The hottest Chemistry Substack posts right now

Natural compounds from nature are a valuable source for potential new drugs.
Graph neural networks are used to predict mass spectra from molecular structure in a novel way.
The graph neural network approach provides a promising path for computational drug discovery advancements.

Computer-augmented hypothesis generation is a promising concept that can help uncover new and valuable ideas from existing data.
Looking at old research in a new light can lead to significant breakthroughs, as seen with Don Swanson's and Sharpless' work in different fields.
Tools like LLMs can assist researchers in finding connections between disparate data points, potentially unlocking new avenues for scientific discovery.

Earth's hot center and thin temperate surface skin are crucial for life to thrive
Silicate rock layer beneath Earth's surface allows for movement creating a dynamic planet
Earth's balanced amount of water allows for life on land without overwhelming it

2C-B is a psychedelic compound created by Sasha Shulgin.
2C-B has a unique 'in the body' high and is relatively short-acting.
Shulgin highlighted 2C-B as one of the key phenethylamines with profound effects.

By 2050, half of consumer packaged goods will be made sustainably with biology.
Production of products from crude oil may have environmental drawbacks.
Using biology in production can lead to more sustainable and resilient supply chains.

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Isotopes are atoms with different numbers of neutrons, which can affect their stability and behavior.
Different isotopes have varying half-lives and can be used for dating materials, such as carbon-14 for archaeological purposes.
Studying isotopes like uranium has practical applications and helps in understanding Earth's history and the origins of life.

Topsoil carbon is a major contributor to the rise in atmospheric carbon dioxide.
Fossil fuels directly contribute 12% of atmospheric carbon dioxide, despite a drop in use during economic lockdowns.
Capturing waste output from smokestacks and using it for plant growth can help mitigate carbon emissions.

Cats are evolutionarily perfect due to their extreme specialization for hunting.
Data visualization can lead to cognitive errors and should be carefully considered.
Polygenic risk scores have marginal benefits in disease screening and may not be effective for population-wide risk stratification.

The second volume of 'The Great Mental Models' explores physics, chemistry, and biology, offering practical and timeless concepts that can improve our thinking.
The second book maintains the high quality aesthetic of the first volume but feels more practical and grounded in the laws of nature.
Exploring concepts from various scientific branches, such as those presented in the book, supports multidisciplinary thinking, helping us solve problems better and avoid repeating mistakes.

Enzymes play crucial roles in converting sugar into energy
Hexokinase, Phosphoglucose isomerase, and Phosphofructokinase-1 are key enzymes in the process
The glycolysis pathway involves multiple steps and enzymes to produce ATP