Pharmaceuticals Innovation Entrepreneurship
  1. Centessa Pharmaceuticals focuses on an asset-centric business model. This means they prioritize specific products and inventions for growth.
  2. Investing early in life sciences companies is key to their strategy. They like to support innovative ideas that are just starting out.
  3. Axial seeks to partner with passionate inventors. They are dedicated to helping those who want to create something lasting and impactful.

The Trump Administration Must Bring Moderna to Heel

QTR’s Fringe Finance • 29 implied HN points • 13 Jan 25
🇺🇸 U.S. Politics Public Health Pharmaceuticals Government Accountability Vaccine Policy Political Reform
  1. Moderna failed to report serious side effects, including a child's death during vaccine trials. This raises concerns about their compliance with federal laws.
  2. The new Trump administration has a chance to investigate these issues and hold pharmaceutical companies accountable for their actions.
  3. Past leadership at the FDA supported Big Pharma, but now there are new appointments that may promote a more honest discussion about vaccine safety.

Novo Nordisk's Ethically Questionable Wegovy Publicity Stunt

Weight and Healthcare • 1078 implied HN points • 09 Aug 23
🏥 Health & Wellness Pharmaceuticals Weight Loss Ethics Research Health Risks
  1. Novo Nordisk released a press release touting study results that were not peer-reviewed or published, raising ethical concerns.
  2. The study population in the trial for the weight loss drug Wegovy was limited to specific criteria, excluding certain groups for evaluation of benefits and risks.
  3. The publicity stunt around the drug's benefits showcases the pharmaceutical company's marketing tactics that may manipulate perceptions and stock prices.

Karuna Therapeutics, a drug repurposing effort, sold for about $14 billion. This is their story.

Trevor Klee’s Newsletter • 1119 implied HN points • 05 Feb 24
🔬 Science Biotechnology Drug Development Pharmaceuticals Clinical Trials Innovation
  1. Karuna Therapeutics achieved a $14 billion sale through drug repurposing.
  2. Drug repurposing can be a highly lucrative business without requiring excessive brilliance or luck.
  3. VCs often prioritize hype and platform-based drug development over drug repurposing success stories.

Latest "Bird Flu" Psyop

Who is Robert Malone • 38 implied HN points • 31 Dec 24
🏥 Health Politics Vaccines Public Health Pharmaceuticals Infectious Diseases Government Policy
  1. The 'bird flu' situation is being used as a psychological operation to manipulate public perception. The reality is that current cases have no risk of spreading between humans and the death rate is much lower than reported.
  2. Vaccination schedules for diseases like tetanus might be overhyped. Research suggests that the immunity from these vaccines lasts much longer than what's currently recommended, meaning fewer shots could be needed.
  3. Public health strategies are becoming overly reliant on vaccination, ignoring other effective treatments. It may be worth considering older treatments and ways to handle infectious diseases without constant vaccination.

"Make America Healthy Again" is a Dumb, Rich Guy's Idea of Public Health

JoeWrote • 54 implied HN points • 19 Dec 24
🏥 Health Politics Public Health Capitalism Pharmaceuticals Health Crisis Vaccination
  1. American health issues stem from capitalism, not just personal choices or corporations. This system often prioritizes profit over people's health, leading to serious public health crises.
  2. Robert F. Kennedy Jr.'s health campaign promises are vague and do not address the fundamental issues behind America's health problems. Instead, they seem designed to raise money rather than provide real solutions.
  3. Critics argue that Kennedy's brand of anti-corporate rhetoric is disingenuous. They point out his connections to the very industries he claims to oppose, suggesting that real change needs to come from collective action rather than relying on wealthy individuals.

Prozac Lessons: 5 Questions for drug historian David Herzberg

The Microdose • 884 implied HN points • 08 May 23
🏥 Health & Wellness Mental health Pharmaceuticals Psychedelics Research Commercialization
  1. Antidepressants have evolved over time, impacting societal views and treatments of depression.
  2. There is a historical pattern of seeking quick-fix solutions for mental health issues through medication.
  3. Concerns exist about the profit-centered approach to mental health treatments, including the potential harms and biases in clinical trials.

Logista: Old Roots, Green Sprouts

Invariant • 491 implied HN points • 07 Jan 24
💼 Business Finance Pharmaceuticals Distribution Mergers & Acquisitions Companies
  1. Quaking aspens have a unique way of growing, with all trees in a colony connected as part of the same single organism.
  2. Logista, a Spanish distribution company, is diversifying away from tobacco distribution and focusing more on next-generation nicotine products and pharmaceutical distribution.
  3. Logista is strategically growing through acquisitions, particularly in the pharmaceutical sector, aiming for inorganic growth to expand its reach.