Vinay Prasad's Observations and Thoughts β’ 106 implied HN points β’ 19 Feb 25
- In vaccine trials, using a control arm that contains something like aluminum may not be truly a placebo, which can make it hard to determine side effects.
- If the control group feels side effects from a placebo, like aluminum, they may think they received the vaccine and change their behavior, affecting the trial results.
- Sometimes, trials need more than one control group to get a clearer picture of both safety and effectiveness, like comparing a true placebo to a placebo that causes some discomfort.