The hottest Longevity Substack posts right now

And their main takeaways
Category
Top Health & Wellness Topics

Well Being: Methylene Blue

Who is Robert Malone • 38 implied HN points • 17 Feb 25
🏥 Health & Wellness Supplements Nutrition Fitness Longevity
  1. Bio-hacking means figuring out new ways to improve your health by experimenting with your body and mind. It's all about using different techniques and supplements to feel better.
  2. Methylene blue is a supplement that may help boost energy levels and improve cognitive function by supporting the health of our mitochondria, the parts of our cells that produce energy.
  3. While there are risks with self-experimentation, some people find that bio-hacking can lead to amazing health benefits, like better energy and improved brain function, especially as we age.

The Three Nutrients You Need More Of on a High-Protein Diet

Harnessing the Power of Nutrients • 3474 implied HN points • 03 Mar 24
🏥 Health & Wellness Diet Nutrients Weight Loss Longevity
  1. A high-protein diet is essential for muscle health and weight loss, as it helps maintain lean mass during weight loss.
  2. The amount of protein needed to preserve lean mass during weight loss is higher than the standard recommendation, with around 1.3 grams per kilogram being favored.
  3. High levels of protein in the diet can stress the body's requirements for certain vitamins and minerals, leading to various health issues like poor sleep, anxiety, and skin problems.

50. Inspiration needs no boundaries!

Spyderdoc Newsletter • 19 implied HN points • 06 Jun 25
🏥 Health & Wellness Longevity Nutrition Mental health Travel
  1. Inspiration can come from anywhere, and it has no limits. It's important to embrace new ideas and experiences to grow.
  2. Preventive medicine is key to living a long and healthy life. Taking care of our health today helps us avoid problems in the future.
  3. Traveling broadens our horizons. Experiencing new cultures and places teaches us valuable lessons and ignites our curiosity.

Some ants can choose to live 5x as long

Trevor Klee’s Newsletter • 746 implied HN points • 11 Feb 25
🔬 Science Biology Physiology Longevity Insulin
  1. Some ants, like Indian jumping ants, can live much longer lives if they become a pseudoqueen. They can live about five times longer than their worker counterparts after winning a duel for queen status.
  2. The lifespan of these ants can actually change based on their circumstances. If a gamergate is placed in a new colony with an active queen, they revert back to being a normal worker with a shorter lifespan.
  3. This interesting case suggests a different relationship between reproduction and lifespan. In these ants, becoming a reproductive figure seems to extend their life instead of shortening it like it does in many other species.

The Longevity Cult

We're Gonna Get Those Bastards • 6 implied HN points • 07 Jun 25
🏥 Health & Wellness Longevity Nutrition Exercise Mental health Lifestyle
  1. Some people are so obsessed with living longer that they forget to really enjoy life. It's important to balance health and happiness.
  2. Living a long life doesn't mean much if it’s boring or unproductive. Focus on doing what makes you happy instead of just extending your years.
  3. Making time for your passions and dreams is crucial. Exercising and focusing on longevity is good, but don't lose sight of what truly matters to you.
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Does CoQ10 Deserve a Spot on Your Longevity Plan?

Harnessing the Power of Nutrients • 1517 implied HN points • 12 Feb 24
🏥 Health & Wellness Supplementation Longevity
  1. CoQ10 supplementation offers various health benefits like improved fertility, blood glucose control, and decreased cardiovascular risks.
  2. The dosage of CoQ10 needs to be carefully personalized as different individuals have varying needs and responses to the supplement.
  3. There are contrasting results on the effects of CoQ10 at different doses, highlighting the importance of determining the right dose and the necessity of using CoQ10 for each person.

I am aging at only 2/3 the normal rate!

Harnessing the Power of Nutrients • 1358 implied HN points • 18 Feb 24
🏥 Health & Wellness Aging Longevity Fitness
  1. The individual shared exciting results from the DunedinPACE aging test, showing they are aging at 2/3 the normal rate.
  2. The DunedinPACE aging clock is considered highly reliable compared to other available options, and is the clock used for the Rejuvenation Olympics.
  3. To achieve top rankings in the aging test leaderboards, multiple tests over six months are required, and the individual plans to provide more detailed analysis of their results.

