The hottest Pharmaceuticals Substack posts right now

And their main takeaways
Top Science Topics
Maryanne Demasi, reports 2692 implied HN points 22 Jan 24
  1. A former TGA boss has been appointed to the board of Medicines Australia to advance mRNA technology in Australia.
  2. John Skerritt, previously with TGA, reflects on his achievements in speeding up drug approvals during his time there.
  3. Concerns are raised about the 'revolving door' practice where agency officials end up working for industries they once regulated.
COVID Intel - by Dr.William Makis 2731 implied HN points 17 Jan 24
  1. Johnson & Johnson is acquiring a $2 billion drug developer to focus on treating aggressive cancers.
  2. This acquisition uses technology similar to Pfizer's $43 billion purchase of Seagen.
  3. Both companies are aiming to address the anticipated increase in cancer cases by 2025.
The Dossier 490 implied HN points 06 Mar 24
  1. 40 Covid vaccine candidates worldwide were claimed to be highly effective, but none of them actually worked.
  2. Pharmaceutical companies and governments globally falsely advertised Covid vaccines as the ultimate protection.
  3. The Covid-19 vaccine situation highlights the importance of scrutinizing statistics and not letting a crisis be exploited.
Trevor Klee’s Newsletter 1119 implied HN points 05 Feb 24
  1. Karuna Therapeutics achieved a $14 billion sale through drug repurposing.
  2. Drug repurposing can be a highly lucrative business without requiring excessive brilliance or luck.
  3. VCs often prioritize hype and platform-based drug development over drug repurposing success stories.
Get a weekly roundup of the best Substack posts, by hacker news affinity:
Trevor Klee’s Newsletter 373 implied HN points 29 Feb 24
  1. Success in biotech often involves licensing and developing existing molecules, rather than creating completely new ones.
  2. To thrive in biotech, it's crucial to strategically select candidates and navigate clinical trials efficiently with the available resources.
  3. Viking Therapeutics' success was built on wisely choosing profitable indications, selecting the right molecules, and executing their development program effectively.
The Dossier 367 implied HN points 29 Feb 24
  1. The CDC has green-lighted a ninth Covid mRNA shot for those following the official vaccination schedule, totaling nine doses within three years.
  2. The latest shot targets a variant that no longer exists, raising questions about continued vaccinations against obsolete threats.
  3. Pharmaceutical companies may be promoting additional shots under the guise of protection against new variants, despite the variants not being present during the shot's creation.
AND Magazine 1061 implied HN points 15 Jan 24
  1. Lab leaks and mishaps involving dangerous viruses are increasing worldwide post COVID-19 pandemic.
  2. Scientists are creating highly lethal viruses through experiments, raising concerns about potential future pandemics.
  3. There is a focus on preparing for 'Disease X' which may lead to profit-making opportunities and increased restrictions.
Invariant 491 implied HN points 07 Jan 24
  1. Quaking aspens have a unique way of growing, with all trees in a colony connected as part of the same single organism.
  2. Logista, a Spanish distribution company, is diversifying away from tobacco distribution and focusing more on next-generation nicotine products and pharmaceutical distribution.
  3. Logista is strategically growing through acquisitions, particularly in the pharmaceutical sector, aiming for inorganic growth to expand its reach.
DrV’s Newsletter, Notes, Essays, Articles, Videos, and Book Chapters 176 implied HN points 27 Jan 24
  1. Two presidential candidates who challenged pharma-globalist power were eliminated from the race in 2024.
  2. The remaining major candidates from both parties supported pandemic measures that led to a significant increase in deaths and costs for the nation.
  3. The influence of drug companies in politics, education, and media remains significant, impacting American elections.
Break Free with Karen Hunt 1395 implied HN points 06 May 23
  1. Our leaders often benefit from wars without considering the consequences for ordinary citizens.
  2. Big Pharma's greed for profits drives the creation of drugs that may not address the root causes of diseases.
  3. People should focus on healthy habits instead of relying solely on medications for their well-being.
DrV’s Newsletter, Notes, Essays, Articles, Videos, and Book Chapters 78 implied HN points 09 Feb 24
  1. The author is going to review a video on 'Hidden Dangers of Vitamins and Supplements.'
  2. There is concern about the influence of drug companies on the US government.
  3. The topic of misinformation regarding nutrition and supplements is a focus of the author's work.
Unreported Truths 67 implied HN points 13 Feb 24
  1. Pfizer's history shows a mix of successful marketing strategies and problematic scientific practices.
  2. The Super Bowl ad by Pfizer focused on science and notable scientists, with minimal mention of specific products.
  3. Despite the high cost of the ad, there was no clear return on investment, leading to questions about Pfizer's motives.
