The hottest Heart Disease Substack posts right now

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Chapter 12: Heart Attacks in South Asians: Understanding the Risks and Seeking Solutions(India, Bangladesh, Pakistan)

Spyderdoc Newsletter • 39 implied HN points • 08 Jun 23
🏥 Health & Wellness Heart Disease Genetics Diet Exercise Stress
  1. Genetics play a significant role in heart health for South Asians.
  2. South Asians are at risk due to smaller coronary arteries and high prevalence of coronary artery disease.
  3. Low physical activity levels, particularly among South Asians, contribute to various health issues.

032: Is Coconut Oil Killing Us?

Harnessing the Power of Nutrients • 39 implied HN points • 24 Jun 17
🏥 Health & Wellness Nutrition Heart Disease Fats Studies Research
  1. Recent headlines on coconut oil are causing discussion about its health impacts, specifically on heart disease.
  2. The position paper from the American Heart Association discusses the risks associated with coconut oil consumption but also highlights its benefits beyond heart health.
  3. Historical examples from traditional Pacific island diets and research studies suggest that coconut oil may not be as harmful as previously thought and can have positive effects on health.

Colpo's The Great Cholesterol Con

Harnessing the Power of Nutrients • 139 implied HN points • 20 Nov 08
🏥 Health & Wellness Cholesterol Heart Disease Diet Research Nutrition
  1. Saturated fat may not be as harmful for heart health as previously thought, with some populations consuming high saturated fat diets showing low rates of heart disease.
  2. The connection between cholesterol and heart disease is not straightforward, and lowering cholesterol may not always be beneficial for overall health.
  3. Various factors, apart from cholesterol, play significant roles in heart disease prevention, such as antioxidants, blood pressure maintenance, and stress management.
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002: As the Cholesterol Consensus Crumbles, the Stance Against Saturated Fat Softens

Harnessing the Power of Nutrients • 19 implied HN points • 28 Apr 16
🏥 Health & Wellness Nutrition Cholesterol Heart Disease
  1. Saturated fats may not be as bad as previously believed, and new data suggests polyunsaturated fats might not be as beneficial for heart health as once thought.
  2. Christopher Ramsden discovered unpublished data challenging the idea that replacing saturated fats with polyunsaturated vegetable oils is beneficial for lowering cholesterol and preventing heart disease.
  3. Despite the findings, the public health community has not fully embraced the shift in thinking around saturated and polyunsaturated fats.

The Central Role of Thyroid Hormone in Governing LDL Receptor Activity and the Risk of Heart Disease

Harnessing the Power of Nutrients • 39 implied HN points • 28 Aug 11
🏥 Health & Wellness Heart Disease Cholesterol
  1. Thyroid hormone plays a central role in governing LDL receptor activity, affecting the risk of heart disease.
  2. Thyroid hormone regulates the expression of LDL receptors in cells, impacting cholesterol levels and the body's overall health needs.
  3. Correcting thyroid hormone deficiency may significantly reduce the risk of heart disease, as shown in historical clinical trials.

Wherefore Art Thy Protection, O HDL?

Harnessing the Power of Nutrients • 0 implied HN points • 20 Mar 09
🏥 Health & Wellness Cholesterol Heart Disease
  1. The medical field has created confusion by confusing 'HDL' with 'HDL-cholesterol', but they are not the same. When testing blood, LDL-cholesterol and HDL-cholesterol levels are measured, not the actual lipoproteins.
  2. A drug that was supposed to boost HDL-cholesterol, torcetrapib, resulted in increased cardiovascular disease instead, indicating the reverse cholesterol transport theory might be flawed.
  3. HDL's protective role may come from its ability to transport vitamin E to endothelial cells, not from reverse cholesterol transport. Drugs aiming to boost HDL-cholesterol through CETP inhibition might undermine this protective role, potentially causing harm.

The Hidden Truth About Cholesterol-Lowering Drugs

Harnessing the Power of Nutrients • 0 implied HN points • 02 Mar 09
🏥 Health & Wellness Cholesterol Heart Disease Cancer Lifestyle changes
  1. The huge profits from cholesterol-lowering drugs drive the production of these medications, as well as the official government recommendations regarding cholesterol and statins.
  2. The myth that lowering LDL cholesterol with statins will protect against disease is not supported by evidence showing cholesterol levels do not always correlate with atherosclerosis.
  3. High cholesterol has been consistently linked to lower mortality in various studies, challenging the prevailing belief that low cholesterol levels are always beneficial.

