The hottest Cancer Substack posts right now

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Genetic Certainty and Mechanistic Ambiguity

Holodoxa • 99 implied HN points • 09 Dec 23
🔬 Science Genetics Cancer Biology Research Health
  1. Genetic information is essential for understanding diseases, but it is just the beginning - further research is needed to unravel how genetic errors impact proteins and disease mechanisms.
  2. Studying cancer syndromes can provide insights into tumor suppressor genes and the genetic risks associated with cancer development.
  3. The discovery of the VHL gene linked to von Hippel-Lindau disease illustrates the complexity of disease mechanisms, such as how disruption of a ubiquitin ligase can lead to cancer and the tissue-specific patterns of risk in affected individuals.

The Tumor Suppressor to Rule Them All

Holodoxa • 119 implied HN points • 03 Nov 23
🏥 Health & Wellness Cancer Genetics Research
  1. TP53, known as the 'Guardian of the Genome,' is a crucial tumor suppressor gene frequently mutated in cancer and associated with poor prognosis.
  2. Research on TP53 and Li-Fraumeni Syndrome highlights the high cancer risk and early onset of cancers in individuals with TP53 mutations, emphasizing the need for surveillance and preventive measures.
  3. _TP53_'s intricate structure and functions, such as its role in the DNA damage response, make it a central player in cellular processes related to stress and aging.

Some Switches Can't Be Unflipped (But We Can Cut the Power)

Holodoxa • 79 implied HN points • 26 Dec 23
🔬 Science Genetics Cancer Pharmacology Thyroid
  1. In hereditary cancer, mutations in tumor suppressor genes are more common than in oncogenes, and a second hit is often required for cancer to develop.
  2. The RET gene, an oncogene, is associated with Multiple Endocrine Neoplasia Type 2 (MEN2) and can lead to various clinical conditions depending on the mutation type.
  3. Mutations in oncogenes like RET can be targeted with drugs, leading to effective treatments for cancers like medullary thyroid cancer, showing the clinical impact of genetic research beyond diagnosis.

Introducing Cancer Genomes

Holodoxa • 119 implied HN points • 10 Aug 23
🔬 Science Genomics Cancer Biology Genetics
  1. The new channel 'Cancer Genomes' on Holodoxa will explore topics like hereditary cancer syndromes and precision oncology.
  2. The author aims to make the complex subject matter accessible to readers with a high school level understanding of biology.
  3. Aside from cancer genomics, the author's Holodoxa channel covers various other science topics like genetics and social outcomes.
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From Clinic to Genome and Back Again: Cowden Syndrome and PTEN

Holodoxa • 119 implied HN points • 17 Aug 23
🏥 Health & Wellness Genetics Cancer Research Diagnosis
  1. Cowden Syndrome, first described in 1963, was named after the patient Rachel Cowden and later found to be associated with the PTEN gene.
  2. The PTEN gene was identified as a tumor suppressor gene responsible for Cowden Syndrome, leading to advancements in genetic diagnosis and personalized medical care.
  3. Cowden Syndrome shows clinical and genetic heterogeneity, with other genes like PIK3CA and AKT1 also implicated, leading to the classification of PTEN Hamartoma Tumor Syndrome for better diagnosis.

Understanding Variation in PTEN

Holodoxa • 99 implied HN points • 07 Sep 23
🔬 Science Genetics Research Data Analysis Cancer
  1. Understanding genomic data variation and its effect is a significant challenge in genetic research.
  2. Deep Mutational Scanning (DMS) and Multiplex Assays of Variant Effects (MAVEs) are crucial methods to study how mutations impact protein function.
  3. MAVE data on PTEN has provided insights into its function, stability, and clinical implications, aiding in the understanding of PTEN variation.

Circling the LNT Wagons

Gordian Knot News • 205 implied HN points • 26 Aug 23
🔬 Science Radiation Health Studies Cancer
  1. The Linear No-Threshold theory (LNT) in radiation protection is being challenged due to its assumption that harm is solely based on cumulative dose, ignoring dose rate and repair ability.
  2. Studies on nuclear workers show limitations as they only focus on cumulative doses and do not consider variations in dose rates, which are crucial for understanding radiation harm.
  3. The INWORKS study, which supports LNT, has faced criticism for excluding certain data, lacking dose rate information, and not making data available, raising questions about its scientific validity.

FFS (For Frizz's Sake)

Ladyparts • 239 implied HN points • 21 Oct 22
🏥 Health & Wellness Cancer
  1. Chemical hair straighteners are linked to uterine cancer, especially affecting Black women.
  2. Black women have been found to have twice the incidence of uterine cancer compared to white women.
  3. Consider the potential health risks when using chemical hair straighteners.

A Century-Long Saga of Familial Colorectal Cancer

Holodoxa • 79 implied HN points • 14 Nov 23
🏥 Health & Wellness Genetics Cancer Immunotherapy Prevention
  1. The study of Michigan and Nebraskan families led to the discovery of mutated mismatch repair genes causing hereditary colorectal cancers like Lynch syndrome.
  2. Mismatch repair genes play a crucial role in maintaining DNA integrity and preventing cancer development. Defects in these genes can lead to conditions like microsatellite instability.
  3. Individuals with Lynch syndrome have higher cancer risks associated with certain genes like MLH1 and MSH2, but a relatively good clinical outcome is observed with improved survival rates.

Playbook for stage xx cancer

Penelope Trunk's Substack • 39 implied HN points • 18 Feb 24
🏥 Health & Wellness Cancer
  1. Waiting for test results can be emotionally challenging and uncertain.
  2. Recognizing potential symptoms and risk factors of esophageal cancer can help with early detection and understanding.
  3. Dealing with the possibility of a serious illness can lead to a range of emotions and reactions, including finding solace in familiar habits or actions.