NMN Probably Won't Make You Live Forever

Harnessing the Power of Nutrients • 1298 implied HN points • 24 Feb 24
🏥 Health & Wellness Nutrition Supplements Longevity Research Disease
  1. The new research challenges the belief that supplements like NMN can significantly extend lifespan. High levels of 4PY, a niacin metabolite, were linked to increased cardiovascular inflammation and risk of early death.
  2. Limit niacin supplements to 250 milligrams per day for safety, and focus on meeting nutrient needs through a balanced diet to support NAD+ production.
  3. The study provides important insights on the potential risks of high-dose niacin supplements, highlighting the importance of moderation in supplementation and the need for more research in this area.

Menopausal Hormone Therapy

The Vajenda • 2476 implied HN points • 19 Jun 23
🏥 Health & Wellness Menopause Hormone Therapy Longevity Exercise Nutrition
  1. Menopausal hormone therapy has both benefits and risks, and it's important for individuals to have accurate information to make informed decisions.
  2. Prioritize exercise, a healthy diet, and not smoking for overall health during menopause.
  3. Menopausal hormone therapy involves prescribing estrogen or progesterone to alleviate symptoms, and progestogen is essential for those taking estrogen to protect against uterine issues.

Ways Of Flourishing

Adjacent Possible • 379 implied HN points • 25 Oct 24
🏥 Health & Wellness Psychology Longevity Aging AI Impact
  1. Human life expectancy has greatly improved in the last century, doubling from around 35 years to over 70 years. This shows how much we have advanced in health and longevity.
  2. Flourishing isn't just about living longer; it's about building meaningful connections across generations. These relationships enrich our lives and help transfer knowledge and wisdom.
  3. With the rise of AI, we are facing rapid changes that could compress decades of progress into just a few years. This raises important questions about how we can adapt and ensure positive outcomes for both humans and AI.

Alcohol’s SURPRISING Role in Your Health and Longevity

Harnessing the Power of Nutrients • 1397 implied HN points • 12 Dec 23
🏥 Health & Wellness Alcohol Longevity Toxins
  1. Alcohol may have surprising health benefits in moderation, with up to one drink per day associated with lower risk of heart disease and all-cause mortality.
  2. Observational data suggest that 0.3-0.5 drinks per day could be the optimal dose for lower risks of diseases like Alzheimer's, diabetes, and chronic pain.
  3. Alcohol might trigger hormetic effects at low doses, potentially improving vitamin A activation and increasing defense against reactive oxygen species.

The 3 things Bryan Johnson is missing from his longevity routine.

Harnessing the Power of Nutrients • 958 implied HN points • 17 Dec 23
🏥 Health & Wellness Longevity Nutrition Genetics Testing
  1. Eating a highly nutritious diet, maintaining a healthy body composition, and systematically testing nutrient status are impactful habits for longevity that we can all adopt.
  2. Key aspects missing from Bryan Johnson's longevity routine are ranked and sorted genetics, functional markers of nutrient status, and thorough screening for energy metabolism impairments.
  3. It may not be necessary for most people to follow an extreme caloric deficit like Johnson's 25%. Opting for a less drastic approach, along with comprehensive nutrient testing, can be more realistic and beneficial.

Biological Age Clocks: Are They Useful?

Harnessing the Power of Nutrients • 778 implied HN points • 19 Dec 23
🏥 Health & Wellness Interventions Health Testing Longevity
  1. Biological aging clocks can help us monitor the effects of our health choices on how fast or slow we age.
  2. If biological aging clocks are inaccurate, they can potentially misinform us and lead to unnecessary worry or misguided actions.
  3. Understanding the effectiveness and reliability of biological aging clocks is crucial to prevent irreversible health damage and take proactive steps to reverse any harm.

Anna Savina: Erik Davis on Longevity as a Spiritual Pursuit

Do Not Research • 339 implied HN points • 25 Mar 24
🕹 Technology AI Longevity Religion Transhumanism Future implications
  1. Tech millionaires' interest in longevity is tied to libertarianism, radical views on overcoming limits, and control through technology.
  2. There is a connection between religion and the scientific pursuit of longevity, with religious longings affecting secular viewpoints.
  3. The transhumanist movement embraces the unnatural and questions conventional human limitations, leading to an 'uncanny valley' where prolonging life can feel repulsive.