The Doctor's Heart Cure

Harnessing the Power of Nutrients • 0 implied HN points • 01 Mar 09
🏥 Health & Wellness Diet Exercise Heart Disease Medications Lifestyle
  1. The Doctor's Heart Cure offers insights into what truly causes heart disease, including factors like elevated homocysteine and deficiencies in CoQ10, providing a proactive approach to heart health.
  2. America's reliance on reactive medicine highlights a lack of understanding about heart disease causes, often leading to unnecessary drugs and their side effects.
  3. Dr. Sears recommends a unique heart-healthy diet emphasizing high-quality red meat, fish, and poultry, and advocates for interval training over conventional endurance exercises for improved heart health.

Kendrick's The Great Cholesterol Con

Harnessing the Power of Nutrients • 0 implied HN points • 28 Feb 09
🏥 Health & Wellness Heart Disease Cholesterol Stress
  1. Teleoanalysis is a technique to determine outcomes of studies that were never conducted, revealing some outrageous scientific approaches.
  2. Critique of statin drugs and cholesterol-lowering industry highlights the minimal life-lengthening benefits at exorbitant costs.
  3. Kendrick's humorous take on saturated fats and cholesterol levels challenges conventional lipid hypothesis, emphasizing the role of stress and blood clotting in heart disease.

The Cholesterol Wars: Steinberg Strikes Back

Harnessing the Power of Nutrients • 0 implied HN points • 28 Feb 09
🏥 Health & Wellness Cholesterol Heart Disease
  1. Cholesterol and lipoproteins like LDL have been implicated in causing atherosclerosis and cardiovascular disease, with decades of research supporting this connection.
  2. The effectiveness of statins in reducing heart disease risk by lowering cholesterol is a key argument in support of the lipid hypothesis, although some question this conclusion.
  3. The debate around cholesterol and heart disease involves complex science, including the role of oxidized LDL, polyunsaturated fats, and the importance of differentiating between saturated and unsaturated fats in the diet.

What's New at Chris Masterjohn's Cholesterol-And-Health.com

Harnessing the Power of Nutrients • 0 implied HN points • 23 Feb 09
🏥 Health & Wellness Cholesterol Heart Disease Nutrition Diet Research
  1. Subscribing to Chris Masterjohn's newsletter provides updates not found on the website, including links to interesting external articles and commentary on new research.
  2. Cholesterol misinformation exists, such as the myth that cholesterol-rich foods raise blood cholesterol levels in everyone, but in reality, the effect varies among individuals.
  3. Site offers a variety of content including book reviews, blog posts, health reports, and articles addressing myths and misconceptions about cholesterol and health.

The Total-to-HDL Cholesterol Ratio — What Does It Mean?

Harnessing the Power of Nutrients • 0 implied HN points • 13 Jan 09
🏥 Health & Wellness Cholesterol Heart Disease Meta-analysis
  1. The total-to-HDL cholesterol ratio is an important predictor of heart disease mortality risk, with lower ratios associated with reduced risk across different age groups.
  2. The ratio can indicate how long LDL particles stay in the blood, potentially reflecting the efficiency of LDL receptor activity.
  3. Different dietary fats have varying effects on the total-to-HDL cholesterol ratio, with unsaturated fats and specific saturated fats like lauric acid decreasing the ratio, while trans fats increase it.

High Cholesterol And Heart Disease — Myth or Truth?

Harnessing the Power of Nutrients • 0 implied HN points • 20 Nov 08
🏥 Health & Wellness Cholesterol Heart Disease Atherosclerosis Antioxidants
  1. The traditional belief that high cholesterol from foods causes heart disease is a myth; the real issue is the oxidation of LDL cholesterol in the blood.
  2. Atherosclerosis is driven by the degeneration of lipids that infiltrate the blood vessel wall, leading to inflammation and plaque formation.
  3. Factors that can help prevent atherosclerosis include increasing antioxidants, reducing intake of polyunsaturated fats, and improving the utilization of LDL cholesterol.

Cholesterol And Heart Disease — Just a Myth?

Harnessing the Power of Nutrients • 0 implied HN points • 01 Nov 08
🏥 Health & Wellness Heart Disease Cholesterol Antioxidants Atherosclerosis
  1. The book arguing against the mainstream theory of heart disease destroys the diet-heart hypothesis and questions the use of cholesterol-lowering drugs.
  2. The idea that atherosclerosis is 'good for you' is debunked, with explanations of why it is not a beneficial process in the body.
  3. The book brings up the importance of analyzing different evidence and viewpoints on cholesterol, PUFA, and heart disease to get a more comprehensive understanding of the topic.

