Gordian Knot News • 124 implied HN points • 29 Jan 26
- Observed human data show a clear dose-rate effect: acute high doses increase cancer around 100–300 mSv, while chronic exposures below about 20 mSv/day have not reliably produced cancer even at cumulative doses above 100,000 mSv, which contradicts a simple LNT prediction.
- Per unit energy absorbed, radiation produces similar numbers of double strand breaks because damage mainly comes from ROS, but alpha particles deposit energy very locally, creating clustered DSBs that are much more likely to misrepair and cause cancer, so alpha exposures are a strong test of dose–response.
- Cancer risk depends on misrepair of closely spaced DSBs and on DNA repair dynamics, so linear damage plus proportional repair does not imply a linear dose–response; models and regulation need to account for dose rate and spatial clustering rather than relying solely on cumulative dose.