The hottest Biotech Substack posts right now

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Comments On "An Illumina Sequencer in 2000"

ASeq Newsletter • 21 implied HN points • 21 Feb 24
🕹 Technology Innovation Biotech Startups Sequencing Acquisition
  1. The acquisition of Solexa by Illumina involved strategic financial decisions and a combination of technology strengths to create a successful sequencing platform.
  2. There were missed opportunities and challenges due to financial constraints and differing viewpoints among key players in the sequencing technology industry.
  3. The early 2000s marked a period of significant innovation and the emergence of next-generation sequencing technologies, with various companies maneuvering to establish themselves in the market.

Oxford Nanopore

axialdaily • 19 implied HN points • 17 Mar 23
🕹 Technology Biotech Genomics Startups Innovation
  1. Oxford Nanopore sequences DNA with a nanopore technology.
  2. ONT has made advancements in base-calling and chemistry for improved accuracy.
  3. The company has created a new genomics category and is exploring various applications beyond COVID surveillance.

Digest 5/26/23

axialdaily • 19 implied HN points • 26 May 23
💼 Business Investing Biotech Innovation Research
  1. Axial partners with inventors and founders in early-stage life sciences companies.
  2. Carbon Biosciences is focused on expanding the gene therapy toolbox, especially for cystic fibrosis.
  3. Scientist David Schaffer focuses on evolving next-gen AAV vectors for gene therapy.
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Structure Therapeutics in the spotlight

Boutique Biotech • 19 implied HN points • 29 Sep 23
🔬 Science Pharmaceuticals Biotech
  1. Structure Therapeutics' GPCR showed significant weight reduction in overweight patients with their oral GLP-1 receptor agonist GSBR-1290.
  2. The once-a-day pill resulted in 4.8kg weight loss, approximately 5.4% at the highest dose after 28 days.
  3. The data from Structure Therapeutics' Phase 1b study is compared with other oral medications for obesity in the same field.

Singular Spatial Sequencing

ASeq Newsletter • 14 implied HN points • 06 Feb 24
🕹 Technology Innovation Startups Biotech
  1. Singular Genomics announced a new spatial instrument called G4X for spatial analysis via in situ sequencing using RNA templates.
  2. The G4X technology is similar to 10X Xenium but appears more limited in terms of addressable targets per cell compared to Xenium.
  3. There are concerns about potential patent issues with 10X's spatial patents and ReadCoor IP, raising commercial uncertainties despite the neat research and technology aspects.

Digest 5/29/23

Axial • 29 implied HN points • 29 May 23
💼 Business Startups Investing Biotech Healthcare
  1. Axial invests in early-stage life sciences companies with great ideas
  2. Matchpoint Therapeutics focuses on developing new covalent inhibitors for immunology
  3. Founder Stories feature individuals like Özlem Türeci, highlighting the importance of balancing naivety and questioning in entrepreneurship

Unpaywalled: Globo Homo Economicus

Reactionary Feminist • 3 implied HN points • 25 Oct 24
🎭️ Culture Ideology Transhumanism Demographics Biotech Philosophy
  1. Replacism is an ideology that looks beyond just changes in demographics. It also connects to broader ideas like transhumanism and biotechnology.
  2. Renaud Camus has a significant viewpoint on the concept of replacism, suggesting it impacts our understanding of identity and existence.
  3. The discussion around replacism invites people to think about how technology and society might change our bodies and identities in the future.

Who's Who in A.I.

Gradient Ascendant • 18 implied HN points • 01 Mar 23
🕹 Technology AI Tech Giants Startups Academia Biotech China
  1. OpenAI is a major player in the AI industry, led by controversial figures like Elon Musk.
  2. Microsoft has made a comeback in the AI field through partnerships and investments, notably with OpenAI.
  3. An increasingly vibrant AI ecosystem is emerging with startups, enthusiasts, and established companies all contributing to the field.

Biotech Basics: Avoiding Common Pitfalls

Boutique Biotech • 0 implied HN points • 15 Jun 23
💰 Finance Biotech Investing
  1. Biotech stock trading down after announcing 'successful results' could indicate data not being truly successful.
  2. Companies may highlight cherry-picked positive results, while the overall study did not meet expectations.
  3. It's important to be cautious when biotech companies start discussing specific parts of their studies.

💥New Chapter 11 Bankruptcy - NanoString Technologies Inc. ($NSTG)💥

PETITION • 0 implied HN points • 11 Feb 24
💰 Finance Bankruptcy Biotech Legal
  1. NanoString Technologies Inc. filed for Chapter 11 bankruptcy due to patent litigation, seeking a buyer.
  2. NanoString is a biotech company supplying technologies for analyzing biological samples in pharmaceutical product development.
  3. NanoString has a significant customer base including academic and government research facilities, biopharma companies, and clinical laboratories.

Y-Combinator’s 2024 RFS - Analyzing the Fastest Growing Companies Across Ep 2

Golden Pineapple • 0 implied HN points • 29 Feb 24
💼 Business Manufacturing Biotech
  1. A top priority across various sectors is bringing manufacturing back to America, with bipartisan support and significant government investments.
  2. SpaceX has shown the effectiveness of private space companies, with companies like Anduril proving the same in the defense technology sector.
  3. Foundational models for biological systems and stablecoin finance are seeing significant growth, with companies like Science and Ava Labs leading the way.