The hottest Pharmacology Substack posts right now

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IVERMECTIN and CANCER, it has at least 15 anti-cancer mechanisms of action. Can Ivermectin Treat COVID-19 mRNA Vaccine Induced Turbo Cancers? - 9 Ivermectin papers reviewed

2nd Smartest Guy in the World • 4992 implied HN points • 08 Jan 24
🏥 Health & Wellness Cancer Treatment Research Holistic Medicine Pharmacology
  1. Ivermectin has at least 15 anti-cancer mechanisms of action.
  2. Studies suggest Ivermectin can treat a variety of cancers.
  3. High doses of Ivermectin, possibly combined with Fenbendazole, may be beneficial for treating cancer.

MASHUP: Aboriginal Smokeless Nicotine, Quinine & Caffeine Therapy, African G6PD Deficiency

Grey Goose Chronicles • 786 implied HN points • 29 Jan 24
🔬 Science Biology Medicine Genetics Pharmacology History
  1. Aboriginal Australians have a unique way of consuming tobacco with varying effects and health benefits.
  2. Quinine has a rich history in colonial expansion and fighting malaria, while caffeine might hold potential as an antimalarial drug.
  3. Genetic conditions like G6PD deficiency in sub-Saharan Africans show adaptations to malaria, impacting medical treatments and outcomes.

Synthetic integrin antibodies discovered by yeast display reveal αV subunit pairing preferences with β subunits

Axial • 7 implied HN points • 31 Jan 25
🔬 Science Biotechnology Medical Research Pharmacology Cell Biology
  1. New antibodies were created that can specifically block integrins, which are important for cell functions like attachment and signaling. This may lead to better treatments for diseases.
  2. Researchers found that different β subunits bind preferentially to the αV subunit in integrins. Understanding these pairings helps explain how integrins work in the body.
  3. The antibodies developed through this study can directly compete with small molecules that normally bind to integrins. This opens the door for more precise therapies in the future.

Bacterial Xanax

Eat Shit and Prosper • 519 implied HN points • 19 Nov 23
🏥 Health & Wellness Mental health Neuroscience Pharmacology Gut Health
  1. The human brain has many neurotransmitters that affect how we feel, much like how different tastes shape our eating experience. Just as tasting food can change our mood, our brain's chemistry can influence our emotions.
  2. Benzodiazepines, like Xanax, were discovered to help with anxiety before scientists fully understood how they worked. They enhance the effects of a natural calming neurotransmitter called GABA, but researchers are still figuring out if our bodies have natural versions of these calming substances.
  3. Gut bacteria might play a role in anxiety by producing compounds that assist with brain function. If these helpful bacteria are reduced or absent, it could lead to anxiety disorders, suggesting that restoring these good bacteria could help some people.

Nootropic or Narcotic? The Dual Faces of Gas Station Heroin (Tianeptine)

Tripsitter • 119 implied HN points • 29 Jan 24
🏥 Health & Wellness Addiction Psychology Pharmacology Research Mental health
  1. Tianeptine is sold as an antidepressant in many countries but is unregulated in the US, marketed as a nootropic, Kratom alternative, and opioid withdrawal remedy.
  2. Improper use of tianeptine can lead to addiction, withdrawals, and even fatalities, emphasizing the importance of education, moderation, and avoiding marketing gimmicks.
  3. Tianeptine's mechanism of action is complex and debated, with conflicting research on how it works in the brain, indicating potential cognitive benefits but also addiction risks.
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Ketamine Science: Dirty Drugs, Dissociation, & Depression

Tripsitter • 159 implied HN points • 09 Dec 23
🏥 Health & Wellness Pharmacology Pain management Depression
  1. Ketamine is a "dirty drug" with unique effects on the body and mind, causing dissociation and a powerful anesthetic effect, but with fewer side effects compared to other anesthetics.
  2. Ketamine shows promise as a rapid and unique antidepressant, working on neuroplasticity and enhancing brain recovery, although its mechanisms and effectiveness vary among individuals.
  3. Ketamine has analgesic properties, particularly effective for certain pain conditions like the wind-up phenomenon, through its action on NMDA receptors in the spinal cord.