GMO bacteria to detect colorectal cancer?

Tessa Fights Robots • 23 implied HN points • 23 Feb 24
🏥 Health & Wellness Cancer Healthcare Technology
  1. Scientists are experimenting with genetically modified bacteria to detect cancerous DNA, particularly in colorectal cancer, by programming them to signal the uptake of cancerous DNA.
  2. The engineered bacteria, named CATCH, shows promise in detecting diseases like infections and cancers using cell-free DNA as input, but more refinement and safety evaluations are needed before clinical use.
  3. The goal is not just disease detection, but also pairing the detection with appropriate biological therapy, allowing for real-time response to diseases detected.

Understanding Cancer

Holodoxa • 39 implied HN points • 30 Oct 22
🏥 Health & Wellness Cancer Biology Research Education Book
  1. Robin Hesketh, a Cambridge biochemistry professor, has written a book, 'Understanding Cancer,' giving a concise primer on cancer for science undergrads or curious lay readers.
  2. The book emphasizes that cancer is a genetic disease and explains how somatic mutations accumulate over time, leading to uncontrolled cell proliferation and metastasis.
  3. While well-organized and informative, 'Understanding Cancer' may feel like a detailed outline rather than a narrative read, catering more to young biomedical science undergrads than casual readers.

Pathologist reports a stunning 52% increase in cancer risk for ages 15-59 who were vaxxed

Steve Kirsch's newsletter • 12 implied HN points • 05 Mar 24
🏥 Health Politics COVID-19 Vaccines Cancer Risk Research
  1. A pathologist in Croatia reported a 52% increase in cancer risk for ages 15-59 who were vaccinated.
  2. The study showed that vaccinated individuals had a higher risk of developing carcinomas compared to unvaccinated individuals.
  3. The pathologist does not recommend vaccinations and most people in Croatia are hesitant to get vaccinated despite medical recommendations.

Nyhetsbrev steigan.no 07.03.2024

steigan.no • 7 implied HN points • 07 Mar 24
🏥 Health & Wellness Cancer Vaccines Research Public Health
  1. Ukrainian special forces are reportedly fighting in the civil war in Sudan, raising questions about the motives and implications of their involvement.
  2. A Croatian pathologist discovered a 52% increase in carcinoma cancer cases among mRNA-vaccinated individuals aged 15-59, raising concerns about potential risks associated with COVID-19 vaccines.
  3. Financial aid provided to Ukraine seems to mostly benefit American defense manufacturers, raising suspicions of ulterior motives behind the aid package.

The Curious Case of Campbell’s Rats — Does Protein Deficiency Prevent Cancer?

Harnessing the Power of Nutrients • 0 implied HN points • 23 Sep 10
🏥 Health & Wellness Nutrition Cancer Prevention
  1. Exploring the relationship between protein deficiency and cancer prevention in Campbell's rats.
  2. Link to an article on the curious case of Campbell's rats and the potential impact of protein deficiency on cancer prevention.
  3. The blog post discusses the interesting topic of whether protein deficiency might play a role in preventing cancer.

Statins Inhibit Squalene Synthesis

Harnessing the Power of Nutrients • 0 implied HN points • 20 Dec 08
🏥 Health & Wellness Nutrition Detoxification Cancer Supplements
  1. Statins inhibit squalene synthesis by cutting off cholesterol synthesis prior to the formation of squalene, which is a cholesterol precursor.
  2. Squalene acts as an antioxidant, accumulating in the skin to prevent oxidative damage from UV light and has potential detoxifying effects.
  3. Squalene might have anti-cancer properties, preventing the initiation of some cancers and aiding in the regression of certain tumors.

The Cholesterol Times, Issue #007 -- Cancer: It's Not the Meat, But How You Cook It

Harnessing the Power of Nutrients • 0 implied HN points • 17 Oct 23
🏥 Health & Wellness Nutrition Diet Cancer Research
  1. The method of preparing and cooking meat can influence its association with cancer, rather than the type of meat itself.
  2. Studies associating dietary factors with pancreatic cancer have been inconsistent, sometimes wrongly attributing the association to fat, saturated fat, or cholesterol without proper justification.
  3. High-cholesterol, high-fat diet showed reduced inflammation in baboons, shedding light on the complexity of interpreting cholesterol levels in relation to heart disease.

Evidence For Vitamin K2

Harnessing the Power of Nutrients • 0 implied HN points • 28 Apr 13
🏥 Health & Wellness Heart Health Metabolic health Dental Health Cancer
  1. Vitamin K plays a crucial role in blood clotting, which is essential for preventing hemorrhages and supporting critical clotting factors in the body.
  2. Vitamin K is important for controlling calcium distribution in the body, promoting healthy bone mineralization, preventing calcification of soft tissues, like in the heart and blood vessels, and supporting growth.
  3. Having adequate levels of Vitamin K is crucial for heart health, bone health, dental health, kidney health, and even may play a role in metabolic health, hormonal health, and cancer prevention.

The Hidden Truth About Cholesterol-Lowering Drugs

Harnessing the Power of Nutrients • 0 implied HN points • 02 Mar 09
🏥 Health & Wellness Cholesterol Heart Disease Cancer Lifestyle changes
  1. The huge profits from cholesterol-lowering drugs drive the production of these medications, as well as the official government recommendations regarding cholesterol and statins.
  2. The myth that lowering LDL cholesterol with statins will protect against disease is not supported by evidence showing cholesterol levels do not always correlate with atherosclerosis.
  3. High cholesterol has been consistently linked to lower mortality in various studies, challenging the prevailing belief that low cholesterol levels are always beneficial.