Unreported Truths 58 implied HN points 14 Feb 24
  1. Pfizer's Super Bowl ad highlighting its history and association with great scientists received mixed reviews, with many criticizing it as overreaching and lacking in substance.
  2. Pfizer, though a major pharmaceutical company, was not historically known for scientific leadership, until it partnered with BioNTech for the creation of the COVID-19 mRNA vaccine.
  3. Despite initial success and recognition, Pfizer's stock price and reputation have suffered due to waning effectiveness of mRNA vaccines and lack of scientific advancements compared to competitors.
The Microdose 884 implied HN points 08 May 23
  1. Antidepressants have evolved over time, impacting societal views and treatments of depression.
  2. There is a historical pattern of seeking quick-fix solutions for mental health issues through medication.
  3. Concerns exist about the profit-centered approach to mental health treatments, including the potential harms and biases in clinical trials.
The DisInformation Chronicle 760 implied HN points 21 May 23
  1. Social media companies censor 'true content' on vaccines in line with government and pharma interests
  2. Big Pharma spends millions on social media ads while platforms regulate vaccine 'misinformation'
  3. There's a conflict in regulating pharma 'misinformation' on social media while Pharma is a major advertising client
eugyppius: a plague chronicle 244 implied HN points 07 May 23
  1. The Biden administration and WHO are ending Covid-19 measures as public interest wanes.
  2. The Covid circus is folding up as winter saw less Corona cases and lack of public interest in testing.
  3. Polish health minister speaks out against Pfizer's vaccine surplus and profiteering.
Apricitas Economics 52 implied HN points 09 Sep 23
  1. Demand for weight loss drugs in Denmark prevented a recession by boosting pharmaceutical exports
  2. Danish pharmaceutical industry experienced massive growth in production but faced challenges meeting demand
  3. The export boom in pharmaceuticals positively impacted Danish economy but did not fully translate to domestic consumption growth
Anxiety Addiction & Ascension 39 implied HN points 22 Aug 23
  1. The series 'Painkiller' presents a complex portrayal of the opioid crisis and the Sackler family, drawing parallels with the COVID vaccine saga.
  2. The show navigates woke elements like diversity representation and challenges the typical portrayal of pharmaceutical companies as villains.
  3. Despite potential corporate interests in avoiding criticism, 'Painkiller' delivers a strong message of systemic corruption and lack of true justice in tackling Big Pharma crimes.
Boutique Biotech 19 implied HN points 29 Sep 23
  1. Structure Therapeutics' GPCR showed significant weight reduction in overweight patients with their oral GLP-1 receptor agonist GSBR-1290.
  2. The once-a-day pill resulted in 4.8kg weight loss, approximately 5.4% at the highest dose after 28 days.
  3. The data from Structure Therapeutics' Phase 1b study is compared with other oral medications for obesity in the same field.
The Future Does Not Fit In The Containers Of The Past 1 HN point 03 Mar 24
  1. The corporate landscape is experiencing shifts in power, demographics, mindsets, and technology, leading to potential tectonic changes in the leading companies and industries.
  2. While there might be some new entrants, the most valuable companies have remained consistently dominated by technology, pharmaceuticals, energy, financial powerhouses, and Walmart for decades.
  3. The future of companies will involve fewer employees leveraging AI for productivity, a more geographically distributed workforce, and a greater focus on employee joy for talent retention and growth.
the rohn report 59 implied HN points 08 Apr 21
  1. Pharmaceutical commercials often follow a predictable formula, portraying idealistic, happy scenarios while downplaying potential side effects and risks.
  2. The pharmaceutical industry in the US is heavily marketed, indicating a significant focus on advertising and promotional activities.
  3. Companies may employ various tactics, like offering gifts to clinic staff, to influence the prescribing and use of their products, raising questions about ethics and integrity.
Boutique Biotech 0 implied HN points 02 Mar 23
  1. Late-stage biotech companies have seen increasing value, while earlier stage companies have seen declines.
  2. Day One Pharma is developing a drug for pediatric low-grade gliomas, showing promising results.
  3. Important updates to look for include duration of response, safety profile, and NDA submission for Day One Pharma.