From Leaf to Life: The Conversation We Should Be Having Around Kratom 🌱

Tripsitter • 219 implied HN points • 08 Sep 23
🏥 Health & Wellness Harm Reduction Drug Safety Pharmacology Regulation
  1. Regulators have targeted kratom in attempts to ban it, but public backlash has prevented complete bans so far.
  2. Kratom is seen as a tool for harm reduction due to its potential as an alternative to prescription painkillers, but it carries risks and should be used carefully.
  3. Misinformation and misrepresentation of kratom-related deaths have fueled the stigma around the plant, highlighting the need for proper regulation and education rather than outright bans.

On the Origins of Multiple Sclerosis

Eat Shit and Prosper • 479 implied HN points • 04 Feb 23
🏥 Health Politics Epidemiology Pharmacology Microbiology Public Health
  1. Taking antibiotics might increase your risk of developing multiple sclerosis (MS). Studies from Denmark show that anyone who gets a prescription for antibiotics has a higher chance of being diagnosed with MS later.
  2. There is a potential connection between certain bacteria in our gut and MS. One particular bacteria, _Clostridium perfringens_, may produce a toxin that damages the cells responsible for protecting nerves in the brain.
  3. Understanding MS as a complex interaction between bacteria, antibiotics, and the immune system can lead to new treatments. There are even hopes for using therapies like fecal transplants or targeted therapies to help those suffering from MS.

Virtual Screening for New Antibiotics: A Machine Learning Approach to LpxC Inhibition

LatchBio • 20 implied HN points • 12 Nov 24
🔬 Science Biochemistry Microbiology Pharmacology Machine Learning Drug Development
  1. Antibiotic resistance is a big problem, and many drug companies are not making new antibiotics anymore. Machine learning can help find new antibiotics by quickly searching through lots of compounds.
  2. In a study, researchers looked at 250,000 chemical compounds to find potential antibiotics that target a specific enzyme in harmful bacteria. This shows how technology can speed up the drug discovery process.
  3. Finding new antibiotics is really important for health, especially as bacteria become more resistant. Using advanced tools to identify promising compounds could save time and money in developing new treatments.

Some Switches Can't Be Unflipped (But We Can Cut the Power)

Holodoxa • 79 implied HN points • 26 Dec 23
🔬 Science Genetics Cancer Pharmacology Thyroid
  1. In hereditary cancer, mutations in tumor suppressor genes are more common than in oncogenes, and a second hit is often required for cancer to develop.
  2. The RET gene, an oncogene, is associated with Multiple Endocrine Neoplasia Type 2 (MEN2) and can lead to various clinical conditions depending on the mutation type.
  3. Mutations in oncogenes like RET can be targeted with drugs, leading to effective treatments for cancers like medullary thyroid cancer, showing the clinical impact of genetic research beyond diagnosis.

GPCRs in kidney disease

Axial • 7 implied HN points • 13 Mar 24
🔬 Science Biotechnology Genetics Healthcare Research Pharmacology
  1. Kidney disease, particularly autosomal dominant polycystic kidney disease (PKD), has been underinvested compared to other conditions like oncology and diabetes.
  2. The development of drugs targeting GPCRs PC-1 and PC-2 in PKD could significantly improve the quality of life for patients by reducing cyst size.
  3. Business models in drug development are shifting towards rare disease candidates like PC-1/2, emphasizing treatments that exceed the current standard of care.

Quacking the Code: Bridging the Animal-Human Divide

Nano Thoughts • 0 implied HN points • 04 Apr 24
🔬 Science Biology Genetics AI Drug Development Pharmacology
  1. Transfer learning allows computers to use knowledge from one area to help in another. This approach helps in drug development by applying what we've learned from studying animals to predict how those drugs might affect humans.
  2. Gene reactomes help us compare how genes respond to drugs across different species. This means we can identify which genes may act similarly in humans and animals, leading to safer drug development.
  3. The Universal Gene Embedding framework acts like a translator for genetic information. It allows scientists to understand gene functions across species, making it easier to predict how drugs will work in humans based on animal studies.