Unlocking the Power of Longevity

Harnessing the Power of Nutrients • 619 implied HN points • 15 Nov 23
🏥 Health & Wellness Longevity Nutrition Diet Health
  1. Longevity studies often rely on questionable animal models like worms and jellyfish to draw conclusions, but humans have specific causes of death.
  2. Rather than searching for a universal principle of aging, focusing on preventing the actual causes of death can contribute to a longer and healthier life.
  3. Nutrition played a major role in battling diseases before antibiotics, and prioritizing it over disease-specific pharmaceuticals can be a key to longevity.

The 3 things Bryan Johnson is missing from his longevity routine.

Harnessing the Power of Nutrients • 499 implied HN points • 17 Dec 23
🏥 Health & Wellness Longevity Anti-aging Self-experimentation Healthy Lifestyle
  1. Bryan Johnson is dedicated to finding anti-aging strategies and sharing them with the world, even if his methods are extreme.
  2. It's important to seek high-impact actions that can improve longevity without sacrificing important aspects of life like relationships, enjoyment, and financial freedom.
  3. Taking steps to optimize health and longevity sooner rather than later is crucial, as aging processes can accelerate and become irreversible if left unaddressed.

Nutrition & Health News This Week

Unsettled Science • 772 implied HN points • 15 Mar 24
🏥 Health & Wellness Nutrition Dietary Guidelines Obesity Longevity
  1. Harvard longevity expert David Sinclair faced challenges in his career due to questions about the science behind his longevity claims for resveratrol, affecting his reputation and leading to his resignation.
  2. Recent dietary guidelines in Germany emphasizing less meat and dairy in favor of grains and vegetables have raised concerns among experts, including questioning the soundness of these plant-based recommendations.
  3. A study using data from the influential Nurses Health Study at Harvard School of Public Health revealed that even those who followed U.S. dietary guidelines on fat consumption still gained weight, shedding doubt on the effectiveness of these dietary recommendations.

My White Whale

Eat Shit and Prosper • 359 implied HN points • 06 Oct 23
🔬 Science Microbiology Health Longevity Nutrition Research
  1. Centenarians tend to have unique gut bacteria that could be linked to their long lives. This suggests that what we have in our gut might play a big role in our health.
  2. Certain types of bacteria, particularly a genus called Bacteroides, are important for a strong immune system and may help fight cancer.
  3. One surprising finding is that a specific bacterium called Epulopiscium is found more often in the guts of centenarians, hinting it could be connected to their longevity.

The Next, Episode #47

The Next Brand • 255 implied HN points • 08 Oct 23
🏥 Health & Wellness Longevity Mental health Physical health
  1. Blue Zones may not hold all the secrets to longevity, but they highlight the importance of organic food, community, and lifestyle factors in promoting health.
  2. Be cautious of weight loss drugs like Ozempic due to potential serious side effects, and consider the broader impact of medicating issues caused by environment and food.
  3. Support initiatives like the PRIME Act to promote local food systems by enabling farmers to access more affordable butchering options.

Questions on Protein and Longevity, SHBG, and Trouble Hydrating

Harnessing the Power of Nutrients • 519 implied HN points • 23 Aug 22
🏥 Health & Wellness Longevity Hydration Nutrition Physiology Membership
  1. Cycling between fasting and feeding states may provide benefits similar to protein or calorie restriction for longevity.
  2. Several factors like vitamin K2, insulin sensitivity, thyroid hormone, and fasting physiology influence levels of SHBG.
  3. When salted water doesn't hydrate as effectively as an IV, it might be due to poor salt absorption, which could be helped by consuming glucose, starch, or a meal alongside.