A Crash Course in Lipoproteins

Harnessing the Power of Nutrients • 0 implied HN points • 26 Aug 08
🏥 Health & Wellness Cholesterol Heart Disease Antioxidants Genetics
  1. Cholesterol is carried in lipoproteins, like a bus carrying fats, cholesterol, and fat-soluble vitamins.
  2. There are different types of lipoproteins besides HDL and LDL, such as chylomicrons, VLDL, IDL, and Lp(a).
  3. The LDL receptor plays a crucial role in heart disease, with mutations affecting its functioning linked to increased risk, while a well-functioning receptor can significantly reduce heart disease risk.

The Cholesterol Times, Issue #014 -- Oxidized Lipids Are the True Cause of Heart Disease

Harnessing the Power of Nutrients • 0 implied HN points • 26 Aug 08
🏥 Health & Wellness Heart Disease Nutrition Research Cholesterol Lifestyle
  1. Oxidized lipids in the blood are the initiating factor of atherosclerosis.
  2. Shear stress in arteries plays a role in the development of heart disease.
  3. The rate at which LDL is used and cleared from the bloodstream is crucial in reducing the risk of heart disease.

Genes, LDL-Cholesterol Levels, and the Central Role of LDL Receptor Activity In Heart Disease

Harnessing the Power of Nutrients • 0 implied HN points • 14 Mar 11
🏥 Health & Wellness Heart Disease Cholesterol Genetics Meta-analysis
  1. High levels of LDL-cholesterol are not the sole cause of heart disease; it is the oxidative destruction of LDL particles, not the cholesterol concentration, that plays a central role.
  2. Genetic mutations affecting LDL receptor activity reveal that poor activity increases the risk of heart disease, while greater activity decreases the risk significantly.
  3. Blood lipid levels, although not determinants, can indicate metabolic issues related to LDL receptor function and should not be ignored as they provide essential clues about heart disease risk.

How Conflating the Lipid Hypothesis With the Diet-Heart Hypothesis Led to the Public Condemnation of Bacon, Butter, and Eggs

Harnessing the Power of Nutrients • 0 implied HN points • 09 Mar 11
🏥 Health & Wellness Nutrition Studies Cholesterol Heart Disease
  1. Distinguishing between the lipid hypothesis and the diet-heart hypothesis is crucial as they have different implications on heart disease.
  2. Extrapolating from drug trials to dietary recommendations can lead to misunderstandings and misinformation in the public.
  3. Understanding the complexity of cholesterol-lowering drug trials and the role of LDL particles in atherosclerosis can help evaluate the effectiveness and potential risks of treatments.

The Proper Use of the Term “Lipid Hypothesis”

Harnessing the Power of Nutrients • 0 implied HN points • 22 Feb 11
🏥 Health & Wellness Diet Cholesterol Heart Disease
  1. The lipid hypothesis and the diet-heart hypothesis are often confused but they are different: the lipid hypothesis is about the role of lipids in the blood, while the diet-heart hypothesis is about the role of lipids in the diet.
  2. The lipid hypothesis postulates that high cholesterol levels in the blood increase the risk of heart disease, but this has not been proven conclusively yet.
  3. It's important to differentiate between the lipid hypothesis and the diet-heart hypothesis to avoid mix-ups and confusion in understanding the truth behind heart disease risks.

The Journal of the American Medical Association Finally Questions Whether the FDA Should be Approving Useless No-Evidence Cholesterol-Lowering Drugs

Harnessing the Power of Nutrients • 0 implied HN points • 21 Jan 10
🏥 Health & Wellness Medicine FDA Cholesterol Heart Disease Pharmaceuticals
  1. The evidence suggests that drugs lowering cholesterol may not actually prevent heart attacks by lowering cholesterol, but by clearing LDL from the bloodstream more quickly.
  2. The FDA approved cholesterol-lowering drugs based on their ability to lower cholesterol levels, without concrete evidence of preventing heart disease.
  3. Recent studies have suggested that some cholesterol-lowering drugs like ezetimibe may not effectively prevent heart disease, sparking questions about the approval process and physician prescribing practices.

The Cholesterol Times, Issue #005 -- A 72-Year Metabolic Mystery Unfolds

Harnessing the Power of Nutrients • 0 implied HN points • 23 Mar 09
🏥 Health & Wellness Cholesterol Metabolism Nutrition Research Heart Disease
  1. Eating cholesterol does not necessarily raise cholesterol levels due to a complex biofeedback system in the liver involving proteins like SREBPs and Insigs.
  2. Omega-3 fatty acids are more effective at reducing mortality and heart disease compared to statins and other drugs, despite not affecting cholesterol levels.
  3. Some oxygenated derivatives of cholesterol have antifungal activity against Candida, and chemicals in red wine lower heart disease markers in rabbits without affecting cholesterol.