When We Live Beyond 200 Years Old

The Digital Anthropologist • 19 implied HN points • 20 Jun 24
🔬 Science Longevity Culture Technology Ethics
  1. Living beyond 200 years poses challenges to existing societal and cultural norms, requiring rethinking of values, education, and social contracts.
  2. Extending human lifespan will impact economic systems, education models, and the concept of identity over a significantly longer period.
  3. Advancements in technology enabling longer lifespans raise questions about governance, immigration, national identity, and the adaptation of sociocultural systems.

Why Shorter People Live Longer (and How Muscle Changes the Game)

Neuro Athletics • 17 implied HN points • 04 Feb 25
🏥 Health & Wellness Aging Fitness Nutrition Longevity Strength Training
  1. Studies show that shorter people tend to live longer because they have lower levels of growth hormones that speed up aging.
  2. Keeping muscle mass is super important for living a long and healthy life, especially for women aged 45-55, but many are told to prioritize cardio instead of strength training.
  3. To age well, it's important to balance protein intake, resistance training, and fasting rather than simply cutting down on protein and exercise.

Ancestral Health vs. Antagonistic Pleiotropy?

Harnessing the Power of Nutrients • 319 implied HN points • 23 Jun 22
🏥 Health & Wellness Nutrition Longevity Evolution Diet
  1. Underestimating the influence of natural selection in promoting longevity in later ages over an extensive period of evolutionary time.
  2. Misconception that adaptations to foods being antagonistically pleiotropic implies the foods themselves are more likely to hurt longevity.
  3. Conflating genetic adaptations to foods with the foods themselves, leading to a faulty conclusion that artificially manipulated foods are more likely to benefit longevity than ancestral foods.

How to Communicate Life Extension Effectively

Extropic Thoughts • 58 implied HN points • 03 Jul 23
🏥 Health & Wellness Longevity Persuasion Communication Meaning
  1. Communicating life extension effectively requires using ethos, pathos, and logos to support each other.
  2. When discussing life extension, emphasize the desire for life and all it can offer, rather than a fear of death.
  3. Be prepared to address common objections such as boredom, societal impact, entropy, and the idea that life extension is only for the rich.

5 ways to slow aging

10x your mind • 79 implied HN points • 13 Oct 22
🏥 Health & Wellness Aging Diet Exercise Longevity Lifestyle
  1. Slowing aging isn't just about increasing lifespan, it's also about improving healthspan.
  2. Skipping a meal randomly can help reduce calorie intake and potentially increase longevity.
  3. Adopting a Mediterranean diet, quitting added sugars, and making your home junk food free are beneficial for health and longevity.

Future of Gut Health and Longevity( Part 10/11)

Gutsphere - Your Ultimate Guide to Optimal Gut Health • 19 implied HN points • 01 Feb 24
🏥 Health & Wellness Gut Health Longevity Microbiome Research Disease Prevention
  1. Advancements in microbiome research have uncovered the importance of gut health in overall well-being and disease prevention.
  2. Personalized medicine based on individual microbiome profiles is a promising frontier that could revolutionize healthcare treatments.
  3. Microbiome-based therapies show potential in redefining treatment approaches for various diseases, particularly those common in aging populations.

Forward Motion

We're Gonna Get Those Bastards • 8 implied HN points • 29 Dec 24
🏥 Health & Wellness Mental health Longevity Personal Growth Creativity Retirement
  1. To keep living fully, it's important to keep creating and challenging yourself. Whether it's a new project, learning a skill, or tackling a personal goal, ongoing motion is key.
  2. Staying mentally active and engaged can help with longevity. People who create and have a purpose tend to live longer and feel more fulfilled than those who don't.
  3. Don't waste time just waiting around or being passive. Use your time to work on things that matter to you, because time is precious and shouldn't just be 'killed.'

Chapter 27: 10 Commandments of Health for Longevity and Healthy Aging.

Spyderdoc Newsletter • 9 implied HN points • 22 Dec 24
🏥 Health & Wellness Longevity Nutrition Exercise Mental health Preventive Care
  1. Regularly check important health markers like blood pressure and cholesterol. This helps you keep track of your health and catch any problems early.
  2. Manage stress through activities like meditation and hobbies. Reducing stress can improve your overall well-being.
  3. Stay active with exercise and maintain a balanced diet. Moving your body and eating healthy foods are key to living a long life.